CN104645015A - Traditional Chinese medicine compound preparation for treating vascular dementia and preparation method of traditional Chinese medicine compound preparation - Google Patents
Traditional Chinese medicine compound preparation for treating vascular dementia and preparation method of traditional Chinese medicine compound preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine compound preparation for treating vascular dementia. The traditional Chinese medicine compound preparation is prepared from the following raw materials in parts by weight: 5-10 parts of platycodon grandiflorum, 5-10 parts of apricot kernels, 10-15 parts of ginseng, 10-15 parts of radix ophiopogonis, 10-15 parts of astragalus membranaceus, 10-15 parts of pseudo-ginseng, 10-15 parts of perillaseed, 10-15 parts of acorus tatarinowii and 3-6 parts of wine-treated rhubarb. A preparation method of the traditional Chinese medicine compound preparation comprises the following steps: carrying out reflux extraction on ginseng with ethanol, and filtering to obtain a ginseng residue and a ginseng extract liquid; concentrating the ginseng extract liquid into a thick ginseng extract; mixing and decocting eight medicine such as the ginseng residue and platycodon grandiflorum, concentrating a decoction into a dry extract; mixing the dry extract with wine-treated rhubarb powder, crushing, adding to the thick ginseng extract, and stirring evenly to prepare a mixed ointment; and extruding, pelletizing, drying, granulating, screening and sub-packing to obtain the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation has a relatively good treatment effect on vascular dementia, and is capable of preventing death of damaged nerve cells, improving the pathological state of the nerve cells, and promoting regeneration of damaged nerve cells.
Description
Technical field
The present invention relates to a kind of take Chinese crude drug as the medicine of raw material, specifically a kind of compound Chinese medicinal preparation for the treatment of vascular dementia.
Background technology
Modern medicine is thought, vascular dementia (vascular dementia, VD) be because various cerebrovascular disease (as cerebral hemorrhage, cerebral infarction etc.) finally causes the damage of cerebral tissue, thus produce the clinical syndrome being main manifestations with intelligence damage and cognitive dysfunction, its main clinical manifestation is the obstacle of study, memory, cognitive function, wherein again based on learning and memory impairment.The generation of vascular dementia and the necrosis and apoptosis of brain nervous cell closely related.And this compound Chinese medicinal preparation is to promoting the survival of neurocyte, growth promoter, differentiation; delay neurocyte natural death; participate in the aspects such as cerebral ischemia protection mechanism and have obvious effect, and have prevent damaged nerve cell after dead, improve neurocyte pathological state, promote the biological effect such as damaged nervous cell regenerating and differentiation.Along with the reinforcement of the health care consciousness of people, the compound Chinese medicinal preparation for its characteristics of incidence is arisen at the historic moment, and it is natural with it, safely, the advantage such as to have no side effect receives the concern of people day by day.Therefore, exploitation has the compound Chinese medicinal preparation of the treatment of vascular dementia of tcm characteristic, not only can make up the deficiency on Modern medical therapy, plays the advantage of Chinese medicine, and suitable population is wide, the market demand large, have wide market prospect.
Summary of the invention
Object of the present invention be just to provide a kind of can prevent damaged nerve cell after dead, the compound Chinese medicinal preparation improving neurocyte pathological state, promote the treatment vascular dementia of damaged nervous cell regenerating.This compound Chinese medicinal preparation, on the basis that the dialectical and microcosmic differential diagnosis of diseases of inventor's macroscopic view combines, Scientific application Chinese medicine dialectical treatmert, there is insufficiency of lung-QI and turbid poison in development and evolution process for vascular dementia further and pent up the pathomechanism of intestinal, adopt lung benefiting lung qi dispersing the turbid descending method, treatment vascular dementia, to promote that neurocyte recovers, improves dementia symptom.
To achieve these goals, present invention employs following technical scheme:
Treat a compound Chinese medicinal preparation for vascular dementia, be made up of the raw material of following weight portion: Radix Platycodonis 5 ~ 10 parts, 5 ~ 10 parts, Semen Armeniacae Amarum, Radix Ginseng 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, 10 ~ 15 parts, Radix Notoginseng, Fructus Perillae 10 ~ 15 parts, Rhizoma Acori Graminei 10 ~ 15 parts and Radix et Rhizoma Rhei (stir-fried with wine) 3 ~ 6 parts.
