CN1663584A - Throat-moistening lozenge with pearl - Google Patents
Throat-moistening lozenge with pearl Download PDFInfo
- Publication number
- CN1663584A CN1663584A CN2004100167966A CN200410016796A CN1663584A CN 1663584 A CN1663584 A CN 1663584A CN 2004100167966 A CN2004100167966 A CN 2004100167966A CN 200410016796 A CN200410016796 A CN 200410016796A CN 1663584 A CN1663584 A CN 1663584A
- Authority
- CN
- China
- Prior art keywords
- parts
- margarita
- larynx moistening
- larynx
- sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a throat-moistening lozenge with pearl comprising the following raw materials (by weight portion), pearl 5-50 parts, India trumpetflower 5-50 parts, root of balloonflower 5-50 parts, ophiopogon root 5-30 parts, peppermint oil 1-50 parts, mentha-camphor 1-50 parts, sweetener 500-2000 parts, glue base 50-500 parts, edible emulsifying agent 1-10 parts, edible bulking agent 5-10 parts, and edible softening agent 0.5-5 parts.
Description
Technical field
What the present invention relates to is a kind of larynx moistening candy, particularly a kind of larynx moistening candy that contains Margarita, Semen Oroxyli, Radix Glycyrrhizae, Radix Platycodonis, Radix Ophiopogonis Chinese medicine ingredients.
Background technology
Margarita has another name called natural pearls, pearl inside the body of a freshwater mussel, always is regarded as rare dotey, still famous and precious simply simultaneously medical material, salty in the mouth cold in nature, nontoxic, go into conscience two warps, energy tranquilizing mind, yin nourishing relieve dizziness, high fever, infantile convulsions, epilepsy, etc., clear gesture is weighed down expectorant, removing nebula makes eye bright, removing toxic substances and promoting granulation, the clinical treatment that can be used for various disease conditions.Margarita mainly contains keratin, several amino acids, calcium carbonate, calcium phosphate, calcium silicates, and various trace elements such as silver, selenium, manganese, zinc, copper.In these compositions, there are many elements all to have the effect that strengthens metabolism, the antiinflammatory of reducing phlegm.History with Margarita treatment pharyngolaryngitis is of long duration, and mainly is to be used for the pharyngitis that causes because of pyretic toxicity, and as smoking or the overlong time of speaking causes does painfully, Margarita powder can play therapeutical effect by the heat clearing away tonifying YIN.In addition, for the oral erosion that chemotherapy causes, when adopting XILEI SAN, BINGPENG SAN poor effect, it is diffusing deposited to use Margarita powder instead, treats 20 examples, all cures.
Semen Oroxyli (having another name called Semen Oroxyli, Cordia dichotoma, seagoing vessel skin) is the dry mature seed of Bignoniaceae plant Semen Oroxyli.The traditional Chinese medical science thinks that Semen Oroxyli is distinguished the flavor of little sweet, bitter, cool in nature, goes into lung, Liver Channel, has the effect of removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.Be used for diseases such as pharyngolaryngitis, cough due to lung-heat, sore throat, hoarseness.
The tonic class of Glycyrrhiza Chinese medicine is the pulse family herbaceos perennial.Its root and stem, sexy flat, GUIXIN, lung, spleen, stomach warp mainly contain effects such as replenishing QI to invigorate the spleen, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mitigation property of medicine.Modern pharmacological research shows: Radix Glycyrrhizae contains glycyrrhizin, liquorice flavonoids compound Radix Glycyrrhizae two, liquiritigenin and Radix Asparagi phthalein amine, mannitol etc.And the chemical compound that extracts from Radix Glycyrrhizae--licoflavone has multiple efficacies in cosmetics.The first, it has the effect of antiinflammatory, antiallergic action, and this mainly comes from glycyrrhizic acid iridium--and glycyrrhizic acid and glycyrrhetate, can also suppress capillary permeability.The second, the effect of adrenocortical hormone sample, Radix Glycyrrhizae has sample effect of salt cortex sterol and the effect of glucocorticosteroid sterol sample.The principle of its hormone-like effect, someone thinks that the chemical constitution of enoxolone and adrenocortical hormone have similarity, be a kind of direct effect, but also the someone thinks indirect action, be that enoxolone has suppressed adrenal cortical steroid class destruction in vivo, thereby the corresponding increase of content in the blood.Simultaneously, licoflavone also has the restraint of tyrosinase activity, removes the oxygen order by base, and its oxidation resistance and vitamin E are more approaching.
