CN103892028B - Chewing gum capable of resisting oral helicobacter pylori, and preparation method thereof - Google Patents
Chewing gum capable of resisting oral helicobacter pylori, and preparation method thereof Download PDFInfo
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- CN103892028B CN103892028B CN201410168319.5A CN201410168319A CN103892028B CN 103892028 B CN103892028 B CN 103892028B CN 201410168319 A CN201410168319 A CN 201410168319A CN 103892028 B CN103892028 B CN 103892028B
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Abstract
The invention belongs to a chewing gum, and relates to a chewing gum capable of resisting oral helicobacter pylori (HP), and a preparation method of the chewing gum, aiming at overcoming the defects that in the prior art, the HP is treated by a large dose of antibiotic, so that a great deal of beneficial bacteria can be killed, and the drug resistance of the HP can be improved. The chewing gum comprises the following components in parts by weight: 1-2 parts of wild buckwheat glycoside, 0.005-0.015 part of total matrines, 0.1-0.6 part of forsythiaside, 0.1-0.5 part of glycyrrhizin, 0.5-1.5 parts of tea polyphenol, 3-6 parts of milk protein, 0.01-0.02 part of phytic acid lanthanum bismuth, 0.01-0.004 part of enzymic preparation, 20-22 parts of gum base, 34-34.88 parts of sorbitol, 12 parts of 75% hydrogenated starch hydrolysate, 16-18 parts of xylitol, 2.5-3.5 parts of glycerinum and 2.5-3.5 parts of menthol. The chewing gum has the advantages of being capable of effectively killing the oral HP and cariogenic bacteria and preventing dental caries, and being convenient to take.
Description
Technical field
The invention belongs to a kind of chewing gum, specifically anti-oral helicobacter pylori chewing gum and preparation method.
Background technology
Helicobacter pylori is called for short HP, is the infectious disease that a kind of per os is propagated.Oral cavity HP is the important depots that stomach HP infects.Helicobacter pylori is classified as the first kind carcinogen bringing out cancer of the stomach by World Health Organization WHO.In China's patients with gastric cancer, the recall rate of helicobacter pylori is 80%; In chronic active gastritis patient, recall rate is 95% to 100%; In duodenal ulcer patients, recall rate is 85% to 95%; In patients w ith peptic ulcer disease, recall rate is 70% to 80%.Within 1989, first Australian scholar Krajden detects HP in the bacterial plaque of Gastritis Buccodental, and confirms that it is identical with HP in stomach from molecular level, proves that oral cavity Hp is the important depots of stomach Hp.The infringement of helicobacter pylori to health is great: helicobacter pylori is 50%-70% at the infection rate of China.The World Health Organization adds up, and the number of gastrointestinal disease is died from every year more than 1,000 ten thousand in the whole world, startling to the threat of the mankind.Within 2005, Nobel prize's soul authorizes Australian Scientists Barry Marshall and Luo Bin Warren, commends the bacterium Helicobacter pylori that they have found to cause gastritis, gastric ulcer and cancer of the stomach.
Prior art is by taking the antibiotic therapy helicobacter pylori of multiple heavy dose, and its shortcoming is: kill a large amount of beneficial bacterium; Add the resistance to the action of a drug of helicobacter pylori, add treatment difficulty and medical treatment cost.
Domestic and foreign literature is reported, through epidemiology survey China less than 12 years old teenager HP infection rate up to 40%, adult HP infection rate reaches more than 60%.Carious tooth is classified as and tumour, disease that the large harm humans of angiocardiopathy arranged side by side three is the most serious by WHO, and China's less than 12 years old teenager's caries incidence is up to 80%.HP and cariogenic bacteria belong to microaerobion together, and the two complements each other, and bacterium collection adheres on the plaque, have generality and disguise, the family of falling ill and the aggregation of infection, have high infection rate in the whole world and China.
Chewing gum is extensively eaten by people, is especially subject to teen-agely liking, chewing gum has and keeps oral cavity delicate fragrance, tempers the effect of facial muscles.Prior art adds antibiotics in chewing gum, adds the resistance to the action of a drug of helicobacter pylori, for treatment adds difficulty, adds medical treatment cost.
The Chinese medicine material with sterilizing function combines with chewing gum by the present invention, and chew time is long in the oral cavity to make full use of chewing gum, and drug absorption is effective, kills oral cavity HP and cariogenic bacteria feature thoroughly, and helicobacter pylori can not be made to develop immunity to drugs.The present invention has maintenance oral cavity delicate fragrance, tempers facial muscles, kills oral cavity HP and thorough, the widely used advantage of cariogenic bacteria.