Treat a preparation method for the compound Chinese medicinal preparation of vascular dementia, comprise the steps:
1) get Radix Ginseng, be the alcohol reflux 2 ~ 3 times of 80 ~ 90% by volumetric concentration, then isolated by filtration, obtains ginseng residue and Radix Ginseng extractive solution;
2) Radix Ginseng extractive solution is condensed into the thick extractum of Radix Ginseng;
3) by ginseng residue and Radix Platycodonis, Semen Armeniacae Amarum, Radix Ophiopogonis, the Radix Astragali, Radix Notoginseng, Fructus Perillae and Rhizoma Acori Graminei altogether 8 taste medicines mix after together with decoct 2 ~ 3 times, filter and remove residue, merge each fried liquid, be then condensed into dry extract;
4) by dry extract and Radix et Rhizoma Rhei (stir-fried with wine) fine powder Homogeneous phase mixing, pulverize, then add the thick extractum of Radix Ginseng, stir, obtain mixing ointment;
5) ointment extruding will be mixed granulate, and be dried to water content and be no more than 6.0%, granulate, sieve, after subpackage and get final product.
Step 1) described first time reflux, extract, time be 2 ~ 3 hours, second time or third time reflux, extract, time be 1 ~ 1.5 hour.
Step 2) relative density of the thick extractum of described Radix Ginseng at 55 ~ 60 DEG C of temperature be 1.40 ~ 1.44.
Step 3) in, when first time decocts, add the water of 8 taste medicine gross weight 7 ~ 8 times, boil 2 ~ 3 hours; Second time or third time be when decocting, and adds the water boil 1 ~ 1.5 hour of 8 taste medicine gross weight 5 ~ 6 times.
Step 3) relative density of described dry extract at 55 ~ 60 DEG C of temperature be 1.35 ~ 1.39.
Step 4) particle diameter of described Radix et Rhizoma Rhei (stir-fried with wine) fine powder is 0.1 ~ 0.3cm.
Step 5) described in sieve into cross 10 ~ 15 mesh sieves.
Attribute and effect of formula Raw of the present invention are as follows:
1, Radix Platycodonis (RADIX PLATYCODONIS): be the dry root of campanulaceae perennial herb Radix Platycodonis Platycodongrandiflorum (Jacq.) A.DC..Bitter in the mouth, pungent, property is put down.Return lung meridian.Primary efficacy for opening lung qi dispersing gas, evacuation of pus of eliminating the phlegm, sore-throat relieving.Its main chemical compositions is platycodin, has stronger phlegm-dispelling functions, also has spasmolytic, analgesia, blood sugar lowering, blood fat reducing, antiinflammatory, enhancing immunity, haemolysis.Be usually used in the disease of pulmonary system such as cough, expectoration, pharyngalgia.Theoretical according to Chinese prescription, this medicine can carry all medicines and be up to mountain peak and push up gods in prescription, and merit reaches disease institute, and the stagnant and the turbid descending relieving constipation of the heap soil or fertilizer over and around the roots of being apt to open lung qi dispersing gas.
2, Semen Armeniacae Amarum (SEMEN ARMENIACAE AMARUM): be the dry mature seed of Rosaceae deciduous tree Fructus Pruni Prunus armeniaca L..Bitter in the mouth, slightly warm in nature.Return lung, large intestine channel.Primary efficacy is relieving cough and asthma, loosening bowel to relieve constipation.This product main chemical compositions is amygdaloside (3%) and fatty oil (50%), still containing volatile ingredient, protein and multiple free amino acid.Amygdaloside has antitussive and antiasthmatic, strengthens immunization, the fatty oil be full of and have lubricity defecating feces excretion.Be usually used in cough with asthma disease and dryness of the intestine constipation.