Radix Platycodonis is the dry root of campanulaceae Platycodon grandiflouorum, has lung qi dispersing, and sore-throat relieving eliminates the phlegm, and effects such as evacuation of pus cure mainly cough ant phlegm, and is uncomfortable in chest not smooth, pharyngalgia, and hoarseness, lung abscess is spat, the skin infection difficulty in discharging of pus.Main pharmacological has: the expelling phlegm for arresting cough effect, and antiinflammatory action, antiinflammatory action suppresses gastric secretion and anti-gastric-ulcer, influences the enterokinesia that smooth muscle weakens mice, influences cardiovascular function, blood sugar lowering and influence the metabolism of cholesterol.
Have nourishing YIN and moistening the lung Radix Ophiopogonis, nourishing the lung to arrest cough, the relieving restlessness that clears away heart-fire, the reinforcing stomach reg fluid function, the impairment of the lung caused by overstrain chronic cough adds and is just protecting Radix Ophiopogonis, and utilization is quite extensive in Chinese medicine.
Hydroxyl isomaltulose (Isomalt) claims Palatinitol (Palatinito1) again, the external isomalt that claims, be to be that raw material generates isomaltulose through the effect of α-glycosyltransferase with sucrose, isomaltulose obtains through hydrogenation, its sugariness has only 0.5-0.6 times of sucrose, be natural plants sugar, sweet taste is pure, without any back bitterness effect.Hydroxyl isomaltulose is succeeded in developing by Germany at first, because its particular performances, just be subjected to extensive concern once coming out, particularly in recent years along with the concern of people to own health, the sales volume of hydroxyl isomaltulose rises at American-European and Japanese straight line, and the year sales volume in China had also reached several kilotons in recent years.Mainly produced in the past at this product of the whole world by Germany and Japanese two companies.
Hydroxyl isomaltulose is as a kind of good sweeting agent, can be applicable to confection, beverage, chocolate, chewing gum, ice cream, fruit jelly, fruit jam, cake, tablespread, mensal sweetening agent etc., it has following superior characteristic: 1. be fit to patients such as diabetes, hyperlipidemia and use; 2. the non-dental caries that causes; 3. hydroxyl isomaltulose is a kind of good bacillus bifidus multiplicaiton factor, though hydroxyl isomaltulose can not be utilized by the enzyme of human body and most microorganisms system, but can be by the utilization that bacillus bifidus decomposes in the human body intestinal canal, promote the growth and breeding of bacillus bifidus, keep the microecological balance of intestinal, help the health of human body; 4. sweet taste is pure natural; 5. property low in calories; 6. chemical property is stable; 7. height endurability; 8. non-hygroscopic.
The food service industry that is applied to hydroxyl isomaltulose adopts extruding and punch forming technology more, seldom adopts casting, no matter is extruding, punching press, the sugar surface is all coarse, poor, the appearance poor of brightness, its outward appearance is not attractive in appearance when entering commercial field, has a strong impact on image product, class and sale.Casting sugar surface is bright and clean, smooth, outward appearance is good.Hydroxyl isomaltulose is compared with other sugar and is fit to be applied to moulding by casting usefulness.Even hydroxyl isomaltulose is in very high temperature, as 150-200 ℃, as control other conditions well, can be not burned, and table sugar such as sucrose are not suitable at the hot conditions compacted under in just coking below 140 ℃.Help drying by the fire fast anhydrate branch and rapid shaping at the higher temperature compacted under, increase work efficiency, be convenient to industrialization.
