KR20180037693A - A food composition for preventing and improving lung diseases - Google Patents

Abstract

A composition of the present invention contains a fermented extract fermenting a combined extract of pear, ripe persimmon, walnut flesh, red ginseng, root of Platycodon grandiflorum A. De Candolle, lily, steamed and dried root of Rehmanneh glutinosa Libosch. var. purpurea Mak., dried sclerotium of Poria cocas Wolf., bark or root bark of Ulmaceae, Schisandra chinensis, onion, corni, and licorice as an active ingredient. Therefore, the composition can increase an inhaling capacity with lung air synergism, can prevent dry cough and phlegm due to pulmonary resonance shortage by fine dust, an abnormal climate, an environmental factor, and so on, and can perform preventive treatment on chronic lung diseases by increasing strength and strengthening a lung after taking the composition when being emaciated and feeling low. In addition, the composition can be effective for rhinitis, bronchial asthma, cough variant asthma, and so on with a high treatment rate as well as performing a function which is beneficial to strength by strengthening the lung to strengthen the lung and to enable bronchial tubes to smoothly function.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a food composition for prevention and improvement of pulmonary disease,

The present invention relates to a composition for prevention and improvement of pulmonary disease, and more particularly, to a composition for prevention and improvement of pulmonary disease, and more particularly to a composition for prevention and improvement of pulmonary disease, A fermented product as an active ingredient, and a food composition for prevention and improvement of pulmonary disease.

Chronic Obstructive Pulmonary Disease (COPD), one of the most common pulmonary diseases with asthma, differs from asthma in that it is associated with irreversible airway obstruction. It currently occupies the fourth highest global mortality rate, It is an important disease that the incidence increases. COPD is a disease caused by a pathologic change of bronchioles and lung parenchyma caused by airway and pulmonary parenchymal inflammation, characterized by obstructive bronchiolitis and emphysema (pulmonary parenchymal destruction). Types of Chronic Obstructive Pulmonary Disease include Chronic obstructive bronchitis, Chronic bronchiolitis, and Emphysema. Smoking is one of the most important causes of COPD. Smoking acts as a strong toxic substance in the lung tissue, promoting the production of oxidants, proinflammatory and chemotactic factors, which promotes excessive migration of inflammatory cells such as neutrophils.

Up to now, COPD, including asthma, has been used for the treatment of inflammatory diseases with therapeutic agents having antiinflammatory or bronchodilating effects. Many of these existing treatments require many caution when used with many side effects. Representative therapeutic agents include glucocorticoid, leukotriene modifiers, theophylline, and the like. Glucocorticoid is powerful but not selective, but it suppresses all immune and anti-inflammatory reactions. Therefore, there is a problem of suppressing the necessary immune response in some cases. As a result of drug side effects, Treatment. Although leukotriene modifiers have few side effects, they have limited efficacy and can not control asthma when used alone. Theophylline is not excellent in efficacy and has a problem of side effects. Although corticosteroids have excellent therapeutic effects, they are known to cause adrenal suppression, bone density reduction, growth disturbance, eye and skin complications, and increased collagen synthesis in proportion to the dose and duration of use, . A persistent beta-2 agonist, such as salmeterol and formeterol, has been shown to prevent seizures, but it has been warned that it may lead to death in some cases . Due to these various side effects, conventional therapeutic agents for inflammatory diseases require careful consideration in their use, and there is a desperate need for the development of therapeutic agents with excellent effects and few side effects. This requires an accurate understanding of the origin of COPD.

In the meantime, the precise mechanism of COPD is unknown until now, and various treatment methods have been used. However, there is no medicament that can fundamentally treat the onset and progress of COPD. Therefore, it is necessary to study the pathogenesis mechanism of COPD and to develop basic medicine based on it.

There may be several factors that can reduce lung function, but the most serious of these is smoking. According to the WHO report, 47% of the world's population and 12% of women are smoking now, and 3.5 million people die from smoking-related diseases every year. In 2020, the proportion of smokers is 12% Which is expected to cost 10 million people every year.

Tobacco smoke contains a large amount of various harmful substances, mainly nicotine, which is contained in particulate matter, and carbon dioxide contained in the gas phase physiologically influence it. Effects of addictive smoking include cancers such as lung, pharynx, oral cavity, larynx, esophagus, stomach, bladder, pelvis, ureter, pancreas, ischemic heart disease, cerebrovascular disease, chronic obstructive pulmonary disease, This is being discussed.

