CN1368318A - Nano medicine 'Shugantiaoqi' and its preparing process - Google Patents
Nano medicine 'Shugantiaoqi' and its preparing process Download PDFInfo
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- CN1368318A CN1368318A CN 01102696 CN01102696A CN1368318A CN 1368318 A CN1368318 A CN 1368318A CN 01102696 CN01102696 CN 01102696 CN 01102696 A CN01102696 A CN 01102696A CN 1368318 A CN1368318 A CN 1368318A
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Abstract
A nanometre (0.1-200 nm) medicine "Shugan Tiaoqi" for regulating liver Qi is prepared from the nanometre powders of 21 Chinese medicinal materials including cyperus root, magnelia bark, immature bitter orang, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Shugantiaoqi ' of a kind of dissipating depression of QI of having a respite, invigorating the stomach and promoting digestion, the invention still further relates to the method for this medication preparation.
Pill for soothing liver and regulating qi is a kind of classical Chinese patent medicine, mainly contains effects such as the dissipating depression of QI of having a respite, invigorating the stomach and promoting digestion, is used for two side of body distensions, unhappy, vomiting is felt sick in the heart, QI rising in reverse order has some setbacks, fall full noisy, dyspepsia, constipation due to dry stool.But traditional pill for soothing liver and regulating qi disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Shugantiaoqi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Shugantiaoqi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano cyperus tuber 60-150 part nanometer Cortex Magnoliae Officinalis 65-140 part nanometer Fructus Aurantii Immaturus 60-150 part
Nanometer Radix Gentianae 40-90 part nanometer Pericarpium Citri Reticulatae Viride 40-90 part nanometer Fructus Amomi Rotundus 35-80 part
Nanometer Radix Aucklandiae 35-80 part nanometer Pericarpium Citri Reticulatae 20-50 part nanometer Rhizoma Corydalis 20-50 part
Nanometer Radix Curcumae 20-50 part nanometer Rhizoma Acori Graminei 20-50 part nanometer Oletum Trogopterori 20-50 part
Nanometer Rhizoma Curcumae 20-50 part nanometer Cortex Moutan 20-50 part nanometer Semen Pharbitidis 20-50 part
Nanometer Radix Paeoniae Alba 20-50 part nanometer Rhizoma Curcumae Longae 15-40 part nanometer Flos Magnoliae Officinalis 12-30 part
Nanometer Semen Pruni 10-25 part nanometer Lignum Aquilariae Resinatum 10-25 part nanometer Semen Raphani 4-15 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano cyperus tuber 80-120 part nanometer Cortex Magnoliae Officinalis 80-120 part nanometer Fructus Aurantii Immaturus 80-120 part
Nanometer Radix Gentianae 50-80 part nanometer Pericarpium Citri Reticulatae Viride 50-80 part nanometer Fructus Amomi Rotundus 40-60 part
Nanometer Radix Aucklandiae 40-60 part nanometer Pericarpium Citri Reticulatae 25-40 part nanometer Rhizoma Corydalis 25-40 part
Nanometer Radix Curcumae 25-40 part nanometer Rhizoma Acori Graminei 25-40 part nanometer Oletum Trogopterori 25-40 part
Nanometer Rhizoma Curcumae 25-40 part nanometer Cortex Moutan 25-40 part nanometer Semen Pharbitidis 25-40 part
Nanometer Radix Paeoniae Alba 25-40 part nanometer Rhizoma Curcumae Longae 20-30 part nanometer Flos Magnoliae Officinalis 15-25 part
Nanometer Semen Pruni 12-20 part nanometer Lignum Aquilariae Resinatum 12-20 part nanometer Semen Raphani 5-12 part
The optimum weight proportioning of medicine of the present invention is:
96 parts of 96 parts of nanometer Fructus Aurantii Immaturuss of 96 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
48 parts in 64 parts of nanometer Fructus Amomi Rotunduss of 64 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Radix Gentianae
32 parts of 32 parts of nanometer Rhizoma Corydalis of 48 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Radix Aucklandiae
32 parts of 32 parts of nanometer Oletum Trogopteroris of 32 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Curcumae
32 parts of 32 parts of nanometer Semen Pharbitidiss of 32 parts of nanometer Cortex Moutans of nanometer Rhizoma Curcumae
18 parts of 24 parts of nanometer Flos Magnoliae Officinalises of 32 parts of nanometer Rhizoma Curcumae Longaes of the nanometer Radix Paeoniae Alba
