CN1157157A - Traditional Chinese medicine composition for curing rheumatism and its preparation method - Google Patents
Traditional Chinese medicine composition for curing rheumatism and its preparation method Download PDFInfo
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- CN1157157A CN1157157A CN 96114168 CN96114168A CN1157157A CN 1157157 A CN1157157 A CN 1157157A CN 96114168 CN96114168 CN 96114168 CN 96114168 A CN96114168 A CN 96114168A CN 1157157 A CN1157157 A CN 1157157A
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- fructus chaenomelis
- monema flavescens
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Abstract
The present invention relates to a Chinese medicine composition for curing rheumatism. Said Chinese medicine composition is made up by using chaenomeles fruit and Queweng (a traditional Chinese medicinal material) as main active components, and adding Chinese angelica root, ligusticum root and licorice, and can be used for curing rheumatic disease, rheumatoid disease, muscular atrophy and myasthenia, etc., and its cure rate is 76.38%. Said invented Chinese medicine has no side effect. Besides, said invention also provides the preparation process of said Chinese medicine composition.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of rheumatism and claim numbness flaccidity health again, specifically, is a kind of Chinese medicine composition for the treatment of rheumatisms such as rheumatism, rheumatoid, hyperosteogeny, amyotrophy, myasthenia.The invention still further relates to the preparation method of said composition.
Rheumatism is a class common clinical and a frequently-occurring disease, and it generally comprises diseases such as rheumatism, rheumatoid, hyperosteogeny, amyotrophy, is the pertinacious disease that very is difficult to cure, and should the disease disability rate very high.At present, using many medicines to treat this disease clinically, comprising Western medicine such as aspirin, ibuprofen, chlofenamic acid, levamisole and glucocorticoid medicine etc.; Chinese medicine comprises Radix Tripterygii Wilfordii, Kunming Caulis et folium euphorbiae milii etc.Although these medicines can play certain therapeutical effect,, final cure rate is lower, most in addition side effect that all exist the stimulating gastrointestinal road.Therefore, need a kind of existing high curative effect rheumatism medicine of non-stimulated gastrointestinal side effect again.
The present invention just provides a kind of like this Chinese medicine composition, and it has higher therapeutic efficiency and without any side effects to gastrointestinal tract to rheumatism.
The present invention also provides the preparation method of this Chinese medicine composition simultaneously.
It is raw material that Chinese medicine composition of the present invention has been selected Fructus Chaenomelis and Monema flavescens Walker for use, wherein Monema flavescens Walker has another name called poplar favus, day slurry, worm cocoon for slimacodiidae insecticide cnidocampa flavescens walker Monem flavescens Walker., the preferred sophisticated Monema flavescens Walker that 7-9 month is about to spin, past attempts record Monema flavescens Walker can be treated diseases such as infantile convulsion, infantum tetanus, can treat rheumatism but never put down in writing; Fructus Chaenomelis has another name called iron pin pear, is the fruit of rosaceous plant chaenomeles lagenaria Chaenomeles lagenaria (Loisel.) Koidz..
Compositions of the present invention is to make with the raw material of following consumption: Fructus Chaenomelis 35-45 weight portion and Monema flavescens Walker 35-45 weight portion.The raw material that in the raw material of compositions of the present invention, also can add in addition, following consumption: Radix Angelicae Sinensis 7-9 weight portion, Rhizoma Chuanxiong 5-7 weight portion and Radix Glycyrrhizae 5-7 weight portion.The composition effect that Fructus Chaenomelis, Monema flavescens Walker and Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae combination are made is better.
Compositions of the present invention can adopt a kind of like this method to make, that is, the Fructus Chaenomelis pulverize separately of 35-45 weight portion, cross 120 mesh sieves and make papaya powder; The Monema flavescens Walker of 35-45 weight portion is put on the iron pan bake and parch to burnt, pulverized 120 mesh sieves and make the Monema flavescens Walker powder; Papaya powder and Monema flavescens Walker powder mix homogeneously; Or the Radix Glycyrrhizae of the Fructus Chaenomelis of 35-45 weight portion, 7-9 weight portion Radix Angelicae Sinensis, 5-7 weight portion Rhizoma Chuanxiong and 5-7 weight portion, drying and crushing is crossed 120 mesh sieves and is made powder respectively; The Monema flavescens Walker of 35-45 weight portion is put on the iron pan bake and parch to burnt, pulverized 120 mesh sieves and make the Monema flavescens Walker powder; The powder of above-mentioned gained and Monema flavescens Walker powder mix homogeneously.
