CN1362152A - Nano hypertension-treating bezoar medicine and its preparation - Google Patents
Nano hypertension-treating bezoar medicine and its preparation Download PDFInfo
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- CN1362152A CN1362152A CN 01100306 CN01100306A CN1362152A CN 1362152 A CN1362152 A CN 1362152A CN 01100306 CN01100306 CN 01100306 CN 01100306 A CN01100306 A CN 01100306A CN 1362152 A CN1362152 A CN 1362152A
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Abstract
The present ivnention discloses a nano Niuhuang-jiangya preparation medicine. It is made up by using 14 Chinese medicinal materials of nano antelope horn, nano pearl, nano water buffalo horn concentrated liquor, nano bovine bezoar, nano borneol and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of clear away heart-fire reduce phlegm, the nano hypertension-treating bezoar medicine of calm blood pressure lowering, the invention still further relates to the method for this medication preparation.
Bezoar pill for lowering blood pressure is a kind of traditional Chinese medicine preparation, mainly contains effects such as blood pressure lowering, calmness, diuresis, cure mainly liver-fire vigorous, have a dizzy spell, dysphoria, phlegm-fire stop up diseases such as Sheng, hypertension; but traditional Bezoar pill for lowering blood pressure disintegrate is slower; absorb not exclusively, bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano hypertension-treating bezoar medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano hypertension-treating bezoar medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano antelope horn 1-10 part nano-pearl 3-20 part nanometer Cornu Bubali concentrated solution 2-10 part
Nano bezoar 2-10 part nanometer Borneolum Syntheticum 1-10 part nanometer Radix Paeoniae Alba 50-250 part
Nanometer Radix Codonopsis 100-300 part nano astragalus 100-300 part nanometer Semen Cassiae 200-400 part
The plain 50-250 part of nanometer Rhizoma Chuanxiong 150-350 part nano astragalus nanometer Radix Et Rhizoma Nardostachyos 50-250 part
Nanometer Herba Menthae 5-30 part nanometer Radix Curcumae 100-300 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano antelope horn 3-7 part nano-pearl 5-15 part nanometer Cornu Bubali concentrated solution 3-7 part
Nano bezoar 3-7 part nanometer Borneolum Syntheticum 3-7 part nanometer Radix Paeoniae Alba 100-200 part
Nanometer Radix Codonopsis 150-250 part nano astragalus 150-250 part nanometer Semen Cassiae 250-350 part
The plain 100-200 part of nanometer Rhizoma Chuanxiong 200-300 part nano astragalus nanometer Radix Et Rhizoma Nardostachyos 100-200 part
Nanometer Herba Menthae 10-20 part nanometer Radix Curcumae 150-250 part
The optimum weight proportioning of medicine of the present invention is:
5 parts of 10 parts of nanometer Cornu Bubalis of 5 parts of nano-pearls of nano antelope horn concentrated solutions
150 parts of 5 parts of nanometer Radix Paeoniae Albas of 5 parts of nanometer Borneolum Syntheticums of nano bezoar
300 parts of 200 parts of nanometer Semen Cassiae of 200 parts of nano astragalus of nanometer Radix Codonopsis
150 parts of the plain 150 parts of nanometer Radix Et Rhizoma Nardostachyos of 250 parts of nano astragalus of nanometer Rhizoma Chuanxiong
200 parts of 15 parts of nanometer Radix Curcumaes of nanometer Herba Menthae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Bezoar pill for lowering blood pressure nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the Bezoar pill for lowering blood pressure preparation medicine is identical.
