CN1943756A - A Chinese traditional medicinal composite used for treatment of hypertension and its preparation method - Google Patents
A Chinese traditional medicinal composite used for treatment of hypertension and its preparation method Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000002131 composite material Substances 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 34
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- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims abstract description 12
- 229960003321 baicalin Drugs 0.000 claims abstract description 12
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims abstract description 12
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 13
- 239000000796 flavoring agent Substances 0.000 claims description 12
- 235000019634 flavors Nutrition 0.000 claims description 12
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 10
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- 229940079593 drug Drugs 0.000 claims description 7
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- 239000002552 dosage form Substances 0.000 claims description 3
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- 235000014435 Mentha Nutrition 0.000 claims description 2
- 241001072983 Mentha Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
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- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 4
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Abstract
The invention discloses a Chinese traditional medicine composition used in treatment of hypertension, belongs to the field of Chinese traditional medicine. The combination is prepared with a certain proportion of calculus bovis, cornu saigae jataricae, baicalin, margarita, semen cassiae, rhizoma chuanxiong, etc. by certain specific technology, used in the treatment of hypertension, dizziness, irritability with significant effect. The invention discloses the preparation method of the Chinese traditional medicine composition in addition.
Description
Technical field
The present invention relates to hypertensive Chinese medicine composition of a kind of treatment and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Hypertension is very clear and definite in the diagnosis of doctor trained in Western medicine, adopts sphygomanometer.Normal arterial pressure: systolic pressure＜140mmHg, diastolic pressure＜90mmHg is exactly a hypertension as if what be higher than above standard; Then according to systolic pressure and diastolic pressure exceed normal value what and have or not the infringement of target organs such as heart and brain kidney, hypertension is divided into I, II, III level.
And ancient Chinese medicine is first from clinical symptoms to hypertensive understanding, and for example patient suffers from headache, dizziness, feeling of fullness in the head, insomnia etc.The traditional Chinese medical science thinks that the formation of hypertension is a secular pathological process, it or not single factors, but by body constitution, spirit, diet, seven emotions, due to the multiple factor reciprocal actions such as labor desire, the decline of either YIN or YANG of body constitution, natural endowment, internal organs losss etc. are the common cause of morbidity, the height psychentonia, overstrain or intensive direct stimulation etc. are the common factors of morbidity, addiction to greasy and sweet foods or tobacco and wine are excessive, or have a liking for the food saline taste and accumulatively wet raise phlegm, living positive fire-transformation is again very important pathogenic factors, hypertensive basic etiology and pathogenesis is that the deficiency in origin table is real, the then positive deficiency of vital energy of void, blame in the hepatic and renal YIN deficiency the kidney failing to nourish the liver; Deficiency of both the heart and spleen, QI and blood are not filled; Deficiency of kidney-essence, brain cervical carcinoma with cachexia.Actually excess of pathogen, duty in excessive rising of liver-YANG, positive wind-transformation is moving, fills on the QI and blood; Stagnation of turbid phlegm in middle-JIAO, on cover clear key; Block sering, give birth in the congestion, not smooth blood vessels are held back impairment of ZANG FU-organs.In a word, attach most importance to Liver and kidney heart spleen in the sick position of hypertension, wherein especially based on Liver and kidney.
Summary of the invention
One of purpose of the present invention provides a kind of hypertensive Chinese medicine composition that is used for the treatment of;
Two of purpose of the present invention provides the preparation method of this Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions:
Medicine of the present invention is made by following bulk drugs:
Artificial Calculus Bovis 10-30 weight portion Cornu Saigae Tataricae 5-15 weight portion baicalin 33-100 weight portion
Margarita 5-15 weight portion Semen Cassiae 40-120 weight portion Rhizoma Chuanxiong 5-15 weight portion
Borneolum Syntheticum 10-30 weight portion Radix Paeoniae Alba 30-90 weight portion Radix Curcumae 20-60 weight portion
Radix Et Rhizoma Nardostachyos 5-15 weight portion Pulvis Cornus Bubali Concentratus 7.5-22.5 weight portion Radix Astragali 12.5-37.5 weight portion
Radix Codonopsis 12.5-37.5 weight portion Herba Menthae 2.5-7.5 weight portion.