In sum, Margarita mainly contains keratin, several amino acids, calcium carbonate, calcium phosphate, calcium silicates in the prescription, and various trace elements such as silver, selenium, manganese, zinc, copper.In these compositions, there are many elements all to have the effect that strengthens metabolism, the antiinflammatory of reducing phlegm.Radix Glycyrrhizae contains glycyrrhizic acid, enoxolone, has antiinflammatory, calmness, and detoxifcation is eliminated the phlegm, and antitussive is antibacterial, improves immunity function.The fatty oily glycoside of wood butterfly, baicaligenin, wooden butterfly glycoside A, wooden butterfly glycoside B, chrysin etc. have effects such as antitussive, antiinflammatory, analgesia.Radix Platycodonis contains multiple Saponins such as kikyosaponin, have eliminate the phlegm, antitussive, antiinflammatory, calmness, analgesia, refrigeration function.Contain the amide Radix Ophiopogonis Radix Ophiopogonis, have antitussive, eliminate the phlegm, bacteriostasis; Contain steroid saponins such as dwarf lilyturf glycoside first, second, third, fourth Radix Ophiopogonis, have calmness, antibacterial, improve immunity function.Full side has lung moistening, and sore-throat relieving protects effects such as throat.The sweeting agent hydroxyl isomaltulose has gentle sweet taste, good fragrance transmission, cariogenicity low in calories, non-, agent of low hygroscopicity, the solid preparation forming of making, hardness height, inlet is smooth, sweet taste is pure, mouthfeel good, the another one key property is that chemical property is stable, high temperature resistant, High Temperature High Pressure is removed moisture in vacuum sugar boiling, and raw material keeps primary characteristic, and it is few to make that caked sugar contains moisture, surface brightness is good, and hygroscopicity is low.Can give the storage stability of final products excellence, below 85%, water absorption is very low in 40 ℃ of temperature, humidity, and the hard sugar that sucrose, glucose are done surfaces of tacky with this understanding.
Summary of the invention
The object of the present invention is to provide a kind of Margarita larynx moistening candy that contains Margarita, Semen Oroxyli composition with effects of clearing and nourishing throat.
Technical scheme of the present invention is:
The Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 1～100 part of Margarita, 1～100 part of Semen Oroxyli, 500～2000 parts of sweeting agents.
Optimized technical scheme has following:
The Margarita larynx moistening candy, 5～50 parts of Margaritas, 5～50 parts of Semen Oroxylis, 500～2000 parts of sweeting agents.
The Margarita larynx moistening candy also contains 1～50 part of 5～30 parts of 5～50 parts of Radix Platycodoniss, Radix Ophiopogonis, Oleum menthae, 1～50 part of the Mentholum of weight proportion in the raw material.
The Margarita larynx moistening candy, it is a hard sugar.
The Margarita larynx moistening candy, it is the no cane sugar type hard sugar, sweeting agent wherein is a hydroxyl isomaltulose.
The Margarita larynx moistening candy, it is a hard sugar of taking the casting preparation.
The Margarita larynx moistening candy also contains 0.5～5 part of 1～10 part of 50～500 parts of gum base, food emulsifier, 5～10 parts of edible filleies, the edible softening agent of weight proportion in the raw material.
The Margarita larynx moistening candy, it is a gum.
Prescription of the present invention can be made into hard sugar or gum by different process.Make hard sugar by hard sugar technology, wherein the composition of sweeting agent is a hydroxyl isomaltulose, and what make is a kind of larynx moistening candy of no cane sugar type, has lubricious mouthfeel, and is suitable for diabetics and has the child of dental caries to use.Add 50～500 parts of gum base, 1～10 part of food emulsifier, 5～10 parts of edible filleies, 0.5～5 part of edible softening agent on the basis of this external above-mentioned prescription, an amount of essence, organic acid etc. are made gum by gum technology.
The wet one's whistle preparation technology of hard sugar of Margarita of the present invention is:
1. Chinese medicine extract preparation
(1) get Semen Oroxyli, Radix Platycodonis, add 10 times of amount 60% soak with ethanol, heated and boiled 1 hour filters, and connects and carries twice.Merge filtrate twice.Reclaim ethanol, be evaporated to relative density 1.06～1.08 (60 ℃).
(2) add Radix Glycyrrhizae, Radix Ophiopogonis 10 times of water gagings and soak, heated and boiled 1 hour filters, and connects and carries twice.Merge filtrate twice.Be evaporated to relative density 1.06～1.08 (60 ℃).
(3) (1) and (2) gained clear paste is mixed spray drying.
2. wet one's whistle hard sugar preparation of Margarita
(1) add the pure and mild suitable quantity of water of isomaltulose in jacketed pan, logical steam heated makes dissolves, and adds Chinese medicine extract and Margarita powder, stirs 30 minutes, filters by 100 mesh sieves, and the mixing molasses after the filtration joins vacuum sugar cooker and stirs off.
(2) massecuite that infusion is taken the dish out of the pot after the appropriateness cooling, adds in advance the Oleum menthae and the Mentholum of mixing, be in harmonious proportion immediately and turn, folding (about 80～70 ℃) when the hard soft appropriateness of candy batch has good plasticity is repeatedly sent into fur lacing machine with the candy batch slivering that stretches, and enters punch forming in the make-up machine.
