WO2018021886A1 - Food composition for relieving hangover, overcoming fatigue and improving immunity comprising extract of mixed herbal medicine as active ingredient - Google Patents
Food composition for relieving hangover, overcoming fatigue and improving immunity comprising extract of mixed herbal medicine as active ingredient Download PDFInfo
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- WO2018021886A1 WO2018021886A1 PCT/KR2017/008193 KR2017008193W WO2018021886A1 WO 2018021886 A1 WO2018021886 A1 WO 2018021886A1 KR 2017008193 W KR2017008193 W KR 2017008193W WO 2018021886 A1 WO2018021886 A1 WO 2018021886A1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/50—Concentrating, enriching or enhancing in functional factors
Definitions
- the present invention relates to a hangover relief, fatigue recovery and immune-enhancing food composition
- a mixed herbal medicine extract as an active ingredient, root, gojija, four ginseng, mountain sand, new song, longan, clove, earth disease, dermis, yellowing, browning
- a mixed herbal extract consisting of maca, macmundong, alder, crust and perilla, it relates to a food composition that helps to relieve hangovers, to recover from fatigue and to boost immunity.
- Alcohol is a product that has been handed down to centuries since the beginning, and drinking is a relatively sustainable social behavior among human social habits (Health, 1990). Alcohol acts on the central nervous system of the brain to make you feel better and to forget the pain, so in ancient times alcohol was used as the primary excipient for all drugs (Marshall and Fritz, 1989).
- Alcohol is absorbed into the body at the time of ingestion and is distributed evenly throughout the body, and most of the alcohol in the liver, alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALLDH), endoplasmic reticulum (microsomal ethanol) It is metabolized by certain enzymes such as oxidizing system (MEOS), catalase and peroxidase, and less than 10% of the absorbed alcohol is excreted through the kidneys or lungs without being metabolized.
- ADH alcohol dehydrogenase
- ALLDH acetaldehyde dehydrogenase
- MEOS oxidizing system
- catalase catalase
- peroxidase peroxidase
- liver dysfunction caused by excessive drinking or frequent drinking which is a characteristic of Korean drinking culture, is increasing day by day. Therefore, prevention and healing of various liver diseases appearing as one of the important research tasks, Much attention is paid to drugs or beverages that can eliminate hangovers.
- choline acid examples include urusodeoxycholic acid, which is known to have effects of improving liver function of liver disease, systemic boredom due to liver dysfunction, indigestion, anorexia, physical fatigue, and the like; Tauroursodeoxycholic acid, which is commercially available as a gallstone dissolving agent and is effective in treating fatty liver, which has an effect of improving liver function and reducing liver fat mass upon oral administration; Chenodeoxycholic acid and dehydrochlic acid are commercially available as gallstone solubilizers.
- Patent Document 1 Republic of Korea Patent No. 10-1539864 "Hangover cancellation drink”
- Patent Document 2 Republic of Korea Patent No. 10-1365794 "Hangover and liver protection improving composition"
- the present invention has been made to solve the problems of the prior art as described above, an object of the present invention to provide a food composition for hangover relief, fatigue recovery and immunity enhancement comprising a mixed herbal extract as an active ingredient.
- the present invention comprises a mixed herbal extract extracted from a mixed herbal medicine consisting of root, gojija, four ginseng, hawthorn, singok, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alderwood, crust and crust as an active ingredient It provides a food composition for relieving hangover, fatigue and enhancing immunity.
- the present invention is the step of mixing the mixed herbal medicine consisting of root, goji berry, samsam, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, macmundong, alder, crust and crust (S10)
- Step (S20) and the step (S30) and the step (S10) of making a mixed herbal medicine extract by concentrating the mixed herbal medicine extract of the step (S10) and the mixed herbal medicine extract in a vacuum state (S20) and the step (S20) Drying and powdering the mixed herbal medicine to prepare a mixed herbal medicine powder (S40) and mixing the mixed herbal medicine concentrate of step (S30) and the mixed herbal medicine powder of step (S40) to prepare granules, powders and pills (S50);
- a method for preparing a food composition for hangover relief, fatigue recovery and immunity enhancement comprising a mixed herbal extract consisting of as an active ingredient.
- the present invention includes a mixed herbal extract to enhance the detoxification of the liver by improving the liver detoxification, and to improve the headache, fatigue, gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea) due to hangover as an active ingredient
- a mixed herbal extract to enhance the detoxification of the liver by improving the liver detoxification, and to improve the headache, fatigue, gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea) due to hangover as an active ingredient
- a mixed herbal extract to enhance the detoxification of the liver by improving the liver detoxification, and to improve the headache, fatigue, gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea) due to hangover as an active ingredient
- gastrointestinal disorders nausea, vomiting, abdominal pain, diarrhea
- the present invention comprises a mixed herbal extract extracted from a mixed herbal medicine consisting of root, gojija, four ginseng, hawthorn, singok, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alderwood, crust and crust as an active ingredient It has the effect of providing a food composition for relieving hangover, fatigue and enhancing immunity.
- the present invention is a mixed herbal extract extracted from a mixed herbal medicine consisting of root, goji berry, samsam, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alderwood, crust and perilla due to hangover It has the effect of improving headache, fatigue and gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea).
- the present invention as a result of repeated studies to solve the problems of the prior art as described above, reed, gojija, samsam, hawthorn, new song, longan meat, clove, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alder,
- a food composition for hangover, fatigue recovery and immunity enhancement from the mixed herbal medicine consisting of perception and fat as an active ingredient.
- the above food composition was prepared as granules, powders and pills, resulting in headache,
- the present invention has been completed by allowing fatigue, gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea) to be improved.
- the food composition of the present invention is effective in extracting mixed herbal medicines extracted from a mixture of herbal medicines consisting of brown root, wolfberry, samsam, hawthorn, new song, longan, clove, earth disease, dermis, yellow, brown, maca, mackmundong, alder, crust and crust It is characterized by a food composition for hangover relief, fatigue recovery and immunity enhancement.
- hangover relief, fatigue recovery and immune-enhancing food composition comprising a mixed herbal extract according to an embodiment of the present invention as an active ingredient 3 ⁇ 7 parts by weight, 3 ⁇ 7 parts by weight of gojija, Samsam 3 To 7 parts by weight, hawthorn 3 to 7 parts by weight, new songs 1 to 5 parts by weight, longan meat 3 to 7 parts by weight, cloves 1 to 3 parts by weight, earth disease 10 to 20 parts by weight, dermis 3 to 7 parts by weight, yellow gold 3 From 7 to 5 parts by weight, 3 to 7 parts by weight of maca, 20 to 30 parts by weight, 3 to 7 parts by weight of Macmundong, 3 to 7 parts by weight of alderwood, 3 to 7 cores of crust and 3 to 7 parts by weight of crust. Characterized in that the extracted mixed herbal medicine extract.
- the roots ( ⁇ ) is a dry root of the cut off the jupiter ( ⁇ ⁇ ) of Pueraria Ohwi belonging to the legume (Leguminosae), sweat, heat to treat high fever and headaches and to quench thirst, It is used to treat indigestion, diabetes, skin disease, cold poisoning and vomiting, and it is effective for digestion.
- the gojija (Lncium chinuse Miller) is a deciduous shrub belonging to the branch of the goji fruit tree, sweet and non-toxic, and protects the liver and kidneys to release fatigue, relax the large intestine and small intestine.
- Dongbogam, etc. 'The quality is cold ( ⁇ ) (Pyeong), the taste is bitter [ ⁇ ] (also called sweet), and there is no poison. It is very hard to breathe and hard to breathe, and it strengthens the tendons and bones, makes it hard to nourish, and heals 5 to 7 phases. Shows regularity, rejuvenates face, blacks gray hair, clears eyes, calms mind, and allows us to live longer.
- the ginseng (Adenophora stricta Mid) is the root of the camphor (Adenophora triphylla var. Japonica Hara) belonging to the Campanulaceae, the taste is sweet and rich in fiber, and the dried one is light in weight and bedbug is good. Old fever, expectoration, sputum, swelling, old age relieves asthma, sputum and blood mixed with pulmonary tuberculosis, or a lot of sputum and blood mixed slightly, mild fever and throat paralysis, dry mouth caused by diabetes, summer fever Sagsam can be used for gugal, etc.
- the hawthorn is a dried fruit of the Rosaceae and the same plant, has a peculiar smell, tastes slightly sour and sweet, weakness is warm. It warms the stomach and promotes digestion, and it is effective when eating meat and preserving, and it is effective in treating abdominal pain, vomiting, diarrhea, excessive stomach acid and chronic enteritis.
- the singok (Tricticum aestivum) is a fermented medicinal malt produced by the powder of wheat flour, a year-old cultivated plant belonging to the family of rice, it is sweet and very toxic. Removes lodging, warms up the stomach and removes bloat. It contains volatile essential oils, lipases, fatty oils, and vitamin B. It helps in planting mainly from alcohol.
- the longan flesh is the flesh of the longan which is an evergreen tree belonging to the patient-free family. Too much thoughtful heart beats, soothes, forgetfulness, unable to sleep, less digestive, relieve diarrhea. It is effective when the body is dry, boredom, can't control the sweat on its own, and the face is white and sometimes yellow due to weakness or senility of the disease, showing anemia. When you address, you become stronger, intelligent, and have no hope. After the postpartum bleeding ( ⁇ ) is weak and edema appears, take the ginger and jujube decoction together.
- the clove is a bud of the clove which is an evergreen tree belonging to the clove family, it is characterized by a stimulating but refreshing and sweet flavor. Cloves are evergreen trees that grow up to 15m in length with bright red flowers. When the flower opens, the fragrance flies away, so when the buds are about 1cm long, they are dried. Clove is the most powerful antiseptic and sterilizing effect among spices. It is also used as a cosmetic, toothpaste, medicine, or perfume, and if you have a toothache, cloves will act as an emergency painkiller.
- the terrestrial disease also known as a hut tree, contains malic acid, glucose, calcium, habenic acid, furclinin, hobenin, hobenoside, and is known to be excellent in alcohol detoxification.
