WO2021187736A1 - Composition for curing hangovers, and healthy food including same - Google Patents

Composition for curing hangovers, and healthy food including same Download PDF

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Publication number
WO2021187736A1
WO2021187736A1 PCT/KR2021/000543 KR2021000543W WO2021187736A1 WO 2021187736 A1 WO2021187736 A1 WO 2021187736A1 KR 2021000543 W KR2021000543 W KR 2021000543W WO 2021187736 A1 WO2021187736 A1 WO 2021187736A1
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Prior art keywords
extract
composition
hangover
relieving
fruit
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PCT/KR2021/000543
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French (fr)
Korean (ko)
Inventor
남종현
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주식회사 그래미
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Publication of WO2021187736A1 publication Critical patent/WO2021187736A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00—Processes
    • A23V2300/14—Extraction

Definitions

  • the present invention relates to a composition for relieving a hangover with improved blood alcohol concentration reduction and hangover relieving efficacy, and healthy food containing the same.
  • hangover is a general term for physical and mental discomfort that occurs after drinking. Although the exact cause of hangover is not yet known, it is reported that it is caused by metabolites generated during alcohol metabolism.
  • turmeric, galgeun, brown flower, chrysanthemum, alder, and heotgae tree have long been known to have a hangover relieving effect, such as Donguibogam, and it is known that aspartic acid and vitamin C contained therein exert an excellent hangover relieving effect.
  • Korean Patent Registration No. 181168 discloses a composition for relieving a hangover using an alder tree extract and a rowan extract as active ingredients.
  • the inventor of the present invention has mixed extracts of numerous edible plants for the invention of a composition for relieving hangover, which is more excellent in reducing blood alcohol concentration and relieving hangover than the conventional composition for relieving hangover, and confirming whether there is a synergistic effect. was completed.
  • the present invention provides a hangover relieving composition with improved blood alcohol concentration reduction and hangover relieving efficacy, and healthy food containing the same.
  • composition for relieving a hangover of the present invention for achieving the above object includes an extract of samchae, a fruit extract of Japanese quince, and a dermis extract as active ingredients.
  • composition for relieving a hangover of the present invention includes a combination of plant extracts that exert a synergistic effect in reducing blood alcohol concentration and in relieving hangover, thereby exhibiting superior hangover relieving effect compared to conventional compositions for relieving hangover.
  • healthy food containing the composition for relieving hangovers in addition to excellent hangover relieving effects, can simultaneously secure health functions such as lowering blood sugar, anti-aging, and strengthening immunity.
  • extraction used in the present invention is an operation of extracting only a specific substance from a solid or liquid using a solvent or reagent, for example, a medicinal ingredient such as a plant, and an organic solvent such as water, ethanol (ethyl alcohol), ether, etc. It refers to the dissolution and separation of only specific components in a mixture, such as extraction using a solvent or reagent, for example, a medicinal ingredient such as a plant, and an organic solvent such as water, ethanol (ethyl alcohol), ether, etc. It refers to the dissolution and separation of only specific components in a mixture, such as extraction using
  • extract used in the present invention is a substance separated by a conventional extraction process as described above from a desired raw material, and an extract or a concentrate thereof using an extraction solvent or a powder thereof, and the extract of the present invention includes all extracts exhibiting substantially the same effect using other extraction solvents as well as the above-described extraction solvent, and the extraction process of the present invention may be repeated several times, and then may be subjected to a conventional concentration process, and reduced pressure It may be prepared in a powder state by additional processes such as distillation and freeze drying or spray drying.
  • the composition for relieving a hangover of the present invention may include an extract of samchae, an extract of a tree fruit and a dermis extract as active ingredients. Based on the total weight of the composition, the active ingredient may be included in an amount of 65 to 95% by weight.
  • the composition may further include one or more edible plant extracts as sub-components in addition to the active ingredient, and may further include other commonly used additives such as purified water and natural and/or artificial sweeteners constituting the remaining amount.
  • the composition for relieving a hangover of the present invention includes a combination of plant extracts that exert a synergistic effect in reducing blood alcohol concentration and in relieving hangover, thereby exhibiting superior hangover relieving effect compared to conventional compositions for relieving hangover.
  • a synergistic effect in reducing blood alcohol concentration and in relieving hangover, thereby exhibiting superior hangover relieving effect compared to conventional compositions for relieving hangover.
  • it is possible to simultaneously secure health functions such as lowering blood sugar, anti-aging, and strengthening immunity.
  • Samchae Allium hookeri
  • samchae ⁇
  • the ginseng extract has the effect of improving diabetes through blood sugar control, preventing hangover, improving liver function, and improving asthma.
  • Dietary sulfur which is abundant in three vegetables, removes free radicals, thereby enhancing immunity.
  • the extract of the three plants may be leaf extracts, flower extracts, stem extracts, or root extracts of the three plants, or a mixture thereof.
  • the rhododendron belongs to the leguminous family, and the bud of the hibiscus tree is called Goehwa ( ⁇ ), and the fruit of the hibiscus tree is called Goesil ( ⁇ ).
  • the tree extract may be a tree fruit extract.
  • the tree fruit extract is rich in rutin and germanium components, and while exhibiting an excellent hangover relieving effect, it exhibits an effect of improving the function of the liver, lungs, and large intestine and preventing hemorrhoids.
  • Dermis is another name for tangerine peel. It is the mature rind of Citrus unshiu Markovich or a closely related plant. The dermis extract exerts an excellent hangover relieving effect, while relieving the clogged air and strengthening the spleen function to relieve the symptoms of flatulence, belching, vomiting, nausea, flatulence, remove seawater, phlegm, and diuretic ( ⁇ ) can be promoted.
  • the three chaechae extracts, the fruit extracts of the sycamore tree, and the extracts of dermis are active ingredients in the composition, and may be included in an amount of 65 to 95%, for example, 70 to 90%, based on the total weight of the composition. If it is less than the above content range, a sufficient hangover relieving effect cannot be expected, and if it exceeds the above content range, there is an adverse effect on hangover relieving, and it may not be preferable because the taste of other extracts may not be harmonized.
  • the three chaechae extracts, the fruit extracts of the sycamore tree, and the extracts of the dermis may be mixed, for example, in a weight ratio of 10 to 80: 10 to 40: 10 to 80.
  • each extract of the main ingredient has the above mixing ratio range, it can exert a synergistic effect in blood alcohol concentration and hangover relieving effect.
  • the composition may further include one or more sub-components that are plant extracts in addition to the active ingredient.
  • the plant extract may be at least one selected from the group consisting of a poison ivy extract, a baekchul extract, an osuyu extract, and an extract of lichen.
  • the poisonous active extract may be a leaf or root extract, and the poisonous active extract has an excellent effect of excreting unnecessary moisture from the body as well as a hangover relieving effect.
  • Baekchul refers to the rhizome from which the bark of sapju belonging to the Asteraceae has been removed. Baekchul has a peculiar odor and tastes slightly bitter and sweet, viscous when chewed, and warm in nature. Baekchul extract exerts a hangover relieving effect and immune enhancement effect, suppresses intestinal tract and controls excitability, protects against ulcers and liver function, dilates blood vessels, diuretics and lowers blood sugar, and exhibits anticancer effects. .
  • Osuyu uses fruits as medicine, and the main components of volatile essential oil are evoden, ocimene, and evodin, and the alkaloid contains evodiamine and rutaecarpine.
  • the fruit of Osuyu is obtained from unripe greenish-brown fruits in September and used dried, and the fruit extract of Osuyu has a hangover relieving effect, warms the rain and stomach, helps the digestive function of the stomach, and is excellent in deworming, detoxification and diuresis. .
  • the fruit is the unripe fruit of the tangja tree. It is bitter and sour in taste and cold in nature. In addition to the hangover relieving effect, the oilseed fruit extract facilitates peristalsis of the stomach and contains hesperidin and vitamin C, which has anti-aging effects on the skin.
