CN115040620A - Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof - Google Patents

Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof Download PDF

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CN115040620A
CN115040620A CN202210666236.3A CN202210666236A CN115040620A CN 115040620 A CN115040620 A CN 115040620A CN 202210666236 A CN202210666236 A CN 202210666236A CN 115040620 A CN115040620 A CN 115040620A
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parts
dizziness
blood pressure
horn
reducing
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李宗悟
彭建玉
郭克洪
张丹丹
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Hebei Shouzheng Pharmaceutical Group Co ltd
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Hebei Shouzheng Pharmaceutical Group Co ltd
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Abstract

The invention discloses a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight: 250-350 parts of goat horn, 8-12 parts of pearl, 12-18 parts of buffalo horn concentrated powder, 16-24 parts of calculus bovis factitius, 16-24 parts of borneol, 48-72 parts of white paeony root, 20-30 parts of codonopsis pilosula, 20-30 parts of astragalus, 65-95 parts of cassia seed, 8-12 parts of szechuan lovage rhizome, 55-80 parts of scutellaria baicalensis extract, 8-12 parts of nardostachys root, 4-6 parts of mint and 32-48 parts of curcuma aromatica, grinding the borneol and the pearl for later use, cleaning and sawing off the goat horn, selecting horn tip and horn stake for later use, grinding the other medicinal materials, uniformly mixing the pulverized medicinal materials with the buffalo horn concentrated powder, the goat horn powder and the pearl powder, and granulating. The traditional Chinese medicine composition of the blood pressure reducing and dizziness clearing capsule and the preparation method thereof are pure traditional Chinese medicine preparations, have the effects of clearing away heart-fire, reducing phlegm, calming the liver and soothing the nerves, are suitable for patients with the symptoms of dizziness, headache, insomnia, dysphoria and hypertension caused by hyperactivity of heart-fire and liver-fire and excessive phlegm-heat, and are particularly suitable for middle-aged and old patients.

Description

Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule and a preparation method thereof.
Background
The blood pressure reducing and dizziness clearing capsule is a pure traditional Chinese medicine preparation, has the effects of clearing away the heart-fire, reducing phlegm, calming the liver and soothing the nerves, is suitable for patients with dizziness, headache, insomnia, dysphoria and hypertension caused by hyperactivity of heart-fire and liver-fire and excessive phlegm-heat, receives a better blood pressure reducing effect through years of clinical application, is safe and free of toxic and side effects, is particularly suitable for middle-aged and old patients, and has higher and higher requirements on the manufacturing process of the blood pressure reducing and dizziness clearing capsule with the continuous development of science and technology.
Some blood pressure lowering medicines, especially chemical medicines, can lower blood pressure when lowering blood pressure, but cannot remove clinical symptoms such as dizziness, headache, insomnia, dysphoria and the like, namely, symptoms and root causes are not treated, the clinical symptoms of patients cannot be well improved, certain adverse effects are brought to the using process of people, and therefore, the traditional Chinese medicine composition of the blood pressure lowering and dizziness clearing capsule can lower blood pressure well, can well remove clinical symptoms such as dizziness, headache, insomnia, dysphoria and the like, and can treat both symptoms and root causes.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the traditional Chinese medicine composition of the blood pressure-reducing and dizziness-clearing capsule and the preparation method thereof, the traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, has the effects of clearing away the heart-fire, reducing phlegm, calming the liver and soothing the nerves, is suitable for patients with dizziness, headache, insomnia, dysphoria and hypertension which are caused by hyperactivity of heart-liver fire and excessive phlegm-heat, receives a better blood pressure-reducing effect through years of clinical application, is safe, has no toxic or side effect, is particularly suitable for middle-aged and elderly patients, and can effectively solve the problems in the background art.