Compositions of the present invention can also adopt another method to make, and, prepares the water of Fructus Chaenomelis or the water or the ethanol extract of ethanol extract and Monema flavescens Walker respectively, then with its mixing that is.Wherein said Fructus Chaenomelis water extract is to make with conventional decocting method, the preferred decoction three times, three times decocting time was respectively 2.5 hours, 2 hours and 1.5 hours, the water consumption that decocts for three times is respectively 6 times, 3 times and 3 times of medical material weight, merge three times decoction liquor, 1/3 of simmer down to original volume is the Fructus Chaenomelis water extract.The ethanol extract of Fructus Chaenomelis is to make with conventional percolation or reflux extraction, and extracting solvent is the ethanol of 50-95%, preferably uses 95% ethanol.When adopting percolation, the consumption of solvent is 4-8 a times of medical material powder, and the time of immersion is 1-2 day.When adopting reflux extraction, the consumption of solvent is 3-4 a times of medical material powder, and the temperature of reflux, extract, is 60-70 ℃, and extraction time was generally 6-8 hour.The water extract of described Monema flavescens Walker is to adopt the preparation of Steam by water bath cooking method, earlier Monema flavescens Walker is put in the iron pan bake and parch to burnt, pulverize 120 mesh sieves and made medicated powder, 6 times the water that in making medicated powder, adds medical material weight, be placed on inherent 70-90 ℃ of water proof steaming and decocting to the worm powder in the container of container and all precipitate, have bubble to overflow filter and remove residue in the medicinal liquid, medicinal liquid is put into the household freezer dissolution precipitation to transparent, concentrate promptly.The ethanol extract of Monema flavescens Walker is to adopt room temperature extraction or reflux extraction preparation, and extracting solvent is 50-95% ethanol, preferably uses 70% ethanol, and extraction time is 3-6 days; The temperature of reflux, extract, is 60-70 ℃, and extraction time is 6-8 hour.Perhaps prepare the water of Fructus Chaenomelis, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Radix Glycyrrhizae or the water or the ethanol extract of ethanol extract and Monema flavescens Walker, then with its mixing.Wherein all the preparation method with the water of above-mentioned Fructus Chaenomelis or alcohol extract is identical except that raw material is different in the preparation of water of Fructus Chaenomelis, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Radix Glycyrrhizae or ethanol extract.The water of Monema flavescens Walker or ethanol extract are as above prepared.
Compositions of the present invention can be made into various pharmaceutical dosage forms such as capsule, injection, medicated wine, tablet, pill, powder, electuary, oral liquid etc.Compositions of the present invention also can comprise Icing Sugar and the dextrin etc. of the excipient use of every kind of dosage form of preparation when preparing electuary when making various dosage form.
Compositions of the present invention is according to theory of Chinese medical science, makes through clinical research for many years, has dispelling wind and removing obstruction in the collateral, warming the meridian removing dampness, analgesia cold relieving, movable blood soft hard, activation muscle, increases muscular strength, improves effects such as immunity, facilitating digestion system and nervous function; And compared with prior art has the not effect in stimulating gastrointestinal road and facilitating digestion and sleep; Can treat diseases such as rheumatism, rheumatoid, amyotrophy, myasthenia, hyperosteogeny, instant effect, good effect, the cure rate height, through 5000 routine clinical observations, total effective rate is 98.72%, total cure rate is 76.38%.
