CN1927342A - Heat clearing and detoxicating dispersant tablet and method for making same - Google Patents
Heat clearing and detoxicating dispersant tablet and method for making same Download PDFInfo
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- CN1927342A CN1927342A CNA2006101244776A CN200610124477A CN1927342A CN 1927342 A CN1927342 A CN 1927342A CN A2006101244776 A CNA2006101244776 A CN A2006101244776A CN 200610124477 A CN200610124477 A CN 200610124477A CN 1927342 A CN1927342 A CN 1927342A
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Abstract
The invention relates to dispersible tablets for heat clearing and detoxicating, as well as the preparing process, wherein the raw materials include gypsum, scrophularia root, dried rehmannia root, capsule of weeping forsythia, cape jasmine, Herba Corydalis bungeanae, rough gentian, isatic root, anemarrhena rhizome, lilyturf root, honeysuckle flower, and baikal skullcap root.
Description
Technical field
The present invention relates to Chinese patent medicine dispersible tablet technical field, relate in particular to a kind of heat-clearing and toxic substances removing dispersible tablet and preparation method thereof.
Background technology
Dispersible tablet is a kind of novel pharmaceutical formulation that development in recent years is got up, and antipyretic and antidotal type has multiple dosage form, has the effect of heat-clearing and toxic substances removing.Be used for the flushed complexion of generating heat due to the pyretic toxicity Yong Sheng, irritated thirsty, diseases such as laryngopharynx swelling and pain; Influenza, upper respiratory infection are seen above-mentioned patient.The heat-clearing and toxic substances removing of one of former dosage form is that oral liquid has been listed 2005 editions one one of Chinese Pharmacopoeia in.Though the QINGRE JIEDU KOUFUYE taking convenience, less stable, packing, transportation, storage are all inconvenient, and are difficult for grasping taking dose.
Compare ordinary tablet, dispersible tablet requires temperature at disperse medium in 20 ± 1 ℃, and disintegration, the granule after the disintegrate should all sieve by No. 2 less than 3 minutes.It is rapid that medicine has a stripping, absorb fast, the bioavailability height, advantages such as taking convenience can swallow, chew, contain and suck or with taking after the aqueous dispersion, the patient who especially is fit to the old man and the difficulty of swallowing takes.Compare with liquid preparation, it is good that dispersible tablet has a medicine stability, packs, transports, preserves advantage easily.
Can use for this reason that the modern pharmaceutical technology changes its dosage form into both can be oral, can be scattered in the dispersible tablet that forms fragrant and sweet good to eat solution in the water again rapidly.
In fact disintegrate finishes and can not represent medicine well to absorb, and medicine need have good dissolution that good bioavailability height just can be arranged.The dissolution index of dispersible tablet is to investigate the important indicator of dispersible tablet performance.
The most effective traditional dispersible tablet disintegrating agent is carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LS-HPC), crospolyvinylpyrrolidone (PVPP), cross-linking sodium carboxymethyl cellulose (CCMC-Na), combination between them needs satisfied temperature in 20 ± 1 ℃, disintegration is less than 3 minutes, the granule after the disintegrate should be all by the requirement of No. 2 sieves.The disintegrate efficient of CMS-Na, LS-HPC, PVPP, CCMC-Na totally is higher than sodium carboxymethyl cellulose, microcrystalline Cellulose, pregelatinized Starch medicine.The disintegrate principle of CMS-Na, LS-HPC, PVPP, CCMC-Na mainly is a suction back volume swelling significantly, thereby dispersible tablet is collapsed out.
Polyvinylpolypyrrolidone is the cross-linked homopolymer of N-vinyl-2-Pyrrolidone, and polyvinylpolypyrrolidone also is the swollen efficient disintegrating agent of a kind of rapid rate, and polyvinylpolypyrrolidone records in American National formulary and European Pharmacopoeia.
Most dispersible tablets of Chinese medicine are because of (1) Chinese medicine principal agent ratio content height, the sticking of macromolecular substances such as (2) pectin, polysaccharide, cause the dispersible tablets of Chinese medicine disintegration rate difficulty reach the requirement that is controlled in 3 minutes, than the more difficult industrialization of Western medicine dispersible tablet.Western medicine dispersible tablet kind in the industrialization of having reported is more, but the dispersible tablets of Chinese medicine kind of industrialization is considerably less.This is also few because be fit to the herbal species of quick disintegrate dispersible tablet.The dispersible tablets of Chinese medicine kind that particularly can very fast disintegrate about time half a minute finishes is very rare.