  • the subcomponent may be contained in an amount of 5 to 30% by weight, for example, 10 to 25% by weight, based on the total weight of the composition.
  • the sub-components can exert synergy in blood alcohol concentration and hangover relieving effect together with the above-described active ingredients, while exhibiting health functions such as strengthening immune function, lowering blood sugar, anti-cancer action and skin aging prevention.
  • composition in addition to the above-mentioned components, other additives, for example, various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, It may further include a stabilizer, a preservative, glycerin, alcohol, a carbonation agent used in carbonated beverages, and the like.
  • additives for example, various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, It may further include a stabilizer, a preservative, glycerin, alcohol, a carbonation agent used in carbonated beverages, and the like.
  • the healthy food of the present invention may be a food for the main purpose of relieving a hangover, including the composition for relieving a hangover.
  • the health functional food is excellent in reducing blood alcohol concentration and relieving hangover, and at the same time, it is possible to secure health functions such as blood sugar lowering, anti-aging, and strengthening immunity at the same time.
  • the healthy food ie, health functional food
  • Types of the health functional food include, for example, beverages, soups, teas, drinks, extracts, vitamin complexes, gels, candy, chocolate, gum, snacks, confectionery, pizza, ramen, other noodles, dairy products including ice cream, meat , sausage, bread, pills, effervescent tablets, etc., but is not particularly limited, and includes all foods in a conventional sense.
  • the health functional food when it is a beverage, it may further include purified water and food additives such as artificial or natural sweeteners, acidulants, and flavorings, like a conventional beverage.
  • the natural sweetener may be, for example, monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, and dextrin, cyclodextrin, and the like.
  • the artificial sweetener may be saccharin, aspartame, or the like.
  • the hangover relieving composition of the present invention may be included in 0.1% to 99.9% by weight, preferably 1 It may be included in an amount of from 11% to 50% by weight, for example from 11% to 50% by weight.
  • compositions for relieving hangovers of Examples 1 to 4 and Comparative Examples 1 to 6 were prepared.
  • the dermis was taken, dried and pulverized, immersed in 80% ethanol, extracted at a temperature of 70° C. for 12 hours, the extraction residue was removed, concentrated under reduced pressure, and dried to obtain a powdery dermis extract.
  • 76 g of the samchae (root) extract, 38 g of the fruit extract and 76 g of the dermis extract were mixed, and 200 g of a composition for relieving a hangover was prepared including 10 g of purified water.
  • the leaves and roots of poison ivy were taken, dried and pulverized, immersed in 80% ethanol, extracted at a temperature of 70° C. for 12 hours, and the extraction residue was removed, concentrated under reduced pressure, and dried to obtain a powdery extract, respectively.
  • the fruit of Osuyu was taken, dried and pulverized, immersed in 80% ethanol, extracted at a temperature of 70° C. for 12 hours, the extraction residue was removed, concentrated under reduced pressure, and dried to obtain a powdery fruit extract of Osuyu.
  • the oil was immersed in 80% ethanol and extracted at a temperature of 70 ° C. for 12 hours.
  • a hangover relieving composition was prepared in the same manner as in Example 2 described above, except that Osuyu fruit extract and fruit extract were not included.
  • a hangover relieving composition was prepared in the same manner as in Example 1 described above, except that the dermis extract was not included.
  • a hangover relieving composition was prepared in the same manner as in Example 1 described above, except that the three chae extracts were not included.
  • a hangover relieving composition was prepared in the same manner as in Example 2 above, except that the dermis extract was not included.
  • a hangover relieving composition was prepared in the same manner as in Example 2 described above, except that it did not include an extract from the fruit of the sycamore tree.
  • a hangover relieving composition was prepared in the same manner as in Example 1 described above, except that the three chae extracts, the Alder tree fruit extract and the dermis extract instead of the hazelnut fruit extract, the alder tree extract, and the rowan fruit extract were included as main ingredients.
  • Comparative Examples 1 to 4 which do not contain any one of the active ingredients, were inferior in the blood alcohol concentration reducing effect compared to the Examples even after time passed, and containing a plant extract other than the active ingredient of the present invention as an active ingredient Comparative Example 5 was confirmed that the effect was significantly lower than that of Examples.
  • the combination of the active ingredients of the present invention such as the ginseng extract, the fruit extract of the sycamore tree, and the dermis extract exerts a synergistic effect in reducing the blood alcohol concentration compared to other plant extracts known to have the effect of reducing the blood alcohol concentration. there was.
  • compositions of Examples 1 to 4 and Comparative Examples 1 to 6 were prepared to compare the hangover relieving efficacy.
  • Five test personnel who answered that they had a similar age, gender, physical condition, and usual drinking habits and had a hangover the next day after drinking were selected.
  • Table 2 shows the symbols according to the evaluation criteria (bad: X average: ⁇ excellent: ⁇ very good: ⁇ ). (One week was given per person until the hangover relieving efficacy of one composition was evaluated, and the total experiment was conducted for 6 weeks.)
  • Examples 1 to 4 including all active ingredients were confirmed to have excellent hangover relieving efficacy compared to Comparative Examples. Among them, in the case of the composition of Example 2 containing both the active ingredient and the sub-component, it was confirmed that most of the inspectors responded that the hangover hardly appeared. However, Example 4, in which the content of the active ingredient was less than 65%, showed a somewhat lower hangover relieving effect compared to Examples 1-3.
  • Comparative Examples 1 to 4 which do not contain any one of the active ingredients, were able to confirm that the hangover relieving effect was inferior compared to the Examples even after time passed, and plant extracts other than the active ingredients of the present invention were used as active ingredients. Comparative Example 5 including the hangover effect was also very inferior.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
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Abstract

The present invention relates to: a composition for curing hangovers; and a healthy food including same, wherein the composition has improved effectiveness in reducing blood alcohol concentration and curing hangovers, and includes an Allium hookeri extract, a quince fruit extract, and a dermis extract as active ingredients.

Description

숙취해소용 조성물 및 이를 포함하는 건강에 좋은 식품Composition for relieving hangover and healthy food containing same
본 발명은 혈중 알코올 농도 감소 및 숙취해소 효능이 향상된 숙취해소용 조성물 및 이를 포함하는 건강에 좋은 식품에 관한 것이다. The present invention relates to a composition for relieving a hangover with improved blood alcohol concentration reduction and hangover relieving efficacy, and healthy food containing the same.
현대인들은 다양한 스트레스에 노출되어 있으며, 스트레스의 강도가 점점 더 높아지고 있다. 사람들은 스트레스를 해소하기 위해서 운동, 수면, 흡연, 여행 등 각기 다른 방법들을 활용하고 있으나, 음주(알코올 섭취)를 통한 스트레스의 경감을 도모하는 것이 가장 보편적인 방법이라고 할 수 있다. 또한, 한국사회는 음주를 통한 스트레스 해소, 친목 도모, 소속감 형성 등의 순기능이 있다고 생각하는 경향이 있기 때문에 음주 문화가 사회적으로 특히 발달해 있다.Modern people are exposed to various stresses, and the intensity of stress is increasing. People use different methods such as exercise, sleep, smoking, and travel to relieve stress, but it can be said that the most common method is to reduce stress through drinking (alcohol consumption). In addition, because Korean society tends to think that drinking has positive functions such as relieving stress, promoting friendship, and forming a sense of belonging, the drinking culture is particularly developed socially.
한국의 음주문화에 대한 사회적 배경으로 인하여 숙취해소를 위한 제품에 대한 소비자의 요구가 지속되고 있으며, 숙취경감을 위하여 다양한 연구가 이루어지고 실제 다양한 제품들이 시중에 판매되고 있다. Due to the social background of Korea's drinking culture, consumer demand for hangover relieving products continues, and various studies are being conducted for hangover relief, and various products are actually being sold on the market.