(II) technical scheme
In order to achieve the purpose, the invention adopts the technical scheme that: a Chinese medicinal composition in the form of capsule for lowering blood pressure and relieving dizziness comprises cornu Naemorhedi, Margarita, pulvis Cornus Bubali Concentratus, artificial bezoar, Borneolum Syntheticum, radix Paeoniae alba, radix Codonopsis, radix astragali, semen Cassiae, rhizoma Ligustici Chuanxiong, Scutellariae radix extract, rhizoma Nardostachyos, herba Menthae and radix Curcumae, wherein the cornu Naemorhedi is 250-350 parts, the Margarita is 8-12 parts, the pulvis Cornus Bubali Concentratus is 12-18 parts, the artificial bezoar is 16-24 parts, the Borneolum Syntheticum is 16-24 parts, the radix Paeoniae alba is 48-72 parts, the radix Codonopsis is 20-30 parts, the radix astragali is 20-30 parts, the semen Cassiae is 65-95 parts, the rhizoma Ligustici Chuanxiong is 8-12 parts, the Scutellariae radix extract is 55-80 parts, the rhizoma Nardostachyos is 8-12 parts, the radix astragali is 20-30 parts, the semen Cassiae is 65-95 parts, the rhizoma Ligustici Chuanxiong is 8-12 parts, the Scutellariae radix extract is 55-80 parts, the radix Et rhizoma Nardostachyos is 8-12 parts, The share of the mint is 4-6 parts, and the share of the turmeric root-tuber is 32-48 parts.
A preparation method of a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule comprises the following operation steps:
s1: the traditional Chinese medicinal materials required for preparing the antihypertensive and anti-dizziness capsules comprise 250-350 parts of goat horn, 8-12 parts of pearl, 12-18 parts of buffalo horn concentrated powder, 16-24 parts of calculus bovis factitius, 16-24 parts of borneol, 48-72 parts of white paeony root, 20-30 parts of codonopsis pilosula, 20-30 parts of astragalus mongholicus, 65-95 parts of cassia seed, 8-12 parts of ligusticum wallichii, 55-80 parts of scutellaria baicalensis extract, 8-12 parts of nardostachyos root, 4-6 parts of mint and 32-48 parts of radix curcumae;
s2: pulverizing Borneolum into fine powder, and refining Margarita with water or pulverizing into superfine powder;
s3: cleaning goat horn, sawing, selecting tip solid core part, called horn tip, soaking in 75% ethanol or steam sterilizing, and pulverizing into fine powder; weighing the rest part, namely, the horn stump, beating the horn stump into coarse particles or slices, taking 280 parts of the horn stump coarse particles or slices, adding 8-12 times of water, decocting for two times, each time for 2-4 hours, merging decoction, filtering, concentrating the filtrate under reduced pressure (40-90 ℃) to 3.6-4.3L, adding the horn tip fine powder, mixing uniformly, drying at the temperature below 80 ℃, and crushing into fine powder for later use;
s4: pulverizing the rest materials into 80-120 mesh powder, mixing with the above pulvis Cornus Bubali Concentratus, cornu Naemorhedi powder and Margarita powder, granulating, sieving with 25-65 mesh sieve, and drying at below 80 deg.C;
s5: adding above artificial bezoar and Borneolum Syntheticum, mixing, and making into capsule, each capsule 0.35-0.5g, to obtain antihypertensive and anti-dizziness capsule.
As a preferred technical scheme in the present application, the traditional Chinese medicinal materials prepared from the blood pressure lowering and dizziness clearing capsule comprise goat horn, pearl, buffalo horn concentrated powder, artificial bezoar, borneol, white paeony root, codonopsis pilosula, astragalus, cassia seed, ligusticum wallichii, scutellaria baicalensis extract, nardostachys chinensis, mint and radix curcumae.
As a preferable technical scheme, in the step S3, the coarse particles or the flakes of the corner piles are processed in a decoction, filtration, concentration, drying and crushing mode, the decoction time is 2-4 hours each time, the filtrate is reduced to 3.6-4.3L after concentration under reduced pressure (40-90 ℃), and the drying temperature is below 80 ℃.
As a preferred technical scheme of the application, the buffalo horn concentrated powder and the goat horn powder are mixed and prepared in the step S4 by adopting a mixing, granulating, screening and drying mode, wherein the screening is performed by a 25-65 mesh sieve, and the drying temperature is below 80 ℃.