- the earth fruit, the fruit of the earth disease fructose, glucose, catalase, phenthase, potassium, calcium, iron, triterpenoids, hobeic acid, rutin, saponin, apelopsin, etc., restore the liver function and hangover. And it is known that hepatotoxicity is excellent.
- the dermis ( ⁇ ) is dried dry skin of the tangerine (Citrus unshin Markovich) or related plants of the incense, has a peculiar smell and a slight irritation, taste is spicy and bitter, warm. It helps to loosen the swelling and strengthen the function of the spleen, so it is good for only the window, belching, vomiting, nausea, indigestion, flatulence and stool. In addition, people who usually urinate or swell well, the swelling subsides, and contains a large amount of hesperidin, a flavonoid compound that is similar to vitamin P, which reduces blood vessel permeability and resists blood vessel rupture. It helps to loosen the poison and prevent colds.
- the citrine is also called round, and has a leaf shape similar to bamboo leaves, also called jade. Hwangjeong do not rest white hair when eaten for a long time, strengthen digestion, strengthen bones and effective in seawater and sputum caused by pulmonary tuberculosis, and also effective when there is no appetite due to the lack of stamina after the disease.
- the hwahwa ( ⁇ ) is a dried bud of the perennial (Pueraria thumbergiana) belonging to the legume (Leguminosea), the smell of grass and the weakness is sweet. Relieves symptoms when the abdomen is stuffy, swelling, and stool is thin, and it is effective in eliminating the lack of physique or the body surface. In addition, it is effective in treating headaches, fever, thirst and anorexia caused by excessive drinking.
- the maca belongs to the Brassicacae and its official name is Lepidium meyenii Walp. Maca is a medicinal herb for nourishing tonic and fatigue recovery. Its shape is like a rose, and the dried roots and kernels are used for food. Maca roots are similar to potatoes, and kernels are also similar to potatoes. Maca enhances male sexual function, corrects hormonal abnormalities in women, and is effective for menstrual cramps and menstrual disorders, and is good for chronic fatigue syndrome and lethargy.
- the mammundong ( ⁇ ⁇ ) is used as a herbal medicine of the tuber of leaflet vegetation dong (silent mistletoe) which is a plant of the liliaceae (Liliaceae). Macmundong is sweet and tastes a little cool and plain, it is a respiratory medicinal herb. According to pharmacological experiments, there is a cardiac effect, diuretic effect, sputum coughing, cough stopping effect, nutrition effect, to see the woman's tone, to relax the lungs, and to soothe the deep (the disease caused by deepening) and pee well. In addition to the lungs and stomach, especially the effect of nourishing tonic is generally good for the weakness of the body is generally used to weaken the strength and weaken the strength rises.
- the alder tree (Alnus japonica) belongs to the birch family (Betulaveae), also known as the glass tree ( ⁇ ⁇ ⁇ ) in Chinese, and called Chajo.
- the young leaves and bark of the alder are called red sheep, and they are collected in spring and autumn and dried in the sun.
- Alder is bitter and salty and has a cool nature.
- the heat of the colon is good for anemia and enteritis, nosebleeds, trauma bleeding, hangover, fatty liver, hepatitis, liver cirrhosis is also good.
- the crust is an evergreen species belonging to the Rutaceae group, Citrus aurantium L. and in Korea, the ripening of tangerines is called crust.
- the taste is a bit sour and bitter, with aroma. Relieves the stuffy chest and stomach swollen, and is effective in stomach pain caused by constipation.
- long-term administration of the perceptual extract has the effect of significantly suppressing weight gain.
- Jisil ( ⁇ ) is the evergreen cultivars belonging to the Rutaceae (citrus aurantium L.) and the less ripe fruit of the tanja in Korea is called Jisil ( ⁇ ). Severe itching and abdominal swelling of the skin, the end of the clear tooth to relieve the sick, to eat and stay a long time after the treatment of symptoms, if you have food poisoning can be used after prescription medicine. It can be applied to all the symptoms such as swelling and constipation due to grouping, but there is a strong effect of dispersing the gathering of the group, but there is a risk of hurting the regular period, so it should be used carefully. In recent years, it has been applied to the stomach and sewage, uterine sewage, desalination and the like.
- the present invention is the step of mixing the mixed herbal medicine consisting of the root, gojija, four ginseng, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, macmundong, alder, crust and crust (S10)
- Step (S20) and the step (S30) and the step (S10) of making a mixed herbal medicine extract by concentrating the mixed herbal medicine extract of the step (S10) and the mixed herbal medicine extract in a vacuum state (S20) and the step (S20) Drying and powdering the mixed herbal medicine to prepare a mixed herbal medicine powder (S40) and mixing the mixed herbal medicine concentrate of step (S30) and the mixed herbal medicine powder of step (S40) to prepare granules, powders and pills (S50);
- a method for producing a hangover relief, fatigue recovery and immune-enhancing food composition comprising a mixed herbal drug extract as an active ingredient.
- a solvent is prepared by extracting a solvent mixture of purified water and food alcohol in a 7: 3 to 5: 5 weight ratio.
- the food alcohol is preferably ethanol.
- the extraction solvent is a relatively increased alcohol component is added to remove the remaining alcohol after extraction, and if the weight ratio of alcohol to purified water is greater than 7 weight ratio, alcohol component is relatively There is a problem that the extract is not evenly extracted from each herbal medicine.
- step S10 1,000 to 5,000 cc of the extraction solvent is added to the mixed herbal medicine of step S10, and the mixed herbal medicine extract is extracted under vacuum at a temperature of 85 to 90 ° C. for 10 hours (S20).
- the low temperature concentration method is carried out at a temperature of 40 to 90 °C in a vacuum to concentrate the components that are affected by heat or oxidized by air.
- the mixed herbal medicine of step S10 is dried and powdered to prepare a mixed herbal medicine powder (S40).
- a mixed herbal medicine powder (S40) to clean and blend the herbal medicines, after drying for 10 hours at a temperature of 65 to 75 °C in a dryer, to prepare a mixed herbal medicine powder of 200 mesh.
- the mixed herbal medicines include roots, goji berry, samsam, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellow flower, brown flower, maca, macmundong, alder, crust and crust.
- the mixed herbal medicine concentrate of step S30 and the mixed herbal powder of step S40 are mixed to prepare granules, powders and pills (S50).
- the extraction solvent was prepared by mixing purified water and ethanol in a 7: 3 weight ratio.
- Hangover, fatigue recovery and immune-enhanced food composition comprising a mixed herbal extract of the present invention as an active ingredient was prepared as follows.
- the mixed herbal medicine was prepared by mixing 5 parts by weight, 5 parts by weight of gallium, 25 parts by weight of maca, 5 parts by weight of Macmundong, 5 parts by weight of Alderwood, 3 parts of crust, and 2 parts by weight of fruit room.
- step (S30) After obtaining the mixed herbal medicine extract, 2,000 mL of the mixed herbal medicine extract of step (S20) was concentrated to 1,000 mL by a low temperature concentration method to prepare a mixed herbal medicine concentrate.
- step (S50) After mixing the mixed herbal medicine concentrate and corn powder (excipient) in a weight ratio of 2: 1 by the step (S30) to prepare a granule by lyophilization, the mixed herbal medicine concentrate of step (A2) and the step (S40) Mixed herbal powder of 2: 1 by weight ratio and dried for 10 hours at a temperature of 65 to 75 °C to prepare a 200 mesh powder, 300 g of the powder was added to 300 g and 1,000 mL of purified water after mixing further Pills were prepared with a diameter of 5 mm.
- the individual evaluation score (average) and the per capita hangover effect rate average (%) was calculated by the following equation (1) and (2) to obtain a result.
- the hangover-relieving beverage of the present invention has excellent hangover-relieving effects such as indigestion, abdominal pain and diarrhea without side effects.
- the hangover relief, fatigue recovery and immune-enhancing food composition using the mixed herbal medicine extract of the present invention as an active ingredient does not cause side effects to the human body, excellent hangover relief effect is useful and convenient as a method for eliminating hangover after drinking May be used.
Abstract
The present invention relates to a food composition for relieving hangover, overcoming fatigue and improving immunity comprising, as an active ingredient, an extract of a mixed herbal medicine extracted from a mixed herbal medicine consisting of Puerariae lobatae, Lycii fructus, Adenophorae radix, Crataegi fructus, Massa medicata fermentata, Longanae arillus, Caryophylli flos, Hoveniae semen seu fructus, Pericarpium citri reticulatae, Polygonati rhizoma, Puerariae flos, Lepidium meyenii, Liriope platyphylla, Alnus japonica, Aurantii fructus immaturus and Poncirii fructus immaturus. The composition is composed of ingredients that helps liver to promote detoxification, relaxes the stomach to relieve symptoms such as gastritis, gastric ulcer and headache, helps kidneys in toxic emission and metabolism, and helps with liver damage due to stress, chronic fatigue due to increased cholesterol and circulation of energy, and is formulated in the form of granule, powder and pill.
Description
본 발명은 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물에 관한 것으로, 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제 추출물을 함유함으로써, 숙취해소, 피로회복 및 면역력 증강에 도움을 주는 식품 조성물에 관한 것이다.The present invention relates to a hangover relief, fatigue recovery and immune-enhancing food composition comprising a mixed herbal medicine extract as an active ingredient, root, gojija, four ginseng, mountain sand, new song, longan, clove, earth disease, dermis, yellowing, browning, By containing a mixed herbal extract consisting of maca, macmundong, alder, crust and perilla, it relates to a food composition that helps to relieve hangovers, to recover from fatigue and to boost immunity.
경제성장과 평균수명의 연장과 함께 현대인들의 질병과 고령화 사회에 따른 삶의 질에 대해 인식이 변하고 있으며, 그에 따른 항산화, 항균, 항암 및 면역 강화활성 등의 생리활성을 갖는 천연물에 대한 관심이 높아가고 있다(Das et al., 2002: Lee and Lee; Park and Kim, 1992).Along with the economic growth and the extension of life expectancy, the awareness of modern people's quality of life due to diseases and aging society is changing, and there is a great interest in natural products with physiological activities such as antioxidant, antibacterial, anticancer and immune enhancing activities. (Das et al., 2002: Lee and Lee; Park and Kim, 1992).