Medicine optimum weight part proportioning of the present invention is:
Artificial Calculus Bovis's 20 weight portion Cornu Saigae Tataricae 10 weight portion baicalins 66.7 weight portions
Margarita 10 weight portion Semen Cassiaes 80 weight portion Rhizoma Chuanxiongs 10 weight portions
The Borneolum Syntheticum 20 weight portion Radix Paeoniae Albas 60 weight portion Radix Curcumaes 40 weight portions
The Radix Et Rhizoma Nardostachyos 10 weight portion Pulvis Cornus Bubali Concentratuss 15 weight portion Radixs Astragali 25 weight portions
Radix Codonopsis 25 weight portion Herba Menthaes 5 weight portions.
Above crude drug can be made multiple oral formulations, comprises tablet, capsule, pill etc., and the common preparation process of these preparations is:
More than 14 flavors, Cornu Saigae Tataricae, Pulvis Cornus Bubali Concentratus, baicalin are ground into impalpable powder, the Radix Paeoniae Alba etc. nine flavor is ground into fine powder; With artificial Calculus Bovis, Borneolum Syntheticum porphyrize and said medicine facing-up, sieve, mixing is made required dosage form.
Common dosage form and preparation method are:
In compositions, add disintegrating agent, binding agent, granulate, be pressed into tablet.
Add disintegrating agent, binding agent in compositions, mixing is prepared into pill.
Compositions is granulated, add fluidizer, mixing incapsulates, and is prepared into capsule.
Best preparation method is:
More than 14 flavors, Cornu Saigae Tataricae, Pulvis Cornus Bubali Concentratus, baicalin are ground into impalpable powder, the Radix Paeoniae Alba etc. nine flavor is ground into fine powder; With artificial Calculus Bovis, Borneolum Syntheticum porphyrize and said medicine facing-up, sieve, mixing is granulated, and is pressed into 1000, the bag film-coat, promptly.
This product can be used for treating hypertension, for determining drug effect, this product has been carried out pharmacodynamics test research, and used capsule is by best proportioning of the present invention and optimum process preparation and get in the test.Concrete test is as follows:
Test method: 60 of the male rats of selection spontaneous hypertensive rat, body weight 230～250g are divided into 6 groups, the 1%CMC group at random, nifedipine 3mg/kg group, nifedipine 9mg/kg group, this product 350mg/kg group, this product 200g/kg group, this product 100mg/kg group, every group 10, before Mus tail manograph is measured administration, 30min after the administration, 1h, the blood pressure of 6h and 24h and the rhythm of the heart.
The results are shown in Table 1, table 2.
Statistical procedures: use t check comparable group differences.
Table 1 gastric infusion is to the influence of SHR blood pressure (X ± s)
| Medicine | Dosage | Blood pressure (Kpa) before the medicine | Blood pressure behind the medicine (Kpa) | |||
| 0.5h | 1h | 6h | 24h | |||
| 1%CMC this product nifedipine | - 100mg/kg 200mg/kg 350mg/kg 3mg/kg 9mg/kg | 26.5±2.41 25.6±1.49 25.7±1.77 26.8±1.21 26.8±1.19 24.5±2.58 | 26.5±2.55 23.1±1.53*** 19.7±3.04*** 17.9±2.75*** 22.0±2.30*** 18.2±1.75*** | 26.7±2.15 23.8±1.78*** 20.2±3.31*** 20.4±2.15*** 22.4±1.74*** 19.6±2.67*** | 26.5±2.50 24.7±2.56*** 23.8±1.18*** 23.1±3.32*** 25.4±1.54*** 23.1±1.75*** | 26.5±2.48 24.9±1.90** 26.2±1.48*** 24.6±2.60*** 25.8±1.71*** 23.8±3.49* |
Table 2 gastric infusion is to the influence of the SHR rhythm of the heart (X ± s)
| Medicine | Dosage | The rhythm of the heart before the medicine (inferior/min) | The rhythm of the heart behind the medicine (inferior/min) | |||
| 0.5h | 1h | 6h | 24h | |||
| 1%CMC this product nifedipine | - 100mg/kg 200mg/kg 350mg/kg 3mg/kg 9mg/kg | 340.0±21.2 354.0±45.9 328.5±22.7 358.2±22.2 351.3±21.9 316.1±30.3 | 343.2±33.7 357.0±22.0* 373.0±49.3* 423.4±50.4*** 379.1±22.2* 403.1±39.9** | 340.0±30.1 357.1±22.2* 375.1±38.1* 390.1±26.2*** 357.9±18.3* 363.2±40.8* | 346.5±33.8 363.1±33.8* 357.2±26.1* 386.1±27.7** 349.1±30.1* 340.1±29.9* | 340.0±25.9 357.1±38.5* 349.9±21,1* 353.3±36.1* 357.7±24,7* 323.4±53.5* |
Below by implementing to further specify technical scheme of the present invention, but this applies for that claimed scope is not limited in the described content of embodiment.