숙취란 음주 후 나타나는 신체적, 정신적 불쾌감을 총칭하는 것으로 객관적인 증상으로는 두통, 메스꺼움, 구토, 졸음, 운동능력저하, 혈액학적 변화, 호르몬의 변화 등의 현상을 말한다. 숙취의 원인은 아직 정확하게 밝혀지지는 않았으나, 알코올 대사과정에서 발생되는 대사산물에 의한 것이라 보고되고 있다.A hangover is a general term for physical and mental discomfort that occurs after drinking. Although the exact cause of hangover is not yet known, it is reported that it is caused by metabolites generated during alcohol metabolism.
현재 시중에 판매되는 제품들은 그 숙취해소 효능에 대하여 아직은 객관적 검증이 미흡하고, 대부분 화학성분이 다량 함유되어 있어 실제 소비자들에게 신뢰도가 전반적으로 높지 않은 것이 현실이다. 이에 따라, 최근에는 약초와 같은 식용 가능한 천연 식물들로부터 혈중 알코올 농도 감소 및 숙취해소 효능에 효과가 있는 성분에 대한 연구가 이루어지고 있다. Currently, the products sold on the market have not yet been objectively verified for their hangover relieving effects, and most of them contain a large amount of chemical components, so the reliability of the actual consumers is not generally high. Accordingly, in recent years, studies have been made on ingredients effective in reducing blood alcohol concentration and in relieving hangover from edible natural plants such as medicinal herbs.
예를 들어, 울금, 갈근, 갈화, 국화, 오리나무, 헛개나무 등은 숙취해소 효과가 있다고 오래 전부터 동의보감 등에 알려져 왔으며, 이들에 포함된 아스파라긴산, 비타민 C가 우수한 숙취해소 효과를 발휘한다고 알려져 있다. 일례로서, 대한민국 등록특허 181168호에서는 오리나무 추출물과 마가목 추출물을 유효성분으로 하는 숙취해소용 조성물을 개시하고 있다. For example, turmeric, galgeun, brown flower, chrysanthemum, alder, and heotgae tree have long been known to have a hangover relieving effect, such as Donguibogam, and it is known that aspartic acid and vitamin C contained therein exert an excellent hangover relieving effect. As an example, Korean Patent Registration No. 181168 discloses a composition for relieving a hangover using an alder tree extract and a rowan extract as active ingredients.
본 발명의 발명자는 종래의 숙취해소용 조성물보다 혈중 알코올 농도 감소 및 숙취해소 효과가 더욱 뛰어난 숙취해소용 조성물 발명을 위해, 수많은 식용 가능한 식물들의 추출물을 혼합하여 상승효과가 있는지 여부를 확인하여 본 발명을 완성하였다. The inventor of the present invention has mixed extracts of numerous edible plants for the invention of a composition for relieving hangover, which is more excellent in reducing blood alcohol concentration and relieving hangover than the conventional composition for relieving hangover, and confirming whether there is a synergistic effect. was completed.
본 발명은 혈중 알코올 농도 감소 및 숙취해소 효능이 향상된 숙취해소 조성물 및 이를 포함하는 건강에 좋은 식품을 제공한다. The present invention provides a hangover relieving composition with improved blood alcohol concentration reduction and hangover relieving efficacy, and healthy food containing the same.
상기 목적을 달성하기 위한 본 발명의 숙취해소용 조성물은, 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물을 유효성분으로 포함한다. The composition for relieving a hangover of the present invention for achieving the above object includes an extract of samchae, a fruit extract of Japanese quince, and a dermis extract as active ingredients.
본 발명의 숙취해소용 조성물은, 혈중 알코올 농도 감소 및 숙취해소 효능에 있어 상승효과를 발휘하는 식물 추출물의 조합을 포함함으로써, 종래 숙취해소용 조성물 대비 우수한 숙취해소 효과를 발휘할 수 있다. The composition for relieving a hangover of the present invention includes a combination of plant extracts that exert a synergistic effect in reducing blood alcohol concentration and in relieving hangover, thereby exhibiting superior hangover relieving effect compared to conventional compositions for relieving hangover.
또한, 숙취해소용 조성물을 포함하는 건강에 좋은 식품은, 뛰어난 숙취해소 효능과 더불어, 혈당강하, 노화방지, 면역력 강화 등의 건강 기능성을 동시에 확보할 수 있다. In addition, healthy food containing the composition for relieving hangovers, in addition to excellent hangover relieving effects, can simultaneously secure health functions such as lowering blood sugar, anti-aging, and strengthening immunity.
이하, 본 발명에 대하여 상세히 설명한다. 그러나, 하기 내용에 의해서만 한정되는 것은 아니며, 필요에 따라 각 구성요소가 다양하게 변형되거나 선택적으로 혼용될 수 있다. 따라서, 본 발명의 사상 및 기술범위에 포함되는 모든 변경, 균등물 내지 대체물을 포함하는 것으로 이해되어야 한다.Hereinafter, the present invention will be described in detail. However, it is not limited only by the following content, and each component may be variously modified or selectively mixed as needed. Accordingly, it should be understood to include all modifications, equivalents and substitutes included in the spirit and scope of the present invention.
본 발명에서 사용되는 용어인 “추출”은 용매 또는 시약 등을 사용하여 고체 또는 액체 속에서 특정물질만을 꺼내는 조작으로 예컨대 식물 등의 약용성분을, 물·에탄올(에틸알코올)·에테르 등의 유기용매를 사용해 추출하는 등 혼합물 속에서 특정성분만을 용해·분리하는 것을 말한다.The term “extraction” used in the present invention is an operation of extracting only a specific substance from a solid or liquid using a solvent or reagent, for example, a medicinal ingredient such as a plant, and an organic solvent such as water, ethanol (ethyl alcohol), ether, etc. It refers to the dissolution and separation of only specific components in a mixture, such as extraction using
본 발명에서 사용되는 용어인 “추출물”은 목적하는 원료로부터 상기한 바와 같은 통상적인 추출 과정에 의해 분리된 물질로서, 추출용매를 이용한 추출액 또는 이의 농축물 또는 이를 분말화한 것으로, 본 발명의 추출물은 상기한 추출 용매뿐만 아니라, 다른 추출 용매를 이용하여 실질적으로 동일한 효과를 나타내는 추출물을 모두 포함하며, 본 발명의 추출 과정은 수회 반복될 수 있고, 그 이후 통상적인 농축 과정을 거칠 수도 있으며, 감압증류 및 동결 건조 또는 분무 건조 등과 같은 추가적인 과정에 의해 분말 상태로 제조될 수도 있다.The term “extract” used in the present invention is a substance separated by a conventional extraction process as described above from a desired raw material, and an extract or a concentrate thereof using an extraction solvent or a powder thereof, and the extract of the present invention includes all extracts exhibiting substantially the same effect using other extraction solvents as well as the above-described extraction solvent, and the extraction process of the present invention may be repeated several times, and then may be subjected to a conventional concentration process, and reduced pressure It may be prepared in a powder state by additional processes such as distillation and freeze drying or spray drying.
<숙취해소용 조성물><Composition for relieving hangover>
본 발명의 숙취해소용 조성물은, 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물을 유효 성분으로 포함할 수 있다. 상기 조성물 총 중량에 대하여 상기 유효 성분은 65 내지 95 중량% 로 포함할 수 있다. 상기 조성물은 상기 유효 성분 이외에 부성분으로 식용 가능한 식물 추출물을 1종 이상 더 포함할 수 있고, 잔량을 이루는 정제수, 천연 및/또는 인공 감미료 등 통상 사용되는 기타 첨가제를 더 포함할 수 있다. The composition for relieving a hangover of the present invention may include an extract of samchae, an extract of a tree fruit and a dermis extract as active ingredients. Based on the total weight of the composition, the active ingredient may be included in an amount of 65 to 95% by weight. The composition may further include one or more edible plant extracts as sub-components in addition to the active ingredient, and may further include other commonly used additives such as purified water and natural and/or artificial sweeteners constituting the remaining amount.