음료에 대한 기호성도 변화하여 단순히 청량감을 주는 콜라, 사이다의 소비는 줄어들고, 차츰 천연물을 주원료로 한 제품의 판매량이 매년 증가되고 있다(Park et al., 1998). 또한 최근에는 건강에 관한 관심이 고조되면서 질병 치료를 위한 약물의 본래 성분인 약리학적 성분을 살리면서도 기능성을 함유한 건강음료가 개발되고 있다. 이에 재료로서 채소류 및 한약재 등 천연성분을 주로 이용하는 추세이다(Seo and Kim, 2001). 이러한 맥락에서 숙취해소음료의 개발은 지속적으로 진행되고 있다.The palatability of beverages is also changing, and the consumption of cola and cider, which is simply refreshing, is decreasing, and the sales volume of products mainly made from natural products is increasing every year (Park et al., 1998). In recent years, as health concerns are heightened, health drinks containing functionalities while developing pharmacological components, which are inherent components of drugs for treating diseases, have been developed. As a result, natural ingredients such as vegetables and herbs are mainly used (Seo and Kim, 2001). In this context, the development of hangover drinks continues.
술은 태초부터 인류에게 전해내려온 산물이며, 음주는 인간이 가지고 있는 여러가지 사회적 습관들 중 비교적 지속성이 있는 사회적 행동이다(Health, 1990). 알코올은 뇌의 중추신경에 작용하여 기분을 좋게 하고, 괴로움을 잊을 수 있어 고대에는 알코올이 모든 약물의 기본 부형제로 이용되었다(Marshall and Fritz, 1989).Alcohol is a product that has been handed down to mankind since the beginning, and drinking is a relatively sustainable social behavior among human social habits (Health, 1990). Alcohol acts on the central nervous system of the brain to make you feel better and to forget the pain, so in ancient times alcohol was used as the primary excipient for all drugs (Marshall and Fritz, 1989).
알코올은 섭취시 체내에 흡수되어 전신에 고루 분포되며, 대부분은 간에서 알코올 탈수소효소(alcohol dehydrogenase: ADH), 아세트알데히드 탈수소효소(acetaldehyde dehydrogenase: ALDH), 소포제(endoplasmic reticulum) 내의 알코올 산화계(microsomal ethanol oxidizing system: MEOS), 카타라제(catalase) 및 과산화효소(peroxidase) 등 특정한 효소들에 의해서 대사되고, 흡수된 알코올의 10% 미만은 대사되지 않은 채 신장이나 폐를 통하여 배설된다.Alcohol is absorbed into the body at the time of ingestion and is distributed evenly throughout the body, and most of the alcohol in the liver, alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALLDH), endoplasmic reticulum (microsomal ethanol) It is metabolized by certain enzymes such as oxidizing system (MEOS), catalase and peroxidase, and less than 10% of the absorbed alcohol is excreted through the kidneys or lungs without being metabolized.
하지만, 알코올의 다량섭취로 인한 급성 알코올성 숙취증상인 메스꺼움, 구토, 현기증, 갈증, 무기력, 두통, 근육통 등의 증상은 업무능률 저하로 인한 사회 경제적 손해를 초래하고 있으며(Swift and Davidson, 1998), 만성적인 알코올 섭취 시에는 췌장염, 심근경색, 신경장애, 결핵 등의 장해가 나타나고 간 조직의 구조 및 기능에치명적인 손상을 가져오게 된다(Lieber and Leo, 1992; Liever et al., 1986). 그러므로 채내의 다른 장기에비하여 알코올이 간에 미치는 영향은 매우 크다고 볼 수 있다(Goodman and Gilman, 1975; Lieber and DeCarli, 1968; Lieber et al., 1986).However, symptoms such as nausea, vomiting, dizziness, thirst, lethargy, headache, and muscle pain, such as acute alcoholic hangover symptoms caused by high intake of alcohol, cause socioeconomic damage due to decreased work efficiency (Swift and Davidson, 1998), Chronic alcohol intake causes disorders such as pancreatitis, myocardial infarction, neuropathy and tuberculosis, and can lead to fatal damage to the structure and function of liver tissue (Lieber and Leo, 1992; Liever et al., 1986). Therefore, the effect of alcohol on the liver is very large compared to other organs in the mine (Goodman and Gilman, 1975; Lieber and DeCarli, 1968; Lieber et al., 1986).
현재 우리나라의 음주문화의 특성으로 나타나는 과음 또는 빈번한 음주로 유발되는 간 기능 장애는 날로 증가하는 추세에 있으며, 이로 말미암아 나타나는 여러 가지 간질환의 예방 및 치유는 중요한 연구과제 중의 하나로 주목받고 있으며 많은 사람들이 숙취를 제거할 수 있는 약물 또는 음료수에 많은 관심을 기울이고 있다.Currently, the liver dysfunction caused by excessive drinking or frequent drinking, which is a characteristic of Korean drinking culture, is increasing day by day. Therefore, prevention and healing of various liver diseases appearing as one of the important research tasks, Much attention is paid to drugs or beverages that can eliminate hangovers.
또한, 숙취 제거와 관련하여, 천연 식품 또는 한약 재료로부터 추출한 성분을 함유한 다양한 건강 보조 식품이 개발되고 있다(김정한 등, 한국농화학회지, 38(6): 549-553, 1995). 이러한 연구의 일환으로서, 이담 작용, 간장 해독, 간혈류 개선 작용, 지방의 흡수 촉진 작용 및 미세 담도를 통한 노폐물 배설 작용을 하는 콜린산류를 함유하는 조성물이 시판되고 있다.In addition, in connection with the elimination of hangovers, various dietary supplements containing ingredients extracted from natural foods or herbal medicines have been developed (Kim Jung-han et al., 38 (6): 549-553, 1995). As part of this research, a composition containing choline acids, which have an effect of edema, hepatic detoxification, hepatic blood flow improvement, promoting fat absorption, and excretion of waste products through fine bile ducts, is commercially available.
이러한 콜린산의 예로서 간질환의 간 기능 개선, 간 기능 장애에 의한 전신 권태, 소화 불량, 식욕 부진, 육체 피로 등의 효과가 있다고 알려져 있는 우루소테옥시콜린산(ursodeoxycholic acid); 담석 용해제로 시판되고 있으며, 지방간 치료에 효과가 있어 경구 투여시 간 기능 개선 및 간 지방량 감소의 효과가 있는 타우로우루소테옥시콜린산(tauroursodeoxycholic acid); 담석 용해제로 시판되고 있는 체노테옥시콜린산(chenodeoxycholic acid) 및 다하이드로콜린산(dehydrochlic acid) 등이 있다. Examples of such choline acid include urusodeoxycholic acid, which is known to have effects of improving liver function of liver disease, systemic boredom due to liver dysfunction, indigestion, anorexia, physical fatigue, and the like; Tauroursodeoxycholic acid, which is commercially available as a gallstone dissolving agent and is effective in treating fatty liver, which has an effect of improving liver function and reducing liver fat mass upon oral administration; Chenodeoxycholic acid and dehydrochlic acid are commercially available as gallstone solubilizers.
한편, 한약재 또는 민간요법제로서 숙취해소에 유용한 효과가 있다고 알려져 있는 인삼, 가시오가피 등의 성분을 주성분으로 하는 각종 제제 형태의 의약품들이 개발되었다. 이 중에서, 인삼을 주성분으로 하는 자양 강장 드링크제가 다수 시판되고 있으며, 이 외에도, 꿀, 비타민 등의 각종 성분들도 적당량의 함량으로 조성하여 자양강장제로 시판되고 있다. 인삼, 가시오가피 (Brekhman et al., Lloydia , 32(1): 46-51, 1969), 오씨뭄(Ocimum sanctum Linn), 티노스포라말라바리카 (tinosporama labarica) (Sen, P., Maiti, PC and Ray, A.Indian J. Exp. Biol., 30: 592-596, 1992)등의 생약과 멜라토닌 등의 생체 물질이 숙취 해소 작용을 나타낸다고 하는 보고되어 있으나, 이들 재료들은 음주에 의해 유발되는 다양한 숙취 증상 중에서 일부 증상에만 효과가 있거나, 숙취 해소 효과가 미미한 것으로 나타났다.On the other hand, as a herbal medicine or folk remedies, various types of medicines have been developed, which are mainly composed of ingredients such as ginseng and thorny ginseng, which are known to have a beneficial effect on hangover. Among them, a number of nourishing tonic drinks are mainly marketed as ginseng, and in addition, various components such as honey and vitamins are also formulated in an appropriate amount and marketed as nourishing tonics. Ginseng, bryce (Brekhman et al., Lloydia, 32 (1): 46-51, 1969), Ocimum sanctum Linn, tinosporama labarica (Sen, P., Maiti, PC and Ray, A. Indian J. Exp. Biol., 30: 592-596, 1992), and herbal substances such as melatonin and other biological substances have been reported to exhibit hangover remedy. Among the symptoms, only some symptoms were effective, or the hangover effect was found to be insignificant.
최근, 콩나물을 주원료로 한 식물 엑기스를 함유한 제품과 미배아와 대두 추출물을 함유한 제품이 시중에 소개되고 있다. 그러나 상기 제품은 제제의 안정성 면에서 해결해야 할 많은 문제점이 지적되었다.In recent years, products containing a plant extract mainly containing soybean sprouts and products containing an embryonic and soybean extract have been introduced on the market. However, it has been pointed out that the product has many problems to be solved in terms of the stability of the formulation.
따라서, 이 분야에서 이러한 문제점을 해결하기 위하여 숙취해소에 효과가 있으면서도 안정성이 확보된 새로운 숙취 제거용 조성물의 개발이 요구되고 있다.Therefore, in order to solve this problem in the field, there is a demand for the development of a new hangover removal composition having an effect on the hangover while ensuring stability.
[선행기술문헌][Preceding technical literature]
[특허문헌][Patent Documents]
(특허문헌 1) 대한민국 등록특허 제10-1539864 "숙취해소 음료"(Patent Document 1) Republic of Korea Patent No. 10-1539864 "Hangover cancellation drink"
(특허문헌 2) 대한민국 등록특허 제10-1365794 "숙취해소 및 간 보호기능 개선 조성물"(Patent Document 2) Republic of Korea Patent No. 10-1365794 "Hangover and liver protection improving composition"
본 발명은 상기와 같은 종래기술의 문제점을 해결하기 위해 마련된 것으로, 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 제공하는 데 목적이 있다.The present invention has been made to solve the problems of the prior art as described above, an object of the present invention to provide a food composition for hangover relief, fatigue recovery and immunity enhancement comprising a mixed herbal extract as an active ingredient.