(3) finished product after the molding is manually rejected substandard sugar grains such as unfilled corner, crackle, bubble, impurity grain, form be whole.Qualified sugar grain changes packaging process over to, and after wrapping paper or packaging bags, vanning, packing are through the warehouse-in that is up to the standards.
3. the Margarita of the present invention gum preparation technology that wets one's whistle is:
(1) prefabricated gum base, stripping and slicing or pelletize after-tack.
(2) the pure and mild suitable quantity of water of isomaltulose is added in the jacketed pan, logical steam heated makes dissolves, and adds Chinese medicine extract and Margarita powder, stirs 30 minutes, filters by 100 mesh sieves, and the mixing molasses after the filtration joins vacuum sugar cooker and stirs off.
(3) massecuite that infusion is taken the dish out of the pot after the appropriateness cooling, adds in advance the Oleum menthae and the Mentholum of mixing, and gum base that makes in the adding (1) and an amount of emulsifying agent, filler, softening agent, essence, organic acid are in harmonious proportion immediately, and mixing stirs.
(4) extrude tabletting, cooling, molding, selection, last packed products.
By the product that above-mentioned technology makes, has the health-care effect of cleaning throat and moistening larynx.Instructions of taking is a buccal, each one, every two hours once.
Principle and advantage of the present invention has:
Product of the present invention is a principal agent with Margarita, Semen Oroxyli, the Margarita tranquilizing mind, and clear gesture is weighed down expectorant, eliminating toxin and beautifying faces; Semen Oroxyli removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach; Be aided with the Radix Glycyrrhizae eliminating phlegm and stopping cough, invigorating the spleen and replenishing QI; The Radix Platycodonis dispersing lung-QI and dissipating phlegm, wind-heat dissipating; Nourishing YIN and moistening the lung helped principal agent to support and moisturized Radix Ophiopogonis.All medicines are harmonious, and moisturize to play, lung heat clearing, sore-throat relieving, protect the merit of making an uproar.The adjuvant hydroxyl isomaltulose has low in calories, and stability is good, and good heat resistance is suitable for advantages such as diabetes patient, high fat patient use.Adopt casting, sugared surface is bright and clean, smooth, outward appearance is good.In sum, this product can effectively alleviate with throat excessively, the pharyngeal drying that causes of air pollution, itch and symptom such as pain, and to the effect of having clear improvement of pharyngeal congestion, follicle hypertrophy and myxedema; This product does not contain sucrose, does not decay tooth, do not contain antiseptic, so the crowd of being suitable for is wide; This product adopts modern crafts, and constant product quality is fit to industrialization.
Description of drawings
Fig. 1 is a baicalin reference substance HPLC collection of illustrative plates.
Fig. 2 Semen Oroxyli crude drug HPLC collection of illustrative plates.
Fig. 3 is the HPLC collection of illustrative plates of No. 1 Margarita larynx moistening candy product.
Describe the present invention in detail below in conjunction with embodiment:
Specific embodiment
Embodiment 1
No. 1 Margarita larynx moistening candy product is made by the following weight proportion raw material: 10 parts of Margaritas, 13 parts of Semen Oroxylis, 15 parts in Radix Glycyrrhizae, 11 parts of Radix Platycodoniss, 7 parts of Radix Ophiopogonis, 2 parts of Oleum menthae, 3 parts of Mentholums, 980 parts of hydroxyl isomaltuloses.Make sugar by the method that summary of the invention of the present invention partly provides.
No. 2 Margarita larynx moistening candy products are made by the following weight proportion raw material: 25 parts of Margaritas, 20 parts of Semen Oroxylis, 20 parts in Radix Glycyrrhizae, 10 parts of Radix Platycodoniss, 5 parts of Oleum menthae, 6 parts of Radix Ophiopogonis, 5 parts of Mentholums, 1250 parts of hydroxyl isomaltuloses, 400 parts of gum base, 4 parts of emulsifying agents, 35 parts of filleies, 4 parts of softening agents, 10 parts in essence, 2 parts of spice, 0.2 part of organic acid.
Make the Margarita gum that wets one's whistle according to this prescription by gum preparation technology.Or make gum by the method that summary of the invention of the present invention partly provides.
The technical specification of this product is as follows:
One, organoleptic indicator
The organoleptic indicator should meet table 1 regulation.