본 발명의 숙취해소용 조성물은, 혈중 알코올 농도 감소 및 숙취해소 효능에 있어 상승효과를 발휘하는 식물 추출물의 조합을 포함함으로써, 종래 숙취해소용 조성물 대비 우수한 숙취해소 효과를 발휘할 수 있다. 또한, 뛰어난 숙취해소 효능과 더불어, 혈당강하, 노화방지, 면역력 강화 등의 건강 기능성을 동시에 확보할 수 있다. The composition for relieving a hangover of the present invention includes a combination of plant extracts that exert a synergistic effect in reducing blood alcohol concentration and in relieving hangover, thereby exhibiting superior hangover relieving effect compared to conventional compositions for relieving hangover. In addition, in addition to the excellent hangover relieving effect, it is possible to simultaneously secure health functions such as lowering blood sugar, anti-aging, and strengthening immunity.
삼채 (Allium hookeri)는 일명 뿌리 부추라고도 불리우고, 단맛, 쓴맛, 매운맛이 난다고 하여 삼채(三菜)라고 부르기도 한다. 상기 삼채 추출물은 혈당조절을 통한 당뇨개선, 숙취(宿醉)예방 및 간기능(肝機能) 개선효과, 천식개선 효과가 있다. 삼채에 풍부한 식이유황은 활성산소를 제거함으로 면역력 강화효능을 발휘한다. 상기 삼채 추출물은 삼채의 잎 추출물, 꽃 추출물, 줄기 추출물 또는 뿌리 추출물이거나, 이들의 혼합물일 수 있다. Samchae (Allium hookeri) is also called root leek, and is also called samchae (三菜) because it has a sweet, bitter, and spicy taste. The ginseng extract has the effect of improving diabetes through blood sugar control, preventing hangover, improving liver function, and improving asthma. Dietary sulfur, which is abundant in three vegetables, removes free radicals, thereby enhancing immunity. The extract of the three plants may be leaf extracts, flower extracts, stem extracts, or root extracts of the three plants, or a mixture thereof.
회화나무는 콩과에 속하며, 회화나무 꽃봉오리를 괴화(槐花), 회화나무 열매는 괴실(槐實)이라 불리우며, 협과(莢果)로 원기둥 또는 염주 모양이다. 상기 회화나무 추출물은 회화나무 열매 추출물일 수 있다. 상기 회화나무 열매 추출물은 루틴 및 게르마늄 성분이 풍부하고, 우수한 숙취해소 효능을 발휘하면서도, 간(肝), 폐(肺), 대장(大腸)의 기능 개선 효과 및 치질예방 효과를 발휘한다. The rhododendron belongs to the leguminous family, and the bud of the hibiscus tree is called Goehwa (槐花), and the fruit of the hibiscus tree is called Goesil (槐實). The tree extract may be a tree fruit extract. The tree fruit extract is rich in rutin and germanium components, and while exhibiting an excellent hangover relieving effect, it exhibits an effect of improving the function of the liver, lungs, and large intestine and preventing hemorrhoids.
진피는 귤피(橘皮)의 다른 이름으로, 운향과의 귤(Citrus unshiu Markovich) 또는 동속 근연식물의 성숙한 과피(果皮)로, 특이취와 자극성이 있고 맛은 맵고 쓰며 성질은 따뜻하다. 상기 진피 추출물은 우수한 숙취해소 효능을 발휘하면서도, 뭉친 기(氣)를 풀어주고 비장기능을 강화하여 복부창만, 트림, 구토, 메스꺼움, 헛배 부른 증상을 완화시키고, 해수, 가래를 없애주며 이뇨작용(利尿作用)을 촉진할 수 있다. Dermis is another name for tangerine peel. It is the mature rind of Citrus unshiu Markovich or a closely related plant. The dermis extract exerts an excellent hangover relieving effect, while relieving the clogged air and strengthening the spleen function to relieve the symptoms of flatulence, belching, vomiting, nausea, flatulence, remove seawater, phlegm, and diuretic (利尿作用) can be promoted.
상기 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물은 조성물 내 유효 성분으로서, 상기 조성물 총 중량 대비 65 내지 95%, 예를 들어, 70 내지 90%로 포함될 수 있다. 상기 함량 범위 미만이면 충분한 숙취해소 효과를 기대할 수 없고, 상기 함량 범위를 초과하게 되면 숙취해소에 역효과가 나며, 다른 추출물과의 맛의 조화가 이루어지지 않게 되어 바람직하지 않을 수 있다. The three chaechae extracts, the fruit extracts of the sycamore tree, and the extracts of dermis are active ingredients in the composition, and may be included in an amount of 65 to 95%, for example, 70 to 90%, based on the total weight of the composition. If it is less than the above content range, a sufficient hangover relieving effect cannot be expected, and if it exceeds the above content range, there is an adverse effect on hangover relieving, and it may not be preferable because the taste of other extracts may not be harmonized.
상기 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물은 예를 들어, 10 내지 80 : 10 내지 40 : 10 내지 80 의 중량비로 혼합될 수 있다. 상기 주 성분의 각 추출물이 상기 혼합비 범위를 가질 경우, 혈중 알코올 농도 및 숙취해소 효능에 있어 상승효과를 발휘할 수 있다. The three chaechae extracts, the fruit extracts of the sycamore tree, and the extracts of the dermis may be mixed, for example, in a weight ratio of 10 to 80: 10 to 40: 10 to 80. When each extract of the main ingredient has the above mixing ratio range, it can exert a synergistic effect in blood alcohol concentration and hangover relieving effect.
상기 조성물은 상기 유효 성분 이외에 1 종 이상의 식물 추출물인 부성분을 더 포함할 수 있다. 구체적으로, 상기 식물 추출물은 독활 추출물, 백출 추출물, 오수유 추출물 및 지실 추출물로 이루어진 군으로부터 선택되는 적어도 하나 이상일 수 있다. The composition may further include one or more sub-components that are plant extracts in addition to the active ingredient. Specifically, the plant extract may be at least one selected from the group consisting of a poison ivy extract, a baekchul extract, an osuyu extract, and an extract of lichen.
독활은 두릅나무과에 속하며 땃두릅이라고도 한다. 독활의 어린 순은 식용하며, 뿌리는 약용하는데, 약성은 온화하고 맛은 쓰고 맵다. 독활은 진통·진정·혈관확장·호흡중추 흥분작용을 돕고, 한의약학적으로 근육통, 하반신 마비, 두통, 중풍 등의 치료에 쓰인다. 독활은 강활(羌活, 미나리과의 풀)에 비하여 해열·발한 작용이 완만하므로 강활과 같이 쓰면 특히 신경통에 더욱 효과적이다. 상기 독활 추출물은 잎 또는 뿌리 추출물일 수 있으며, 상기 독활 추출물은 숙취해소효능뿐만 아니라 체내 불필요한 수분을 배설하는 효능이 뛰어나다. It belongs to the family Araliaceae and is also referred to as the hornwort. The young shoots of poisonous vitality are edible, and the roots are medicinal. The weakness is mild and the taste is bitter and spicy. Toxin helps with pain relief, sedation, vasodilation, and excitation of the respiratory center, and is used in oriental medicine for the treatment of muscle pain, paralysis of the lower body, headache, and stroke. Compared to ganghwal (羌活, buttercup), the antipyretic and sweating action is milder, so it is particularly effective for neuralgia when used with ganghwal. The poisonous active extract may be a leaf or root extract, and the poisonous active extract has an excellent effect of excreting unnecessary moisture from the body as well as a hangover relieving effect.
백출은 국화과에 속한 삽주의 주피를 제거한 뿌리 줄기를 의미한다. 백출은 특이한 냄새가 있고 맛은 약간 쓰고 달며 씹으면 점성을 띠고 성질은 따뜻하다. 백출 추출물은 숙취해소 효능과 함께 면역증강 효능을 발휘하고, 장관(腸管)의 억제 및 흥분작용 조절, 항궤양 및 간기능 보호, 혈관확장, 이뇨작용 및 혈당강하, 항암작용 등의 기능성을 발휘한다. Baekchul refers to the rhizome from which the bark of sapju belonging to the Asteraceae has been removed. Baekchul has a peculiar odor and tastes slightly bitter and sweet, viscous when chewed, and warm in nature. Baekchul extract exerts a hangover relieving effect and immune enhancement effect, suppresses intestinal tract and controls excitability, protects against ulcers and liver function, dilates blood vessels, diuretics and lowers blood sugar, and exhibits anticancer effects. .