Transform the form that existing herbal species makes it to become dispersible tablet, the adjuvant combination that efficiency of selection is higher according to qualifications, very fast disintegrate finishes about time half a minute, so that obtain the better medicament bioavailability certain meaning is arranged.
And according to qualifications the higher adjuvant of efficiency of selection to be combined in about time half a minute that disintegrate finishes be very very difficult, the disintegrate of most herbal species was above 1 minute in a plurality of herbal species of our preparation.
Summary of the invention
The purpose of this invention is to provide the very fast heat-clearing and toxic substances removing dispersible tablet of a kind of heat-clearing and toxic substances removing dispersible tablet, particularly disintegrate, conveniently take to better meet needs of medical treatment.Preparation technology's preparation method of simple heat-clearing and toxic substances removing dispersible tablet also is provided simultaneously.
Technical scheme of the present invention has following:
The heat-clearing and toxic substances removing dispersible tablet, the composition of this dispersible tablet comprises heat-clearing and toxic substances removing extract, adjuvant; Adjuvant comprises disintegrating agent, filler, binding agent, lubricant, correctives.
The heat-clearing and toxic substances removing compound recipe is formed: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g.
The heat-clearing and toxic substances removing dispersible tablet, each constituent weight proportion is: heat-clearing and toxic substances removing extract 60-80 part, disintegrating agent 10-50 part, filler 0-60 part, binding agent 0-10 part, lubricant 0-8 part, correctives 0-8 part.
The heat-clearing and toxic substances removing dispersible tablet, each constituent weight proportion is: 75 parts of heat-clearing and toxic substances removing extracts, disintegrating agent 20-45 part, filler 30-60 part, binding agent 0-10 part, lubricant 0-8 part, correctives 0-5 part.
The heat-clearing and toxic substances removing dispersible tablet, each constituent weight proportion is: the fine powder 150g of heat-clearing and toxic substances removing extract, crospolyvinylpyrrolidone 45g, low-substituted hydroxypropyl cellulose 30g, magnesium stearate 5g, micropowder silica gel 14g, microcrystalline Cellulose 86g, stevioside 5g.
The heat-clearing and toxic substances removing dispersible tablet, each constituent weight proportion is: the fine powder 150g of heat-clearing and toxic substances removing extract, microcrystalline Cellulose 77g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 21g, magnesium stearate 1g, acesulfame potassium 6g.
The key of dispersible tablet is its disintegration rate in water, so the selection of the disintegrate system in the tablet is extremely important, the disintegrating agent that the present invention chooses is any one or a few in carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LS-HPC), crospolyvinylpyrrolidone (PVPP), cross-linking sodium carboxymethyl cellulose (CCMC-Na), sodium carboxymethyl cellulose, microcrystalline Cellulose, polyvinylpolypyrrolidone, micropowder silica gel, the pregelatinized Starch.
Filler is in order to increasing the weight and volume of dispersible tablet, to be beneficial to molding and divided dose, the filler that the present invention chooses be in microcrystalline Cellulose, micropowder silica gel, pregelatinized Starch, starch, mannitol, the dextrin any one or a few.
Lubricant be for can feed in raw material smoothly and slice, make the pharmaceutic adjuvant of tablet smooth and beautiful appearance, the lubricant that the present invention chooses be in magnesium stearate, micropowder silica gel, calcium stearate, Pulvis Talci, Stepanol MG, the silicon dioxide any one or a few.
Correctives be in stevioside, aspartame, glycyrrhizin, citric acid, the vanillin any one or a few.
Binding agent is to be convenient to wet granulation and the adherent pharmaceutic adjuvant of tabletting, and the binding agent of dispersible tablet of the present invention comprises in Different concentrations of alcohol, polyvinylpyrrolidone (PVP), polyethylene glycol 6000, the Macrogol 4000 any one or a few.
In order to guarantee the stable of principal agent, can also add an amount of antioxidant etc.
Disintegrating agent add, add in can adopting or in add and add combination.
Usage and consumption: oral, one time 4,3 times on the one.
