CN1364550A - Nano Rugi asthma-relieving medicine and its preparing method - Google Patents
Nano Rugi asthma-relieving medicine and its preparing method Download PDFInfo
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- CN1364550A CN1364550A CN 01100817 CN01100817A CN1364550A CN 1364550 A CN1364550 A CN 1364550A CN 01100817 CN01100817 CN 01100817 CN 01100817 A CN01100817 A CN 01100817A CN 1364550 A CN1364550 A CN 1364550A
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Abstract
The nano Ruyi asthma relieving medicine is prepared with nano gecko, nano toad cake, nano Astragalus membranaceus, nano earthworm, nano ephedra and other 16 kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to the nano Rugi asthma-relieving medicine of a kind of lung qi dispersing Dingchuan, relieving cough and resolving phlegm, supplementing QI and nourishing YIN, the invention still further relates to the method for this medication preparation.
RUYI DINGCHUAN PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as lung qi dispersing Dingchuan, relieving cough and resolving phlegm, supplementing QI and nourishing YIN, is used for the disease such as bronchial asthma, asthenia chronic cough, emphysema, pulmonary heart disease due to the lung qi Yin bivacuity.But traditional RUYI DINGCHUAN PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Rugi asthma-relieving medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Rugi asthma-relieving medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Gecko 100-200 part nanometer Venenum Bufonis 5-15 part nano astragalus 200-800 part
Nanometer earthworm 350-700 part nanometer Herba Ephedrae 300-800 part nanometer Radix Codonopsis 300-800 part
Nanometer Semen Armeniacae Amarum 500-1200 part nanometer Semen Ginkgo 300-800 part nanometer Fructus Aurantii Immaturus 200-450 part
Nanometer Radix Asparagi 300-550 part nanometer Fructus Schisandrae Chinensis 300-800 part nanometer 300-800 Radix Ophiopogonis part
Nanometer Radix Asteris 300-600 part nanometer Radix Stemonae 100-350 part nanometer Fructus Lycii 200-450 part
Nanometer Radix Rehmanniae Preparata 350-800 part nanometer Radix Polygalae 100-350 part nanometer Semen Lepidii (Semen Descurainiae) 100-350 part
Nanometer Flos Daturae 100-350 part nanometer Gypsum Fibrosum 100-300 part nanometer Radix Glycyrrhizae 350-700 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Gecko 120-180 part nanometer Venenum Bufonis 7-10 part nano astragalus 400-600 part
Nanometer earthworm 400-600 part nanometer Herba Ephedrae 400-600 part nanometer Radix Codonopsis 400-600 part
Nanometer Semen Armeniacae Amarum 600-1000 part nanometer Semen Ginkgo 400-600 part nanometer Fructus Aurantii Immaturus 250-350 part
Nanometer Radix Asparagi 320-450 part nanometer Fructus Schisandrae Chinensis 400-600 part nanometer 320-500 Radix Ophiopogonis part
Nanometer Radix Asteris 320-500 part nanometer Radix Stemonae 150-250 part nanometer Fructus Lycii 250-350 part
Nanometer Radix Rehmanniae Preparata 400-600 part nanometer Radix Polygalae 150-250 part nanometer Semen Lepidii (Semen Descurainiae) 150-250 part
Nanometer Flos Daturae 150-250 part nanometer Gypsum Fibrosum 150-250 part nanometer Radix Glycyrrhizae 400-600 part
The optimum weight proportioning of medicine of the present invention is:
500 parts of 9 parts of nano astragalus of 150 parts of nanometer Venenum Bufoniss of nanometer Gecko
500 parts of 500 parts of nanometer Radix Codonopsis of 500 parts of nanometer Herba Ephedraes of nanometer earthworm
300 parts of 500 parts of nanometer Fructus Aurantii Immaturuss of 800 parts of nanometer Semen Ginkgoes of nanometer Semen Armeniacae Amarum
400 parts of 500 parts of nanometers of 400 parts of nanometer Fructus Schisandrae Chinensis of nanometer Radix Asparagi Radix Ophiopogonis
300 parts of 200 parts of nanometer Fructus Lycii of 400 parts of nanometer Radixs Stemonae of nanometer Radix Asteris
200 parts of 200 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 500 parts of nanometer Radix Polygalaes of nanometer Radix Rehmanniae Preparata