In addition, smokers are exposed to secondhand smokers, so they are required to pay a penalty if they are caught smoking in public places where many people gather. In recent years, smokers have been smoking in some places including restaurants There are also various efforts to prevent the harm caused by smoking, such as the imposition of a fine on street fines and a bill to prohibit street smoking due to smoking in the streets.

It is known that the effect of health recovery is also great when the illness caused by smoking is great but smoking cessation is large. For example, one year after quitting smoking, the risk of developing coronary heart disease is reduced by 50%, and 15 years later, lung cancer and stroke are also included.

In addition to smoking, recently, yellow dust and fine dusts containing heavy metals from China have been affecting Korea, and at one time they have been concentrated in spring. Recently, however, they have occurred regardless of the season, There is a fear that it will have an adverse effect on the environment.

In order to protect the lungs or lungs from dust or fine dust, it is generally necessary to use a mask or to clean after the ear, but additional efforts are needed.

Accordingly, the present inventors have conducted intensive studies to develop a natural-derived material capable of preventing lung disease by enhancing pulmonary function and protecting lungs from fine dusts and various environmental pollutants. When the fermented product of mixed extract consisting of Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Yukunpie, Omija, onion, corn oil and licorice is used when the dry cough, sputum and body are not smooth and weak, The present invention has been accomplished based on this finding.

Accordingly, it is a technical object of the present invention to provide a food composition for enhancing pulmonary function and preventing or improving pulmonary disease.

In order to solve the above technical problems, the present invention provides an extract fermented product obtained by fermenting a mixed extract of Bae, Hongxi, Hodo, Red ginseng, Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Yukuni, Omija, Onion, A food composition for enhancing pulmonary function or preventing or improving pulmonary disease as an active ingredient is provided.

According to one preferred embodiment of the present invention, the present invention provides a method for producing a pearl of the present invention which comprises blending 25 to 35% by weight of pear, 15 to 25% of pear, 5 to 15% of pear, 5 to 15% 3 to 5% by weight of oyster, 3 to 5% by weight of onion, 3 to 5% by weight of corn oil, 3 to 5% by weight of licorice, 3 to 5% % Of a fermented product of a mixed extract as an active ingredient, and a food composition for preventing or improving pulmonary disease.

In the present invention, the term "chronic obstructive pulmonary disease" refers to a respiratory disease caused by an abnormal inflammatory reaction caused by inhalation of harmful particles or gas, It says. The main symptoms of chronic obstructive pulmonary disease are chronic cough or chronic sputum (sputum) as well as dyspnea, and bronchodilator such as beta agonist, anticholinergic agent, methylzantine system, or corticosteroid inhalant do. In the present invention, the chronic obstructive pulmonary disease may be, but is not limited to, chronic bronchitis or emphysema.

The term "chronic bronchitis " in the present invention means a disease in which the sputum is persistent for two consecutive years, three months or more per year, and cough persists. It is presumed that bronchial damage caused by stimulation of smoking, air pollution, occupational exposure, etc., is the main symptom, such as chronic cough, sputum and dyspnea during exercise. In addition, there may be acute exacerbation of chronic obstructive pulmonary disease. In this time, the breathing difficulty rapidly deteriorates from several hours to several days, the quantity of sputum increases, or the characteristic of sputum changes from mucous to purulent, and dark yellow or bluish It becomes colored and becomes viscous, making it difficult to spit.

The term "emphysema " in the present invention means an abnormal and permanent peripheral airway and alveolar expansion due to the destruction of the distal bronchioleast airspace. It is caused by inhalation of harmful particles and gas. The most clinically significant risk factor is known as smoking. The main symptoms are chronic cough, sputum and dyspnea.

As used herein, the term "prophylactic " refers to any act that inhibits or delays the onset of multiple sclerosis, acute and chronic pulmonary disease, including chronic obstructive pulmonary disease by administration of the composition according to the present invention.

In the composition of the present invention, the composition of the present invention contains 25 to 35% by weight of pear, 15 to 25% of horseshoe, 5 to 15% by weight of horsemeat, 3 to 5% by weight of red ginseng, 3 to 5% by weight of ginseng, 3 to 5% 3 to 5% by weight of oyster, 3 to 5% by weight of onion, 3 to 5% by weight of corn oil and 3 to 5% by weight of licorice to be.