본 발명은 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제로부터 추출한 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 제공한다.The present invention comprises a mixed herbal extract extracted from a mixed herbal medicine consisting of root, gojija, four ginseng, hawthorn, singok, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alderwood, crust and crust as an active ingredient It provides a food composition for relieving hangover, fatigue and enhancing immunity.
또한, 본 발명은 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제를 혼합하는 단계(S10)와 상기 단계(S10)의 혼합 생약제를 진공상태에서 혼합 생약제 추출물을 추출하는 단계(S20)와 상기 단계(S20)의 혼합 생약제 추출물을 농축하여 혼합 생약제 농축액을 만드는 단계(S30)와 상기 단계(S10)의 혼합 생약제를 건조하고 분말화하여 혼합 생약제 분말을 제조하는 단계(S40)와 상기 단계(S30)의 혼합 생약제 농축액과 상기 단계(S40)의 혼합 생약제 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(S50);로 이루어진 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물의 제조방법을 제공한다.In addition, the present invention is the step of mixing the mixed herbal medicine consisting of root, goji berry, samsam, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, macmundong, alder, crust and crust (S10) Step (S20) and the step (S30) and the step (S10) of making a mixed herbal medicine extract by concentrating the mixed herbal medicine extract of the step (S10) and the mixed herbal medicine extract in a vacuum state (S20) and the step (S20) Drying and powdering the mixed herbal medicine to prepare a mixed herbal medicine powder (S40) and mixing the mixed herbal medicine concentrate of step (S30) and the mixed herbal medicine powder of step (S40) to prepare granules, powders and pills (S50); Provides a method for preparing a food composition for hangover relief, fatigue recovery and immunity enhancement comprising a mixed herbal extract consisting of as an active ingredient.
아울러, 본 발명은 혼합 생약제 추출물을 포함함으로써 간의 해독작용을 증진시키고, 숙취로 인한 두통, 피로, 위장장애(소화불량, 메스꺼움, 구토, 복통, 설사)를 개선하는 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물의 과립제, 산제, 환제를 제공한다.In addition, the present invention includes a mixed herbal extract to enhance the detoxification of the liver by improving the liver detoxification, and to improve the headache, fatigue, gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea) due to hangover as an active ingredient To provide a granule, powder, pills of the food composition for relieving hangover, fatigue and enhancing immunity.
본 발명은 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제로부터 추출한 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 제공하는 효과를 가진다.The present invention comprises a mixed herbal extract extracted from a mixed herbal medicine consisting of root, gojija, four ginseng, hawthorn, singok, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alderwood, crust and crust as an active ingredient It has the effect of providing a food composition for relieving hangover, fatigue and enhancing immunity.
또한, 본 발명은 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제로부터 추출한 혼합 생약제 추출물이 숙취로 인한 두통, 피로, 위장장애(소화불량, 메스꺼움, 구토, 복통, 설사)를 개선하는 효과를 가진다.In addition, the present invention is a mixed herbal extract extracted from a mixed herbal medicine consisting of root, goji berry, samsam, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alderwood, crust and perilla due to hangover It has the effect of improving headache, fatigue and gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea).
본 발명은 상기와 같은 종래기술의 문제를 해결하기 위해 예의 연구를 거듭한 결과, 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제로부터 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 개발하였고, 상기의 식품 조성물을 과립제, 산제, 환제로 제조하여 숙취로 인한 두통, 피로, 위장장애(소화불량, 메스꺼움, 구토, 복통, 설사)를 개선할 수 있도록 함으로써 본 발명을 완성하였다.The present invention, as a result of repeated studies to solve the problems of the prior art as described above, reed, gojija, samsam, hawthorn, new song, longan meat, clove, earth disease, dermis, yellowing, brown flower, maca, mackmundong, alder, We have developed a food composition for hangover, fatigue recovery and immunity enhancement from the mixed herbal medicine consisting of perception and fat as an active ingredient.The above food composition was prepared as granules, powders and pills, resulting in headache, The present invention has been completed by allowing fatigue, gastrointestinal disorders (digestion, nausea, vomiting, abdominal pain, diarrhea) to be improved.
이하, 본 발명의 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 상세하게 설명한다.Hereinafter, the hangover relief, fatigue recovery and immunity enhancing food composition comprising the mixed herbal medicine extract of the present invention as an active ingredient will be described in detail.
본 발명의 식품 조성물은 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제 혼합물로부터 추출한 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물인 것을 특징으로 한다.The food composition of the present invention is effective in extracting mixed herbal medicines extracted from a mixture of herbal medicines consisting of brown root, wolfberry, samsam, hawthorn, new song, longan, clove, earth disease, dermis, yellow, brown, maca, mackmundong, alder, crust and crust It is characterized by a food composition for hangover relief, fatigue recovery and immunity enhancement.
또한, 본 발명의 일 실시예에 따른 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물은 총 중량대비 갈근 3 내지 7 중량부, 구기자 3 내지 7 중량부, 사삼 3 내지 7 중량부, 산사 3 내지 7 중량부, 신곡 1 내지 5 중량부, 용안육 3 내지 7 중량부, 정향 1 내지 3 중량부, 지구병 10 내지 20 중량부, 진피 3 내지 7 중량부, 황정 3 내지 7 중량부, 갈화 3 내지 7 중량부, 마카 20 내지 30 중량부, 맥문동 3 내지 7 중량부, 오리목 3 내지 7 중량부, 지각 3 내지 7 중랑부 및 지실 3 내지 7 중량부로 이루어진 혼합 생약제로부터 추출한 혼합 생약제 추출물을 포함하는 것을 특징으로 한다.In addition, hangover relief, fatigue recovery and immune-enhancing food composition comprising a mixed herbal extract according to an embodiment of the present invention as an active ingredient 3 ~ 7 parts by weight, 3 ~ 7 parts by weight of gojija, Samsam 3 To 7 parts by weight, hawthorn 3 to 7 parts by weight, new songs 1 to 5 parts by weight, longan meat 3 to 7 parts by weight, cloves 1 to 3 parts by weight, earth disease 10 to 20 parts by weight, dermis 3 to 7 parts by weight, yellow gold 3 From 7 to 5 parts by weight, 3 to 7 parts by weight of maca, 20 to 30 parts by weight, 3 to 7 parts by weight of Macmundong, 3 to 7 parts by weight of alderwood, 3 to 7 cores of crust and 3 to 7 parts by weight of crust. Characterized in that the extracted mixed herbal medicine extract.
상기 갈근(葛根)은 콩과(Leguminosae)에 속하는 칡(Pueraria Ohwi)의 주피(周皮)를 제거한 뿌리를 건조한 것으로, 땀을 내고, 열을 내리게 하여 고열 및 두통을 치료하고 갈증을 멎게 하며, 소화불량, 당뇨, 피부병, 술독 감기 및 구토를 치료하는데 쓰이고 소화를 돕는 효능이 있다.The roots (葛根) is a dry root of the cut off the jupiter (周 皮) of Pueraria Ohwi belonging to the legume (Leguminosae), sweat, heat to treat high fever and headaches and to quench thirst, It is used to treat indigestion, diabetes, skin disease, cold poisoning and vomiting, and it is effective for digestion.
상기 구기자(Lncium chinuse Miller)는 가지과에 속한 낙엽관목인 구기자 나무의 열매로, 맛이 달고 독이 없으며, 간과 신장을 보호하면서 피로를 풀어주며, 대장과 소장을 편안하게 한다. 동의보감 등에서는 '성질은 차고[寒](평[平]한다고도 한다), 맛이 쓰며[苦](달다[甘]고도 한다), 독이 없다. 내상으로 몹시 피로하고 숨쉬기도 힘든 것을 보하며, 힘줄과 뼈를 튼튼하게 하고, 양기를 세게 하며 5로 7상을 낫게 한다. 정기를 보하며, 얼굴빛을 젊어지게 하고, 흰머리를 검게하며, 눈을 맑게 하고, 정신을 안정시키며, 오래 살 수 있게 한다. The gojija (Lncium chinuse Miller) is a deciduous shrub belonging to the branch of the goji fruit tree, sweet and non-toxic, and protects the liver and kidneys to release fatigue, relax the large intestine and small intestine. In Dongbogam, etc., 'The quality is cold (寒) (Pyeong), the taste is bitter [苦] (also called sweet), and there is no poison. It is very hard to breathe and hard to breathe, and it strengthens the tendons and bones, makes it hard to nourish, and heals 5 to 7 phases. Shows regularity, rejuvenates face, blacks gray hair, clears eyes, calms mind, and allows us to live longer.
상기 사삼(Adenophora stricta Mid)은 초롱꽃과(Campanulaceae)에 속하는 잔대(Adenophora triphylla var. japonica Hara)의 뿌리로, 맛은 달고 섬유질이 많으며, 건조된 것은 무게가 가볍고 벌래가 잘 생긴다. 해열, 거담, 생진, 지갈작용으로 오래된 해소 천식, 폐결핵으로 가래와 피가 섞여나오는 증상, 혹은 가래가 많고 피가 조금씩 섞여 있는 증상, 미열과 인후마비증상, 당뇨로 인한 구갈, 여름의 열(暑熱)로 인한 구갈 등에 사삼을 사용할 수 있다.The ginseng (Adenophora stricta Mid) is the root of the camphor (Adenophora triphylla var. Japonica Hara) belonging to the Campanulaceae, the taste is sweet and rich in fiber, and the dried one is light in weight and bedbug is good. Old fever, expectoration, sputum, swelling, old age relieves asthma, sputum and blood mixed with pulmonary tuberculosis, or a lot of sputum and blood mixed slightly, mild fever and throat paralysis, dry mouth caused by diabetes, summer fever Sagsam can be used for gugal, etc.