The specific embodiment:
Embodiment 1:
The Chinese medicine extract of heat-clearing and toxic substances removing dispersible tablet and auxiliary material weight proportion: the fine powder 150g of heat-clearing and toxic substances removing extract, micropowder silica gel 20g, carboxymethyl starch sodium 75g, microcrystalline Cellulose 50g, magnesium stearate 8g, acesulfame potassium 7g.
The heat-clearing and toxic substances removing proportion of composing is on the books on Chinese Pharmacopoeia: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g.
The heat-clearing and toxic substances removing dispersible tablet obtains by following concrete steps: get after the flavor medicine added water temperature earlier and soaked Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis ten, decoct secondary again, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae filter slightly, collecting decoction, after filtrate concentrates, add ethanol, cold preservation 48 hours, filter, get the supernatant concentrating under reduced pressure and become the thick paste shape, obtain the fine powder of heat-clearing and toxic substances removing extract after vacuum drying, dry extract are pulverized.
Earlier above-mentioned material is crossed 100 mesh sieves respectively, progressively increase method with the fine powder of heat-clearing and toxic substances removing extract and the mixture mixing of filler, disintegrating agent by equivalent, the material behind the mixing is put in the appropriate containers, the adding binding agent, and water or ethanol dissolve in right amount, make soft material; 35 mesh sieves are made wet granular, drying, and 35 mesh sieve granulate add the adjuvant of remainder again, mixing, tabletting promptly gets the heat-clearing and toxic substances removing dispersible tablet.
Embodiment 2:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, sodium carboxymethyl cellulose 52g, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 26g, polyvinylpyrrolidone 28g, micropowder silica gel 7g, Stepanol MG 3g, citric acid 10g.All the other are with embodiment 1.
Embodiment 3:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, cross-linking sodium carboxymethyl cellulose 45g, crospolyvinylpyrrolidone 13g, low-substituted hydroxypropyl cellulose 12g, pregelatinized Starch 75g, mannitol 20g, calcium stearate 2g, magnesium stearate 3g.All the other are with embodiment 1.
Embodiment 4:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, crospolyvinylpyrrolidone 30g, polyvinylpyrrolidone 20g, magnesium stearate 10g, micropowder silica gel 105g, aspartame 5g.All the other are with embodiment 1.
Embodiment 5:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, low-substituted hydroxypropyl cellulose 45g, polyvinylpyrrolidone 45g, pregelatinized Starch 32g, micropowder silica gel 40g, aspartame 8g.All the other are with embodiment 1.
Embodiment 6:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, crospolyvinylpyrrolidone 30g, polyvinylpyrrolidone 20g, sodium carboxymethyl cellulose 25g, magnesium stearate 10g, micropowder silica gel 40g, microcrystalline Cellulose 40g, aspartame 5g.All the other are with embodiment 1.
Embodiment 7:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, crospolyvinylpyrrolidone 45g, low-substituted hydroxypropyl cellulose 30g, magnesium stearate 5g, micropowder silica gel 14g, microcrystalline Cellulose 86g, stevioside 5g.
Earlier above-mentioned material is crossed 100 mesh sieves respectively, by the equivalent mixture mixing of method that progressively increase with the fine powder of heat-clearing and toxic substances removing extract and crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose, material behind the mixing is put in the appropriate containers, and water or ethanol dissolve in right amount, make soft material; 35 mesh sieves are made wet granular, drying, and 35 mesh sieve granulate add micropowder silica gel, magnesium stearate, stevioside again, mixing, tabletting promptly gets the heat-clearing and toxic substances removing dispersible tablet.
All the other are with embodiment 1.
Embodiment 8:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, low-substituted hydroxypropyl cellulose 30g, polyvinylpyrrolidone 25g, carboxymethyl starch sodium 25g, magnesium stearate 10g, micropowder silica gel 40g, microcrystalline Cellulose 35g, aspartame 5g.All the other are with embodiment 1.
Embodiment 9:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, crospolyvinylpyrrolidone 40g, polyvinylpyrrolidone 35g, magnesium stearate 8g, micropowder silica gel 10g, microcrystalline Cellulose 70g, stevioside 7g.All the other are with embodiment 1.
Embodiment 10:
Heat-clearing and toxic substances removing dispersible tablet: the fine powder 150g of the heat-clearing and toxic substances removing extract of weight proportion, microcrystalline Cellulose 77g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 21g, magnesium stearate 1g, acesulfame potassium 6g.All the other are with embodiment 1.