The boat can be eaten as a fresh fruit, juice, canned food, jam, and boiled sake. The abalone has an abundance of enzymes that can help soften the protein and soften it. The belly is low in calories and is good for obese people. Pectin, which is abundant in the abdomen, lowers the cholesterol level in the blood, and when there is a lack of water due to lack of water, it softens the stool to prevent constipation.

The hongsi is also known as a year or yearbook. Hongshi is the name given in terms of the red color of persimmon, and the name of the new year is the texture is soft and soft. Persimmon is divided into persimmon and persimmon. Feeling is subdivided into complete feeling, incomplete feeling, incomplete persimmon. It is because it contains a tannin ingredient called diosphrin in the perspiration. Because this ingredient is water-soluble (water-soluble), it mixes with saliva in the mouth and melts to give a bitter taste. The elimination of this bitter taste is called de-picking. There is a natural way to get rid of the bitter taste, to keep it so that it becomes soft and flaky, and to remove the bitter taste artificially. Anthropogenic methods include hot tap dehydration, alcohol dephosphorization, gas dephosphorization, freeze-thaw dehydration, and the like, which are traditionally introduced in farmhouses. In this case, the depolarization only changes the water-soluble tannin component to insoluble (insoluble) and does not remove the tannin component. According to Donguibogam, Hongsi has the effect of releasing a hangover, and it has the effect of strengthening the heart and lungs, eliminating thirst, and improving the digestive function. On the other hand, there is a method of removing the bitter taste by immersing it in brine or alcohol, which is called impregnation or penetration.

It is a treatment for the low back pain caused by weakness of the bone due to the wrinkle of the walnut flesh and the treatment for the cough and asthma that are caused by weakness of the lung kidney. Is a medicinal product.

The red ginseng is ginseng which has been selected from 6-year-old root ginseng produced in suitable place of ginseng cultivation and is dried with steam for a long time in a state without peeling, and is dried in a dark yellowish brown or light reddish brown. Ginseng usually grows up to 4 years, but from 4 years onwards, quality varies greatly depending on the soil, environment, and technology of the grower. If the environment and cultivation techniques do not match, most of the ginseng begins to rot after 4 years. After more than 6 years, most ginsengs are ligneous (hardening like wood). In the manufacturing process of red ginseng, various new physiologically active ingredients which are good for our body are produced. These ingredients are unique to ginseng and white ginseng. Also, red ginseng can be kept longer than ginseng. Functional properties of red ginseng ingredients include refreshing, improving immunity, and helping nourishment. Red ginseng contains maltose which is an antioxidant ingredient not found in white ginseng and various amino acids and organic fatty acids. Seasonally, May is the best time to take ginseng as the amount of activity increases and it is prone to exhaustion. Especially in the digestive system such as gastrointestinal system is weak, the effect is good for people who have fallen.

Gakgyeong is a medicinal substance made by removing roots or juniper of Platycodon grandiflorum A. De Candolle, and the name Gakyung is attached because it is hard and straight. This medicine has a little smell, taste is very high, and the quality is flat without any bias. Gyungyung works on the lungs to treat symptoms with a lot of seawater and sputum, uncomfortable breathing, clearing the lungs, releasing the stiff chest, releasing cold air in the stomach, stopping the cough and removing the wall. I do not see my urine, I have generalized edema, and even when the amount of urine is small. Sore throat, cold cough, sputum, nasal congestion, asthma, bronchial inflammation, pleurisy, headache, chills and tonsillitis. The pharmacological action was reported to be a gadam action, a hypoglycemic action, a cholesterol lowering action, and an inhibiting action of improving bacteria. Other names include Giligyeong, Gyeongcho, Gamyeong, Gamgikyeong, Reiji, 房 圖, 白药, 扈 扈, .

The lily is plain, flavorless and poisonous. It makes it better to cure the back-to-back merger (lily disease) and make it go well with all the scams and voids (100 邪 鬼 魅) It kills solitude (poison), and it heals the yuong (背 背 背), 背 背 (發 背) Here, the term "lupus disease" refers to a disease that manifests itself as mental anxiety, masturbation, guppy, urination.