As a preferable technical scheme of the present application, in the step S5, the blood pressure reducing and dizziness relieving capsules are mixed and encapsulated, and the mass of each blood pressure reducing and dizziness relieving capsule is 0.35 to 0.5 g.
As a preferred technical scheme of the present application, the total effective rate of the blood pressure reducing and dizziness clearing capsule for reducing blood pressure is 81.60%, and the significant efficiency is 46.32%, and the total effective rate of the symptom curative effect of the blood pressure reducing and dizziness clearing capsule for reducing blood pressure is 87.12%, and the significant efficiency is 48.78%.
As a preferred technical scheme, the internal medicinal materials of the blood pressure reducing and dizziness relieving capsule are prepared by adopting the modes of crushing, decocting, filtering, concentrating, mixing, drying, granulating, sieving and the like.
(III) advantageous effects
Compared with the prior art, the invention provides a traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and a preparation method thereof, and the traditional Chinese medicine composition has the following beneficial effects: the Chinese medicinal composition of the blood pressure reducing and dizziness clearing capsule and the preparation method thereof are pure Chinese medicinal preparations, have the efficacies of clearing away the heart-fire, reducing phlegm, calming the liver and tranquilizing the mind, are suitable for patients with dizziness, headache, insomnia, dysphoria and hypertension which are caused by hyperactivity of heart-fire and liver-fire and excessive phlegm-heat, have better blood pressure reducing effect through years of clinical application, are safe without toxic and side effects, are particularly suitable for middle-aged and old patients, have scientific and reasonable formula and good effect of strengthening and recovering, are prepared from artificial bezoar for clearing away heat and toxic materials, clearing away the heart-fire and relieving restlessness, eliminating phlegm and arresting convulsion, are cold and salty in goat horn nature, have the functions of clearing away heat and toxic materials, calming the liver and stopping wind, and relieving pain, are monarch drugs, mother of pearl is sweet, salty, cold, subduing yang and tranquillizing, clearing away heat and calming the liver-wind, borneol for clearing away the heart-fire and inducing resuscitation, clear away the stagnant fire, clear away the throat and improve hearing and improve eyesight, clear the upper-heat and clear the blood heat in the evil in the upper part, the traditional Chinese medicine composition has the effects of clearing away fire evil in liver channel, serving as ministerial medicines, assisting with astragalus and codonopsis pilosula for strengthening spleen and replenishing qi, stabilizing liver yang, astringing yin and nourishing blood, activating blood by curcuma aromatica, soothing liver and relieving depression, promoting blood circulation by promoting qi circulation, and regulating qi in blood by promoting qi circulation of ligusticum wallichii; semen Cassiae can clear liver and relieve dizziness, and herba Menthae can soothe liver and relieve depression; the gansong soothes liver and regulates qi, are adjuvant drugs together, the medicines are used together, the effects of clearing heart fire and reducing phlegm, calming liver and soothing nerves are achieved, the product provides a new medicine for patients with dizziness, headache and insomnia, dysphoria, angioneurotic headache, flushed face and red eyes, bitter taste and hypertension, in particular for patients with dizziness, headache and insomnia and dysphoria caused by hyperactivity of heart-liver fire, hyperactivity of liver-yang and phlegm-heat congestion, when western medicines and other medicines have no better treatment effect, the product obtains better treatment effect, is particularly suitable for middle-aged and elderly patients, has better clinical treatment effect on the hypertension with symptoms of dizziness, the total effective rate of the product is 81.60 percent, the significant efficiency is 46.32 percent, the total effective rate of the symptoms is 87.12 percent and the significant efficiency is 48.78 percent through clinical observation, the clinical treatment effect on the hypertension with symptoms and signs of the patients with excessive liver-fire and phlegm-fire congestion type can be obviously improved, and the whole preparation method of the capsule for reducing blood pressure and clearing dizziness is simple in structure, convenient operation, the effect of using is better than traditional mode.