Embodiment 1: the preparation of capsule I
Fructus Chaenomelis 40 grams are pulverized, crossed 120 mesh sieves and make papaya powder; Monema flavescens Walker 40 gram is put on the iron pan bake and parch to be pulverized 120 mesh sieves and made the Monema flavescens Walker powder to burnt; Papaya powder and Monema flavescens Walker powder mix homogeneously, high-temperature sterilization incapsulates.Embodiment 2: the preparation of capsule II
With Fructus Chaenomelis 400 gram, Radix Angelicae Sinensis 80 grams, Rhizoma Chuanxiong 60 grams and Radix Glycyrrhizae 60 gram pulverize separately, cross 120 mesh sieves and mixed medicated powder; Monema flavescens Walker 400 gram is put on the iron pan bake and parch to be pulverized 120 mesh sieves and made the Monema flavescens Walker powder to burnt; Above-mentioned medicated powder that makes and Monema flavescens Walker powder mix homogeneously, high-temperature sterilization incapsulates.Embodiment 3: the preparation of injection
Get Fructus Chaenomelis 1000 grams, add 6000 milliliters in water for the first time, decocted 2.5 hours; For the second time add 3000 milliliters in water, decocted 2 hours, add 3000 milliliters in water for the third time, decocted 1.5 hours, filter the back and merge three decoction liquor, be evaporated to 4000 milliliters and make the Fructus Chaenomelis water extract.The sophisticated Monema flavescens Walker that 7-9 month is about to spin is put on the iron pan bake and parch to burnt, pulverized 120 mesh sieves, take by weighing 1000 gram Monema flavescens Walker powder and add 6000 milliliters in water, being placed on inherent 80 ℃ of water proof steaming and decocting to the worm powder in the container of container all precipitates, there is bubble to overflow in the medicinal liquid, filter and remove residue, it is heavy clear to transparent that medicinal liquid is put into household freezer dissolving, is concentrated into 4000 milliliters and promptly gets the Monema flavescens Walker water extract.Fructus Chaenomelis water extract and Monema flavescens Walker water extract mix homogeneously, add 5 times 95% ethanol, stir evenly, cold preservation was placed precipitation 24 hours, filter 23, after the concentrating under reduced pressure filtrate, 4000 milliliters of adding distil waters, with 6N hydrochloric acid adjust pH is about 2.0, cold preservation was placed precipitation 24 hours, filtered, and the sodium hydroxide solution with 20% transfers to neutrality, concentrating under reduced pressure becomes the thick paste shape, add 8-10 and doubly measure 95% ethanol, stir evenly, cold preservation was placed precipitation 24 hours, filter, decompression filtrate recycling ethanol adds 4000 milliliters of injection waters, is 7.0-7.5 with 8% sodium hydroxide solution adjust pH, add 50 gram tween 80 and 80 milliliters of benzyl alcohol, add injection water to 8000 milliliter, add active carbon, consider through No. 4 sintered filter funnels are smart, embedding, with flowing steam 100 ℃ of sterilizations 45 minutes promptly.Embodiment 4: the preparation of electuary
Fructus Chaenomelis 1000 gram, Radix Angelicae Sinensis 200 grams, rhizome of chuanxiong 150 grams and Radix Glycyrrhizae 150 grams clean respectively dry by the fire in and mix, 70% the ethanol that adds 4 times of amounts was 70 ℃ of reflux, extract, 7 hours, filter, the ethanol in the reclaim under reduced pressure filtrate makes the thick extractum extract that proportion is 1.30-1.35; The sophisticated Monema flavescens Walker that 7-9 month is about to spin is put on the iron pan bake and parch to burnt, pulverized 120 mesh sieves, take by weighing 1000 gram Monema flavescens Walker powder and add 70% alcohol at normal temperature and extracted 4 days, filter, decompression recycling ethanol obtains the thick extractum Monema flavescens Walker extract that proportion is 1.30-1.35; Two kinds of extract uniform mixing above-mentioned gained connect cream: Icing Sugar: dextrin=add Icing Sugar and dextrin at 1: 3: 1, make electuary.
Claims (6)
1. a pharmaceutical composition for the treatment of rheumatism is characterized in that it is to make with the raw material of following consumption: Fructus Chaenomelis 35-45 weight portion and Monema flavescens Walker 35-45 weight portion.
2. a pharmaceutical composition for the treatment of rheumatism is characterized in that it is to make with the raw material of following consumption: Fructus Chaenomelis 35-45 weight portion, Monema flavescens Walker 35-45 weight portion, Radix Angelicae Sinensis 7-9 weight portion, Rhizoma Chuanxiong 5-7 weight portion and Radix Glycyrrhizae 5-7 weight portion.
3. a method for preparing treatment rheumatism pharmaceutical composition is characterized in that: the Fructus Chaenomelis of 35-45 weight portion is pulverized, cross 120 mesh sieves and make papaya powder; The Monema flavescens Walker of 35-45 weight portion is put on the iron pan bake and parch to burnt, pulverized 120 mesh sieves and make the Monema flavescens Walker powder; Papaya powder and Monema flavescens Walker powder mix homogeneously.
4. one kind prepares the method for the treatment of the rheumatism pharmaceutical composition, it is characterized in that: the Radix Glycyrrhizae of the Fructus Chaenomelis of 35-45 weight portion, 7-9 weight portion Radix Angelicae Sinensis, 5-7 weight portion Rhizoma Chuanxiong and 5-7 weight portion is distinguished drying and crushing, and mistake 120 mesh sieves make powder and mixing makes medicated powder; The Monema flavescens Walker of 35-45 weight portion is put on the iron pan bake and parch to burnt, pulverized 120 mesh sieves and make the Monema flavescens Walker powder; Above-mentioned medicated powder that makes and Monema flavescens Walker powder mix homogeneously.