3, Radix Ginseng (RADX GINSENG): be the dry root of Araliaceae perennial herb Radix Ginseng Panax ginseng C.A.Mey.Sweet in the mouth, micro-hardship, slightly warm in nature.GUIXIN, lung, spleen channel.Primary efficacy is strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves.Principle active component is ginsenoside and polysaccharide.Its pharmacological action is extensive: Radix Ginseng can regulate central nervous system stimulant and process of inhibition mutually to balance, and to the acquisition remembered, consolidation and reproduction, has facilitation in various degree.Ginsenoside has stimulation to Pituitary Adrenalcortical system; physical stress state can be improved; and have the sudden change of anti-tissue ischemia, anoxia, shock, antioxidation, anti-cell, apoptosis, necrosis; two-ways regulation blood pressure, blood glucose; anticoagulant, blood fat reducing, atherosclerosis; protection and stimulation bone marrow hematogenesis, all multiactions such as life-saving.For emergency treatment of collapse holds up good dose of danger, treat asthenia internal injury first key medicine.
4, Radix Ophiopogonis (RADX OPHIOPOGONIS): be the dried root of Liliaceae perennial herb Ophiopogonjaponicus Radix Ophiopogonis (Thunb.) Ker-Gawl..Sweet in the mouth, micro-hardship, cold nature.GUIXIN, lung, stomach warp.Primary efficacy is nourishing YIN and moistening the lung, reinforcing stomach reg fluid, and clear away heart-fire relieving restlessness.This product mainly contains multiple steroidal saponin, as Ophiopogonin A, B, C, D, and sitosterol, stigmasterol, flavone, several amino acids, saccharide, vitamin A, copper, zinc, ferrum, potassium etc.Its water decoction has very strong antioxidation; body's hypoxia tolerance can be improved; can oxygen-derived free radicals effectively in purged body; this antioxidation effectively can stop degeneration, the aging of cell; and have obvious protective effect to heart and brain tissues ischemia, improve blood circulation, reduce cholesterol; these effects greatly reduce the sickness rate of cardiovascular and cerebrovascular disease, also can improve the symptom of cardiovascular and cerebrovascular disease.
5, the Radix Astragali (RADX ASTRAGALI): be the dry root of pulse family perennial herb Radix Astagali Astragalusmembranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao.Sweet in the mouth, slightly warm in nature.Return spleen, lung meridian.Primary efficacy is tonifying Qi and lifting yang, and benefit defends consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting.Be usually used in the cerebrovas-cularaccidents such as the numb limbs and tense tendons of blood stagnancy due to deficiency of QI, hemiplegia or arthralgia pain.This product is mainly containing saponin, flavone, astragalus polysaccharides, its decoct can promote DNA, RNA and protein synthesis, improve the content of cAMP, cGMP in blood plasma and tissue, strengthen immunologic function, also protect the liver, improve renal function, improve hemorheological property, promote the multiple effects such as hemopoietic function, defying age, anti-stress, antiinflammatory, blood vessel dilating, blood pressure lowering, heart tonifying, raising body's hypoxia tolerance.
6, Radix Notoginseng (RADX NOTOGINSENG): be the dry root of Araliaceae perennial herb Radix Notoginseng Panaxnotoginseng (Burk.) F.H.Chen.Sweet in the mouth, micro-hardship, warm in nature.Return liver, stomach warp.Function removing stasis to stop bleeding, subduing swelling and relieving pain, having hemostasis not stay the stasis of blood, blood stasis dispelling not to hinder feature just, is really blood disorder good medicine, traumatology key medicine.Modern times are widely used in angina pectoris, apoplexy sequela etc., all have satisfactory effect.This product mainly containing tetracyclic triterpene saponin active component, has significant hemostasis, can shorten clotting time; There is anticoagulation again, promote fibrinolytic, whole blood viscosity is declined; Can also expansion of cerebral vascular, increase cerebrovascular flow, regulate carbohydrate metabolism, anti-ageingly to wait for a long time.