Detailed Description
A Chinese medicinal composition in the form of capsule for lowering blood pressure and relieving dizziness comprises cornu Naemorhedi, Margarita, pulvis Cornus Bubali Concentratus, artificial calculus bovis, Borneolum Syntheticum, radix Paeoniae alba, radix Codonopsis, radix astragali, semen Cassiae, rhizoma Ligustici Chuanxiong, Scutellariae radix extract, rhizoma Nardostachyos, herba Menthae and radix Curcumae, 350 parts of goat horn, 8-12 parts of pearl, 12-18 parts of buffalo horn concentrated powder, 16-24 parts of artificial bezoar, 16-24 parts of borneol, 48-72 parts of white paeony root, 20-30 parts of codonopsis pilosula, 20-30 parts of astragalus root, 65-95 parts of cassia seed, 8-12 parts of szechuan lovage rhizome, 55-80 parts of scutellaria baicalensis extract, 8-12 parts of nardostachyos root, 4-6 parts of mint and 32-48 parts of radix curcumae.
A preparation method of a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule comprises the following operation steps:
s1: the traditional Chinese medicinal materials required for preparing the blood pressure-reducing and dizziness-clearing capsule comprise 350 parts of 250-one goat horn, 8-12 parts of pearl, 12-18 parts of buffalo horn concentrated powder, 16-24 parts of artificial bezoar, 16-24 parts of borneol, 48-72 parts of white paeony root, 20-30 parts of codonopsis pilosula, 20-30 parts of astragalus, 65-95 parts of cassia seed, 8-12 parts of ligusticum wallichii, 55-80 parts of scutellaria baicalensis extract, 8-12 parts of nardostachyos root and rhizome, 4-6 parts of mint and 32-48 parts of radix curcumae;
s2: pulverizing Borneolum into fine powder, and refining Margarita with water or pulverizing into superfine powder;
s3: cleaning goat horn, sawing, selecting tip solid core part, called horn tip, soaking in 75% ethanol or steam sterilizing, and pulverizing into fine powder; weighing the rest part, namely, the horn stump, beating the horn stump into coarse particles or slices, taking 280 parts of the horn stump coarse particles or slices, adding 8-12 times of water, decocting for two times, each time for 2-4 hours, merging decoction, filtering, concentrating the filtrate under reduced pressure (40-90 ℃) to 3.6-4.3L, adding the horn tip fine powder, mixing uniformly, drying at the temperature below 80 ℃, and crushing into fine powder for later use;
s4: pulverizing the rest materials into 80-120 mesh powder, mixing with the above pulvis Cornus Bubali Concentratus, cornu Naemorhedi powder and Margarita powder, granulating, sieving with 25-65 mesh sieve, and drying at below 80 deg.C;
s5: adding above artificial bezoar and Borneolum Syntheticum, mixing, and making into capsule, each capsule 0.35-0.5g, to obtain antihypertensive and anti-dizziness capsule.
Further, the Chinese medicinal materials for preparing the blood pressure lowering and dizziness clearing capsule comprise goat horn, pearl, buffalo horn concentrated powder, artificial bezoar, borneol, white paeony root, codonopsis pilosula, astragalus, cassia seed, szechuan lovage rhizome, baical skullcap root extract, nardostachys root, mint and turmeric root-tuber.
Further, in the step S3, the coarse particles or slices of the corner posts are processed in a decoction, filtration, concentration, drying and crushing mode, the decoction time is 2-4 hours each time, the filtrate is reduced to 3.6-4.3L after concentration under reduced pressure (40-90 ℃), and the drying temperature is below 80 ℃.
Further, in the step S4, the buffalo horn concentrated powder and the goat horn powder are mixed and prepared in a mixing, granulating, screening and drying mode, wherein the screening is performed by a 25-65-mesh sieve, and the drying temperature is below 80 ℃.
Further, in the step S5, the blood pressure reducing and dizziness removing capsules are mixed and encapsulated, and the mass of each blood pressure reducing and dizziness removing capsule is 0.35-0.5 g.