5. a method for preparing treatment rheumatism pharmaceutical composition is characterized in that: prepare the water of Fructus Chaenomelis or the water or the ethanol extract of ethanol extract and Monema flavescens Walker respectively, then with its mixing; Wherein said Fructus Chaenomelis water extract is that the Fructus Chaenomelis of 35-45 weight portion is decocted three times, three times decocting time was respectively 2.5 hours, 2 hours and 1.5 hours, the water consumption that decocts for three times is respectively 6 times, 3 times and 3 times of medical material weight, merge three times decoction liquor, 1/3 of simmer down to original volume promptly obtains the Fructus Chaenomelis water extract; Described Fructus Chaenomelis ethanol extract makes with percolation or reflux extraction, and extracting solvent is the ethanol of 50-95%, and when adopting percolation, the consumption of solvent is 4-8 a times of medical material powder, and the time of immersion is 1-2 day; When adopting reflux extraction, the consumption of solvent is 3-4 a times of medical material, and the temperature of reflux, extract, is 60-70 ℃, and extraction time was generally 6-8 hour; Described Monema flavescens Walker water extract is to adopt the preparation of Steam by water bath cooking method, earlier the Monema flavescens Walker of 35-45 weight portion is put in the iron pan bake and parch to burnt, pulverize 120 mesh sieves and made medicated powder, 6 times the water that in making medicated powder, adds medicated powder weight, be placed on inherent 70-90 ℃ of water proof steaming and decocting to the worm powder in the container of container and all precipitate, have bubble to overflow filter and remove residue in the medicinal liquid, medicinal liquid is put into the household freezer dissolution precipitation to transparent, concentrate promptly; Described Monema flavescens Walker ethanol extract is to adopt room temperature extraction or reflux extraction preparation, and extracting solvent is 50-95% ethanol, preferably uses 70% ethanol; Extraction time is 3-6 days; The temperature of reflux, extract, is 60-70 ℃, and extraction time is 6-8 hour.
6. according to the method for claim 5, it is characterized in that: the Radix Angelicae Sinensis, the Rhizoma Chuanxiong of 5-7 weight portion and the Radix Glycyrrhizae of 5-7 weight portion that in water for preparing Fructus Chaenomelis or ethanol extract step, add the 7-9 weight portion, make water or the ethanol extract of Fructus Chaenomelis, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Radix Glycyrrhizae with the Fructus Chaenomelis of 35-45 weight portion, then it is mixed with the water or the ethanol extract of Monema flavescens Walker.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96114168 CN1157157A (en) | 1996-12-30 | 1996-12-30 | Traditional Chinese medicine composition for curing rheumatism and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96114168 CN1157157A (en) | 1996-12-30 | 1996-12-30 | Traditional Chinese medicine composition for curing rheumatism and its preparation method |
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| CN1157157A true CN1157157A (en) | 1997-08-20 |
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| CN 96114168 Pending CN1157157A (en) | 1996-12-30 | 1996-12-30 | Traditional Chinese medicine composition for curing rheumatism and its preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381129C (en) * | 2006-03-28 | 2008-04-16 | 康成礼 | Antitumor animal medicine and its preparing method |
| CN102406702A (en) * | 2011-11-30 | 2012-04-11 | 宋爱民 | Traditional Chinese medicine preparation for treating arthroncus of knee |
| CN103536857A (en) * | 2013-11-01 | 2014-01-29 | 车莉 | Traditional Chinese medicine for treating flaccid paralysis |
| CN112535718A (en) * | 2020-12-28 | 2021-03-23 | 中国人民解放军总医院第七医学中心 | Traditional Chinese medicine formula for treating muscle reduction atrophy caused by psychosomatic stress |
-
1996
- 1996-12-30 CN CN 96114168 patent/CN1157157A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381129C (en) * | 2006-03-28 | 2008-04-16 | 康成礼 | Antitumor animal medicine and its preparing method |
| CN102406702A (en) * | 2011-11-30 | 2012-04-11 | 宋爱民 | Traditional Chinese medicine preparation for treating arthroncus of knee |
| CN103536857A (en) * | 2013-11-01 | 2014-01-29 | 车莉 | Traditional Chinese medicine for treating flaccid paralysis |
| CN103536857B (en) * | 2013-11-01 | 2015-02-11 | 车莉 | Traditional Chinese medicine for treating flaccid paralysis |
| CN112535718A (en) * | 2020-12-28 | 2021-03-23 | 中国人民解放军总医院第七医学中心 | Traditional Chinese medicine formula for treating muscle reduction atrophy caused by psychosomatic stress |
| CN112535718B (en) * | 2020-12-28 | 2022-03-08 | 中国人民解放军总医院第七医学中心 | Traditional Chinese medicine composition for treating muscle reduction atrophy caused by psychosomatic stress |
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