500 parts in 200 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Gypsum Fibrosum of nanometer Flos Daturae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Rugi asthma-relieving nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Rugi asthma-relieving medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common RUYI DINGCHUAN PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano Rugi asthma-relieving medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of diseases such as the bronchial asthma, asthenia chronic cough, emphysema, pulmonary heart disease due to the lung qi Yin bivacuity, and clinical efficacy significantly is better than traditional RUYI DINGCHUAN PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
500 parts of 9 parts of nano astragalus of 150 parts of nanometer Venenum Bufoniss of nanometer Gecko
500 parts of 500 parts of nanometer Radix Codonopsis of 500 parts of nanometer Herba Ephedraes of nanometer earthworm
300 parts of 500 parts of nanometer Fructus Aurantii Immaturuss of 800 parts of nanometer Semen Ginkgoes of nanometer Semen Armeniacae Amarum
400 parts of 500 parts of nanometers of 400 parts of nanometer Fructus Schisandrae Chinensis of nanometer Radix Asparagi Radix Ophiopogonis
300 parts of 200 parts of nanometer Fructus Lycii of 400 parts of nanometer Radixs Stemonae of nanometer Radix Asteris
200 parts of 200 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 500 parts of nanometer Radix Polygalaes of nanometer Radix Rehmanniae Preparata
500 parts in 200 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Gypsum Fibrosum of nanometer Flos Daturae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
500 parts of 9 parts of nano astragalus of 150 parts of nanometer Venenum Bufoniss of nanometer Gecko
500 parts of 500 parts of nanometer Radix Codonopsis of 500 parts of nanometer Herba Ephedraes of nanometer earthworm
300 parts of 500 parts of nanometer Fructus Aurantii Immaturuss of 800 parts of nanometer Semen Ginkgoes of nanometer Semen Armeniacae Amarum
400 parts of 500 parts of nanometers of 400 parts of nanometer Fructus Schisandrae Chinensis of nanometer Radix Asparagi Radix Ophiopogonis
300 parts of 200 parts of nanometer Fructus Lycii of 400 parts of nanometer Radixs Stemonae of nanometer Radix Asteris
200 parts of 200 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 500 parts of nanometer Radix Polygalaes of nanometer Radix Rehmanniae Preparata
500 parts in 200 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Gypsum Fibrosum of nanometer Flos Daturae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer Dingchuan powder needle injection as one wishes, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
500 parts of 9 parts of nano astragalus of 150 parts of nanometer Venenum Bufoniss of nanometer Gecko
500 parts of 500 parts of nanometer Radix Codonopsis of 500 parts of nanometer Herba Ephedraes of nanometer earthworm
300 parts of 500 parts of nanometer Fructus Aurantii Immaturuss of 800 parts of nanometer Semen Ginkgoes of nanometer Semen Armeniacae Amarum
400 parts of 500 parts of nanometers of 400 parts of nanometer Fructus Schisandrae Chinensis of nanometer Radix Asparagi Radix Ophiopogonis
300 parts of 200 parts of nanometer Fructus Lycii of 400 parts of nanometer Radixs Stemonae of nanometer Radix Asteris
200 parts of 200 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 500 parts of nanometer Radix Polygalaes of nanometer Radix Rehmanniae Preparata
500 parts in 200 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Gypsum Fibrosum of nanometer Flos Daturae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Dingchuan membrane as one wishes, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano Rugi asthma-relieving medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Gecko 100-200 part nanometer Venenum Bufonis 5-15 part nano astragalus 200-800 part
Nanometer earthworm 350-700 part nanometer Herba Ephedrae 300-800 part nanometer Radix Codonopsis 300-800 part