8 parts of 16 parts of nanometer Semen Raphanis of 16 parts of nanometer Lignum Aquilariae Resinatum of nanometer Semen Pruni
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Shugantiaoqi ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Shugantiaoqi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common pill for soothing liver and regulating qi preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Shugantiaoqi ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for two side of body distensions, unhappy, vomiting is felt sick in the heart, QI rising in reverse order has some setbacks, fall treatment of conditions such as full noisy, dyspepsia, constipation due to dry stool, and clinical efficacy significantly is better than traditional pill for soothing liver and regulating qi.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
96 parts of 96 parts of nanometer Fructus Aurantii Immaturuss of 96 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
48 parts in 64 parts of nanometer Fructus Amomi Rotunduss of 64 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Radix Gentianae
32 parts of 32 parts of nanometer Rhizoma Corydalis of 48 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Radix Aucklandiae
32 parts of 32 parts of nanometer Oletum Trogopteroris of 32 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Curcumae
32 parts of 32 parts of nanometer Semen Pharbitidiss of 32 parts of nanometer Cortex Moutans of nanometer Rhizoma Curcumae
18 parts of 24 parts of nanometer Flos Magnoliae Officinalises of 32 parts of nanometer Rhizoma Curcumae Longaes of the nanometer Radix Paeoniae Alba
8 parts of 16 parts of nanometer Semen Raphanis of 16 parts of nanometer Lignum Aquilariae Resinatum of nanometer Semen Pruni
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
96 parts of 96 parts of nanometer Fructus Aurantii Immaturuss of 96 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
48 parts in 64 parts of nanometer Fructus Amomi Rotunduss of 64 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Radix Gentianae
32 parts of 32 parts of nanometer Rhizoma Corydalis of 48 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Radix Aucklandiae
32 parts of 32 parts of nanometer Oletum Trogopteroris of 32 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Curcumae
32 parts of 32 parts of nanometer Semen Pharbitidiss of 32 parts of nanometer Cortex Moutans of nanometer Rhizoma Curcumae
18 parts of 24 parts of nanometer Flos Magnoliae Officinalises of 32 parts of nanometer Rhizoma Curcumae Longaes of the nanometer Radix Paeoniae Alba
8 parts of 16 parts of nanometer Semen Raphanis of 16 parts of nanometer Lignum Aquilariae Resinatum of nanometer Semen Pruni
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer soothing liver and regulating qi powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
96 parts of 96 parts of nanometer Fructus Aurantii Immaturuss of 96 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
48 parts in 64 parts of nanometer Fructus Amomi Rotunduss of 64 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Radix Gentianae
32 parts of 32 parts of nanometer Rhizoma Corydalis of 48 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Radix Aucklandiae
32 parts of 32 parts of nanometer Oletum Trogopteroris of 32 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Curcumae
32 parts of 32 parts of nanometer Semen Pharbitidiss of 32 parts of nanometer Cortex Moutans of nanometer Rhizoma Curcumae
18 parts of 24 parts of nanometer Flos Magnoliae Officinalises of 32 parts of nanometer Rhizoma Curcumae Longaes of the nanometer Radix Paeoniae Alba
8 parts of 16 parts of nanometer Semen Raphanis of 16 parts of nanometer Lignum Aquilariae Resinatum of nanometer Semen Pruni
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer soothing liver and regulating qi membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Shugantiaoqi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano cyperus tuber 60-150 part nanometer Cortex Magnoliae Officinalis 65-140 part nanometer Fructus Aurantii Immaturus 60-150 part
Nanometer Radix Gentianae 40-90 part nanometer Pericarpium Citri Reticulatae Viride 40-90 part nanometer Fructus Amomi Rotundus 35-80 part
Nanometer Radix Aucklandiae 35-80 part nanometer Pericarpium Citri Reticulatae 20-50 part nanometer Rhizoma Corydalis 20-50 part