Embodiment 11
The heat-clearing and toxic substances removing dispersible tablet: Fructus Forsythiae, Radix Scutellariae powder are broken into fine powder, decoct with water all the other Gypsum Fibrosum, Flos Lonicerae, Radix Scrophulariae, Radix Rehmanniae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis three times, warm macerating decocted 1.5 hours after 2 hours for the first time, decocted 1.5 hours for the second time, decocted for the third time 1 hour.Filter respectively, merging filtrate, the relative density that is concentrated into 80 ℃ is 1.30, adds above-mentioned fine powder, mixing, drying is ground into the fine powder of heat-clearing and toxic substances removing extract.All the other are with embodiment 7.
Embodiment 12
The heat-clearing and toxic substances removing dispersible tablet: Fructus Forsythiae, Radix Scutellariae powder are broken into fine powder, decoct with water all the other Gypsum Fibrosum, Flos Lonicerae, Radix Scrophulariae, Radix Rehmanniae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis three times, warm macerating decocted 1.5 hours after 2 hours for the first time, decocted 1.5 hours for the second time, decocted for the third time 1 hour.Filter respectively, merging filtrate, the relative density that is concentrated into 80 ℃ is 1.30, adds above-mentioned fine powder, mixing, drying is ground into the fine powder of heat-clearing and toxic substances removing extract.All the other are with embodiment 10.
The dispersible tablet made from above embodiment carries out dissolution relatively, as the data of following table 1 and table 2:
Table 1 different auxiliary material comparative test design
The different disintegrating agent comparative test of table 2 result
All within 1 minute, embodiment 7 disintegration times have only 49 seconds to the disintegration time of process contrast discovery embodiment 7,10, and faster than 3 minutes disintegrations of dispersible tablet of version pharmacopeia regulation in 2005, selecting embodiment 10 or 7 is priority scheme of the present invention far away.The present invention has improved disintegration rate greatly, helps medicine fast Absorption in vivo.
Although what adopt is the disintegrating agent of using always, different disintegrating agent combinations is variant slightly to have caused disintegration rate widely different, can't not screen the heat-clearing and toxic substances removing dispersible tablet that obtains 34-49 rapid disintegrate in second by a large amount of experiments.
Claims (6)
1, a kind of heat-clearing and toxic substances removing dispersible tablet, it is characterized in that: the composition of this dispersible tablet comprises heat-clearing and toxic substances removing extract, disintegrating agent, filler, binding agent, lubricant, correctives; Wherein the weight proportion of heat-clearing and detoxifying herb raw material be Gypsum Fibrosum 670, Flos Lonicerae 134, Radix Scrophulariae 107, Radix Rehmanniae 80, Fructus Forsythiae 67, Fructus Gardeniae 67, Herba Gueldenstaedtiae 67, Radix Scutellariae 67, Radix Gentianae 67, Radix Isatidis 67, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g.
2, heat-clearing and toxic substances removing dispersible tablet as claimed in claim 1 is characterized in that: each constituent weight proportion is: heat-clearing and toxic substances removing extract 60-80 part, disintegrating agent 10-50 part, filler 0-60 part, binding agent 0-10 part, lubricant 0-8 part, correctives 0-8 part.
3, heat-clearing and toxic substances removing dispersible tablet as claimed in claim 1 is characterized in that: each constituent weight proportion is: 75 parts of heat-clearing and toxic substances removing extracts, disintegrating agent 20-45 part, filler 30-60 part, binding agent 0-10 part, lubricant 0-8 part, correctives 0-5 part.
4, heat-clearing and toxic substances removing dispersible tablet is characterized in that: each constituent weight proportion is: the fine powder 150g of heat-clearing and toxic substances removing extract, crospolyvinylpyrrolidone 45g, low-substituted hydroxypropyl cellulose 30g, magnesium stearate 5g, micropowder silica gel 14g, microcrystalline Cellulose 86g, stevioside 5g; Wherein the weight proportion of heat-clearing and detoxifying herb raw material is Gypsum Fibrosum 670, Flos Lonicerae 134, Radix Scrophulariae 107, Radix Rehmanniae 80, Fructus Forsythiae 67, Fructus Gardeniae 67, Herba Gueldenstaedtiae 67, Radix Scutellariae 67, Radix Gentianae 67, Radix Isatidis 67, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54.