7, Fructus Perillae (FRUCTUS PERILLAE): be the dry mature fruit of Labiatae annual herb Folium Perillae Perilla frutescens (L.) Britt..Acrid in the mouth, warm in nature.Return lung, large intestine channel.Primary efficacy is lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, loosening bowel to relieve constipation.Main component is linoleic acid, linolenic acid, fatty wet goods, is longer than to fall lung qi and conduct to help large intestine, for controlling the non-defective unit of dryness of the intestine constipation.
8, Rhizoma Acori Graminei (RHIZOMA ACORI TATARINOWII): be the dry rhizome of Araeceae perennial herb Rhizoma Acori Graminei Acorustatarinowii Schott.Acrid in the mouth, hardship, slightly warm in nature.This product pungent drugs can disperse and bitter drugs can purge temperature is led to, and fragrance is walked to alter, GUIXIN, stomach warp.The happy key of function, damp eliminating are turbid, refreshment will, appetizing of being amusing again, and kind phlegm-damp of controlling hoodwinks the unconsciousness and delirium of key clearly, dizzy drowsiness, forgetful tinnitus etc.Main chemical compositions is asaricin, sekishone etc., and this product decoct has central calmness, anticonvulsant action; And can facilitating digestion.Water extract-alcohol precipitation liquid has the effect of enhancing learning and memory.
9, Radix et Rhizoma Rhei (stir-fried with wine) (RADIX ET RHIZOMA RHEI): be the dry rhizome of Polygonaceae perennial herb sorrel Rheum palmatumL..This product bitter in the mouth, cold in nature, sedimentation.Return spleen, stomach, large intestine, liver, heart channel.Radix et Rhizoma Rhei (stir-fried with wine) is mixed thoroughly through spraying with yellow wine by rhubarb tablets, puts in pot and slightly fries, and takes out and dries and obtain.Function heat and toxic materials clearing away, clearing away heat-fire, hemostasis, removing toxic substances, blood circulation promoting and blood stasis dispelling.Main containing anthraquinone derivatives, main component is physcione-8-glucoside, tannin, organic acid etc.Its pharmacological action has promotion enterokinesia, promotes defecation, and energy antiinflammatory infection, antithrombus formation, function of gallbladder promoting protects the liver, blood pressure lowering, hemostasis, reduces cholesterol etc.
Compared with prior art, the advantage that the present invention possesses is:
Adopt comparatively common Chinese medicinal herbs as raw material, by Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and herbal pharmacology formulated.Its preparation technology is simple, low production cost, this product has the effects such as QI invigorating Fructus Alpiniae Oxyphyllae, waking up the patient from unconsciousness by dissipating phlegm, purging FU-organs removing blood stasis, good therapeutical effect is had to symptoms such as the hypophrenias caused after cerebrovas-cularaccident, dead after preventing damaged nerve cell, improve neurocyte pathological state, promote damaged nervous cell regenerating, thus alleviate clinical symptoms.Said preparation can anticoagulant and inflammatory cell infiltration, and antioxidant radical damages, and improves brain microcirculation, alleviates cerebral edema, alleviates clinical symptoms, reaches the protection to ischemic neurological cell and short regeneration.Primary efficacy: tonification vigour, Fructus Alpiniae Oxyphyllae refreshment, blood circulation promoting and blood stasis dispelling, the turbid descending relieving constipation.Main disease to be treated: the intelligence damage caused because of various cerebrovas-cularaccident and cognitive dysfunction, as vascular dementia etc.
Detailed description of the invention
Below by embodiment, technical scheme of the present invention is further elaborated.
Embodiment 1
Treat a compound Chinese medicinal preparation for vascular dementia, be made up of the raw material of following weight portion: Radix Platycodonis 5 parts, 5 parts, Semen Armeniacae Amarum, Radix Ginseng 10 parts, Radix Ophiopogonis 10 parts, the Radix Astragali 10 parts, 10 parts, Radix Notoginseng, Fructus Perillae 10 parts, Rhizoma Acori Graminei 10 parts and Radix et Rhizoma Rhei (stir-fried with wine) 3 parts.