상기 산사는 장미과(Rosaceae) 및 동속식물의 익은 열매를 건조한 것으로, 특이한 냄새가 있고 맛은 약간 시고 달며, 약성은 따듯하다. 비위를 따듯하게 하여 소화를 촉진하며, 고기를 먹고 체했을 때 효과가 있고, 복통, 구토, 설사, 위산 과다 및 만성장염을 치료하는 효능이 있다.The hawthorn is a dried fruit of the Rosaceae and the same plant, has a peculiar smell, tastes slightly sour and sweet, weakness is warm. It warms the stomach and promotes digestion, and it is effective when eating meat and preserving, and it is effective in treating abdominal pain, vomiting, diarrhea, excessive stomach acid and chronic enteritis.
상기 신곡(Tricticum aestivum)은 벼과에 속한 1년생 재배식물인 참밀의 분말로 제조하여 발효한 약누룩으로서, 맛을 달고 매우며 무독하다. 숙식을 제거하며 위를 따듯하게 하고 속이 더부룩한 것을 없앤다. 휘발성 정유, 리파제, 지방유, 비타민B 등을 함유하며 주로 술로 인한 식체에 도움을 준다.The singok (Tricticum aestivum) is a fermented medicinal malt produced by the powder of wheat flour, a year-old cultivated plant belonging to the family of rice, it is sweet and very toxic. Removes lodging, warms up the stomach and removes bloat. It contains volatile essential oils, lipases, fatty oils, and vitamin B. It helps in planting mainly from alcohol.
상기 용안육은 무환자나무과의 속하는 상록교목인 용안의 과육이다. 사려가 과도하여 가슴이 뛰고 진정되지 않으며 건망증이 있고 잠을 못 이루고 소화력이 떨어지며 변이 묽은 증상을 해소시킨다. 병후의 허약이나 노인성으로 기운이 없고 빈혈증상을 보이면서 몸이 마르고 권태감이 잦으며 땀을 스스로 제어할 수 없으며 얼굴빛이 희고 때로 노랗게 보일 때 효력이 있다. 장복하면 강해지고 총명해지며 건망이 없어진다. 산후에 기혈(氣血)이 허약하고 부종이 나타나면 생강과 대추를 달여서 함께 복용한다.The longan flesh is the flesh of the longan which is an evergreen tree belonging to the patient-free family. Too much thoughtful heart beats, soothes, forgetfulness, unable to sleep, less digestive, relieve diarrhea. It is effective when the body is dry, boredom, can't control the sweat on its own, and the face is white and sometimes yellow due to weakness or senility of the disease, showing anemia. When you bless, you become stronger, intelligent, and have no hope. After the postpartum bleeding (氣血) is weak and edema appears, take the ginger and jujube decoction together.
상기 정향은 정향나무과에 속한 상록교목인 정향의 꽃봉오리로, 자극적이지만 상쾌하고 달콤한 향이 특징이다. 정향나무는 15m까지 자라는 상록수로 밝고 붉은 꽃이 핀다. 꽃이 벌어지면 향기가 날아가 버리므로 꽃이 피기 전, 봉오리가 1㎝ 정도가 되면 따서 말린다. 정향은 향신료 중 방부 효과와 살균력이 가장 강력해서 중국에서는 약재로 사용된다. 화장품, 치약, 약품이나 향수의 재료로도 쓰이며 치통이 있을 때 정향을 물고 있으면 응급진통제 역할을 한다.The clove is a bud of the clove which is an evergreen tree belonging to the clove family, it is characterized by a stimulating but refreshing and sweet flavor. Cloves are evergreen trees that grow up to 15m in length with bright red flowers. When the flower opens, the fragrance flies away, so when the buds are about 1cm long, they are dried. Clove is the most powerful antiseptic and sterilizing effect among spices. It is also used as a cosmetic, toothpaste, medicine, or perfume, and if you have a toothache, cloves will act as an emergency painkiller.
상기 지구병(Hovenia dulcis)은 헛개 나무라고도 하며, 사과산, 포도당, 칼슘, 하벤산, 후랑크리닌, 호베닌, 호베노시드를 함유하고 있으며, 술해독 작용이 뛰어난 것으로 알려져 있다. 특히, 상기 지구병의 열매인 지구자는 과당, 포도당, 카탈라제, 페톡시다아제, 칼륨, 칼슘, 철, 트리테르페노이드인, 호베인산, 루틴, 사포닌, 압페롭신 등이 호간기능 회복과 숙취해소 및 간독성 해소효과가 뛰어난 것으로 알려져 있다. The terrestrial disease (Hovenia dulcis), also known as a hut tree, contains malic acid, glucose, calcium, habenic acid, furclinin, hobenin, hobenoside, and is known to be excellent in alcohol detoxification. In particular, the earth fruit, the fruit of the earth disease, fructose, glucose, catalase, phenthase, potassium, calcium, iron, triterpenoids, hobeic acid, rutin, saponin, apelopsin, etc., restore the liver function and hangover. And it is known that hepatotoxicity is excellent.
상기 진피(陳皮)는 운향과의 귤(Citrus unshin Markovich) 또는 근연식물의 성숙한 과피를 건조한 것으로, 특이한 냄사와 약간의 자극성이 있으며 맛은 맵고 쓰며, 약성은 따듯하다. 기가 뭉친 것을 풀어주고, 비장의 기능을 강화하여 복무창만, 트림, 구토, 메스꺼움, 소화불량, 헛배가 부르고 나른한 증상 및 대변이 묽은 증상에 좋다. 또 평소에 소변량이 적거나 잘 붓는 사람도 먹으면 붓기가 가라앉으며, 혈관의 침투성을 줄이고 혈관에 저항력을 주어 혈관의 파열을 방지하는 비타민 P와 유사한 효능이 있는 플라보노이드 화합물인 헤스페리딘이 다량 함유되어있어 술독을 풀어주고 감기 예방에도 좋다.The dermis (陳皮) is dried dry skin of the tangerine (Citrus unshin Markovich) or related plants of the incense, has a peculiar smell and a slight irritation, taste is spicy and bitter, warm. It helps to loosen the swelling and strengthen the function of the spleen, so it is good for only the window, belching, vomiting, nausea, indigestion, flatulence and stool. In addition, people who usually urinate or swell well, the swelling subsides, and contains a large amount of hesperidin, a flavonoid compound that is similar to vitamin P, which reduces blood vessel permeability and resists blood vessel rupture. It helps to loosen the poison and prevent colds.
상기 황정은 둥글레라고도 하며, 대나무 잎과 비슷한 잎 모양을 가지고 있어 옥죽이라고도 부른다. 황정은 오랫동안 먹으면 머리털이 하얗게 쉬지 않고, 소화기능을 강화하며, 뼈를 튼튼하게 해주며 폐결핵으로 인한 해수와 가래에도 효과가 있고, 질병 이후에 체력이 떨어져서 식욕이 없을 때도 효과적이다. The citrine is also called round, and has a leaf shape similar to bamboo leaves, also called jade. Hwangjeong do not rest white hair when eaten for a long time, strengthen digestion, strengthen bones and effective in seawater and sputum caused by pulmonary tuberculosis, and also effective when there is no appetite due to the lack of stamina after the disease.
상기 갈화(葛花)는 콩과(Leguminosea)에 속한 다년생 등본인 칡(Pueraria thumbergiana)의 꽃봉오리를 건조한 것으로, 풀냄새가 나며 약성은 달다. 복부가 답답하거나 속이 울렁거리고 대변이 묽을때의 증상을 완화시키며, 관설에 힘이 없거나 체표의 습(濕)을 해소하는데 효과가 있다. 또한, 과음으로 인한 두통, 발열, 갈증, 식욕부진을 다스리는 효능이 있다.The hwahwa (葛花) is a dried bud of the perennial (Pueraria thumbergiana) belonging to the legume (Leguminosea), the smell of grass and the weakness is sweet. Relieves symptoms when the abdomen is stuffy, swelling, and stool is thin, and it is effective in eliminating the lack of physique or the body surface. In addition, it is effective in treating headaches, fever, thirst and anorexia caused by excessive drinking.
상기 마카(maca)는 십자화과(Brassicacae)에 속하며 정식 학명은 Lepidium meyenii Walp이다. 마카는 자양강장과 피로회복을 위한 생약으로서, 꽃 모양이 장미와 비슷하며, 땅 속에 묻힌 뿌리와 알맹이 부분을 건조시킨 것이 식용으로 쓰인다. 마카의 뿌리는 감자와 비슷하며, 알맹이 또한 감자와 비슷하다. 마카는 남성의 성기능을 증강시키며, 여성의 호르몬 계통의 이상을 바로잡아 생리통이나 생리불순에 효과가 있고, 만성피로 증후군, 무기력증에도 좋다.The maca belongs to the Brassicacae and its official name is Lepidium meyenii Walp. Maca is a medicinal herb for nourishing tonic and fatigue recovery. Its shape is like a rose, and the dried roots and kernels are used for food. Maca roots are similar to potatoes, and kernels are also similar to potatoes. Maca enhances male sexual function, corrects hormonal abnormalities in women, and is effective for menstrual cramps and menstrual disorders, and is good for chronic fatigue syndrome and lethargy.
상기 맥문동(麥門冬)은 백합과(Liliaceae)의 식물인 소엽맥문동(실겨우살이)의 덩이뿌리를 한약재로 사용한다. 맥문동은 맛이 달고 성질이 약간 서늘하면서도 평이해서 호흡기를 보강하는 약재이다. 약리실험에 의하면 강심 작용, 이뇨작용, 가래삭임작용, 기침멈춤작용, 영양작용이 있으며, 여자의 음을 보하고 폐를 편안히 하며, 심열(심화로 생기는 병)을 다스리고 오줌을 잘 누게 한다. 폐와 위장을 보하는 가운데 특히 자양강장의 효과가 뛰어나서 일반적으로 신체 허약에 널리 쓰고 기력이 뚝 떨어지는데 약용하면 힘이 솟는다.The mammundong (麥 門冬) is used as a herbal medicine of the tuber of leaflet vegetation dong (silent mistletoe) which is a plant of the liliaceae (Liliaceae). Macmundong is sweet and tastes a little cool and plain, it is a respiratory medicinal herb. According to pharmacological experiments, there is a cardiac effect, diuretic effect, sputum coughing, cough stopping effect, nutrition effect, to see the woman's tone, to relax the lungs, and to soothe the deep (the disease caused by deepening) and pee well. In addition to the lungs and stomach, especially the effect of nourishing tonic is generally good for the weakness of the body is generally used to weaken the strength and weaken the strength rises.