Table 1 organoleptic indicator
| Project | Index |
| Color and luster abnormal smells from the patient form impurity | Brownish red, the oval lamellar solid of translucent specificity cool smell, even, intact chink seam do not allow to exist impurity such as tangible breeze |
Two, physical and chemical index
Physical and chemical index should meet table 2 regulation.
Table 2 physical and chemical index
| Project | Unit | Index |
| Moisture ash reducing sugar saccharin sodium | ????％ ????％ ????％ ????mg/kg | ≤ 1.5≤1.5≤2.5 must not detect |
Three, the limit index of poisonous metal and harmful substance
The limit index of poisonous metal and harmful substance should meet table 3 regulation.
The limit index of table 3 poisonous metal and harmful substance
| Project | Unit | Index |
| Plumbous (in Pb) copper (in Cu) hydrargyrum (in the Hg) Gamma Hexaochlorocyclohexane of arsenic (in As) clofenotane | ????mg/kg ????mg/kg ????mg/kg ????mg/kg ????mg/kg ????mg/kg | ????≤0.3 ????≤0.5 ????≤5.0 ????≤0.3 ????≤0.1 ????≤0.1 |
Four, microbiological indicator
Microbiological indicator should meet table 4 regulation.
Table 4 microbiological indicator
| Project | Unit | Index |
| Total plate count coliform pathogenic bacterium (Salmonella, shigella, staphylococcus aureus, Hemolytic streptococcus) mycete yeast | ????cfu/g ????MPN/100g ????cfu/g ????cfu/g | ≤ 750≤30 must not detect≤25≤25 |
Five, the assay index and the method for inspection of functional component,
(1) effective component: total Saponin
(2) effective component content: this product contains total Saponin in glycyrrhizic acid, must not be less than 0.8mg/g
(3) the effective component method of inspection
Total Saponin colorimetric analysis method of testing: according to 2000 editions appendix VB of Chinese Pharmacopoeia colorimetric method for determining.
In addition, adopt the prescription of embodiment 1 and product reference " the HPLC method is measured content of baicalin in the Semen Oroxyli " [Liu Fan, what the U.S. and Britain of prepared.Chinese medicine Leader, Hunan, 2002:8 (6): 365] carry out high performance liquid chromatogram and detect, and with the contrast of baicalin reference substance and Semen Oroxyli crude drug, the result can obviously identify the composition of Semen Oroxyli from the high performance liquid chromatogram collection of illustrative plates of product shown in Fig. 1 (baicalin reference substance), Fig. 2 (Semen Oroxyli crude drug), Fig. 3 (product).
The product that adopts the prescription of embodiment 1 and prepared is with reference to carrying out stability test " medicine stability test guideline " (" two appendix XIX of Chinese pharmacopoeia version in 2000 C).40 ℃ ± 2 ℃ of temperature, placed 6 months under the condition of relative humidity 75% ± 5%, respectively 25 ℃ ± 2 ℃ of temperature, place after 12 months under the condition of relative humidity 60% ± 10%, investigate character, and press the content of total Saponin in the method working sample of above-mentioned assay, the results are shown in Table 5.As can be known from the results, this product has good stable.
No. 1 product stability of table 5 is investigated
| Lot number | The investigation time | Total Saponin (mg/g) | Character |
| ? ??021018 ? ? ??021019 ? ? ? ? ?021020 | Accelerated in 0 month to accelerate in 0 month long-term December of June to accelerate long-term December in June in 0 month long-term December of June | ????1.51 ????1.44 ????1.38 ????1.48 ????1.32 ????1.35 ????1.43? ? ? ????1.29 ????1.37 | The translucent oval lamellar of brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, the translucent oval lamellar of tool specificity cool smell brownish red, tool specificity cool smell |
Embodiment 3
No. 3 Margarita larynx moistening candy products are made by the following weight proportion raw material: 10 parts of Margaritas, 15 parts in Radix Glycyrrhizae, 11 parts of Radix Platycodoniss, 7 parts of Radix Ophiopogonis, 2 parts of Oleum menthae, 3 parts of Mentholums, 980 parts of hydroxyl isomaltuloses.Make sugar by the method that summary of the invention of the present invention partly provides.