Furthermore, the total effective rate of the blood pressure reducing and dizziness clearing capsules for reducing blood pressure is 81.60 percent, the significant efficiency is 46.32 percent, and the total effective rate of the symptom curative effect of the blood pressure reducing and dizziness clearing capsules for reducing blood pressure is 87.12 percent, and the significant efficiency is 48.78 percent.
Furthermore, the internal medicinal materials of the blood pressure reducing and dizziness clearing capsule are prepared by the modes of crushing, decocting, filtering, concentrating, mixing, drying, granulating, sieving and the like.
Example 1:
a preparation method of a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule comprises the following operation steps:
s1: preparing traditional Chinese medicinal materials required for preparing the antihypertensive and anti-glare capsules, wherein the traditional Chinese medicinal materials comprise 250 parts of goat horn, 8 parts of pearl, 12 parts of buffalo horn concentrated powder, 16 parts of calculus bovis factitius, 16 parts of borneol, 48 parts of white paeony root, 20 parts of radix codonopsitis, 20 parts of astragalus root, 65 parts of cassia seed, 8 parts of ligusticum wallichii, 55 parts of scutellaria root extract, 8 parts of nardostachyos root and rhizome, 4 parts of mint and 32 parts of radix curcumae;
s2: pulverizing Borneolum into fine powder, and refining Margarita with water or pulverizing into superfine powder;
s3: cleaning goat horn, sawing, selecting tip solid core part, called horn tip, soaking in 75% ethanol or steam sterilizing, and pulverizing into fine powder; weighing the rest part, weighing into horn stake, making into coarse granule or making into sheet, taking 240 parts of horn stake coarse granule or sheet, adding 8 times of water, decocting twice for 2 hr each time, mixing decoctions, filtering, concentrating the filtrate under reduced pressure (60 deg.C) to 3.6L, adding above horn tip fine powder, mixing, drying below 80 deg.C, and pulverizing into fine powder;
s4: pulverizing the rest materials into 80 mesh powder, mixing with the above pulvis Cornus Bubali Concentratus, cornu Naemorhedi powder and Margarita powder, granulating, sieving with 25 mesh sieve, and drying at 80 deg.C or below;
s5: adding above artificial bezoar and Borneolum Syntheticum, mixing, and making into capsule, each capsule 0.35-0.5g, to obtain antihypertensive and anti-dizziness capsule.
Example 2:
a preparation method of a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule comprises the following operation steps:
s1: preparing traditional Chinese medicinal materials required for preparing the antihypertensive and anti-glare capsules, wherein the traditional Chinese medicinal materials comprise 300 parts of goat horn, 10 parts of pearl, 14 parts of buffalo horn concentrated powder, 20 parts of artificial bezoar, 20 parts of borneol, 60 parts of white paeony root, 25 parts of radix codonopsitis, 25 parts of astragalus root, 75 parts of cassia seed, 10 parts of ligusticum wallichii, 70 parts of scutellaria baicalensis extract, 10 parts of nardostachyos root and rhizome, 5 parts of mint and 45 parts of radix curcumae;
s2: pulverizing Borneolum into fine powder, and refining Margarita with water or pulverizing into superfine powder;
s3: cleaning goat horn, sawing, selecting tip solid core part, called horn tip, soaking in 75% ethanol or steam sterilizing, and pulverizing into fine powder; weighing the rest part, weighing into horn stake, making into coarse granule or making into sheet, collecting 260 parts of horn stake coarse granule or sheet, decocting with 10 times of water twice (each for 3 hr), mixing decoctions, filtering, concentrating the filtrate under reduced pressure (70 deg.C) to 4L, adding the above horn tip fine powder, mixing, drying at below 80 deg.C, and pulverizing into fine powder;
s4: pulverizing the rest materials into 100 mesh powder, mixing with the above pulvis Cornus Bubali Concentratus, cornu Naemorhedi powder and Margarita powder, granulating, sieving with 45 mesh sieve, and drying at 80 deg.C or below;
s5: adding above artificial bezoar and Borneolum Syntheticum, mixing, and making into capsule, each capsule 0.35-0.5g, to obtain antihypertensive and anti-dizziness capsule.