5, heat-clearing and toxic substances removing dispersible tablet is characterized in that: each constituent weight proportion is: the fine powder 150g of heat-clearing and toxic substances removing extract, microcrystalline Cellulose 77g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 21g, magnesium stearate 1g, acesulfame potassium 6g; Wherein the weight proportion of heat-clearing and detoxifying herb raw material is Gypsum Fibrosum 670, Flos Lonicerae 134, Radix Scrophulariae 107, Radix Rehmanniae 80, Fructus Forsythiae 67, Fructus Gardeniae 67, Herba Gueldenstaedtiae 67, Radix Scutellariae 67, Radix Gentianae 67, Radix Isatidis 67, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54.
6, the preparation method of the described heat-clearing and toxic substances removing dispersible tablet of claim 4, it is characterized in that: the heat-clearing and toxic substances removing dispersible tablet, obtain by following concrete steps: get after the flavor medicine added water temperature earlier and soaked Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis ten, decoct secondary again, after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae slightly, filter, collecting decoction is after filtrate concentrates, add ethanol, cold preservation 48 hours filters, and gets the supernatant concentrating under reduced pressure and becomes the thick paste shape, after pulverizing, vacuum drying, dry extract obtain the fine powder of heat-clearing and toxic substances removing extract; Earlier above-mentioned material is crossed 100 mesh sieves respectively, by the equivalent mixture mixing of method that progressively increase with the fine powder of heat-clearing and toxic substances removing extract and crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose, material behind the mixing is put in the appropriate containers, and water or ethanol dissolve in right amount, make soft material; 35 mesh sieves are made wet granular, drying, and 35 mesh sieve granulate add micropowder silica gel, magnesium stearate, stevioside again, mixing, tabletting promptly gets the heat-clearing and toxic substances removing dispersible tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006101244776A CN1927342A (en) | 2006-09-05 | 2006-09-05 | Heat clearing and detoxicating dispersant tablet and method for making same |
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| CNA2006101244776A CN1927342A (en) | 2006-09-05 | 2006-09-05 | Heat clearing and detoxicating dispersant tablet and method for making same |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199747B (en) * | 2007-12-12 | 2012-03-07 | 陈德顺 | Oral administration Chinese medicine for treating liver stomach heat evil toothache |
| CN102961469A (en) * | 2012-12-12 | 2013-03-13 | 重庆邮电大学 | Traditional Chinese medicine dispersible tablet for treating upper respiratory infection, and preparation method and quality detection method thereof |
| CN104784127A (en) * | 2014-01-16 | 2015-07-22 | 南京瑞尔医药有限公司 | Acyclovir tablet composition |
| CN104784126A (en) * | 2014-01-16 | 2015-07-22 | 南京瑞尔医药有限公司 | Acyclovir tablet composition preparation method |
| CN105287417A (en) * | 2015-11-25 | 2016-02-03 | 济南舜祥医药科技有限公司 | Forsythia suspensa common anti-common-cold dispersible tablets and preparation method thereof |
-
2006
- 2006-09-05 CN CNA2006101244776A patent/CN1927342A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199747B (en) * | 2007-12-12 | 2012-03-07 | 陈德顺 | Oral administration Chinese medicine for treating liver stomach heat evil toothache |
| CN102961469A (en) * | 2012-12-12 | 2013-03-13 | 重庆邮电大学 | Traditional Chinese medicine dispersible tablet for treating upper respiratory infection, and preparation method and quality detection method thereof |
| CN102961469B (en) * | 2012-12-12 | 2015-04-08 | 重庆邮电大学 | Traditional Chinese medicine dispersible tablet for treating upper respiratory infection, and preparation method and quality detection method thereof |
| CN104784127A (en) * | 2014-01-16 | 2015-07-22 | 南京瑞尔医药有限公司 | Acyclovir tablet composition |
| CN104784126A (en) * | 2014-01-16 | 2015-07-22 | 南京瑞尔医药有限公司 | Acyclovir tablet composition preparation method |
| CN104784126B (en) * | 2014-01-16 | 2018-09-21 | 南京瑞尔医药有限公司 | A kind of preparation method of Acyclovir Tablet composition |
| CN105287417A (en) * | 2015-11-25 | 2016-02-03 | 济南舜祥医药科技有限公司 | Forsythia suspensa common anti-common-cold dispersible tablets and preparation method thereof |
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Open date: 20070314 |