오수유는 열매를 약재로 사용하며, 휘발성 정유의 주성분은 에보덴(evoden)·오시멘(ocimene)·에보딘(evodin)이며, 알칼로이드 성분은 에보디아민·루타에카르핀이 들어있다. 오수유 열매는 9월경 녹갈색의 미숙과를 채취하여 말린 것을 사용하고, 상기 오수유 열매 추출물은 숙취해소 효능과 함께 비, 위장을 따뜻하게 하고, 위의 소화기능을 도우며 구충, 해독작용 및 이뇨작용에 탁월하다. Osuyu uses fruits as medicine, and the main components of volatile essential oil are evoden, ocimene, and evodin, and the alkaloid contains evodiamine and rutaecarpine. The fruit of Osuyu is obtained from unripe greenish-brown fruits in September and used dried, and the fruit extract of Osuyu has a hangover relieving effect, warms the rain and stomach, helps the digestive function of the stomach, and is excellent in deworming, detoxification and diuresis. .
지실은 탱자나무의 덜익은 열매로 맛은 쓰고 시며 성질은 차다. 지실 추출물은 숙취해소 효능뿐만 아니라, 위의 연동운동을 원활하게 해주고 헤스페리딘 성분과 비타민 C를 함유하고 있어 피부의 노화방지 효과가 있다.The fruit is the unripe fruit of the tangja tree. It is bitter and sour in taste and cold in nature. In addition to the hangover relieving effect, the oilseed fruit extract facilitates peristalsis of the stomach and contains hesperidin and vitamin C, which has anti-aging effects on the skin.
상기 부성분은 상기 조성물 총 중량에 대하여 5 내지 30 중량%, 예를 들어, 10 내지 25 중량%로 함유될 수 있다. 상기 부성분은 전술한 유효 성분과 함께 혈중 알코올 농도 및 숙취해소 효능에 있어 시너지를 발휘하면서도, 면역 기능 강화, 혈당 강하, 항암 작용 및 피부 노화 방지 등의 건강 기능성을 발휘할 수 있다. The subcomponent may be contained in an amount of 5 to 30% by weight, for example, 10 to 25% by weight, based on the total weight of the composition. The sub-components can exert synergy in blood alcohol concentration and hangover relieving effect together with the above-described active ingredients, while exhibiting health functions such as strengthening immune function, lowering blood sugar, anti-cancer action and skin aging prevention.
상기 조성물은 전술한 성분 외에, 기타 첨가제인, 예를 들어, 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 더 포함할 수 있다.The composition, in addition to the above-mentioned components, other additives, for example, various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, It may further include a stabilizer, a preservative, glycerin, alcohol, a carbonation agent used in carbonated beverages, and the like.
<건강에 좋은 식품><Healthy food>
본 발명의 건강에 좋은 식품은 상기 숙취해소용 조성물을 포함하여 숙취해소를 주 목적으로 하는 식품일 수 있다. 상기 건강기능 식품은, 혈중 알코올 농도 감소 및 숙취해소 효능이 뛰어남과 동시에, 혈당강하, 노화방지, 면역력 강화 등의 건강 기능성을 동시에 확보할 수 있다. The healthy food of the present invention may be a food for the main purpose of relieving a hangover, including the composition for relieving a hangover. The health functional food is excellent in reducing blood alcohol concentration and relieving hangover, and at the same time, it is possible to secure health functions such as blood sugar lowering, anti-aging, and strengthening immunity at the same time.
상기 건강에 좋은 식품, 즉, 건강기능 식품은, 상기 조성물 이외에 식품원료 및 식품첨가물과 함께 포함할 수 있으며, 상기 식품원료 및 식품첨가물은 상기 식품의 종류에 따라 달라질 수 있다. 상기 건강기능 식품의 종류는 예를 들어, 음료, 수프, 차, 드링크제, 엑기스, 비타민 복합제, 젤류, 캔디류, 초콜릿, 껌, 스낵류, 과자류, 피자, 라면, 기타 면류, 아이스크림을 포함한 낙농제품, 육류, 소시지, 빵, 환, 발포정 등일 수 있으나, 특별히 제한되지는 않으며, 통상적인 의미에서의 식품을 모두 포함한다. The healthy food, ie, health functional food, may be included together with food raw materials and food additives in addition to the composition, and the food raw materials and food additives may vary depending on the type of the food. Types of the health functional food include, for example, beverages, soups, teas, drinks, extracts, vitamin complexes, gels, candy, chocolate, gum, snacks, confectionery, pizza, ramen, other noodles, dairy products including ice cream, meat , sausage, bread, pills, effervescent tablets, etc., but is not particularly limited, and includes all foods in a conventional sense.
예를 들어, 상기 건강기능 식품이 음료일 경우, 통상의 음료와 같이 정제수와 인공 또는 천연 감미료, 산미료, 향료 등의 식품첨가물을 더 포함할 수 있다. 상기 천연 감미료는 예를 들어, 포도당, 과당과 같은 모노사카라이드, 말토오스, 수크로오스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린 등일 수 있다. 상기 인공 감미료는 사카린, 아스파르탐 등일 수 있다. For example, when the health functional food is a beverage, it may further include purified water and food additives such as artificial or natural sweeteners, acidulants, and flavorings, like a conventional beverage. The natural sweetener may be, for example, monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, and dextrin, cyclodextrin, and the like. The artificial sweetener may be saccharin, aspartame, or the like.
상기 건강기능 식품에서 배합수(정제수)를 제외한 식품 전체 중량 (100 중량%)을 기준으로 할 때, 본 발명의 숙취해소용 조성물이 0.1 중량% 내지 99.9 중량%로 포함될 수 있으며, 바람직하게는 1 중량% 내지 50 중량%, 예를 들어, 11 중량% 내지 50 중량% 로 포함될 수 있다.Based on the total weight (100% by weight) of the food excluding the compounding water (purified water) in the health functional food, the hangover relieving composition of the present invention may be included in 0.1% to 99.9% by weight, preferably 1 It may be included in an amount of from 11% to 50% by weight, for example from 11% to 50% by weight.
이하, 실시예를 통하여 본 발명을 보다 구체적으로 설명한다. 그러나, 하기 실시예는 본 발명의 이해를 돕기 위한 것일 뿐 어떠한 의미로든 본 발명의 범위가 실시예로 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail through examples. However, the following examples are provided to help the understanding of the present invention, and the scope of the present invention is not limited to the examples in any sense.
숙취해소용 조성물의 제조Preparation of a composition for relieving hangover
[실시예 1~4 및 비교예 1~6][Examples 1-4 and Comparative Examples 1-6]
이하, 실시예 1~4 및 비교예 1~6 의 숙취해소용 조성물을 제조하였다. Hereinafter, the compositions for relieving hangovers of Examples 1 to 4 and Comparative Examples 1 to 6 were prepared.
<실시예 1 : 유효성분만을 포함><Example 1: Including only active ingredients>
삼채 추출물 제조Preparation of ginseng extract
삼채 뿌리, 잎, 꽃, 줄기를 각각 취하여 물기를 없애고 분쇄한 후 80% 에탄올에 침지시키고 12 시간 동안 70 ℃의 온도로 추출한 후 추출 잔사를 제거하고 감압농축하고 건조시켜 분말 형태의 삼채 추출물을 각각 얻었다.After taking each root, leaf, flower, and stem of Samchae, removing moisture and pulverizing, immersed in 80% ethanol, extracted at a temperature of 70 ℃ for 12 hours, removed the extraction residue, concentrated under reduced pressure, and dried to obtain a powdery extract of Samchae, respectively. got it
회화나무 열매 추출물 제조Manufacture of fruit extract
회화나무 열매를 취하여 물기를 없애고 분쇄한 후 80% 에탄올에 침지시키고 12 시간 동안 70 ℃의 온도로 추출한 후 추출 잔사를 제거하고 감압농축하고 건조시켜 분말 형태의 회화나무 꽃, 열매 추출물을 얻었다.After removing the water from the fruit of the sycamore tree and pulverizing it, it was immersed in 80% ethanol and extracted at a temperature of 70 ° C. for 12 hours.