The preparation method of the compound Chinese medicinal preparation of the treatment vascular dementia described in the present embodiment, comprises the steps:
1) get Radix Ginseng, be the alcohol reflux 2 times of 80% by volumetric concentration, the time of reflux, extract, first time is 2 hours, and the time of second time reflux, extract, is 1 hour, and then isolated by filtration, obtains ginseng residue and Radix Ginseng extractive solution;
2) Radix Ginseng extractive solution is condensed into the thick extractum of Radix Ginseng, the relative density of the thick extractum of described Radix Ginseng at 55 DEG C of temperature is 1.44;
3) by ginseng residue and Radix Platycodonis, Semen Armeniacae Amarum, Radix Ophiopogonis, the Radix Astragali, Radix Notoginseng, Fructus Perillae and Rhizoma Acori Graminei altogether 8 taste medicines mix after together with decoct 2 times, when first time decocts, add the water of 8 taste medicine gross weight 7 times, boil 2 hours; Second time is when decocting, and adds the water boil 1 hour of 8 taste medicine gross weight 5 times; Filter and remove residue, merges each fried liquid, is then condensed into dry extract; The relative density of described dry extract at 55 DEG C of temperature is 1.39.
4) by dry extract and particle diameter be the Radix et Rhizoma Rhei (stir-fried with wine) fine powder Homogeneous phase mixing of 0.1cm, pulverize, then add the thick extractum of Radix Ginseng, stir, obtain mixing ointment;
5) will mix ointment extruding to granulate, being dried to water content is 5.0%, granulate, crosses 10 mesh sieves, after subpackage and get final product.
Embodiment 2
Treat a compound Chinese medicinal preparation for vascular dementia, be made up of the raw material of following weight portion: Radix Platycodonis 6 parts, 6 parts, Semen Armeniacae Amarum, Radix Ginseng 11 parts, Radix Ophiopogonis 11 parts, the Radix Astragali 11 parts, 11 parts, Radix Notoginseng, Fructus Perillae 11 parts, Rhizoma Acori Graminei 11 parts and Radix et Rhizoma Rhei (stir-fried with wine) 4 parts.
The preparation method of the compound Chinese medicinal preparation of the treatment vascular dementia described in the present embodiment, comprises the steps:
1) get Radix Ginseng, be the alcohol reflux 3 times of 80 ~ 90% by volumetric concentration, the time of reflux, extract, first time is 3 hours, second time and third time reflux, extract, time be 1.5 hours, then isolated by filtration, obtains ginseng residue and Radix Ginseng extractive solution;
2) Radix Ginseng extractive solution is condensed into the thick extractum of Radix Ginseng; The relative density of the thick extractum of described Radix Ginseng at 60 DEG C of temperature is 1.40.
3) by ginseng residue and Radix Platycodonis, Semen Armeniacae Amarum, Radix Ophiopogonis, the Radix Astragali, Radix Notoginseng, Fructus Perillae and Rhizoma Acori Graminei altogether 8 taste medicines mix after together with decoct 2 ~ 3 times, when first time decocts, add the water of 8 taste medicine gross weight 8 times, boil 3 hours; Second time and third time be when decocting, and adds the water boil 1.5 hours of 8 taste medicine gross weight 6 times; Filter and remove residue, merges each fried liquid, is then condensed into dry extract; The relative density of described dry extract at 60 DEG C of temperature is 1.35;
4) by dry extract and particle diameter be the Radix et Rhizoma Rhei (stir-fried with wine) fine powder Homogeneous phase mixing of 0.3cm, pulverize, then add the thick extractum of Radix Ginseng, stir, obtain mixing ointment;
5) will mix ointment extruding to granulate, being dried to water content is 4.0%, granulate, crosses 15 mesh sieves, after subpackage and get final product.
Embodiment 3
Treat a compound Chinese medicinal preparation for vascular dementia, be made up of the raw material of following weight portion: Radix Platycodonis 7 parts, 7 parts, Semen Armeniacae Amarum, Radix Ginseng 12 parts, Radix Ophiopogonis 12 parts, the Radix Astragali 12 parts, 12 parts, Radix Notoginseng, Fructus Perillae 12 parts, Rhizoma Acori Graminei 12 parts and Radix et Rhizoma Rhei (stir-fried with wine) 5 parts.