With reference to Ministry of Public Health " health food check with assessment technique standard ", carry out human feeding trial, No. 3 Margarita larynx moistening candy products and No. 1 Margarita larynx moistening candy product contrast, and No. 1 product efficacy obviously is better than reference product No. 3 as a result, sees Table 6, table 7, table 8.Effect criterion is: 1, effective: sx 1 degree, pharyngeal sign check result alleviates 1 grade.2, invalid: symptom, sign all do not have obvious change.Do not observe any discomfort and untoward reaction.
Table 6 cleaning throat and moistening larynx effect
| Group | Example number (people) | Effectively | Invalid |
| Number % | Number % | ||
| No. 3 contrasts of No. 1 product (containing Semen Oroxyli) (not containing Semen Oroxyli) | ????49? ? ????48 | ????42????85.7?? ?? ????32????66.7 | ????7?????14.3 ????16????33.3 |
Table 7 cardinal symptom is improved situation
| Symptom | Group | Example number (people) | Effectively (people) | Invalid (people) | Improvement rate (%) |
| Pharyngalgia is swallowed the dry throat dry cough foreign body sensation of itching | No. 3 contrasts of No. 1 product of No. 3 contrasts of No. 1 product of No. 3 contrasts of No. 1 product of No. 3 contrasts of No. 1 product of No. 3 contrasts of No. 1 product | ????34 ????36 ????38 ????35 ????40 ????39 ????31 ????30 ????41 ????42 | ????28 ????24 ????33 ????25 ????31 ????24 ????24 ????18 ????30 ????28 | ????6 ????12 ????5 ????10 ????9 ????15 ????7 ????12 ????11 ????14 | ????82.4 ????66.7 ????86.8 ????71.4 ????77.5 ????61.5 ????77.4 ????60.0 ????73.2 ????66.7 |
The pharyngeal sign of table 8 is improved situation
| Symptom | Group | Example number (people) | Effectively (people) | Invalid (people) | Improvement rate (%) |
| Mucous hyperemia myxedema pharynx rear wall lymph foilicie hyperplasia secretion adheres to | No. 3 contrasts of No. 1 product of No. 3 contrasts of No. 1 product of No. 3 contrasts of No. 1 product of No. 3 contrasts of No. 1 product | ????43 ????39 ????33 ????36 ????34 ????32 ????28 ????31 | ????36 ????27 ????29 ????25 ????27 ????21 ????25 ????22 | ????7 ????12 ????4 ????11 ????7 ????11 ????13 ????9 | ????83.7 ????69.2 ????87.9 ????69.4 ????79.4 ????65.6 ????89.3 ????71.0 |
Embodiment 4
No. 4 Margarita larynx moistening candy products are made by the following weight proportion raw material: 10 parts of Margaritas, 980 parts of hydroxyl isomaltuloses.Make sugar by the method that summary of the invention of the present invention partly provides.
No. 5 Margarita larynx moistening candy products are made by the following weight proportion raw material: 10 parts of Margaritas, 13 parts of Semen Oroxylis, 980 parts of hydroxyl isomaltuloses.Make sugar by the method that summary of the invention of the present invention partly provides.
With reference to Ministry of Public Health " health food check with assessment technique standard ", carry out human feeding trial, No. 4 Margarita larynx moistening candy products and No. 5 Margarita larynx moistening candy products contrast, and No. 5 product efficacy obviously are better than reference product No. 4 as a result, see Table 9, table 10, table 11.Effect criterion is: 1, effective: sx 1 degree, pharyngeal sign check result alleviates 1 grade.2, invalid: symptom, sign all do not have obvious change.Do not observe any discomfort and untoward reaction.