Example 3:
a preparation method of a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule comprises the following operation steps:
s1: preparing traditional Chinese medicinal materials required for preparing the antihypertensive and anti-glare capsules, wherein the traditional Chinese medicinal materials comprise 350 parts of goat horn, 12 parts of pearl, 18 parts of buffalo horn concentrated powder, 24 parts of artificial bezoar, 24 parts of borneol, 72 parts of white paeony root, 30 parts of radix codonopsitis, 30 parts of astragalus root, 95 parts of cassia seed, 12 parts of szechuan lovage rhizome, 80 parts of scutellaria root extract, 12 parts of nardostachyos root and rhizome, 6 parts of mint and 48 parts of radix curcumae;
s2: pulverizing Borneolum into fine powder, and refining Margarita with water or pulverizing into superfine powder;
s3: cleaning goat horn, sawing, selecting tip solid core part, called horn tip, soaking in 75% ethanol or steam sterilizing, and pulverizing into fine powder; weighing the rest part, weighing into horn stake, pulverizing into coarse granule or making into sheet, collecting 280 parts of horn stake coarse granule or sheet, decocting with 12 times of water for two times (4 hr each time), mixing decoctions, filtering, concentrating the filtrate under reduced pressure (90 deg.C) to 4.3L, adding the above horn tip fine powder, mixing, drying at below 80 deg.C, and pulverizing into fine powder;
s4: pulverizing the rest nine materials into 120 mesh powder, mixing with the above pulvis Cornus Bubali Concentratus, cornu Naemorhedi powder and Margarita powder, granulating, sieving with 65 mesh sieve, and drying at 80 deg.C or below;
s5: adding above artificial bezoar and Borneolum Syntheticum, mixing, and making into capsule, each capsule 0.35-0.5g, to obtain antihypertensive and anti-dizziness capsule.
Through clinical observation, the total effective rate of the blood pressure reducing and dizziness clearing capsule for reducing blood pressure is 81.60 percent, the obvious effective rate is 46.32 percent, and the total effective rate of the blood pressure reducing and dizziness clearing capsule for treating symptoms is 87.12 percent, and the obvious effective rate is 48.78 percent.
It is noted that, herein, relational terms such as first and second (a, b, etc.) and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.

Claims (8)

1. A Chinese medicinal composition of antihypertensive and anti-glare capsules comprises goat horn, pearl, buffalo horn concentrated powder, artificial bezoar, borneol, white paeony root, codonopsis pilosula, astragalus, cassia seed, ligusticum wallichii, scutellaria baicalensis extract, nardostachys chinensis, mint and radix curcumae, and is characterized in that: the traditional Chinese medicine composition comprises, by weight, 250-350 parts of goat horn, 8-12 parts of pearl, 12-18 parts of buffalo horn concentrated powder, 16-24 parts of calculus bovis factitius, 16-24 parts of borneol, 48-72 parts of white paeony root, 20-30 parts of codonopsis pilosula, 20-30 parts of astragalus membranaceus, 65-95 parts of semen cassiae, 8-12 parts of ligusticum wallichii, 55-80 parts of scutellaria baicalensis extract, 8-12 parts of nardostachys chinensis, 4-6 parts of mint and 32-48 parts of radix curcumae.