The above - mentioned Sukjwanghwang is the ginseng and the plant, which is geohang (黄黄) Rehmanneh glutinosa Libosch. there is. The root of purpurea mak. is steamed and dried. Rhubarb is planted in various places. It is called 지 황 黄 (黄 地 黄) to drink, and it is steamed and dried three or four times repeatedly. Or steamed for 48 hours. The taste is sweet, a little bit warm, and the nature is warm. It acts on the nerves (肾 经), liver (肝 经), heart (心 经), and cardiopathy (经 包 经). It nourishes mainly blood and groaning, replenishes pure water, and darkens hair. Atherosclerosis was found in pharmacological experiments. It is used for sweating when it sleeps, osteoporosis (血虛 证), menopenia (menoxenia), osteoporosis (肾阴 虛) due to osteoporosis. It is soft and has softness in waist and knee, and it also writes that hair gets whitish early. 9 to 30 grams a day is made in the form of a tablet, pills, powder, liquor, ginger (膏 剤). It is also good for meiwan (六味 丸), which is also used for diabetes, and has a lot of medicine. It is not appetite, it is not digestible, it is not used for diarrhea patients. If you need to use this medicine, you can mix it with digestive medication such as citrus peel and cinnamon. Do not use underwear, 荑 荑 when you use Suhjipgang.

The Baek Bok-ryeong is also called Bongsool Byeongryeong. It grows and grows where pine trees are scattered all over the country. It grows like a lump in a pine tree roots that has been bloomed for many years. The pine tree stubs around the stubble to find it. It is roughly 30 ~ 50㎝ in diameter and rough on the outside like a pine bark, white or pink inside. White is white rosette and pink rosette is red rooster. White roe is parasitized in the roots of red roots, and red rooster is parasitized in roots of roots. And the thing surrounding the solitary root is called the double. The taste is sweet and bored, the quality is flat, and there is a function to complement, and diuretic action, but not strong. It has long been used as a tonic. It acts on menopause (肺 经), necrosis (脾 经), heart (经 经), nerve (肾 经), bladder (膀胱 经) to see the spleen, sputum, and stabilizes the spirit. Pharmacological studies have shown that diuretic action, lowering of blood sugar level, sedation, etc. It is also known that the immune revival function. The spleen is hung (虛) to swell the body and used in the bottle. In addition, Ghee also prescribes such as diarrhea, diarrhea, forgetfulness, sleep disorder. It is known to have excellent effects on diseases such as stomach, liver, stomach, and kidney, and is used as a medicament for the treatment of people who are weak or chronic gastroenteritis after suffering from a disease. It is also known to be effective against sexually transmitted diseases as well as sexually transmitted diseases and women's diseases.

The yukee pei are bark or root bark of elm and elm. Rhinitis, empyema relief, fatigue recovery, anti-inflammatory effect, respiratory strengthening, gastritis, stomach disorders such as gastric ulcers are effective to prevent.

The Omija is said to be a name given to it because it has all the five flavors of peel and flesh, the seeds are spicy and the outpouring has a salty taste. If you only mention that it is tasty, it is because the tree (tree) is the highest priority and the sour taste is actually the main one among the five. This medicine has a slight peculiar smell, and the taste is warm and sweet at first. Omija is effective for seawater and asthma, and it is effective for sweating and sweating by producing seaweed. Urine, uremia, urinary frequency, old diathesis, diarrhea, chest and sleep are not able to sleep, dreams are used for many symptoms. It is also effective in reducing symptoms of memory loss and concentration. Pharmacological action, cerebral cortex excitement, hypotensive action, genomic action, respiratory excitement, cardiac action, glucose metabolism promotion and glycosylation, cell immune function enhancement, uterus stimulation, bile secretion promoting action, gastric secretion regulation Action, and insect action have been reported.

The onion is mainly used as seasoning material for cooking. It can be used for quick cooking if it is eaten by storing it in a refrigerator after putting it in a plastic bag. When you consume it with meat, it balances nutrition, and the quercetin ingredient of onion makes antioxidant effect and catches active oxygen. Onion is low in calories and low in cholesterol concentration, so it is good for diet. The pungent flavor and irritating odor peculiar to onion are allyl allyl, which helps secretion of digestive juices and facilitates metabolism.