Summary of the invention
The object of the invention is to provide one to be had and keeps oral cavity delicate fragrance, tempers facial muscles, kills oral cavity HP and thorough, the widely used anti-oral helicobacter pylori chewing gum of cariogenic bacteria and preparation method.
The present invention seeks to realize like this:
A chewing gum for anti-oral helicobacter pylori, weight ratio ingredient is as follows:
The preparation method of the chewing gum of anti-oral helicobacter pylori, step is as follows:
(1) matrix is inserted kneading machine kneading 1 ~ 2 minute;
(2) each for remainder raw material is added in step (1) product;
(3) by step (2) product kneading 15 ~ 2 minutes in kneading machine, kneading temperature 45 C;
(4) step (3) product is taken out from kneading machine to put into extruder extruded;
(5) by step (3) product slice packaging.
Main points of the present invention are:
By monarch drug in a prescription RHIZOMA FAGOPYRI CYMOSI glucoside, ministerial drug Banlangen, Forsythoside, Tea Polyphenols, adjutant glycyrrhizin, cow's milk protein, Phytic acid lanthanum bismuth, enzyme preparation, join in chewing-gum material matrix, D-sorbite, 75% hydrogenated starch hydrolysate, xylitol, glycerine, menthol, through kneading, the extruded chewing gum making anti-oral helicobacter pylori.
Monarch drug in a prescription RHIZOMA FAGOPYRI CYMOSI glucoside of the present invention is the rhizome extract of polygonaceae plant RHIZOMA FAGOPYRI CYMOSI, generates p-Coumaric Acid, forulic acid and glucose, dimercyanidin (dimeric procyanidin) after the basic hydrolysis of RHIZOMA FAGOPYRI CYMOSI glucoside.Cool in nature, puckery, micro-pungent, there is effect of heat-clearing, sterilization, removing toxic substances, clearing lung-heat expectoration, apocenosis detumescence, dampness elimination of dispeling the wind.For lung abscess, abscess of throat, dysentery, nameless sores or boils, traumatic injury, rheumatic arthritis.
Ministerial drug Banlangen of the present invention has the infection such as heat-clearing and damp-drying drug, desinsection, diuresis, anti-arrhythmia, antiviral, anticancer, anti-shigella dysenteriae, dermatophyte, Amoeba, has increasing leukocyte number, improves the effect of immunity of organisms.
Ministerial drug Forsythoside of the present invention, comprises forsythiaside A, molecular formula C
29h
36o
15; Molecular weight 624.59; Capsule of weeping forsythia fat glycosides B, molecular formula: C
34h
44o
19, molecular weight: 756.7.The dry fruit extract of this Rhinocerotidae plant capsule of weeping forsythia.Outward appearance: white crystalline powder.There is antibacterial, anti-inflammatory, antipyretic, treatment anemopyretic cold, carbuncle sore tumefacting virus, scrofula, urinary tract infections.
Ministerial drug Tea Polyphenols of the present invention, English name: Tea Polyphenols; Have another name called: tea tannin, tea tannin, molecular formula C
17h
19n
3O, molecular weight 281.36.Tea Polyphenols is the Main Ingredients and Appearance forming tealeaves color, is the Main Ingredients and Appearance that tealeaves has health care.Tea Polyphenols is the general name of Polyphenols of Tea, comprises flavanol compound, anthocyanin class, flavonoids, flavonols and phenolic acid class etc., wherein important with flavanol compound material catechin.The minimizing that Tea Polyphenols can suppress human body calcareous, caries prevention effectively, has the effect of protecting tooth, hard tooth.The compositions such as the vitamin C simultaneously in tealeaves, can reduce eyes lens opacity degree, all have effect to minimizing eye illness, eyeshield improving eyesight.The removing toxic substances of Tea Polyphenols tool and radiation resistance, can effectively stop radioactive substance to invade, make it excrete rapidly.The present invention is ministerial drug with Tea Polyphenols, play take care of one's teeth, the effect of caries prevention.
Adjutant glycyrrhizin of the present invention, cow's milk protein, enzyme preparation, in order to eliminate or to slow down the mouthfeel of monarch drug in a prescription, ministerial drug.
Matrix is a kind of without nutrition, indigestion and water-fast easy chewiness solid.For carrying sweetener and other compositions in chewing gum is produced, be the most substantially in chewing gum chew material.The matrix used in the present invention is the raw material used during existing chewing gum is produced.