A kind of important feature of the present invention is; the made drug material of the present invention has reached nanoscale; common Bezoar pill for lowering blood pressure preparation material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano hypertension-treating bezoar medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treating treatment of conditions such as hypertension, and clinical efficacy significantly is better than traditional Bezoar pill for lowering blood pressure.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
5 parts of 10 parts of nanometer Cornu Bubalis of 5 parts of nano-pearls of nano antelope horn concentrated solutions
150 parts of 5 parts of nanometer Radix Paeoniae Albas of 5 parts of nanometer Borneolum Syntheticums of nano bezoar
300 parts of 200 parts of nanometer Semen Cassiae of 200 parts of nano astragalus of nanometer Radix Codonopsis
150 parts of the plain 150 parts of nanometer Radix Et Rhizoma Nardostachyos of 250 parts of nano astragalus of nanometer Rhizoma Chuanxiong
200 parts of 15 parts of nanometer Radix Curcumaes of nanometer Herba Menthae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
5 parts of 10 parts of nanometer Cornu Bubalis of 5 parts of nano-pearls of nano antelope horn concentrated solutions
150 parts of 5 parts of nanometer Radix Paeoniae Albas of 5 parts of nanometer Borneolum Syntheticums of nano bezoar
300 parts of 200 parts of nanometer Semen Cassiae of 200 parts of nano astragalus of nanometer Radix Codonopsis
150 parts of the plain 150 parts of nanometer Radix Et Rhizoma Nardostachyos of 250 parts of nano astragalus of nanometer Rhizoma Chuanxiong
200 parts of 15 parts of nanometer Radix Curcumaes of nanometer Herba Menthae
Production method is as follows:
In the GMP cleaning shop; after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio; according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard; do not add any adjuvant; make nano bezoar blood pressure lowering powder needle injection; every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
5 parts of 10 parts of nanometer Cornu Bubalis of 5 parts of nano-pearls of nano antelope horn concentrated solutions
150 parts of 5 parts of nanometer Radix Paeoniae Albas of 5 parts of nanometer Borneolum Syntheticums of nano bezoar
300 parts of 200 parts of nanometer Semen Cassiae of 200 parts of nano astragalus of nanometer Radix Codonopsis
150 parts of the plain 150 parts of nanometer Radix Et Rhizoma Nardostachyos of 250 parts of nano astragalus of nanometer Rhizoma Chuanxiong
200 parts of 15 parts of nanometer Radix Curcumaes of nanometer Herba Menthae
Production method is as follows:
In the GMP cleaning shop; after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio; according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard; filmogen adopts polyvinyl alcohol; make nano bezoar blood pressure lowering membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest, cervical region.
Claims (6)
1, a kind of nano hypertension-treating bezoar medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nano antelope horn 1-10 part nano-pearl 3-20 part nanometer Cornu Bubali concentrated solution 2-10 part
Nano bezoar 2-10 part nanometer Borneolum Syntheticum 1-10 part nanometer Radix Paeoniae Alba 50-250 part
Nanometer Radix Codonopsis 100-300 part nano astragalus 100-300 part nanometer Semen Cassiae 200-400 part
The plain 50-250 part of nanometer Rhizoma Chuanxiong 150-350 part nano astragalus nanometer Radix Et Rhizoma Nardostachyos 50-250 part
Nanometer Herba Menthae 5-30 part nanometer Radix Curcumae 100-300 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano hypertension-treating bezoar medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano antelope horn 3-7 part nano-pearl 5-15 part nanometer Cornu Bubali concentrated solution 3-7 part
Nano bezoar 3-7 part nanometer Borneolum Syntheticum 3-7 part nanometer Radix Paeoniae Alba 100-200 part
Nanometer Radix Codonopsis 150-250 part nano astragalus 150-250 part nanometer Semen Cassiae 250-350 part
The plain 100-200 part of nanometer Rhizoma Chuanxiong 200-300 part nano astragalus nanometer Radix Et Rhizoma Nardostachyos 100-200 part
Nanometer Herba Menthae 10-20 part nanometer Radix Curcumae 150-250 part
3, nano hypertension-treating bezoar medicine according to claim 1, wherein the weight proportion of each nano raw material is:
5 parts of 10 parts of nanometer Cornu Bubalis of 5 parts of nano-pearls of nano antelope horn concentrated solutions
150 parts of 5 parts of nanometer Radix Paeoniae Albas of 5 parts of nanometer Borneolum Syntheticums of nano bezoar
300 parts of 200 parts of nanometer Semen Cassiae of 200 parts of nano astragalus of nanometer Radix Codonopsis
150 parts of 150 parts of nanometer Radix Et Rhizoma Nardostachyos of 250 parts of nano astragalus ropes of nanometer Rhizoma Chuanxiong
200 parts of 15 parts of nanometer Radix Curcumaes of nanometer Herba Menthae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano hypertension-treating bezoar medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano hypertension-treating bezoar medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100306 CN1362152A (en) | 2001-01-02 | 2001-01-02 | Nano hypertension-treating bezoar medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100306 CN1362152A (en) | 2001-01-02 | 2001-01-02 | Nano hypertension-treating bezoar medicine and its preparation |
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| CN1362152A true CN1362152A (en) | 2002-08-07 |
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| CN 01100306 Pending CN1362152A (en) | 2001-01-02 | 2001-01-02 | Nano hypertension-treating bezoar medicine and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943756B (en) * | 2005-10-08 | 2011-05-04 | 周小明 | A Chinese traditional medicinal composition used for treatment of hypertension and its preparation method |
| CN115040620A (en) * | 2022-06-14 | 2022-09-13 | 河北守正医药集团有限公司 | Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof |
-
2001
- 2001-01-02 CN CN 01100306 patent/CN1362152A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943756B (en) * | 2005-10-08 | 2011-05-04 | 周小明 | A Chinese traditional medicinal composition used for treatment of hypertension and its preparation method |
| CN115040620A (en) * | 2022-06-14 | 2022-09-13 | 河北守正医药集团有限公司 | Traditional Chinese medicine composition of blood pressure-reducing and dizziness-clearing capsules and preparation method thereof |
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