The preparation method of the compound Chinese medicinal preparation of the treatment vascular dementia described in the present embodiment, comprises the steps:
1) get Radix Ginseng, be the alcohol reflux 2 times of 85% by volumetric concentration, the time of reflux, extract, first time is 2.5 hours, and the time of second time reflux, extract, is 1.2 hours, and then isolated by filtration, obtains ginseng residue and Radix Ginseng extractive solution;
2) Radix Ginseng extractive solution is condensed into the thick extractum of Radix Ginseng; The relative density of the thick extractum of described Radix Ginseng at 58 DEG C of temperature is 1.42.
3) by ginseng residue and Radix Platycodonis, Semen Armeniacae Amarum, Radix Ophiopogonis, the Radix Astragali, Radix Notoginseng, Fructus Perillae and Rhizoma Acori Graminei altogether 8 taste medicines mix after together with decoct 2 times, when first time decocts, add the water of 8 taste medicine gross weight 7.5 times, boil 2.5 hours; Second time is when decocting, and adds the water boil 1.2 hours of 8 taste medicine gross weight 5.5 times; Filter and remove residue, merges each fried liquid, is then condensed into dry extract; The relative density of described dry extract at 58 DEG C of temperature is 1.37;
4) by dry extract and particle diameter be the Radix et Rhizoma Rhei (stir-fried with wine) fine powder Homogeneous phase mixing of 0.2cm, pulverize, then add the thick extractum of Radix Ginseng, stir, obtain mixing ointment;
5) will mix ointment extruding to granulate, being dried to water content is 2.0%, granulate, crosses 12 mesh sieves, after subpackage and get final product.
Embodiment 4
Treat a compound Chinese medicinal preparation for vascular dementia, be made up of the raw material of following weight portion: Radix Platycodonis 8 parts, 8 parts, Semen Armeniacae Amarum, Radix Ginseng 13 parts, Radix Ophiopogonis 13 parts, the Radix Astragali 13 parts, 13 parts, Radix Notoginseng, Fructus Perillae 13 parts, Rhizoma Acori Graminei 13 parts and Radix et Rhizoma Rhei (stir-fried with wine) 5 parts.
The preparation method of the compound Chinese medicinal preparation of the treatment vascular dementia described in the present embodiment, comprises the steps:
1) get Radix Ginseng, be the alcohol reflux 3 times of 80 ~ 90% by volumetric concentration, the time of reflux, extract, first time is 2.5 hours, second time and third time reflux, extract, time be 1.2 hours, then isolated by filtration, obtains ginseng residue and Radix Ginseng extractive solution;
2) Radix Ginseng extractive solution is condensed into the thick extractum of Radix Ginseng; The relative density of the thick extractum of described Radix Ginseng at 57 DEG C of temperature is 1.43;
3) by ginseng residue and Radix Platycodonis, Semen Armeniacae Amarum, Radix Ophiopogonis, the Radix Astragali, Radix Notoginseng, Fructus Perillae and Rhizoma Acori Graminei altogether 8 taste medicines mix after together with decoct 3 times, when first time decocts, add the water of 8 taste medicine gross weight 7.5 times, boil 2.5 hours; Second time and third time be when decocting, and adds the water boil 1.2 hours of 8 taste medicine gross weight 5.5 times; Filter and remove residue, merges each fried liquid, is then condensed into dry extract; The relative density of described dry extract at 57 DEG C of temperature is 1.38;
4) by dry extract and particle diameter be the Radix et Rhizoma Rhei (stir-fried with wine) fine powder Homogeneous phase mixing of 0.2cm, pulverize, then add the thick extractum of Radix Ginseng, stir, obtain mixing ointment;
5) will mix ointment extruding to granulate, being dried to water content is 6.0%, granulate, crosses 12 mesh sieves, after subpackage and get final product.
Embodiment 5
Treat a compound Chinese medicinal preparation for vascular dementia, be made up of the raw material of following weight portion: Radix Platycodonis 10 parts, 10 parts, Semen Armeniacae Amarum, Radix Ginseng 15 parts, Radix Ophiopogonis 15 parts, the Radix Astragali 15 parts, 15 parts, Radix Notoginseng, Fructus Perillae 15 parts, Rhizoma Acori Graminei 15 parts and Radix et Rhizoma Rhei (stir-fried with wine) 6 parts.