Nanometer Semen Armeniacae Amarum 500-1200 part nanometer Semen Ginkgo 300-800 part nanometer Fructus Aurantii Immaturus 200-450 part
Nanometer Radix Asparagi 300-550 part nanometer Fructus Schisandrae Chinensis 300-800 part nanometer 300-800 Radix Ophiopogonis part
Nanometer Radix Asteris 300-600 part nanometer Radix Stemonae 100-350 part nanometer Fructus Lycii 200-450 part
Nanometer Radix Rehmanniae Preparata 350-800 part nanometer Radix Polygalae 100-350 part nanometer Semen Lepidii (Semen Descurainiae) 100-350 part
Nanometer Flos Daturae 100-350 part nanometer Gypsum Fibrosum 100-300 part nanometer Radix Glycyrrhizae 350-700 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Rugi asthma-relieving medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Gecko 120-180 part nanometer Venenum Bufonis 7-10 part nano astragalus 400-600 part
Nanometer earthworm 400-600 part nanometer Herba Ephedrae 400-600 part nanometer Radix Codonopsis 400-600 part
Nanometer Semen Armeniacae Amarum 600-1000 part nanometer Semen Ginkgo 400-600 part nanometer Fructus Aurantii Immaturus 250-350 part
Nanometer Radix Asparagi 320-450 part nanometer Fructus Schisandrae Chinensis 400-600 part nanometer 320-500 Radix Ophiopogonis part
Nanometer Radix Asteris 320-500 part nanometer Radix Stemonae 150-250 part nanometer Fructus Lycii 250-350 part
Nanometer Radix Rehmanniae Preparata 400-600 part nanometer Radix Polygalae 150-250 part nanometer Semen Lepidii (Semen Descurainiae) 150-250 part
Nanometer Flos Daturae 150-250 part nanometer Gypsum Fibrosum 150-250 part nanometer Radix Glycyrrhizae 400-600 part
3, nano Rugi asthma-relieving medicine according to claim 1, wherein the weight proportion of each nano raw material is:
500 parts of 9 parts of nano astragalus of 150 parts of nanometer Venenum Bufoniss of nanometer Gecko
500 parts of 500 parts of nanometer Radix Codonopsis of 500 parts of nanometer Herba Ephedraes of nanometer earthworm
300 parts of 500 parts of nanometer Fructus Aurantii Immaturuss of 800 parts of nanometer Semen Ginkgoes of nanometer Semen Armeniacae Amarum
400 parts of 500 parts of nanometers of 400 parts of nanometer Fructus Schisandrae Chinensis of nanometer Radix Asparagi Radix Ophiopogonis
300 parts of 200 parts of nanometer Fructus Lycii of 400 parts of nanometer Radixs Stemonae of nanometer Radix Asteris
200 parts of 200 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 500 parts of nanometer Radix Polygalaes of nanometer Radix Rehmanniae Preparata
500 parts in 200 parts of nanometer Radix Glycyrrhizaes of 200 parts of nanometer Gypsum Fibrosum of nanometer Flos Daturae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Rugi asthma-relieving medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Rugi asthma-relieving medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100817 CN1364550A (en) | 2001-01-11 | 2001-01-11 | Nano Rugi asthma-relieving medicine and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100817 CN1364550A (en) | 2001-01-11 | 2001-01-11 | Nano Rugi asthma-relieving medicine and its preparing method |
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| CN1364550A true CN1364550A (en) | 2002-08-21 |
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| CN 01100817 Pending CN1364550A (en) | 2001-01-11 | 2001-01-11 | Nano Rugi asthma-relieving medicine and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655927A (en) * | 2012-09-11 | 2014-03-26 | 解玉启 | Special-effect drug for treating asthma |
| CN105582428A (en) * | 2014-12-25 | 2016-05-18 | 耿福能 | Transdermal patch for acupoint sticking therapy and preparation method thereof |
-
2001
- 2001-01-11 CN CN 01100817 patent/CN1364550A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655927A (en) * | 2012-09-11 | 2014-03-26 | 解玉启 | Special-effect drug for treating asthma |
| CN103655927B (en) * | 2012-09-11 | 2016-02-17 | 解玉启 | A kind of medicine for the treatment of asthma |
| CN105582428A (en) * | 2014-12-25 | 2016-05-18 | 耿福能 | Transdermal patch for acupoint sticking therapy and preparation method thereof |
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