The above-mentioned corn oil is the fruit of the seedling tree which is a deciduous tree of the debris. Elliptical nuclei are green at first, but ripen reddish from October to October. Seeds are long oval and have ridges. It has a bitter sweetness and strong acidity. It is harvested after the frost fall in mid-October. The flesh is separated from the seeds and the meat is used as a material for sake, tea and Chinese medicine. The pulp contains the glycosides such as cornin, Morroniside, Loganin, tannin and saponin and organic acids such as wine, malic acid and tartaric acid. In addition, it contains vitamin A and a large amount of sugars. Seeds include palmitic acid, oleic acid, linoleic acid and the like. Among the components, cornin is known to have an excitatory action of parasympathetic nerves. From the past, the pulp was weakened in one batch. According to the "Dongbibogam" and the "Fragrant Bulgari", it is said that it has effects such as strengthening of 阴 阴, 肾 精 and 肾气, and convergence. It is used as a medicinal product for headache, tinnitus, sea water, fever and menstrual overuse. It is also used for folk remedies such as cold sweat and enuresis. There are effects such as stopping sweat, consonance and so on.

The licorice has a peculiar smell and taste is sweet. Licorice harmonizes the toxicity of all medicines and makes the medicinal effect appear, regulates the fever and morale of the book, makes good communication of all blood vessels, and strengthens the muscles and bones. Pharmacological action is effective in detoxification, hepatitis, urticaria, dermatitis, eczema. Jinhae, geomung, muscle relaxation, diuretic, anti-inflammatory action and suppress peptic ulcer.

In the present invention, the "extract" is an extract obtained by mixing the above lily, hwanggi, liquorice, red ginseng, raw persimmon, The present invention includes not only the extracts extracted from a mixture of lily, hwanggi, liquorice, red ginseng, raw persimmon, Jawwan, corn oil, Baekbokryeong, Ohmyum, Omija,

The extract can be extracted with water or an organic solvent, and the extracted liquid can be used in liquid form or can be used by concentration and / or drying. The organic solvent may be selected from the group consisting of methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N, N-dimethylformamide (DMF), dimethylsulfoxide , 3-butylene glycol, propylene glycol, or a mixed solvent thereof. The extract can be extracted at room temperature or with heating under the condition that the active ingredient of the extract is not destroyed or minimized.

In a specific embodiment, 10 times (w / v) distilled water was added to the mixed extract of Bae, Hongxi, Hodo, Red ginseng, Gyungyang, Lily, For 4 hours and then collecting the supernatant with filter paper is repeated 3 times, and then collected and dried under reduced pressure.

The extraction method is not limited, and examples thereof include cold extraction, ultrasonic extraction, and reflux cooling extraction.

The mixed extracts of the present invention can be obtained by extracting, fractionating, or purifying (extracting, fractionating) all the extracts obtained in each step of the present invention, such as pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, An extract, a fraction, a purified product, a diluted solution thereof, a concentrate, or a dried product.

In the present invention, all parts such as stems, roots, leaves, flowers, etc. can be used as the extraction sites of pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, The roots are particularly preferred, but are not limited to any particular site.

In the present invention, "extracted fermented product" means that the extract is fermented in lactic acid bacteria. In this case, lactic acid bacteria are used as the fermenting bacteria, for example, Lactobacillus casei casei, L. plantarum , L. acidophilus , L. bulgaricus , Bifidobacterium longum , Bifidobacterium, Bifidobacterium longum , Bifidobacterium longum , B. bifidum or a mixed microorganism thereof may be used. Preferably, L. plantarum, B. bifidum or a mixed microorganism thereof can be used. And L. plantarum and B. bifidum are particularly preferable.

In a preferred embodiment of the present invention, the extracted fermented products of Bae, Hongxi, Hodo, Red ginseng, Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Yukuni, Omija, Onion, Sansui and Licorice are obtained from Lactobacillus planta (L. plantarum fermented with Bifidobacterium bifidum fermented at a weight ratio of 1: 1 to 1: 3, preferably 1: 2.

In a preferred embodiment of the present invention, the fermented extract is prepared by mixing lactic acid bacterium with the mixed extract of Bae, Hongxi, Hodo, Red ginseng, Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Ryukyu, Omija, Onion, To 6% by weight and incubating for 10 to 20 hours.