진피 추출물 제조Dermal extract preparation
진피를 취하여 물기를 없애고 분쇄한 후 80% 에탄올에 침지시키고 12 시간 동안 70 ℃의 온도로 추출한 후 추출 잔사를 제거하고 감압농축하고 건조시켜 분말 형태의 진피 추출물을 얻었다.The dermis was taken, dried and pulverized, immersed in 80% ethanol, extracted at a temperature of 70° C. for 12 hours, the extraction residue was removed, concentrated under reduced pressure, and dried to obtain a powdery dermis extract.
숙취해소용 조성물 제조Preparation of composition for relieving hangover
상기 삼채(뿌리) 추출물 76g, 회화나무 열매 추출물 38g 및 진피 추출물 76g 을 혼합하고, 정제수 10g을 포함하여 숙취해소용 조성물 200g을 제조하였다. 76 g of the samchae (root) extract, 38 g of the fruit extract and 76 g of the dermis extract were mixed, and 200 g of a composition for relieving a hangover was prepared including 10 g of purified water.
<실시예 2 : 유효 성분 + 부성분 모두 포함><Example 2: Including all active ingredients + sub-ingredients>
독활 추출물 제조Preparation of poisonous extract
독활의 잎, 뿌리를 각각 취하여 물기를 없애고 분쇄한 후 80% 에탄올에 침지시키고 12 시간 동안 70 ℃의 온도로 추출한 후 추출 잔사를 제거하고 감압농축하고 건조시켜 분말 형태의 독활 추출물을 각각 얻었다.The leaves and roots of poison ivy were taken, dried and pulverized, immersed in 80% ethanol, extracted at a temperature of 70° C. for 12 hours, and the extraction residue was removed, concentrated under reduced pressure, and dried to obtain a powdery extract, respectively.
백출 추출물 제조Preparation of baekchul extract
백출을 취하여 물기를 없애고 분쇄한 후 80% 에탄올에 침지시키고 12 시간 동안 70 ℃의 온도로 추출한 후 추출 잔사를 제거하고 감압농축하고 건조시켜 분말 형태의 백출 추출물을 얻었다.After removing the water and grinding the baekchul, immersed in 80% ethanol and extracted at a temperature of 70 °C for 12 hours, the extraction residue was removed, concentrated under reduced pressure, and dried to obtain a baekchul extract in powder form.
오수유 열매 추출물 제조Manufacture of Osuyu Fruit Extract
오수유 열매를 취하여 물기를 없애고 분쇄한 후 80% 에탄올에 침지시키고 12 시간 동안 70 ℃의 온도로 추출한 후 추출 잔사를 제거하고 감압농축하고 건조시켜 분말 형태의 오수유 열매 추출물을 얻었다.The fruit of Osuyu was taken, dried and pulverized, immersed in 80% ethanol, extracted at a temperature of 70° C. for 12 hours, the extraction residue was removed, concentrated under reduced pressure, and dried to obtain a powdery fruit extract of Osuyu.
지실 추출물 제조Manufacture of fruit extract
지실을 취하여 물기를 없애고 분쇄한 후 80% 에탄올에 침지시키고 12 시간 동안 70 ℃의 온도로 추출한 후 추출 잔사를 제거하고 감압농축하고 건조시켜 분말 형태의 지실 추출물을 얻었다.After removing the water and grinding the oil, the oil was immersed in 80% ethanol and extracted at a temperature of 70 ° C. for 12 hours.
숙취해소용 조성물 제조Preparation of composition for relieving hangover
실시예 1의 상기 삼채(뿌리) 추출물 52g , 회화나무 열매 추출물 26g, 진피 추출물 52g과, 독활 추출물 16g, 백출 추출물 16g, 오수유 열매 추출물 16g 및 지실 추출물 12g 을 혼합하고, 정제수 10g을 포함하여 숙취해소용 조성물 200g을 제조하였다. 52 g of the three vegetables (root) extract of Example 1, 26 g of fruit extract, 52 g of dermis extract, 16 g of poison ivy extract, 16 g of baekchul extract, 16 g of Osuyu fruit extract and 12 g of fruit extract were mixed, 200 g of a useful composition was prepared.
<실시예 3 : 유효 성분 + 부성분 일부 포함 > <Example 3: Active ingredient + part of sub-ingredients>
숙취해소용 조성물 제조Preparation of composition for relieving hangover
오수유 열매 추출물 및 지실 추출물을 미포함하는 것을 제외하고는 전술된 실시예 2와 동일한 방법으로 숙취해소 조성물을 제조하였다. A hangover relieving composition was prepared in the same manner as in Example 2 described above, except that Osuyu fruit extract and fruit extract were not included.
<실시예 4 : 유효 성분의 함량 미달인 예><Example 4: Example of insufficient content of active ingredient>
숙취해소용 조성물 제조Preparation of composition for relieving hangover
상기 삼채(뿌리) 추출물 48g , 회화나무 열매 추출물 24g 및 진피 추출물 48g 을 혼합하고, 정제수 80g을 포함하여 숙취해소용 조성물 200g을 제조하였다. 48 g of the samchae (root) extract, 24 g of the fruit extract and 48 g of the dermis extract were mixed, and 200 g of a composition for relieving a hangover was prepared, including 80 g of purified water.
<비교예 1 : 유효 성분 중 진피 추출물 미포함 + 부 성분 미포함> <Comparative Example 1: No dermis extract + no subcomponents among active ingredients>
숙취해소용 조성물 제조Preparation of composition for relieving hangover
진피 추출물을 미포함하는 것을 제외하고는 전술된 실시예 1와 동일한 방법으로 숙취해소 조성물을 제조하였다. A hangover relieving composition was prepared in the same manner as in Example 1 described above, except that the dermis extract was not included.
<비교예 2 : 유효 성분 중 삼채 추출물 미포함 + 부 성분 미포함><Comparative Example 2: No extracts from three plants among active ingredients + no subcomponents>
숙취해소용 조성물 제조Preparation of composition for relieving hangover
삼채 추출물을 미포함하는 것을 제외하고는 전술된 실시예 1와 동일한 방법으로 숙취해소 조성물을 제조하였다. A hangover relieving composition was prepared in the same manner as in Example 1 described above, except that the three chae extracts were not included.
<비교예 3: 유효 성분 중 진피 추출물 미포함 + 부 성분 모두 포함><Comparative Example 3: No dermis extract among active ingredients + all minor ingredients included>
숙취해소용 조성물 제조Preparation of composition for relieving hangover
진피 추출물을 미포함하는 것을 제외하고는 전술된 실시예 2와 동일한 방법으로 숙취해소 조성물을 제조하였다. A hangover relieving composition was prepared in the same manner as in Example 2 above, except that the dermis extract was not included.
<비교예 4: 유효 성분 중 회화나무 열매 추출물 미포함 + 부 성분 모두 포함><Comparative Example 4: None of the active ingredients, but not including the extract of the fruit of the sycamore tree + all of the sub-ingredients>
숙취해소용 조성물 제조Preparation of composition for relieving hangover
회화나무 열매 추출물을 미포함하는 것을 제외하고는 전술된 실시예 2와 동일한 방법으로 숙취해소 조성물을 제조하였다. A hangover relieving composition was prepared in the same manner as in Example 2 described above, except that it did not include an extract from the fruit of the sycamore tree.