상기 오리목(Alnus japonica)은 자작나무과(Betulaveae)에 속하며 한자로는 유리목(楡理木)이라고도 하고, 중국은 차조라 했다. 오리목의 어린 지엽 및 수피를 적양이라고 하며, 봄, 가을에 채취하여 햇볕에 건조하여 사용한다. 오리목은 맛이 쓰고 떫으며 성질은 서늘하다. 대장의 열을 내려주어 빈혈, 장염에 좋으며, 코피, 외상 출혈, 숙취, 지방간, 간염, 간경화에도 좋다.The alder tree (Alnus japonica) belongs to the birch family (Betulaveae), also known as the glass tree (楡 理 木) in Chinese, and called Chajo. The young leaves and bark of the alder are called red sheep, and they are collected in spring and autumn and dried in the sun. Alder is bitter and salty and has a cool nature. The heat of the colon is good for anemia and enteritis, nosebleeds, trauma bleeding, hangover, fatty liver, hepatitis, liver cirrhosis is also good.
상기 지각(枳殼)은 운황과(Rutaceae)에 속한 상록소교목인 산등(酸燈, Citrus aurantium L.)과 우리나라에서는 탱자나무의 완숙된 것을 지각(枳殼)이라고 한다. 맛은 조금 시고 쓰며, 방향이 있다. 가슴과 배가 부불어 오른듯한 답답함을 해소해주며 변비로 인한 복통 등에도 효과가 있다. 또한, 지각 추출물을 장기간 투여했을 경우 체중증가가 현저히 억제되는 효능도 있다.The crust is an evergreen species belonging to the Rutaceae group, Citrus aurantium L. and in Korea, the ripening of tangerines is called crust. The taste is a bit sour and bitter, with aroma. Relieves the stuffy chest and stomach swollen, and is effective in stomach pain caused by constipation. In addition, long-term administration of the perceptual extract has the effect of significantly suppressing weight gain.
상기 지실(枳實)은 운황과(Rutaceae)에 속한 상록소교목인 산등(酸燈, Citrus aurantium L.)과 우리나라에서는 탱자나무의 덜 익은 열매를 지실(枳實)이라고 한다. 피부의 심한 가려움증과 복부창만, 명치끝이 그득하면서 아픈 것을 낫게 하고 음식을 먹고 체한지 오래 된 증상을 치료하며, 식중독에 걸렸을 시 양약 처방 후 사용해도 좋다. 기가 뭉쳐져서 생긴 창만, 변비 등의 모든 증상에 응용 가능하나 기가 모여 있는 것을 분산시키는 작용이 강한 반면 기를 보하는 효능이 없기에 정기를 상하게 할 위험이 있으므로 신중히 사용하여야 한다. 최근에는 위하수, 자궁하수, 탈항 등에도 효과가 있어 응용되고 있다. Jisil (실) is the evergreen cultivars belonging to the Rutaceae (citrus aurantium L.) and the less ripe fruit of the tanja in Korea is called Jisil (枳實). Severe itching and abdominal swelling of the skin, the end of the clear tooth to relieve the sick, to eat and stay a long time after the treatment of symptoms, if you have food poisoning can be used after prescription medicine. It can be applied to all the symptoms such as swelling and constipation due to grouping, but there is a strong effect of dispersing the gathering of the group, but there is a risk of hurting the regular period, so it should be used carefully. In recent years, it has been applied to the stomach and sewage, uterine sewage, desalination and the like.
이하, 본 발명은 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제를 혼합하는 단계(S10)와 상기 단계(S10)의 혼합 생약제를 진공상태에서 혼합 생약제 추출물을 추출하는 단계(S20)와 상기 단계(S20)의 혼합 생약제 추출물을 농축하여 혼합 생약제 농축액을 만드는 단계(S30)와 상기 단계(S10)의 혼합 생약제를 건조하고 분말화하여 혼합 생약제 분말을 제조하는 단계(S40)와 상기 단계(S30)의 혼합 생약제 농축액과 상기 단계(S40)의 혼합 생약제 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(S50);로 이루어진 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물의 제조방법을 상세하게 설명한다.Hereinafter, the present invention is the step of mixing the mixed herbal medicine consisting of the root, gojija, four ginseng, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellowing, brown flower, maca, macmundong, alder, crust and crust (S10) Step (S20) and the step (S30) and the step (S10) of making a mixed herbal medicine extract by concentrating the mixed herbal medicine extract of the step (S10) and the mixed herbal medicine extract in a vacuum state (S20) and the step (S20) Drying and powdering the mixed herbal medicine to prepare a mixed herbal medicine powder (S40) and mixing the mixed herbal medicine concentrate of step (S30) and the mixed herbal medicine powder of step (S40) to prepare granules, powders and pills (S50); will be described in detail a method for producing a hangover relief, fatigue recovery and immune-enhancing food composition comprising a mixed herbal drug extract as an active ingredient.
상기 단계(S10)의 혼합 생약제를 진공상태에서 혼합 생약제 추출물을 추출하는 단계(S20)에서 용매는 정제수와 식품용 알코올을 7 : 3 내지 5 : 5 중량비로 혼합한 추출용매를 제조한다. 상기 식품용 알코올은 에탄올인 것이 바람직하다.In the step (S20) of extracting the mixed herbal medicine extract of the mixed herbal medicine in the step (S10) under vacuum (S20), a solvent is prepared by extracting a solvent mixture of purified water and food alcohol in a 7: 3 to 5: 5 weight ratio. The food alcohol is preferably ethanol.
상기 추출용매는 알코올 대비 정제수의 중량비가 5 중량비 미만이면 알코올 성분이 상대적으로 늘어나 추출 후 잔존하는 알코올을 제거하기 위한 공정이 추가되며, 알코올 대비 정제수의 중량비가 7 중량비 초과이면, 알코올 성분이 상대적으로 줄어 각각의 생약제에서 추출물들이 균일하게 추출되지 않는 문제점이 있다. When the weight ratio of purified water to alcohol is less than 5 weight ratio, the extraction solvent is a relatively increased alcohol component is added to remove the remaining alcohol after extraction, and if the weight ratio of alcohol to purified water is greater than 7 weight ratio, alcohol component is relatively There is a problem that the extract is not evenly extracted from each herbal medicine.
우선, 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실로 이루어진 혼합 생약제를 깨끗이 세척하여 혼합하는 단계(S10)를 수행한다.First, cleans and mixes the mixed herbal medicine consisting of brown root, wolfberry, samsam, hawthorn, singok, yongan meat, cloves, earth disease, dermis, citrine, brown flower, maca, macmundong, alderwood, crust and crust (S10). do.
상기 단계(S10)의 혼합 생약제에 1,000 내지 5,000 cc의 추출 용매를 넣고, 85 내지 90 ℃의 온도로 10 시간 동안 진공상태에서 혼합 생약제 추출물을 추출하는 단계(S20)를 수행한다.1,000 to 5,000 cc of the extraction solvent is added to the mixed herbal medicine of step S10, and the mixed herbal medicine extract is extracted under vacuum at a temperature of 85 to 90 ° C. for 10 hours (S20).
상기 단계(S20)의 혼합 생약제 추출물을 농축하여 500 내지 1000 cc의 혼합 생약제 농축액으로 만드는 단계(S30)를 수행한다. 1,000 내지 5,000 cc의 혼합 생약제 추출물을 저온 농축방법으로 500 내지 1000 cc의 혼합 생약제 농축액을 만든다. Concentrating the mixed herbal medicine extract of step (S20) to make a mixed herbal medicine concentrate of 500 to 1000 cc (S30). 1,000 to 5,000 cc of the mixed herbal medicine extract is prepared at 500 to 1000 cc of the mixed herbal medicine concentrate by low temperature concentration.
상기 저온 농축 방법은 열의 영향을 받는 성분이나 공기에 의해 산화되는 성분을 농축하기 위해 진공상태에서 40 내지 90 ℃의 온도에서 한다.The low temperature concentration method is carried out at a temperature of 40 to 90 ℃ in a vacuum to concentrate the components that are affected by heat or oxidized by air.
상기 단계(S10)의 혼합 생약제를 건조하고 분말화하여 혼합 생약제 분말을 제조하는 단계(S40)수행한다. 상기 단계(S40)에서는 생약제를 깨끗이 세척하여 배합한 후, 건조기에서 65 내지 75 ℃의 온도로 10시간 동안 건조한 후, 200 mesh의 혼합 생약제 분말을 제조한다.The mixed herbal medicine of step S10 is dried and powdered to prepare a mixed herbal medicine powder (S40). In the step (S40) to clean and blend the herbal medicines, after drying for 10 hours at a temperature of 65 to 75 ℃ in a dryer, to prepare a mixed herbal medicine powder of 200 mesh.
상기 혼합 생약제는 갈근, 구기자, 사삼, 산사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실를 포함한다.The mixed herbal medicines include roots, goji berry, samsam, hawthorn, new song, longan meat, cloves, earth disease, dermis, yellow flower, brown flower, maca, macmundong, alder, crust and crust.
상기 단계(S30)의 혼합 생약제 농축액과 상기 단계(S40)의 혼합 생약제 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(S50)를 수행한다.The mixed herbal medicine concentrate of step S30 and the mixed herbal powder of step S40 are mixed to prepare granules, powders and pills (S50).
이하, 하기 실시예 및 실험예를 통해 본 발명을 보다 상세히 설명하기로 한다. 하기 실시예 및 실험예는 본 발명을 예시하는 것일 뿐, 본 발명이 하기 실시예 및 실험예에 한정되는 것이 아니다.Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. The following Examples and Experimental Examples are merely illustrative of the present invention, and the present invention is not limited to the following Examples and Experimental Examples.
< 제조예 > 추출 용매의 제조 Preparation Example Preparation of Extraction Solvent
추출 용매는 정제수와 에탄올을 7 : 3 중량비로 혼합하여 제조하였다.The extraction solvent was prepared by mixing purified water and ethanol in a 7: 3 weight ratio.