In a preferred embodiment of the present invention, the extracted fermented product may be contained in an amount of 0.00001 to 15.0 wt%, more preferably 0.0001 to 10 wt%, and most preferably 0.0001 to 5 wt%, based on the total composition .

The food composition of the present invention can be used not only as an active ingredient but also as an active ingredient in fermented foods such as pear, red pepper, hodo, red ginseng, royal ginseng, lily, And includes, for example, proteins, carbohydrates, fats, nutrients, flavoring agents, and flavoring agents. Examples of the above-mentioned carbohydrates are monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And polysaccharides such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavorings such as tau martin and stevia extract (e.g., rebaudioside A and glycyrrhizin) and synthetic flavorings (saccharine, aspartame, etc.) can be used as flavorings.

For example, when the food composition of the present invention is prepared as a drink, in addition to the fermented extract of the present invention, such as pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, Liquid fructose, sugar, glucose, acetic acid, malic acid, juice, mulberry extract, jujube extract, licorice extract, and the like.

On the other hand, as a result of confirming the cytotoxicity of the fermented extract of Bae, Hongxi, Hodo, Red ginseng, Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Yukuni, Omija, Onion, It was found to be a harmless substance. Therefore, the fermented extract of the present invention has little toxicity and side effects and can be safely used for long-term use, so that it can be safely applied to food compositions.

As described above, the composition comprising the fermented extract of the present invention as an active ingredient in the fermented product of the present invention, such as pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, And fine dust. Ideally, it is necessary to prevent dry cough and sputum due to shortage of environment due to lack of exhaustion due to environmental conditions. If you take it when you are sick and tired, your energy will increase and you will be able to prevent and treat chronic lung disease. In addition, the lungs to see the bronchial lubrication, as well as the action of the blind, rhinitis. Bronchial asthma. Seawater asthma can also be highly cured.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments of the invention and, together with the description of the invention, It should not be construed as limited.
Fig. 1 is a graph showing a process for producing a mixed extract of Bae, Hongxi, Hodo, Red ginseng, Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Yukuni, Omija, Onion, Sansui and Licorice.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

Preparation Example 1 Preparation of Extracts of Bae, Hongxi, Hodo Meat, Red Ginseng, Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Yukuni, Omija, Onion, Sansui and Licorice

(W / v) of distilled water was added to the mixture as shown in Table 1, and the mixture was mixed with the mixture as shown in Table 1, After the extraction at 90 ° C for 4 hours, the supernatant was recovered with filter paper. This process was repeated three times and then dried under reduced pressure and stored at -20 ° C. Fig. 1 shows a process for producing a mixed extract of pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, sorghum, baekbokgyeong, yukuni, omija, onion, corn oil and licorice.

ship Hongsi Hodo Meat Red ginseng Gakyung Lily Sookmyung White Border Yugunpi Schisandra onion Corn oil licorice weight% 30 20 10 4 4 4 4 4 4 4 4 4 4

Example 1 Preparation of Extracted Fermented Product

Lactobacillus plantarum (L. plantarum ) was added to the extracts obtained in Preparation Example 1 to obtain the extracts of pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, sorghum, baekbokryeong, 5% by weight on the basis of weight, and cultured for 12 hours to prepare an extract fermented product.

Bifidobacterium bifidum was inoculated to the extract obtained in Preparation Example 1 in an amount of 5% by weight based on the weight of the extract and cultured for 60 hours to prepare an extract fermented product.

Lactobacillus planta (L. plantarum ) fermented product of the above-prepared extracts of pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, Bifidum bifidum fermentation products were mixed at a weight ratio of 1: 2, respectively, and extracted fermented products of Bae, Hongsi, Hodo, Red ginseng, Gakyung, Lily, Seokgi, Baekbokryeong, Yukee, Omija, Onion, .

≪ Test Example 1 >

Using the method of Engler et al. (Engler H, Szelenyi I, J. Pharmacol. Moth., 1984, 11, 151-157; Jian-Hua Shang et al., J. Ethnopharmacology 2010,129, 293-298) The fermentation efficiency of the fermented extracts of the present invention was measured in the fermented product of the present invention, hongsi, hodo, red ginseng, gyeonggyeong, lily, sorghum, baekbokryeong, yukuni, omija, onion, corn oil and licorice.