Table 9 cleaning throat and moistening larynx effect
| Group | Example number (people) | Effectively | Invalid |
| Number % | Number % | ||
| No. 4 contrasts of No. 5 products (containing Semen Oroxyli) (not containing Semen Oroxyli) | ????45 ????47 | ????32????71.1 ????20????42.6 | ????13????28.9 ????27????57.4 |
Table 10 cardinal symptom is improved situation
| Symptom | Group | Example number (people) | Effectively (people) | Invalid (people) | Improvement rate (%) |
| Pharyngalgia is swallowed the dry throat dry cough foreign body sensation of itching | No. 4 contrasts of No. 5 products of No. 4 contrasts of No. 5 products of No. 4 contrasts of No. 5 products of No. 4 contrasts of No. 5 products of No. 4 contrasts of No. 5 products | ????37 ????40 ????36 ????37 ????36 ????32 ????34 ????33 ????35 ????37 | ????23 ????17 ????24 ????18 ????21 ????14 ????17 ????13 ????19 ????15 | ????14 ????23 ????12 ????19 ????15 ????18 ????17 ????20 ????16 ????22 | ????62.2 ????42.5 ????66.6 ????48.6 ????58.3 ????43.8 ????50.0 ????39.4 ????54.3 ????40.5 |
The pharyngeal sign of table 11 is improved situation
| Symptom | Group | Example number (people) | Effectively (people) | Invalid (people) | Improvement rate (%) |
| The mucous hyperemia myxedema | No. 5 products of No. 4 contrasts of No. 5 products | ????40 ????41 ????35 | ????26 ????18 ????20 | ????14 ????23 ????15 | ????65.0 ????43.9 ????57.1 |
| Retropharyneal folliculosis secretions adheres to | No. 4 contrasts of No. 5 products of No. 4 contrasts of No. 5 products of No. 4 contrasts | ????38 ????36 ????37 ????30 ????32 | ????15 ????18 ????14 ????17 ????14 | ????23 ????18 ????23 ????13 ????18 | ????39.5 ????50.0 ????37.8 ????56.7 ????43.8 |
Embodiment 5
One group of Margarita larynx moistening candy, all the method that partly provides by summary of the invention of the present invention is made sugar:
A kind of Margarita larynx moistening candy, it contains the composition of Margarita, Semen Oroxyli.
A kind of Margarita larynx moistening candy, it contains the composition of Margarita, Semen Oroxyli, Radix Platycodonis, Radix Ophiopogonis.
A kind of Margarita larynx moistening candy, it contains the composition of Margarita, Semen Oroxyli, Radix Platycodonis, Radix Ophiopogonis, Radix Glycyrrhizae, Flos Lonicerae.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 1 part of Margarita, 100 parts of Semen Oroxylis, 500 parts of sweeting agents.Sweeting agent wherein is an xylose.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 100 parts of Margaritas, 100 parts of Semen Oroxylis, 2000 parts of sweeting agents.Sweeting agent wherein is a fructose.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 5 parts of Margaritas, 50 parts of Semen Oroxylis, 500 parts of sweeting agents.Sweeting agent wherein is a sucrose.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 50 parts of Margaritas, 5 parts of Semen Oroxylis, 2000 parts of sweeting agents, 5 parts in Radix Glycyrrhizae.Sweeting agent wherein is oligomeric trehalose.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 25 parts of Margaritas, 45 parts of Semen Oroxylis, 1800 parts of sweeting agents.Sweeting agent wherein is a fructose.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 50 parts of Margaritas, 5 parts of Semen Oroxylis, 2000 parts of sweeting agents, 50 parts in Radix Glycyrrhizae.Sweeting agent wherein is oligomeric trehalose.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 50 parts of Margaritas, 5 parts of Semen Oroxylis, 2000 parts of sweeting agents, 30 parts in Radix Glycyrrhizae, 5 parts of Radix Platycodoniss, 5 parts of Radix Ophiopogonis, 1 part of Oleum menthae, 50 parts of Mentholums.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 1 part of 20 parts of Margarita, 5 parts of Semen Oroxylis, 1000 parts of sweeting agents, 30 parts in Radix Glycyrrhizae, 50 parts of Radix Platycodoniss, 30 parts of Radix Ophiopogonis, Peppermint Oil 50 part, Mentholum.Sweeting agent wherein is oligomeric trehalose.
A kind of Margarita larynx moistening candy, it mainly is to be made by following materials of weight proportions: 1 part of 20 parts of Margarita, 5 parts of Semen Oroxylis, 1000 parts of sweeting agents, 30 parts in Radix Glycyrrhizae, 50 parts of Radix Platycodoniss, 30 parts of Radix Ophiopogonis, Peppermint Oil 50 part, Mentholum.It is the no cane sugar type hard sugar, and sweeting agent wherein is a hydroxyl isomaltulose.
Embodiment 6
With the Margarita larynx moistening candy of embodiment 5, take casting preparation becoming hard sugar.
Embodiment 7
A kind of Margarita larynx moistening candy also contains 0.5 part of 1 part of 50 parts of gum base, food emulsifier, 5 parts of edible filleies, the edible softening agent of weight proportion in the raw material.All the method that partly provides by summary of the invention of the present invention is made gum.