< 실시예 > 제조방법
EXAMPLES Manufacturing Method
본 발명의 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물의 제조는 아래와 같이 제조하였다.Hangover, fatigue recovery and immune-enhanced food composition comprising a mixed herbal extract of the present invention as an active ingredient was prepared as follows.
(S10) 갈근 5 중량부, 구기자 5 중량부, 사삼 5 중량부, 산사 5 중량부, 신곡 3 중량부, 용안육 5 중량부, 정향 2 중량부, 지구병 15 중량부, 진피 5 중량부, 황정 5 중량부, 갈화 5 중량부, 마카 25 중량부, 맥문동 5 중량부, 오리목 5 중량부, 지각 3 중랑부 및 지실 2 중량부로 생약제를 혼합하여 혼합 생약제를 제조하였다.(S10) 5 parts by weight, 5 parts by weight of wolfberry, 5 parts by weight of Sasam, 5 parts by weight of mountain sand, 3 parts by weight of new song, 5 parts by weight of clove meat, 2 parts by weight of clove, 15 parts by weight of earth disease, 5 parts by weight of dermis The mixed herbal medicine was prepared by mixing 5 parts by weight, 5 parts by weight of gallium, 25 parts by weight of maca, 5 parts by weight of Macmundong, 5 parts by weight of Alderwood, 3 parts of crust, and 2 parts by weight of fruit room.
(S20) 상기 단계(S10)의 혼합 생약제에 상기 제조예의 추출 용매 2,000 mL를 넣고 85 내지 90 ℃의 온도로 10 시간 동안 진공상태에서 추출하여 혼합 생약제 추출물을 제조하였다.(S20) To the mixed herbal medicine of the step (S10) was added 2,000 mL of the extraction solvent of the preparation example and extracted under vacuum at a temperature of 85 to 90 ℃ for 10 hours to prepare a mixed herbal medicine extract.
(S30) 상기 혼합 생약제 추출물을 얻은 후, 2,000 mL의 상기 단계(S20)의 혼합 생약제 추출물을 저온 농축 방법으로 1,000 mL로 농축하여 혼합 생약제 농축액을 제조하였다.(S30) After obtaining the mixed herbal medicine extract, 2,000 mL of the mixed herbal medicine extract of step (S20) was concentrated to 1,000 mL by a low temperature concentration method to prepare a mixed herbal medicine concentrate.
(S40) 갈근 5 중량부, 구기자 5 중량부, 사삼 5 중량부, 산사 5 중량부, 신곡 3 중량부, 용안육 5 중량부, 정향 2 중량부, 지구병 15 중량부, 진피 5 중량부, 황정 5 중량부, 갈화 5 중량부, 마카 25 중량부, 맥문동 5 중량부, 오리목 5 중량부, 지각 3 중랑부 및 지실 2 중량부의 생약제를 깨끗이 씻은 후, 건조기에서 65 내지 75 ℃의 온도로 10 시간 동안 건조한 후 200 mesh의 혼합 생약제 분말을 제조하였다.(S40) 5 parts by weight, 5 parts by weight of wolfberry, 5 parts by weight of samsam, 5 parts by weight of mountain sand, 3 parts by weight of new song, 5 parts by weight of clove meat, 2 parts by weight of clove, 15 parts by weight of earth disease, 5 parts by weight of dermis 5 parts by weight, 5 parts by weight of gallium, 25 parts by weight of maca, 5 parts by weight of Macmundong, 5 parts by weight of Alder, 5 parts by weight of crust, 2 parts by weight of herbal medicine, and then washed in a dryer for 10 hours at a temperature of 65 to 75 ° C. After drying, a mixed herbal powder of 200 mesh was prepared.
(S50) 상기 단계(S30)의 혼합 생약제 농축액과 옥수수 분말(부형제)을 2 : 1 중량비로 배합한 후 동결건조로 과립제를 제조하고, 상기 단계(A2)의 혼합 생약제 농축액과 상기 단계(S40)의 혼합 생약제 분말을 2 : 1 중량비로 혼합하여 65 내지 75 ℃의 온도로 10 시간 동안 건조한 후 200 mesh 산제를 제조하며, 상기 산제 300 g에 찹쌀 300 g과 정제수 1,000 mL를 더 포함하여 혼합한 후 5 mm의 직경으로 환제를 제조하였다.(S50) After mixing the mixed herbal medicine concentrate and corn powder (excipient) in a weight ratio of 2: 1 by the step (S30) to prepare a granule by lyophilization, the mixed herbal medicine concentrate of step (A2) and the step (S40) Mixed herbal powder of 2: 1 by weight ratio and dried for 10 hours at a temperature of 65 to 75 ℃ to prepare a 200 mesh powder, 300 g of the powder was added to 300 g and 1,000 mL of purified water after mixing further Pills were prepared with a diameter of 5 mm.
< 실험예 1 > Experimental Example 1
평소 주량이 1병 360 ml(소주기준)을 일주일에 2 내지 3회 정도 음용하는 22세 내지 45세 성인 남녀 50명을 대상으로 하여 숙취해소 효과를 확인하는 실험을 하였다. 실험 대상자의 구체적인 신체 특징은 하기 표 1에 기재하였다.An experiment was conducted to confirm the hangover relief effect of 50 male and female adults aged 22 to 45 years who drink 1 bottle 360 ml (soju standard) 2-3 times a week. Specific body characteristics of the test subjects are listed in Table 1 below.
실험 대상자 50명에게 알코올 함량 19%의 소주 한잔에 안주로 삼겹살 1점을 같이 섭취하게 하고, 1인당 총 1병(360ml)을 30분 동안 마시게 하였으며, 음주 4시간 후 발열, 갈증, 취기, 두통, 피로, 소화불량, 메스꺼움(욕지기), 구토, 복통 및 설사의 10개 항목에 숙취가 없고 있음에 따라 하기와 같은 평가 기준을 적용해 중복응답으로 점수를 매기게 하였다.50 subjects were given one point of pork belly with snacks in a glass of alcoholic beverage containing 19% alcohol, and a total of 1 bottle (360ml) per person for 30 minutes.Fever, thirst, odor, As 10 items of headache, fatigue, indigestion, nausea (vomiting), vomiting, abdominal pain and diarrhea were not hangover, the following evaluation criteria were applied and scored as a duplicate response.
[평가기준 : 1=젼혀 없음, 2=없음, 3=보통, 4=있음, 5=아주 심함][Evaluation Criteria: 1 = None at all, 2 = None, 3 = Normal, 4 = Yes, 5 = Very severe]
상기 10개 항목의 값을 모두 합한 평가 결과를 하기 표 2에 나타낸다.Evaluation results obtained by adding up the values of all ten items are shown in Table 2 below.
< 실험예 2 >Experimental Example 2
상기 실험예 1을 실시한 50명을 대상으로 7일 후에 상기 실험예 1과 동일한 방법인 알코올 함량 19%의 소주 한잔에 안주로 삼겹살 1점을 같이 섭취하게 하고, 1인당 총 1병(360ml)을 30분 동안 마시게 한 후, 섭취하기 편한 상기 실시예에서 제조한 환제를 복용하게 하였다.7 days after 50 days of the Experimental Example 1 was subjected to intake one point of pork belly with a snack in a cup of alcohol content 19% alcohol in the same way as Experimental Example 1, a total of 1 bottle (360ml) per person After 30 minutes of drinking, the pill prepared in the above-mentioned easy-to-eat example was taken.
음주 4시간 후 발열, 갈증, 취기, 두통, 피로, 소화불량, 매스꺼움(욕지기), 구토, 복통 및 설사의 10개 항목에 숙취가 없고 있음에 따라 하기와 같은 평가 기준을 적용해 중복응답으로 점수를 매기게 하였다.After 4 hours of drinking, fever, thirst, odor, headache, fatigue, indigestion, nausea (nausea), vomiting, abdominal pain and diarrhea were not found in 10 items. To be tied.
[평가기준 : 1=젼혀 없음, 2=없음, 3=보통, 4=있음, 5=아주 심함][Evaluation Criteria: 1 = None at all, 2 = None, 3 = Normal, 4 = Yes, 5 = Very severe]
상기 10개 항목의 값을 모두 합한 평가 결과를 하기 표 2에 나타낸다.Evaluation results obtained by adding up the values of all ten items are shown in Table 2 below.
| 임상실험대상자Clinical subject | 총 50명50 people in total |
| 성별비율(남:여)Gender Ratio (Male: Female) | 남:여 = 25:25M: F = 25:25 |
| 연령(세)Age (years) | 평균 33세 (최저 22세, 최고 45세)Average age 33 (min 22, max 45) |
| 체중(kg)Weight (kg) | 평균 68kg (최저 48kg, 최고 88kg)Average 68 kg (48 kg minimum, 88 kg maximum) |
| 키(cm)Height (cm) | 평균 170cm (최저 156cm, 최고 185cm)Average 170cm (minimum 156cm, maximum 185cm) |
| 숙취증상Hangover Symptoms | 대상자수Target number | 실험예 1Experimental Example 1 | 실험예 2Experimental Example 2 | 1인당 숙취해소 효과율 평균(%)Average hangover removal rate per capita (%) | ||
| 평가점수합계Total score | 개인별 평가점수(평균)Individual score (average) | 평가점수합계Total score | 개인별 평가점수(평균)Individual score (average) | |||
| 발열(pyrexy)Pyrexy | 5050 | 201201 | 4.024.02 | 138138 | 2.762.76 | 31.3431.34 |
| 갈증(thirst)Thirst | 5050 | 225225 | 4.504.50 | 136136 | 2.722.72 | 39.5639.56 |
| 취기 (intoxication)Intoxication | 5050 | 233233 | 4.664.66 | 126126 | 2.522.52 | 45.9245.92 |
| 두통 (headahe)Headache (headahe) | 5050 | 158158 | 3.163.16 | 6464 | 1.281.28 | 59.4959.49 |
| 피로(tiredness)Tiredness | 5050 | 187187 | 3.743.74 | 129129 | 2.582.58 | 31.0231.02 |
| 소화불량(maldigestiom)Maldigestiom | 5050 | 126126 | 2.522.52 | 5757 | 1.141.14 | 54.7654.76 |
| 메스꺼움(nausea)Nausea | 5050 | 155155 | 3.103.10 | 7575 | 1.501.50 | 51.6151.61 |
| 구토(vomiting)Vomiting | 5050 | 105105 | 2.102.10 | 4444 | 0.880.88 | 58.0958.09 |
| 복통(abdominalgia)Abdominalgia | 5050 | 116116 | 2.322.32 | 3535 | 0.700.70 | 69.8369.83 |
| 설사(diarrhea)Diarrhea | 5050 | 8686 | 1.921.92 | 2020 | 0.400.40 | 79.1779.17 |
상기 개인별 평가점수(평균) 및 1인당 숙취해소 효과율 평균(%)은 하기 수학식 1 및 수학식 2로 계산하여 결과를 얻었다.The individual evaluation score (average) and the per capita hangover effect rate average (%) was calculated by the following equation (1) and (2) to obtain a result.