For this purpose, male ICR mice weighing 30 ~ 33g (Orient Bio, Korea) were used as experimental animals. The extracted fermented product of the present invention and amoxicillin (250 mg / kg, ambroxol, Sigma) and ammonium chloride (500 mg / kg, ammonium chloride) were orally administered to the mice fasted the previous day for 30 minutes 5% phenol red was intraperitoneally injected. After 30 minutes, the cervical dislocations were performed to bleed the abdominal aorta and the entire trachea was excised. The isolated organs were placed in 1 ml of physiological saline and refrigerated. After 24 hours, the refrigerated organs were centrifuged at 3000 rpm for 10 minutes, and 1 N sodium hydroxide (NaOH) was added to the supernatant (0.1 N NaOH per 1 ml of the supernatant). The absorbance at 546 nm was measured, The results are shown in Table 2 below.

Oral dose (mg / kg) Sputum Emission Rate (%) Example 1 100 11 200 24 400 38 Armbrook Sol 250 27 Ammonium chloride 500 33

As shown in Table 2, the fermented extracts of the present invention exhibited excellent activity in a dose-dependent manner, indicating that the fermented products of the present invention exhibited excellent activity in a dose-dependent manner. . In particular, it was confirmed that the sputum - releasing ability was the most excellent in the 400 mg / kg administration group.

≪ Test Example 2 >

Evaluation of Jinhae Activity on Extracted Fermented Extracts of Pears, Hongxi, Hodo Meat, Red Ginseng, Gyungyang, Lily, Sukjiwang, Baekbokryeong, Yukuni, Omiza, Onion, Sansui and Licorice (American Journal of Respiratory and Critical Care Medicine , 158 [1], 42-48), the extract fermented in Example 1 was administered to guinea pigs, citric acid was sprayed to induce coughing, and the number of coughs was measured. Citric acid is a substance that is widely used to study the sensory neuronal activity of airways. When inhaled, it causes bronchoconstriction, nasal irritation, coughing, and bronchial hyperresponsiveness.

As experimental animals, male Hartely guinea pigs (Orient Bio, domestic) weighing 350 ~ 400g were used at 10 ~ 12 per group. The guinea pigs fasted the previous day were orally administered with the herbal composition fraction and the comparative drug theobromine (50 mg / kg, theobromine, Sigma) prepared in Example 2, and after 1 hour, 0.3 M citric acid was sprayed for 10 minutes to induce coughing. The number of coughs that occurred for 15 minutes from the start of exposure to the cough inducer was measured using a Whole Body Plethysmometer (BUXCO), and the percent inhibition (%) was calculated based on the number of coughs in the negative control (1% CMC group) The results are shown in Table 3 below. The comparative drug, tebuin, was used.

Oral dose (mg / kg) Cough suppression rate (%) Example 1 100 17 200 44 400 57 Teof of Robin 250 35

As shown in Table 3, the fermented extracts of the present invention exhibited excellent activity in a dose-dependent manner, indicating that the fermented products of the present invention exhibited excellent activity in a dose-dependent manner. , And it was confirmed that the cough suppression rate was the most excellent in 400 mg / kg administration group.

Examples of formulations for the composition of the present invention are illustrated below.

≪ Formulation Example 1 > Preparation of health food

Extracted fermented product of the pear, hongsi, hodoki, red ginseng, gyeonggyeong, lily, sorghum, baekbokryeong, yukuni, omija, onion, corn oil and licorice of Example 1 ... 200 mg

Vitamin mixture ......................................

Vitamin A Acetate ............................ 70 ㎍

Vitamin E .......................................... 1.0 mg

Vitamin B1 .......................................... 0.13 mg

Vitamin B2 .......................................... 0.15 mg

Vitamin B6 .......................................... 0.5 mg

Vitamin B12 .............................. 0.2 g

Vitamin C ............................................. 10 mg

Biotin ............................................... 10 μg

Nicotinic acid amide .................................... 1.7 mg

Folic acid ................................................. 50 [mu] g

Calcium pantothenate ....................................... 0.5 mg

Mineral mixture ........................................

Ferrous sulfate ........................................... 1.75 mg

Zinc oxide ............................................ 0.82 mg

Magnesium carbonate ........................................ 25.3 mg

Potassium Phosphate ......................................... 15 mg

Secondary calcium phosphate ...................................... 55 mg

Potassium citrate ........................................... 90 mg

Calcium carbonate ............................................ 100 mg

Magnesium chloride ......................................... 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.