<비교예 5 : 다른 식물 추출물을 유효성분으로 포함+ 부 성분 미포함><Comparative Example 5: Including other plant extracts as active ingredients + not including sub-components>
숙취해소용 조성물 제조Preparation of composition for relieving hangover
삼채 추출물, 회화나무 열매 추출물 및 진피 추출물 대신 개암나무 열매 추출물, 오리나무 추출물, 마가목 열매 추출물을 주성분으로 포함하는 것을 제외하고는 전술된 실시예 1와 동일한 방법으로 숙취해소 조성물을 제조하였다. A hangover relieving composition was prepared in the same manner as in Example 1 described above, except that the three chae extracts, the Alder tree fruit extract and the dermis extract instead of the hazelnut fruit extract, the alder tree extract, and the rowan fruit extract were included as main ingredients.
<비교예 6 : 시중 판매되는 숙취해소 음료><Comparative Example 6: Commercially available hangover relieving drink>
시판되는 숙취해소 음료인 'CJ 헬스케어 헛개 컨디션' 제품을 준비하였다. A commercially available hangover relieving drink, 'CJ Healthcare Heotgae Condition', was prepared.
실험예 1 : 인체 혈중 알코올 농도 분석Experimental Example 1: Analysis of human blood alcohol concentration
실험 의도 및 방법에 대해 동의를 얻은 실험참가자 10명을 선별하였다. 참가자는 연령, 성별, 신체조건, 평상시 음주습관 등이 유사한 군으로 선별되었다. 음주 시작 전 실시예 1~4 및 비교예 1~6의 조성물들을 각각 섭취하거나, 또는 음주 종료 후 각 조성물들을 섭취하게 하고 간호사가 음주 종료 후 시간 경과에 따라 혈액을 채취하고 (주)녹십자에 의뢰하여 혈중 알코올 농도를 측정하였다. (채혈간격 : 음주 종료 후 60, 90, 150, 240 분) 실험 결과는 표 1에 나타내었다. Ten participants who obtained consent on the intention and method of the experiment were selected. Participants were selected into groups with similar age, gender, physical condition, and drinking habits. Each of the compositions of Examples 1 to 4 and Comparative Examples 1 to 6 was ingested before starting drinking, or each composition was ingested after drinking was finished, and the nurse collected blood over time after drinking was stopped and requested to Green Cross Co., Ltd. to measure the blood alcohol concentration. (Blood sampling interval: 60, 90, 150, 240 minutes after drinking) The experimental results are shown in Table 1.
혈중 알코올 농도(%) 단위[μM]Blood alcohol concentration (%) unit [μM]
알코올 투여
90분 후alcohol administration
after 90 minutes 		알코올 투여
150분 후alcohol administration
after 150 minutes 		알코올 투여
240분후alcohol administration
after 240 minutes
실시예 1Example 1 512512 432432 345345
실시예 2Example 2 489489 383383 278278
실시예 3Example 3 498498 391391 285285
실시예 4Example 4 523523 475475 387387
비교예 1Comparative Example 1 586586 502502 412412
비교예 2Comparative Example 2 576576 493493 397397
비교예 3Comparative Example 3 595595 486486 401401
비교예 4Comparative Example 4 538538 435435 395395
비교예 5Comparative Example 5 675675 589589 503503
비교예 6Comparative Example 6 601601 554554 475475
표 1에서와 같이, 유효 성분을 모두 포함하는 실시예 1~4는 비교예들에 비하여 시간이 경과할수록 혈중 알코올 농도가 현저히 낮아지는 것을 확인할 수 있었다. 그 중에서도 유효 성분 및 부 성분을 모두 포함하는 실시예 2의 혈중 알코올 농도 감소 효과가 가장 뛰어난 것을 확인할 수 있었다. 다만, 주성분의 함량이 65% 미만인 실시예 4는 주성분의 바람직한 함량 범위를 갖는 실시예 1~3에 비하여, 혈중 알코올 농도 감소 효과가 다소 열세한 것을 확인할 수 있었다. As shown in Table 1, it was confirmed that Examples 1 to 4 including all active ingredients significantly lowered the blood alcohol concentration as time elapsed compared to Comparative Examples. Among them, it was confirmed that the effect of reducing the blood alcohol concentration of Example 2 including both the active ingredient and the sub-component was the most excellent. However, it was confirmed that Example 4, in which the content of the main component was less than 65%, was somewhat inferior in the effect of reducing the blood alcohol concentration compared to Examples 1 to 3 having a preferred content range of the main component.
한편, 유효 성분 중 어느 하나를 포함하지 않는 비교예 1 내지 4는 시간이 지나도 실시예들에 비하여 혈중 알코올 농도 감소 효과가 열세하였고, 본 발명의 유효 성분이 아닌 다른 식물 추출물을 유효 성분으로 포함하는 비교예 5는 실시예 들에 비해 효과가 현저히 떨어지는 것을 확인할 수 있었다. On the other hand, Comparative Examples 1 to 4, which do not contain any one of the active ingredients, were inferior in the blood alcohol concentration reducing effect compared to the Examples even after time passed, and containing a plant extract other than the active ingredient of the present invention as an active ingredient Comparative Example 5 was confirmed that the effect was significantly lower than that of Examples.
이로써, 본 발명의 유효 성분인 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물의 조합은 기존에 혈중 알코올 농도 감소 효과가 있다고 알려진 다른 식물 추출물에 비하여 혈중 알코올 농도 감소 효과에 있어 시너지를 발휘하는 것을 확인할 수 있었다. Thus, it can be confirmed that the combination of the active ingredients of the present invention, such as the ginseng extract, the fruit extract of the sycamore tree, and the dermis extract exerts a synergistic effect in reducing the blood alcohol concentration compared to other plant extracts known to have the effect of reducing the blood alcohol concentration. there was.
실험예 2 Experimental Example 2
숙취해소 효능 평가Hangover Relief Efficacy Evaluation
실시예 1~4 및 비교예 1~6의 조성물을 준비하여 숙취해소 효능을 비교하였다. 연령, 성별, 신체조건, 평상시 음주습관 등이 유사하고, 평소 음주 후 다음날 숙취가 있는 편이라고 응답한 검사요원 5명을 선별하였다. 검사요원 5명에게 일정량(대략 소주 4잔~7잔(개인차 있음))의 술을 마시도록 한 뒤 2시간이 경과하였을 때, 상기 각 조성물들을 음용하게 하고 다음날 두통, 속쓰림의 정도, 숙면시간 등에 대하여 평가기준(나쁘다: X 보통이다: △ 우수하다: ○ 매우 우수하다: ◎ )에 따라 기호로 표시하도록 하여 이를 표 2에 나타내었다. (하나의 조성물에 대한 숙취해소 효능을 평가하기까지 한 사람당 일주일을 부여하였으며, 총 실험은 6주간 수행되었다.)The compositions of Examples 1 to 4 and Comparative Examples 1 to 6 were prepared to compare the hangover relieving efficacy. Five test personnel who answered that they had a similar age, gender, physical condition, and usual drinking habits and had a hangover the next day after drinking were selected. After 2 hours have elapsed after having 5 inspectors drink a certain amount of alcohol (approximately 4-7 glasses of soju (individual differences)), make them drink each of the above compositions, and the next day, such as headache, heartburn, sleep time, etc. Table 2 shows the symbols according to the evaluation criteria (bad: X average: △ excellent: ○ very good: ◎). (One week was given per person until the hangover relieving efficacy of one composition was evaluated, and the total experiment was conducted for 6 weeks.)