The preparation method of the compound Chinese medicinal preparation of the treatment vascular dementia described in the present embodiment, comprises the steps:
1) get Radix Ginseng, be the alcohol reflux 2 ~ 3 times of 80 ~ 90% by volumetric concentration, the time of reflux, extract, first time is 3 hours, second time or third time reflux, extract, time be 1.5 hours, then isolated by filtration, obtains ginseng residue and Radix Ginseng extractive solution;
2) Radix Ginseng extractive solution is condensed into the thick extractum of Radix Ginseng; The relative density of the thick extractum of described Radix Ginseng at 60 DEG C of temperature is 1.44.
3) by ginseng residue and Radix Platycodonis, Semen Armeniacae Amarum, Radix Ophiopogonis, the Radix Astragali, Radix Notoginseng, Fructus Perillae and Rhizoma Acori Graminei altogether 8 taste medicines mix after together with decoct 3 times, when first time decocts, add the water of 8 taste medicine gross weight 8 times, boil 3 hours; Second time or third time be when decocting, and adds the water boil 1.5 hours of 8 taste medicine gross weight 6 times; Filter and remove residue, merges each fried liquid, is then condensed into dry extract; The relative density of described dry extract at 60 DEG C of temperature is 1.39;
4) by dry extract and particle diameter be the Radix et Rhizoma Rhei (stir-fried with wine) fine powder Homogeneous phase mixing of 0.2cm, pulverize, then add the thick extractum of Radix Ginseng, stir, obtain mixing ointment;
5) ointment extruding will be mixed granulate, and be dried to water content and be no more than 6.0%, granulate, cross 10 ~ 15 mesh sieves, after subpackage and get final product.
Model case is illustrated:
1, land, female, 58 years old, former diagnosis cerebral hemorrhage, rear something lost had the diseases such as inattentive, aphasia, hypomnesis, apathetic expression, dimly pale tongue, and tongue is white, deep and stringy pulse.Fall ill more than May, upper disease is increased the weight of, and I treats at institute then.Give Chinese medicine preparation of the present invention every day 3 times, each 1 time of morning, noon and afternoon, warm water is taken after mixing it with water.After taking 5 courses for the treatment of, inattentive improvement, the simple speech of energy, can do simple interchange with household.
2, Bai, female, 66 years old, former diagnosis cerebral infarction, through doctor trained in Western medicine diagnosis and treatment, still left over the diseases such as drowsiness, inattentive, forgetful, sialorrhea, indigestion and loss of appetite, stool is difficult to resolve, dimly pale tongue had the stasis of blood, and tongue is few, deep and stringy pulse.Fall ill more than August, upper disease having no is clearly better, then to our hospital.Give Chinese medicine preparation of the present invention every day 3 times, each 1 time of morning, noon and afternoon, warm water is taken after mixing it with water.After taking 5 courses for the treatment of, not drowsiness, god is clear, receives improvement of sleeping, free movement of the bowels.
3, Huang, man, 45, former diagnosis cerebral hemorrhage, hypertension.Hemiplegia of limb on the right side of during morbidity, headache, after being hospitalized for treatment, the diseases such as headache, hemiplegia of limb are taken a turn for the better, and have left over hypomnesis, slurred speech, and intelligence, interest are low, apathetic expression, anorexia, the diseases such as constipation.Give Chinese medicine preparation of the present invention every day 3 times, each 1 time of morning, noon and afternoon, warm water is taken after mixing it with water.After taking 8 courses for the treatment of, intelligent restoration can, ability of thinking trend is normal.
Claims (8)
1. treat the compound Chinese medicinal preparation of vascular dementia for one kind, it is characterized in that, be made up of the raw material of following weight portion: Radix Platycodonis 5 ~ 10 parts, 5 ~ 10 parts, Semen Armeniacae Amarum, Radix Ginseng 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, 10 ~ 15 parts, Radix Notoginseng, Fructus Perillae 10 ~ 15 parts, Rhizoma Acori Graminei 10 ~ 15 parts and Radix et Rhizoma Rhei (stir-fried with wine) 3 ~ 6 parts.