A kind of Margarita larynx moistening candy also contains 5 parts of 10 parts of 500 parts of gum base, food emulsifiers, 10 parts of edible filleies, the edible softening agents of weight proportion in the raw material.All the method that partly provides by summary of the invention of the present invention is made gum.
A kind of Margarita larynx moistening candy also contains 3 parts of 8 parts of 100 parts of gum base, food emulsifiers, 8 parts of edible filleies, the edible softening agents of weight proportion in the raw material.All the method that partly provides by summary of the invention of the present invention is made gum.
Claims (9)
1, a kind of Margarita larynx moistening candy is characterized in that it mainly is to be made by following materials of weight proportions: 1～100 part of Margarita, 1～100 part of Semen Oroxyli, 500～2000 parts of sweeting agents.
2, Margarita larynx moistening candy according to claim 1 is characterized in that: 5～50 parts of Margaritas, 5～50 parts of Semen Oroxylis, 500～2000 parts of sweeting agents.
3, Margarita larynx moistening candy according to claim 1 is characterized in that: 5～50 parts in the Radix Glycyrrhizae that also contains weight proportion in the raw material.
4, according to claim 1 or 3 described Margarita larynx moistening candys, it is characterized in that: 1～50 part of 5～30 parts of 5～50 parts of Radix Platycodoniss, Radix Ophiopogonis, the Oleum menthae, 1～50 part of the Mentholum that also contain weight proportion in the raw material.
5, according to claim 1 or 2 or 3 described Margarita larynx moistening candys, it is characterized in that: it is a hard sugar.
6, according to claim 1 or 2 or 3 described Margarita larynx moistening candys, it is characterized in that: it is the no cane sugar type hard sugar, and sweeting agent wherein is a hydroxyl isomaltulose.
7, according to claim 1 or 2 or 3 described Margarita larynx moistening candys, it is characterized in that: it is a hard sugar of taking the casting preparation.
8, according to claim 1 or 2 or 3 described Margarita larynx moistening candys, it is characterized in that: 0.5～5 part of 1～10 part of 50～500 parts of gum base, food emulsifier, 5～10 parts of edible filleies, edible softening agent also containing weight proportion in the raw material.
9, Margarita larynx moistening candy according to claim 1, it is characterized in that: it is a gum.
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| CNB2004100167966A CN1297308C (en) | 2004-03-05 | 2004-03-05 | Throat-moistening lozenge with pearl |
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| CN1297308C CN1297308C (en) | 2007-01-31 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105685769A (en) * | 2016-01-20 | 2016-06-22 | 安徽福来生物医药有限公司 | Mint flavored cool lozenges and production process of mint flavored cool lozenges |
| CN107372999A (en) * | 2017-08-29 | 2017-11-24 | 成都中医药大学 | A kind of composition and technique of tuber of dwarf lilyturf thoat-soothing drops formula |
| CN108030857A (en) * | 2017-12-28 | 2018-05-15 | 山东金诃药物研究开发有限公司 | It is a kind of to be used for anti-fog haze and the thoat-soothing drops to wet one's whistle and preparation method thereof |
| CN109661180A (en) * | 2016-08-04 | 2019-04-19 | 西雅图咖米公司 | Composition and production and preparation method thereof for sports achievement |
| CN110856516A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free coffee functional food and preparation method thereof |
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2004
- 2004-03-05 CN CNB2004100167966A patent/CN1297308C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105685769A (en) * | 2016-01-20 | 2016-06-22 | 安徽福来生物医药有限公司 | Mint flavored cool lozenges and production process of mint flavored cool lozenges |
| CN109661180A (en) * | 2016-08-04 | 2019-04-19 | 西雅图咖米公司 | Composition and production and preparation method thereof for sports achievement |
| CN107372999A (en) * | 2017-08-29 | 2017-11-24 | 成都中医药大学 | A kind of composition and technique of tuber of dwarf lilyturf thoat-soothing drops formula |
| CN108030857A (en) * | 2017-12-28 | 2018-05-15 | 山东金诃药物研究开发有限公司 | It is a kind of to be used for anti-fog haze and the thoat-soothing drops to wet one's whistle and preparation method thereof |
| CN108030857B (en) * | 2017-12-28 | 2021-05-04 | 金诃藏药（山东）健康产业有限公司 | Throat-smoothing candy for resisting haze and smoothing throat and preparation method thereof |
| CN110856516A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free coffee functional food and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1297308C (en) | 2007-01-31 |
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