[수학식 1][Equation 1]
[수학식 2][Equation 2]
상기 표 2의 결과를 통하여 본 발명의 숙취해소 음료는 부작용이 없으면서 소화불량, 복통 및 설사 등의 숙취해소 효과가 우수하다는 것을 알았다. Through the results of Table 2, it was found that the hangover-relieving beverage of the present invention has excellent hangover-relieving effects such as indigestion, abdominal pain and diarrhea without side effects.
실험 평가 대상자 총 50명 중 24명은 평소 음주 시 발열이 있거나 갈증이 있었지만 본 발명의 혼합 생약제 추출물을 유효성분으로 하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 섭취 후 열이 나지 않고, 갈증이 해소가 되었다고 응답하였다.Twenty-four of the total 50 subjects tested had fever or thirst when drinking alcohol, but did not get fever after eating hangover relief, fatigue recovery and immunity enhancing food composition using the mixed herbal medicine extract of the present invention as an active ingredient. Responded to the resolution.
또한, 실험 평가 대상자 총 50명 중 10명은 평소에 술을 많이 마시지 못하여 소주 3잔을 마시면 얼굴이 붉어지고 화끈거려 대인관계에서도 어려움을 겪었지만, 본 발명의 혼합 생약제 추출물을 유효성분으로 하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 섭취 후에는 갈증이 사라졌다고 응답하였다.In addition, 10 out of a total of 50 subjects of the test evaluation suffered from the interpersonal relationship with the redness and swelling in the interpersonal relationship when drinking three glasses of soju was not able to drink much alcohol as usual, but the hangover relief using the mixed herbal extract of the present invention as an active ingredient After eating the food composition for fatigue recovery and immune system, thirst disappeared.
또한, 실험 평가 대상자 총 50명 중 7명은 위장기능이 약하여 술자리에서 화장실을 가는 경우가 많다고 하였지만, 본 발명의 혼합 생약제 추출물을 유효성분으로 하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 섭취 후 화장실을 가지 않고, 배가 편안해졌다고 응답하였다. In addition, seven out of 50 subjects of the experimental evaluation was said to be a lot of people go to the toilet in the drinking room because of weak gastrointestinal function, but after ingesting a food composition for hangover relief, fatigue recovery and immunity enhancement using the mixed herbal medicine extract of the present invention as an active ingredient Instead of going to the toilet, she replied that her stomach was comfortable.
또한, 실험 평가 대상자 총 50명 중 23명은 본 발명의 혼합 생약제 추출물을 유효성분으로 하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물을 섭취 후 술이 빨리 깨고 몸이 가뿐해졌다고 하였으며, 또 다른 20명은 한 달 동안 계속된 숙취해소 효과 실험에서 부작용이 발견되거나 문제점이 발생하지 않은 것으로 보고되었다.In addition, 23 out of a total of 50 test subjects said that after a hangover, fatigue recovery and immune-enhancing food composition containing the mixed herbal medicine extract of the present invention, the alcohol was quickly broken and the body became relaxed. Nine people reported no side effects or problems during the month-long hangover test.
따라서, 본 발명의 혼합 생약제 추출물을 유효성분으로 하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물은 인체에 부작용이 발생하지 않으며, 숙취해소 효과가 뛰어나 음주 후 숙취를 해소하기 위한 방법으로 유용하고 간편하게 이용될 수 있을 것이다. Therefore, the hangover relief, fatigue recovery and immune-enhancing food composition using the mixed herbal medicine extract of the present invention as an active ingredient does not cause side effects to the human body, excellent hangover relief effect is useful and convenient as a method for eliminating hangover after drinking May be used.
Claims (5)
- 갈근, 구기자, 사삼, 신사, 신곡, 용안육, 정향, 지구병, 진피, 황정, 갈화, 마카, 맥문동, 오리목, 지각 및 지실으로 이루어진 혼합 생약제로부터 추출한 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물.Hangover relief including mixed herbal extract extracted from mixed herbal medicine consisting of brown root, goji berry, samsam, shrine, new song, longan meat, cloves, earth disease, dermis, citrine, brown flower, maca, mackmundong, alder tree, crust and crust, Fatigue recovery and food composition for enhancing immunity.
- 제 1 항에 있어서,The method of claim 1,상기 혼합 생약제는 갈근 3 내지 7 중량부, 구기자 3 내지 7 중량부, 사삼 3 내지 7 중량부, 산사 3 내지 7 중량부, 신곡 1 내지 5 중량부, 용안육 3 내지 7 중량부, 정향 1 내지 3 중량부, 지구병 10 내지 20 중량부, 진피 3 내지 7 중량부, 황정 3 내지 7 중량부, 갈화 3 내지 7 중량부, 마카 20 내지 30 중량부, 맥문동 3 내지 7 중량부, 오리목 3 내지 7 중량부, 지각 3 내지 7 중랑부 및 지실 3 내지 7 중량부로 이루어진 것을 특징으로 하는 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물.The mixed herbal medicines 3 to 7 parts by weight of brown root, 3 to 7 parts by weight of goji berry, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of mountain sand, 1 to 5 parts by weight of new song, 3 to 7 parts by weight of clove meat, 1 to 3 cloves Parts by weight, terrestrial disease 10 to 20 parts by weight, dermis 3 to 7 parts by weight, citrine 3 to 7 parts by weight, trituration 3 to 7 parts by weight, maca 20 to 30 parts by weight, macmundong 3 to 7 parts by weight, alder 3 to 7 Hangover, fatigue recovery and immune-enhancing food composition comprising a mixed herbal extract as an active ingredient, characterized in that consisting of 3 parts by weight, crust 3 to 7 middle part and crust 3-7 parts by weight.
- 제 1 항에 있어서,The method of claim 1,상기 식품 조성물은 과립제, 분말제 및 환제 중 어느 하나의 제형으로 제조되는 것을 특징으로 하는 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물.The food composition is a hangover relief, fatigue recovery and immune boost food composition comprising a mixed herbal extract as an active ingredient, characterized in that the formulation of any one of granules, powders and pills.
- 갈근 3 내지 7 중량부, 구기자 3 내지 7 중량부, 사삼 3 내지 7 중량부, 산사 3 내지 7 중량부, 신곡 1 내지 5 중량부, 용안육 3 내지 7 중량부, 정향 1 내지 3 중량부, 지구병 10 내지 20 중량부, 진피 3 내지 7 중량부, 황정 3 내지 7 중량부, 갈화 3 내지 7 중량부, 마카 20 내지 30 중량부, 맥문동 3 내지 7 중량부, 오리목 3 내지 7 중량부, 지각 3 내지 7 중랑부 및 지실 3 내지 7 중량부로 이루어진 혼합 생약제를 혼합하는 단계(S10);3-7 parts by weight of brown root, 3-7 parts by weight of wolfberry, 3-7 parts by weight of samsam, 3-7 parts by weight of hawthorn, 1-5 parts by weight of new song, 3-7 parts by weight of dragon meat, 1-3 parts by weight of clove, earth Bottles 10 to 20 parts by weight, dermis 3 to 7 parts by weight, citrine 3 to 7 parts by weight, browning 3 to 7 parts by weight, maca 20 to 30 parts by weight, ganmundong 3 to 7 parts by weight, alder 3 to 7 parts by weight, crust Mixing the mixed herbal medicine consisting of 3 to 7 middle parts and 3 to 7 parts by weight of the basement (S10);상기 단계(S10)의 혼합 생약제를 진공상태에서 혼합 생약제 추출물을 추출하는 단계(S20);Extracting the mixed herbal medicine extract of the mixed herbal medicine of the step (S10) in a vacuum state (S20);상기 단계(S20)의 혼합 생약제 추출물을 농축하여 혼합 생약제 농축액을 만드는 단계(S30);Concentrating the mixed herbal medicine extract of the step (S20) to create a mixed herbal drug concentrate (S30);상기 단계(S10)의 혼합 생약제를 건조하고 분말화하여 혼합 생약제 분말을 제조하는 단계(S40) 및 Drying and powdering the mixed herbal medicine of the step (S10) to produce a mixed herbal medicine powder (S40) and상기 단계(S30)의 혼합 생약제 농축액과 상기 단계(S40)의 혼합 생약제 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(S50);로 이루어진 특징으로 하는 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물의 제조방법.Hanging the mixed herbal medicine extract of step (S30) and the mixed herbal medicine powder of step (S40) to prepare granules, powders, pills (S50); a mixed herbal medicine extract characterized in that the active ingredient Method for preparing food composition for relieving, fatigue recovery and immunity enhancement.
- 제 4 항에 있어서,The method of claim 4, wherein상기 단계(S10)의 혼합 생약제를 진공상태에서 혼합 생약제 추출물을 추출하는 단계(S20)에서 정제수와 에탄올을 7 : 3 내지 5 :5 중량비로 혼합한 추출용매를 사용하는 것을 특징으로 하는 혼합 생약제 추출물을 유효성분으로 포함하는 숙취해소, 피로회복 및 면역력 증강용 식품 조성물의 제조방법Mixed herbal medicine extract, characterized in that to use the extraction solvent mixed with purified water and ethanol in a 7: 3 to 5: 5 weight ratio in the step (S20) to extract the mixed herbal medicine in a vacuum in the mixed herbal medicine of step (S10) Method for preparing hangover, fatigue recovery and immune boost food composition comprising as an active ingredient
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