The specific embodiment:
Embodiment 1
[prescription] artificial Calculus Bovis 20g Cornu Saigae Tataricae 10g baicalin 66.7g
Margarita 10g Semen Cassiae 80g Rhizoma Chuanxiong 10g
Borneolum Syntheticum 20g Radix Paeoniae Alba 60g Radix Curcumae 40g
Radix Et Rhizoma Nardostachyos 10g Pulvis Cornus Bubali Concentratus 15g Radix Astragali 25g
Radix Codonopsis 25g Herba Menthae 5g
[method for making] above 14 flavors are got nine flavors such as Folium Apocyni Veneti, the Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Curcumae, Semen Cassiae, Radix Et Rhizoma Nardostachyos, Herba Menthae and are given as one thinks fit cataclasmly, add 10 times of amounts of water, decoct three times, each 1 hour, filter, collecting decoction is concentrated into relative density and is the clear paste of 1.30 (80 ℃), and is standby.Get Margarita, Cornu Saigae Tataricae, baicalin and be ground into fine powder, with above-mentioned clear paste mixing, granulate, drying with artificial Calculus Bovis, Borneolum Syntheticum porphyrize, with above-mentioned granule mixing, incapsulates, and makes 1000, promptly.
Embodiment 2
[prescription] artificial Calculus Bovis 10g Cornu Saigae Tataricae 5g baicalin 33.3g
Margarita 5g Semen Cassiae 40g Rhizoma Chuanxiong 5g
Borneolum Syntheticum 10g Radix Paeoniae Alba 30g Radix Curcumae 20g
Radix Et Rhizoma Nardostachyos 5g Pulvis Cornus Bubali Concentratus 7.5g Radix Astragali 12.5g
Radix Codonopsis 12.5g Herba Menthae 2.5g
[method for making] above 14 flavors are got nine flavors such as Folium Apocyni Veneti, the Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Curcumae, Semen Cassiae, Radix Et Rhizoma Nardostachyos, Herba Menthae and are given as one thinks fit cataclasmly, add 10 times of amounts of water, decoct three times, each 1 hour, filter, collecting decoction is concentrated into relative density and is the clear paste of 1.30 (80 ℃), and is standby.Get Margarita, Cornu Saigae Tataricae, baicalin and be ground into fine powder, with above-mentioned clear paste mixing, granulate, drying with artificial Calculus Bovis, Borneolum Syntheticum porphyrize, with above-mentioned granule mixing, tabletting, is made 500, promptly.
Embodiment 3:
[prescription] artificial Calculus Bovis 40g Cornu Saigae Tataricae 20g baicalin 133.3g
Margarita 20g Semen Cassiae 160g Rhizoma Chuanxiong 20g
Borneolum Syntheticum 40g Radix Paeoniae Alba 120g Radix Curcumae 80g
Radix Et Rhizoma Nardostachyos 20g Pulvis Cornus Bubali Concentratus 30g Radix Astragali 50g
Radix Codonopsis 50g Herba Menthae 10g
[method for making] above 14 flavors are got nine flavors such as Folium Apocyni Veneti, the Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Curcumae, Semen Cassiae, Radix Et Rhizoma Nardostachyos, Herba Menthae and are given as one thinks fit cataclasmly, add 10 times of amounts of water, decoct three times, each 1 hour, filter, collecting decoction is concentrated into relative density and is the clear paste of 1.30 (80 ℃), and is standby.Get Margarita, Cornu Saigae Tataricae, baicalin and be ground into fine powder, with above-mentioned clear paste mixing, pulverize, with artificial Calculus Bovis, Borneolum Syntheticum porphyrize, with above-mentioned powder mixing, adding soybean oil to total amount is 1200g, and mixing is made 2000 of soft capsules, promptly.