2. treat a preparation method for the compound Chinese medicinal preparation of vascular dementia, it is characterized in that, comprise the steps:
1) get Radix Ginseng, be the alcohol reflux 2 ~ 3 times of 80 ~ 90% by volumetric concentration, then isolated by filtration, obtains ginseng residue and Radix Ginseng extractive solution;
2) Radix Ginseng extractive solution is condensed into the thick extractum of Radix Ginseng;
3) by ginseng residue and Radix Platycodonis, Semen Armeniacae Amarum, Radix Ophiopogonis, the Radix Astragali, Radix Notoginseng, Fructus Perillae and Rhizoma Acori Graminei altogether 8 taste medicines mix after together with decoct 2 ~ 3 times, filter and remove residue, merge each fried liquid, be then condensed into dry extract;
4) by dry extract and Radix et Rhizoma Rhei (stir-fried with wine) fine powder Homogeneous phase mixing, pulverize, then add the thick extractum of Radix Ginseng, stir, obtain mixing ointment;
5) ointment extruding will be mixed granulate, and be dried to water content and be no more than 6.0%, granulate, sieve, after subpackage and get final product.
3. preparation method according to claim 2, is characterized in that, step 1) described first time reflux, extract, time be 2 ~ 3 hours, second time or third time reflux, extract, time be 1 ~ 1.5 hour.
4. preparation method according to claim 2, is characterized in that, step 2) relative density of the thick extractum of described Radix Ginseng at 55 ~ 60 DEG C of temperature be 1.40 ~ 1.44.
5. preparation method according to claim 2, is characterized in that, step 3) in, when first time decocts, add the water of 8 taste medicine gross weight 7 ~ 8 times, boil 2 ~ 3 hours; Second time or third time be when decocting, and adds the water boil 1 ~ 1.5 hour of 8 taste medicine gross weight 5 ~ 6 times.
6. preparation method according to claim 2, is characterized in that, step 3) relative density of described dry extract at 55 ~ 60 DEG C of temperature be 1.35 ~ 1.39.
7. preparation method according to claim 2, is characterized in that, step 4) particle diameter of described Radix et Rhizoma Rhei (stir-fried with wine) fine powder is 0.1 ~ 0.3cm.
8. preparation method according to claim 2, is characterized in that, step 5) described in sieve into cross 10 ~ 15 mesh sieves.
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| CN201510040448.0A CN104645015A (en) | 2015-01-27 | 2015-01-27 | Traditional Chinese medicine compound preparation for treating vascular dementia and preparation method of traditional Chinese medicine compound preparation |
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| CN105935439A (en) * | 2016-06-28 | 2016-09-14 | 广西中医药大学 | Traditional Chinese medicine with functions of warming lung and reducing turbidity, preparation method and applications thereof |
| CN107898960A (en) * | 2017-11-24 | 2018-04-13 | 广西中医药大学第附属医院 | A kind of herbal mixture preparation method with the turbid effect of benefiting intelligence of tonifying Qiization |
| CN110934996A (en) * | 2019-12-19 | 2020-03-31 | 广西中医药大学第一附属医院 | Composition and preparation for treating mild dementia and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105935439A (en) * | 2016-06-28 | 2016-09-14 | 广西中医药大学 | Traditional Chinese medicine with functions of warming lung and reducing turbidity, preparation method and applications thereof |
| CN105935439B (en) * | 2016-06-28 | 2020-01-14 | 广西中医药大学 | Traditional Chinese medicine with effects of warming lung and descending turbidity and preparation method and application thereof |
| CN107898960A (en) * | 2017-11-24 | 2018-04-13 | 广西中医药大学第附属医院 | A kind of herbal mixture preparation method with the turbid effect of benefiting intelligence of tonifying Qiization |
| CN110934996A (en) * | 2019-12-19 | 2020-03-31 | 广西中医药大学第一附属医院 | Composition and preparation for treating mild dementia and application thereof |
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