검사
요원test
agent 		평가
항목evaluation
item 		실시예Example 비교예comparative example
1One 22 33 44 1One 22 33 44 55 66
1One 두통headache ○○ ◎◎ ○○ ○○ △△ XX △△ ○○ XX △△
속쓰림water brash ○○ ○○ ◎◎ ○○ △△ △△ ◎◎ △△ △△ △△
메스꺼움sickness ○○ ◎◎ ○○ △△ ○○ △△ △△ ○○ △△ XX
숙면시간sleep time ◎◎ ○○ ◎◎ ○○ ○○ XX △△ XX △△ ○○
22 두통headache ○○ ◎◎ ○○ ◎◎ ○○ △△ △△ △△ XX △△
속쓰림water brash ○○ ◎◎ ○○ ○○ △△ ○○ △△ ○○ △△ ○○
메스꺼움sickness ◎◎ ◎◎ ◎◎ △△ △△ △△ ◎◎ △△ ○○ XX
숙면시간sleep time ○○ ○○ ◎◎ ○○ △△ XX ○○ XX XX ○○
33 두통headache ◎◎ ○○ ◎◎ ○○ △△ XX △△ △△ ○○ △△
속쓰림water brash ◎◎ ◎◎ ○○ △△ ○○ XX △△ △△ XX ○○
메스꺼움sickness ○○ ◎◎ ○○ ○○ △△ △△ △△ ○○ △△ XX
숙면시간sleep time ○○ ○○ ◎◎ XX XX △△ ○○ ○○ ○○ ○○
44 두통headache ○○ ◎◎ ○○ ○○ ◎◎ XX △△ △△ XX △△
속쓰림water brash ◎◎ ○○ ◎◎ △△ △△ △△ ○○ ○○ △△ ○○
메스꺼움sickness ○○ ◎◎ ○○ ◎◎ ○○ △△ ○○ △△ ○○ XX
숙면시간sleep time ◎◎ ○○ ◎◎ ○○ XX XX △△ ○○ XX ○○
55 두통headache ○○ ◎◎ ◎◎ △△ ○○ ○○ △△ △△ △△ △△
속쓰림water brash ○○ ○○ ○○ XX △△ XX ○○ ○○ △△ XX
메스꺼움sickness ○○ ◎◎ ◎◎ ◎◎ ○○ △△ XX ○○ △△ △△
숙면시간 sleep time ◎◎ ○○ ○○ △△ XX △△ △△ XX XX △△
표 2에서와 같이, 유효 성분을 모두 포함하는 실시예 1~4는 비교예들에 비하여 숙취해소 효능이 뛰어남을 확인할 수 있었다. 그 중에서도 유효 성분 및 부성분을 모두 포함하는 실시예 2의 조성물의 경우, 숙취가 거의 나타나지 않는다고 대부분의 검사요원이 응답한 것을 확인할 수 있었다. 다만, 유효 성분의 함량이 65% 미만인 실시예 4는 실시예 1~3에 비하여 다소 낮은 숙취해소 효능을 나타내었다. As shown in Table 2, Examples 1 to 4 including all active ingredients were confirmed to have excellent hangover relieving efficacy compared to Comparative Examples. Among them, in the case of the composition of Example 2 containing both the active ingredient and the sub-component, it was confirmed that most of the inspectors responded that the hangover hardly appeared. However, Example 4, in which the content of the active ingredient was less than 65%, showed a somewhat lower hangover relieving effect compared to Examples 1-3.
한편, 유효 성분 중 어느 하나를 포함하지 않는 비교예 1~4는 시간이 지나도 실시예들에 비하여 숙취해소 효과가 열세한 것을 확인할 수 있었고, 본 발명의 유효 성분이 아닌 다른 식물 추출물을 유효 성분으로 포함하는 비교예 5 또한 숙취해소 효과가 매우 열세하였다. On the other hand, Comparative Examples 1 to 4, which do not contain any one of the active ingredients, were able to confirm that the hangover relieving effect was inferior compared to the Examples even after time passed, and plant extracts other than the active ingredients of the present invention were used as active ingredients. Comparative Example 5 including the hangover effect was also very inferior.
이로써, 본 발명의 유효 성분인 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물의 조합은 종래 숙취해소 효과가 있다고 알려진 다른 식물 추출물에 비하여 숙취해소 효능에 있어 시너지를 발휘하는 것을 확인할 수 있었다. As a result, it was confirmed that the combination of the three active ingredients of the present invention, the ginseng extract, the fruit extract and the dermis extract, exerts a synergistic effect on the hangover relieving effect compared to other plant extracts known to have a hangover relieving effect.

Claims (9)

  1. 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물을 유효성분으로 포함하는, 숙취해소용 조성물.A composition for relieving a hangover, comprising an extract of samchae extract, an extract from the fruit of a tree of fig tree and a dermis extract as active ingredients.
  2. 제1항에 있어서, According to claim 1,
    상기 조성물 총 중량에 대하여 상기 유효성분은 65 내지 95 중량% 로 포함하는 것인, 숙취해소용 조성물. With respect to the total weight of the composition, the active ingredient is included in an amount of 65 to 95% by weight, a hangover relieving composition.
  3. 제1항에 있어서, According to claim 1,
    상기 삼채 추출물은, 삼채의 잎 추출물, 꽃 추출물, 줄기 추출물 또는 뿌리 추출물이거나, 이들의 혼합물인 것인, 숙취해소용 조성물.The three-chae extract is a three-leaf extract, a flower extract, a stem extract or a root extract, or a mixture thereof, a composition for relieving a hangover.
  4. 제1항에 있어서, According to claim 1,
    상기 조성물에서, 상기 삼채 추출물, 회화나무 열매 추출물 및 진피 추출물은 10~80 : 10~40 : 10~80 의 중량비로 혼합되는 것인, 숙취해소용 조성물.In the composition, the three chaechae extract, the fruit extract and the dermis extract are mixed in a weight ratio of 10 to 80: 10 to 40: 10 to 80, a composition for relieving a hangover.
  5. 제1항에 있어서,According to claim 1,
    상기 조성물은, 독활 추출물, 백출 추출물, 오수유 추출물 및 지실 추출물로 이루어진 군으로부터 선택되는 1종 이상인 부성분을 더 포함하는 것인, 숙취해소용 조성물.The composition further comprises one or more sub-components selected from the group consisting of poison ivy extract, baekchul extract, osuyu extract, and oleaginous extract.
  6. 제5항에 있어서,6. The method of claim 5,
    상기 부성분의 추출물들은 열수 추출 또는 주정 추출에 의하여 제조된 것인, 숙취해소용 조성물.The extracts of the subcomponents are prepared by hot water extraction or alcohol extraction, hangover relieving composition.
  7. 제5항에 있어서,6. The method of claim 5,
    상기 부성분의 추출물은 숙취해소 조성물의 총 중량의 5 내지 30 중량% 로 포함되는 숙취해소용 조성물.The extract of the subcomponent is included in 5 to 30% by weight of the total weight of the hangover relief composition for hangover relief.
  8. 제1항 내지 제7항 중 어느 한 항에 의한 숙취해소용 조성물을 포함하는 건강기능 식품.A health functional food comprising the composition for relieving a hangover according to any one of claims 1 to 7.
  9. 제8항에 있어서, 9. The method of claim 8,
    상기 건강기능 식품은 음료, 젤리, 환 또는 발포정인 것인, 건강기능 식품.The health functional food is a beverage, jelly, pill or effervescent tablet, health functional food.
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KR20120010464A (en) * 2010-07-26 2012-02-03 이의영 Composition having herb extract as active incredient for treating hangover and preparation method thereof
KR20120115443A (en) * 2011-04-08 2012-10-18 한봉재 A medicinal infusion drink removing the effect of hangover and method for manufacturing the same
KR101447674B1 (en) * 2014-04-07 2014-10-07 김태진 Herbal medicine composition for removing hangover and forms thereof
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WO2018021886A1 (en) * 2016-07-29 2018-02-01 천지인초 주식회사 Food composition for relieving hangover, overcoming fatigue and improving immunity comprising extract of mixed herbal medicine as active ingredient

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KR20120115443A (en) * 2011-04-08 2012-10-18 한봉재 A medicinal infusion drink removing the effect of hangover and method for manufacturing the same
KR101447674B1 (en) * 2014-04-07 2014-10-07 김태진 Herbal medicine composition for removing hangover and forms thereof
KR20170028636A (en) * 2015-09-04 2017-03-14 대한민국(농촌진흥청장) Composition for removing hangover comprising an extract of Allium hookeri
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