Claims (5)
1, the hypertensive Chinese medicine composition of a kind of treatment is characterized in that this Chinese medicine composition made by following raw material medicaments:
Artificial Calculus Bovis 10-30 weight portion Cornu Saigae Tataricae 5-15 weight portion baicalin 33-100 weight portion
Margarita 5-15 weight portion Semen Cassiae 40-120 weight portion Rhizoma Chuanxiong 5-15 weight portion
Borneolum Syntheticum 10-30 weight portion Radix Paeoniae Alba 30-90 weight portion Radix Curcumae 20-60 weight portion
Radix Et Rhizoma Nardostachyos 5-15 weight portion Pulvis Cornus Bubali Concentratus 7.5-22.5 weight portion Radix Astragali 12.5-37.5 weight portion
Radix Codonopsis 12.5-37.5 weight portion Herba Menthae 2.5-7.5 weight portion.
2, Chinese medicine composition according to claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Artificial Calculus Bovis's 20 weight portion Cornu Saigae Tataricae 10 weight portion baicalins 66.7 weight portions
Margarita 10 weight portion Semen Cassiaes 80 weight portion Rhizoma Chuanxiongs 10 weight portions
The Borneolum Syntheticum 20 weight portion Radix Paeoniae Albas 60 weight portion Radix Curcumaes 40 weight portions
The Radix Et Rhizoma Nardostachyos 10 weight portion Pulvis Cornus Bubali Concentratuss 15 weight portion Radixs Astragali 25 weight portions
Radix Codonopsis 25 weight portion Herba Menthaes 5 weight portions.
3, Chinese medicine composition according to claim 1 and 2 is characterized in that making multiple oral formulations, comprises tablet, capsule, pill etc.
4,, it is characterized in that the preparation method of this Chinese medicine composition is as follows according to the preparation method of the described Chinese medicine composition of claim 3: above 14 flavors, Cornu Saigae Tataricae, Pulvis Cornus Bubali Concentratus, baicalin are ground into impalpable powder, and nine flavors such as the Radix Paeoniae Alba are ground into fine powder; With artificial Calculus Bovis, Borneolum Syntheticum porphyrize and said medicine facing-up, sieve, with the other drug mixing, make required dosage form.
5, be used for the treatment of application in the hypertensive medicine according to claim 1 or 2 described Chinese medicine compositions in preparation.
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| CN2005101059357A CN1943756B (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition used for treatment of hypertension and its preparation method |
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| CN1943756B CN1943756B (en) | 2011-05-04 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456527A (en) * | 2017-08-14 | 2017-12-12 | 裴然 | A kind of effectively Chinese medicine and boiling method for the treatment of hypertension and complication |
| CN110237096A (en) * | 2019-07-13 | 2019-09-17 | 金自荣 | The improvement of the traditional Chinese medicine of the five flavours Dispensing working method such as antelope's horn |
| CN115040620A (en) * | 2022-06-14 | 2022-09-13 | 河北守正医药集团有限公司 | Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof |
| CN115919969A (en) * | 2023-01-10 | 2023-04-07 | 陇西县营养学会 | Astragalus and codonopsis composition for treating hypertension and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362152A (en) * | 2001-01-02 | 2002-08-07 | 杨孟君 | Nano hypertension-treating bezoar medicine and its preparation |
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2005
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456527A (en) * | 2017-08-14 | 2017-12-12 | 裴然 | A kind of effectively Chinese medicine and boiling method for the treatment of hypertension and complication |
| CN110237096A (en) * | 2019-07-13 | 2019-09-17 | 金自荣 | The improvement of the traditional Chinese medicine of the five flavours Dispensing working method such as antelope's horn |
| CN115040620A (en) * | 2022-06-14 | 2022-09-13 | 河北守正医药集团有限公司 | Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof |
| CN115919969A (en) * | 2023-01-10 | 2023-04-07 | 陇西县营养学会 | Astragalus and codonopsis composition for treating hypertension and preparation method thereof |
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| Publication number | Publication date |
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| CN1943756B (en) | 2011-05-04 |
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