In the present invention, other raw material is raw material conventional in prior art.
In formula, RHIZOMA FAGOPYRI CYMOSI glucoside, Banlangen, Forsythoside, Tea Polyphenols, glycyrrhizin are bactericide, have the function suppressing and kill HP and cariogenic bacteria.Phytic acid lanthanum bismuth and enzyme preparation are that bacterial plaque suppresses and cleaning agent, can reduce sticking and assembling of bacterium.Lactoferrin has anticancer, antimicrobial, anti-oxidant, to improve immunity effect.D-sorbite, xylitol, menthol, glycerine are raw material conventional during existing chewing gum is produced, and have the effect regulating mouthfeel.75% hydrogenated starch hydrolysate is forming agent.The result of said components comprehensive function, makes the existing function killing oral helicobacter pylori and other bacterium of chewing gum, have again keep oral cavity delicate fragrance, function, achieve object of the present invention.
Method for preparing chewing gum of the present invention is simple: matrix is inserted kneading machine kneading 1 ~ 2 minute; All the other each raw materials are added in kneading machine matrix; Kneading 15 ~ 2 minutes in kneading machine, kneading temperature 45 C; Then micelle is taken out from kneading machine that to put into extruder extruded; Slice packaging is made.
Formula also slightly can adjust and make lozenge and keep in the mouth by the present invention, reaches the object killing oral helicobacter pylori and other bacterium equally.Described for formula raw material is slightly adjusted, fully granulates after mixing, dry under 55 ~ 65 DEG C of conditions, water content is reduced to 2% ~ 4%; By obtained granular flavored; Add dolomol and superfine silica gel powder again, mix rear compressing tablet, make buccal tablet.The present invention can also adjust formula, remove matrix, makes the oral cavity sugar that can swallow.Reach the effect killing oral helicobacter pylori and other bacterium equally.
Product instructions of taking of the present invention is simple, often takes product of the present invention, and to the disease of preventing teenager's carious tooth and helicobacter pylori infections, effect is very remarkable.Chewing gum or lozenge everyone every day two to four, after taking one month continuously, turning negative of oral cavity HP reaches more than 90%.
Advantage of the present invention is:
1. good absorbing effect, has significant killing action to the HP bacterium in oral cavity.
2. effectively suppress and remove bacterial plaque, reducing bacterial adhesion and gathering, kill cariogenic bacteria, caries prevention.
3. taking convenience of the present invention, all kinds of crowd can take.
Detailed description of the invention
Below by detailed description of the invention, the present invention will be further described.
Embodiment 1: prepare anti-oral cavity HP chewing gum:
Get RHIZOMA FAGOPYRI CYMOSI glucoside 2 kilograms, Banlangen 0.01 kilogram, forsythiaside A and each 0.25 kilogram of capsule of weeping forsythia fat glycosides B, glycyrrhizin 0.3 kilogram, Tea Polyphenols 1 kilogram, cow's milk protein 5 kilograms, Phytic acid lanthanum bismuth 0.01 kilogram, enzyme preparation 0.004 kilogram, matrix 22 kilograms, D-sorbite 34.88 kilograms, 75% hydrogenated starch hydrolysate 12 kilograms, xylitol 18 kilograms, glycerine 3 kilograms, menthol 3 kilograms is for subsequent use.
Preparation method is: first inserted in kneading machine after kneading 1 ~ 2min by matrix, then adds above-mentioned each raw material successively, and abundant kneading makes agglomerate homogenising, temperature 45 C; The agglomerate taking out kneading puts into extruder, and 15 ~ 20min is extruded.
The anti-oral cavity HP chewing gum of preparation, everyone every day of being grown up, turning negative of oral cavity HP reached more than 90% containing taking 2 ~ 3, after taking one month continuously; Without cariogenic bacteria.
Embodiment 2: the buccal tablet preparing anti-oral cavity HP:
Get RHIZOMA FAGOPYRI CYMOSI glucoside 2 kilograms, Banlangen 0.01 kilogram, glycyrrhizin 0.3 kilogram, Tea Polyphenols 1 kilogram, Forsythoside 0.01 kilogram, cow's milk protein 5 kilograms, Phytic acid lanthanum bismuth 0.01 kilogram, enzyme preparation 0.004 kilogram, menthol 2.8 kilograms, sucrose 25 kilograms, starch 5 kilograms, maltodextrin 15 kilograms, 45 kilograms, sweet mellow wine, dolomol 0.01 kilogram; Superfine silica gel powder 0.02 kilogram is for subsequent use.