≪ Formulation Example 2 > Preparation of health drink

Extracted fermented product of the pear, hongsi, hodoki, red ginseng, gyeonggyeong, lily, sorghum, baekbokryeong, yukuni, omija, onion, corn oil and licorice of Example 1 ... 200 mg

Citric acid ............................................. 1000 mg

Oligosaccharides ............................................ 100 g

Plum concentrate ............................................ 2 g

Taurine ................................................ 1 g

Add purified water .................................. Total 900 ml

The above components were mixed according to a conventional health drink manufacturing method, and the mixture was heated at 85 DEG C for about 1 hour with stirring, and the solution thus prepared was filtered to obtain a sterilized 2-liter container, which was sealed and sterilized, ≪ / RTI >

Although the composition ratio is a mixture of the components suitable for the preferred beverage as a preferred embodiment, the compounding ratio may be arbitrarily varied depending on the regional and national preferences such as the demand level, the demanding country, and the intended use.

As described above, the composition comprising the fermented extract of the present invention as an active ingredient in the fermented product of the present invention, such as pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, And fine dust. Ideally, it is necessary to prevent dry cough and sputum due to shortage of environment due to lack of exhaustion due to environmental conditions. If you take it when you are sick and tired, your energy will increase and you will be able to prevent and treat chronic lung disease. In addition, not only does it perform the action of the abdominal afferent to see the lungs and lubricate the bronchial tubes, but also has a high treatment rate for rhinitis, bronchial asthma, and seaweed asthma. Therefore, the fermented extracts of the present invention can be used as a food composition for enhancing pulmonary function and preventing and improving pulmonary diseases as a fermented product of the present invention, such as pear, hongsi, hodo, red ginseng, gyeonggyeong, lily, It is expected to be safe and useful.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the present invention. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (6)

Enhancement of pulmonary function or prevention of pulmonary disease including extract fermented by fermentation with lactic acid bacterium, mixed extract of Bae, Hongsei, Hodo, Red ginseng, Gyungyang, Lily, Seokjyang, Baekbokryeong, Yukuni, Omiza, Onion, And food compositions for improvement. The method according to claim 1,
The present invention relates to a method for producing a white pearl liquor, comprising the steps of blending 25 to 35% by weight of pearl, 15 to 25% of pearl, 5 to 15% by weight of pearl liquor, 3 to 5% by weight of red ginseng, 3 to 5% A fermented product of the mixed extract consisting of 3 to 5% by weight of the herbal composition, 3 to 5% by weight of rhizome, 3 to 5% by weight of omija, 3 to 5% by weight of onion, 3 to 5% Wherein the food composition is for enhancing pulmonary function or for preventing or improving pulmonary disease. The method according to claim 1,
The extracts were extracted with distilled water in an amount of 10 times (w / v) of the total amount of pear, red pepper, hodo, red ginseng, gilyung, lily, And recovering the supernatant with a filter paper, and collecting the supernatant by repeating the process three times, followed by drying under reduced pressure, thereby improving the lung function and preventing or improving lung disease. The method according to claim 1,
When the lactic acid bacterium is Lactobacillus casei casei, L. plantarum , L. acidophilus , L. bulgaricus , Bifidobacterium longum , Bifidobacterium, Bifidobacterium longum , Bifidobacterium longum , B. bifidum , or a mixture thereof. The food composition for enhancing pulmonary function and for preventing or improving pulmonary disease. The method according to claim 1,
Lactobacillus plantarum (L. plantarum ) was added to the mixed extract of the extracted fermented product of Bae, Hongsei, Hodo, Red ginseng, Gyungyang, Lily, Seokjanghwang, Baekbokryeong, Yukuni, Omija, Onion, By weight, based on the total weight of the composition, and fermented for 10 to 20 hours. 6. The method according to any one of claims 1 to 5,
The extracted fermented product obtained by fermenting the mixed extracts of Bae, Hongxi, Hodo, Red ginseng, Gakyung, Lily, Seokjanghwang, Baekbokryeong, Yukuni, Omija, Onion, Sansui and Licorice with lactic acid bacterium is 0.00001-15.0% Of the total weight of the food composition.

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