Nanometer Radix Curcumae 20-50 part nanometer Rhizoma Acori Graminei 20-50 part nanometer Oletum Trogopterori 20-50 part
Nanometer Rhizoma Curcumae 20-50 part nanometer Cortex Moutan 20-50 part nanometer Semen Pharbitidis 20-50 part
Nanometer Radix Paeoniae Alba 20-50 part nanometer Rhizoma Curcumae Longae 15-40 part nanometer Flos Magnoliae Officinalis 12-30 part
Nanometer Semen Pruni 10-25 part nanometer Lignum Aquilariae Resinatum 10-25 part nanometer Semen Raphani 4-15 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Shugantiaoqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano cyperus tuber 80-120 part nanometer Cortex Magnoliae Officinalis 80-120 part nanometer Fructus Aurantii Immaturus 80-120 part
Nanometer Radix Gentianae 50-80 part nanometer Pericarpium Citri Reticulatae Viride 50-80 part nanometer Fructus Amomi Rotundus 40-60 part
Nanometer Radix Aucklandiae 40-60 part nanometer Pericarpium Citri Reticulatae 25-40 part nanometer Rhizoma Corydalis 25-40 part
Nanometer Radix Curcumae 25-40 part nanometer Rhizoma Acori Graminei 25-40 part nanometer Oletum Trogopterori 25-40 part
Nanometer Rhizoma Curcumae 25-40 part nanometer Cortex Moutan 25-40 part nanometer Semen Pharbitidis 25-40 part
Nanometer Radix Paeoniae Alba 25-40 part nanometer Rhizoma Curcumae Longae 20-30 part nanometer Flos Magnoliae Officinalis 15-25 part
Nanometer Semen Pruni 12-20 part nanometer Lignum Aquilariae Resinatum 12-20 part nanometer Semen Raphani 5-12 part
3, nano medicine ' Shugantiaoqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
96 parts of 96 parts of nanometer Fructus Aurantii Immaturuss of 96 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
48 parts in 64 parts of nanometer Fructus Amomi Rotunduss of 64 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Radix Gentianae
32 parts of 32 parts of nanometer Rhizoma Corydalis of 48 parts of nanometer Pericarpium Citri Reticulataes of the nanometer Radix Aucklandiae
32 parts of 32 parts of nanometer Oletum Trogopteroris of 32 parts of nanometer Rhizoma Acori Graminei of nanometer Radix Curcumae
32 parts of 32 parts of nanometer Semen Pharbitidiss of 32 parts of nanometer Cortex Moutans of nanometer Rhizoma Curcumae
18 parts of 24 parts of nanometer Flos Magnoliae Officinalises of 32 parts of nanometer Rhizoma Curcumae Longaes of the nanometer Radix Paeoniae Alba
8 parts of 16 parts of nanometer Semen Raphanis of 16 parts of nanometer Lignum Aquilariae Resinatum of nanometer Semen Pruni
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Shugantiaoqi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Shugantiaoqi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102696 CN1368318A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Shugantiaoqi' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102696 CN1368318A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Shugantiaoqi' and its preparing process |
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| CN1368318A true CN1368318A (en) | 2002-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01102696 Pending CN1368318A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Shugantiaoqi' and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433694B (en) * | 2007-11-15 | 2012-11-28 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Novel pill for soothing liver and regulating qi |
| CN101394859B (en) * | 2006-02-28 | 2013-03-20 | 东亚制药株式会社 | Extract of herbal and the composition containing the same |
| CN103300092A (en) * | 2013-06-27 | 2013-09-18 | 叶建斌 | Cows' milk cake with function of calming liver and harmonizing stomach and preparation method of cows' milk cake |
-
2001
- 2001-02-06 CN CN 01102696 patent/CN1368318A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394859B (en) * | 2006-02-28 | 2013-03-20 | 东亚制药株式会社 | Extract of herbal and the composition containing the same |
| CN101433694B (en) * | 2007-11-15 | 2012-11-28 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Novel pill for soothing liver and regulating qi |
| CN103300092A (en) * | 2013-06-27 | 2013-09-18 | 叶建斌 | Cows' milk cake with function of calming liver and harmonizing stomach and preparation method of cows' milk cake |
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