2. A preparation method of a traditional Chinese medicine composition of a blood pressure-reducing and dizziness-clearing capsule is characterized by comprising the following steps: the method comprises the following operation steps:
s1: the traditional Chinese medicinal materials required for preparing the antihypertensive and anti-dizziness capsules comprise 250-350 parts of goat horn, 8-12 parts of pearl, 12-18 parts of buffalo horn concentrated powder, 16-24 parts of calculus bovis factitius, 16-24 parts of borneol, 48-72 parts of white paeony root, 20-30 parts of codonopsis pilosula, 20-30 parts of astragalus mongholicus, 65-95 parts of cassia seed, 8-12 parts of ligusticum wallichii, 55-80 parts of scutellaria baicalensis extract, 8-12 parts of nardostachyos root, 4-6 parts of mint and 32-48 parts of radix curcumae;
s2: pulverizing Borneolum into fine powder, and refining Margarita with water or pulverizing into superfine powder;
s3: cleaning goat horn, sawing, selecting tip solid core part, called horn tip, soaking in 75% ethanol or steam sterilizing, and pulverizing into fine powder; weighing the rest part, namely, the horn stump, beating the horn stump into coarse particles or slices, taking 280 parts of the horn stump coarse particles or slices, adding 8-12 times of water, decocting for two times, each time for 2-4 hours, merging decoction, filtering, concentrating the filtrate under reduced pressure (40-90 ℃) to 3.6-4.3L, adding the horn tip fine powder, mixing uniformly, drying at the temperature below 80 ℃, and crushing into fine powder for later use;
s4: pulverizing the rest materials into 80-120 mesh powder, mixing with the above pulvis Cornus Bubali Concentratus, cornu Naemorhedi powder and Margarita powder, granulating, sieving with 25-65 mesh sieve, and drying at below 80 deg.C;
s5: adding above artificial bezoar and Borneolum Syntheticum, mixing, and making into capsule, each capsule 0.35-0.5g, to obtain antihypertensive and anti-dizziness capsule.
3. The preparation method of the traditional Chinese medicine composition of the blood pressure-reducing and dizziness-clearing capsule according to claim 2, which is characterized in that: the Chinese medicinal materials for preparing the blood pressure lowering and dizziness clearing capsule comprise cornu Naemorhedi, Margarita, pulvis Cornus Bubali Concentratus, artificial calculus bovis, Borneolum Syntheticum, radix Paeoniae alba, radix Codonopsis, radix astragali, semen Cassiae, rhizoma Ligustici Chuanxiong, Scutellariae radix extract, rhizoma Nardostachyos, herba Menthae and radix Curcumae.
4. The preparation method of the traditional Chinese medicine composition of the blood pressure-reducing and dizziness-clearing capsule according to claim 2, which is characterized in that: in the step S3, the coarse particles or slices of the corner posts are processed in a decoction, filtration, concentration, drying and crushing mode, the decoction time is 2-4 hours each time, the filtrate is reduced to 3.6-4.3L after the reduced pressure concentration (40-90 ℃), and the drying temperature is below 80 ℃.
5. The preparation method of the traditional Chinese medicine composition of the blood pressure-reducing and dizziness-clearing capsule according to claim 2, which is characterized in that: in the step S4, the buffalo horn concentrated powder and the goat horn powder are mixed and prepared in a mixing, granulating, screening and drying mode, wherein the screening is performed by a 25-65-mesh sieve, and the drying temperature is below 80 ℃.
6. The preparation method of the traditional Chinese medicine composition of the blood pressure-reducing and dizziness-clearing capsule according to claim 2, characterized in that: and S5, mixing and encapsulating the blood pressure reducing and dizziness relieving capsules, wherein the mass of each blood pressure reducing and dizziness relieving capsule is 0.35-0.5 g.
7. The preparation method of the traditional Chinese medicine composition of the blood pressure-reducing and dizziness-clearing capsule according to claim 2, which is characterized in that: the total effective rate of the blood pressure reducing and dizziness clearing capsules for reducing blood pressure is 81.60 percent, the significant efficiency is 46.32 percent, and the total effective rate of the symptom curative effect of the blood pressure reducing and dizziness clearing capsules for reducing blood pressure is 87.12 percent, and the significant efficiency is 48.78 percent.
8. The preparation method of the traditional Chinese medicine composition of the blood pressure-reducing and dizziness-clearing capsule according to claim 2, which is characterized in that: the internal medicinal materials of the blood pressure reducing and dizziness clearing capsule are prepared by the modes of crushing, decocting, filtering, concentrating, mixing, drying, granulating, sieving and the like.
CN202210666236.3A 2022-06-14 2022-06-14 Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof Pending CN115040620A (en)

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