Sweet mellow wine is added and sucrose, starch fully mix in the raw materials such as RHIZOMA FAGOPYRI CYMOSI glucoside, Banlangen, Tea Polyphenols, Forsythoside, glycyrrhizin, cow's milk protein, Phytic acid lanthanum bismuth, enzyme preparation, menthol; Again compound is mixed with ethanol, then granulate, dry under 55 ~ 65 DEG C of conditions, make water content reduce to 2% ~ 4%, obtained particle, then routinely technology perfuming, add dolomol and superfine silica gel powder, after mixing, carry out compressing tablet, every sheet 1 gram, obtained buccal tablet.
Less than 14 years old children everyone every days, everyone every day of being grown up, after taking one month continuously, turning negative of oral cavity HP reached more than 90% containing taking four containing taking two; Without cariogenic bacteria.
Above-described embodiment is only preference of the present invention, is not used for limiting the present invention, and all within principle of the present invention, any modifications and variations done, all within protection scope of the present invention.
Claims (2)
1. a chewing gum for anti-oral helicobacter pylori, weight ratio ingredient is as follows:
RHIZOMA FAGOPYRI CYMOSI glucoside 1 ~ 2 weight portion Banlangen 0.005 ~ 0.015 weight portion
Forsythoside 0.1 ~ 0.6 weight portion glycyrrhizin 0.1 ~ 0.5 weight portion
Tea Polyphenols 0.5 ~ 1.5 weight portion cow's milk protein 3 ~ 6 weight portion
Phytic acid lanthanum bismuth 0.01 ~ 0.02 weight portion enzyme preparation 0.01 ~ 0.004 weight portion
Matrix 20 ~ 22 weight portion D-sorbite 34 ~ 34.88 weight portion
75% hydrogenated starch hydrolysate 12 weight portion xylitol 16 ~ 18 weight portion
Glycerine 2.5 ~ 3.5 weight portion menthol 2.5 ~ 3.5 weight portion.
2. the method for preparing chewing gum of anti-oral helicobacter pylori according to claim 1 is as follows:
(1) matrix is inserted kneading machine kneading 1 ~ 2 minute;
(2) each for the remainder described in claim 1 except matrix raw material is added in step (1) product;
(3) by step (2) product kneading 15 ~ 2 minutes in kneading machine, kneading temperature 45 C;
(4) step (3) product is taken out from kneading machine to put into extruder extruded;
(5) by step (3) product slice packaging.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410168319.5A CN103892028B (en) | 2014-04-24 | 2014-04-24 | Chewing gum capable of resisting oral helicobacter pylori, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410168319.5A CN103892028B (en) | 2014-04-24 | 2014-04-24 | Chewing gum capable of resisting oral helicobacter pylori, and preparation method thereof |
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| CN103892028A CN103892028A (en) | 2014-07-02 |
| CN103892028B true CN103892028B (en) | 2015-05-20 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012201B (en) * | 2015-08-17 | 2018-10-26 | 杭州华胄科技有限公司 | The oral care product with anti-helicobacter pylori of the alcohol extract containing Chinese hawthorn seed |
| CN106472800A (en) * | 2016-10-12 | 2017-03-08 | 肥西久盛食品有限公司 | A kind of deer's-tongue dish chewing gum for preventing and treating mouth disease |
| CN114748608A (en) * | 2020-12-25 | 2022-07-15 | 上海利康消毒高科技有限公司 | Bead chewing gum pill for resisting oral cavity helicobacter pylori explosion and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242703A (en) * | 1996-11-01 | 2000-01-26 | 约瑟曼实验室公司 | Chewing gum contg. colloidal bismuth subcitrate |
| CN1481897A (en) * | 2002-09-10 | 2004-03-17 | 上海高科生物工程有限公司 | Biotechnological formulation for suppressing and killing helicobacter pylori, its preparation and use |
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2014
- 2014-04-24 CN CN201410168319.5A patent/CN103892028B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242703A (en) * | 1996-11-01 | 2000-01-26 | 约瑟曼实验室公司 | Chewing gum contg. colloidal bismuth subcitrate |
| CN1481897A (en) * | 2002-09-10 | 2004-03-17 | 上海高科生物工程有限公司 | Biotechnological formulation for suppressing and killing helicobacter pylori, its preparation and use |
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