CN1364490A - Nano sixteen ingredient Dongqingque medicine and its preparing method - Google Patents
Nano sixteen ingredient Dongqingque medicine and its preparing method Download PDFInfo
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- CN1364490A CN1364490A CN 01100264 CN01100264A CN1364490A CN 1364490 A CN1364490 A CN 1364490A CN 01100264 CN01100264 CN 01100264 CN 01100264 A CN01100264 A CN 01100264A CN 1364490 A CN1364490 A CN 1364490A
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Abstract
The nano sixteen ingredient Dongqingque medicine is prepared with nano holly leaf, nano megranate, nano gypsum, nano cassia, nano cardamomum and other level kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to pleasant, the relieving cough, relieving asthma of a kind of the chest stuffiness relieving, cure mainly fullness in the chest abdominal distention, dizzy edema, the nano sixteen ingredient Dongqingque medicine of cough of cold type phlegm dyspnea the invention still further relates to the method for this medication preparation.
The true ball of ten Six-element Ilicis Purpureaes is a kind of classical Chinese patent medicine, mainly contains effects such as the chest stuffiness relieving is pleasant, relieving cough, relieving asthma, is used for fullness in the chest abdominal distention, dizzy edema, cough of cold type phlegm dyspnea.But traditional true ball disintegrate of ten Six-element Ilicis Purpureaes is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano sixteen ingredient Dongqingque medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano sixteen ingredient Dongqingque medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Folium Ilicis Purpureae 100-200 part nanometer Punica granatum L. 15-40 part nanometer Gypsum Fibrosum 50-95 part
Nanometer Cortex Cinnamomi 30-70 part nanometer Fructus Amomi Rotundus 30-70 part nanometer Radix Aucklandiae 30-70 part
Nano clove 30-70 part nanometer Radix Glycyrrhizae 30-80 part nanometer Fructus Vins is done 80-200 part
Nanometer Lignum Aquilariae Resinatum 50-95 part nanometer Rhizoma Bistortae 50-95 part nanometer Fructus Piperis Longi 30-80 part
Nanometer Semen Myristicae 30-80 part nano safflower 30-80 part nanometer Fructus Choerospondiatis 30-80 part
Sea, nanometer side 30-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Folium Ilicis Purpureae 120-180 part nanometer Punica granatum L. 20-30 part nanometer Gypsum Fibrosum 60-90 part
Nanometer Cortex Cinnamomi 40-60 part nanometer Fructus Amomi Rotundus 40-60 part nanometer Radix Aucklandiae 40-60 part
Nano clove 40-60 part nanometer Radix Glycyrrhizae 40-60 part nanometer Fructus Vins is done 100-150 part
Nanometer Lignum Aquilariae Resinatum 60-90 part nanometer Rhizoma Bistortae 60-90 part nanometer Fructus Piperis Longi 40-60 part
Nanometer Semen Myristicae 40-60 part nano safflower 40-60 part nanometer Fructus Choerospondiatis 40-60 part
Sea, nanometer side 40-60 part
The optimum weight proportioning of medicine of the present invention is:
75 parts in 25 parts of nanometer Gypsum Fibrosum of 150 parts of nanometer Punica granatum L.s of nanometer Folium Ilicis Purpureae
50 parts of 50 parts of nanometer Radix Aucklandiae of 50 parts of nanometer Fructus Amomi Rotunduss of nanometer Cortex Cinnamomi
50 parts of nanometer Fructus Vins of 50 parts of nanometer Radix Glycyrrhizaes of nano clove are done 125 parts
50 parts of 75 parts of nanometer Fructus Piperis Longi of 75 parts of nanometer Rhizoma Bistortaes of nanometer Lignum Aquilariae Resinatum
50 parts of 50 parts of nanometer Fructus Choerospondiatis of 50 parts of nano safflowers of nanometer Semen Myristicae
50 parts in sea, nanometer side
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at product circle places makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the sixteen ingredient Dongqingque nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano sixteen ingredient Dongqingque medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the true pill material of common ten Six-element Ilicis Purpureaes is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano sixteen ingredient Dongqingque medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for fullness in the chest abdominal distention, dizzy edema, and treatment of conditions such as cough of cold type phlegm dyspnea, clinical efficacy significantly is better than traditional true ball of ten Six-element Ilicis Purpureaes.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
75 parts in 25 parts of nanometer Gypsum Fibrosum of 150 parts of nanometer Punica granatum L.s of nanometer winter notopodium
50 parts of 50 parts of nanometer Radix Aucklandiae of 50 parts of nanometer Fructus Amomi Rotunduss of nanometer Cortex Cinnamomi
50 parts of nanometer Fructus Vins of 50 parts of nanometer Radix Glycyrrhizaes of nano clove are done 125 parts
50 parts of 75 parts of nanometer Fructus Piperis Longi of 75 parts of nanometer Rhizoma Bistortaes of nanometer Lignum Aquilariae Resinatum
50 parts of 50 parts of nanometer Fructus Choerospondiatis of 50 parts of nano safflowers of nanometer Semen Myristicae
50 parts in sea, nanometer side
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
75 parts in 25 parts of nanometer Gypsum Fibrosum of 150 parts of nanometer Punica granatum L.s of nanometer Folium Ilicis Purpureae
50 parts of 50 parts of nanometer Radix Aucklandiae of 50 parts of nanometer Fructus Amomi Rotunduss of nanometer Cortex Cinnamomi
50 parts of nanometer Fructus Vins of 50 parts of nanometer Radix Glycyrrhizaes of nano clove are done 125 parts
50 parts of 75 parts of nanometer Fructus Piperis Longi of 75 parts of nanometer Rhizoma Bistortaes of nanometer Lignum Aquilariae Resinatum
50 parts of 50 parts of nanometer Fructus Choerospondiatis of 50 parts of nano safflowers of nanometer Semen Myristicae
50 parts in sea, nanometer side
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the true powder needle injection of nanometer ten Six-element Ilicis Purpureaes, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
75 parts in 25 parts of nanometer Gypsum Fibrosum of 150 parts of nanometer Punica granatum L.s of nanometer Folium Ilicis Purpureae
50 parts of 50 parts of nanometer Radix Aucklandiae of 50 parts of nanometer Fructus Amomi Rotunduss of nanometer Cortex Cinnamomi
50 parts of nanometer Fructus Vins of 50 parts of nanometer Radix Glycyrrhizaes of nano clove are done 125 parts
50 parts of 75 parts of nanometer Fructus Piperis Longi of 75 parts of nanometer Rhizoma Bistortaes of nanometer Lignum Aquilariae Resinatum
50 parts of 50 parts of nanometer Fructus Choerospondiatis of 50 parts of nano safflowers of nanometer Semen Myristicae
50 parts in sea, nanometer side
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the true membrane of nanometer ten Six-element Ilicis Purpureaes, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano sixteen ingredient Dongqingque medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Folium Ilicis Purpureae 100-200 part nanometer Punica granatum L. 15-40 part nanometer Gypsum Fibrosum 50-95 part
Nanometer Cortex Cinnamomi 30-70 part nanometer Fructus Amomi Rotundus 30-70 part nanometer Radix Aucklandiae 30-70 part
Nano clove 30-70 part nanometer Radix Glycyrrhizae 30-80 part nanometer Fructus Vins is done 80-200 part
Nanometer Lignum Aquilariae Resinatum 50-95 part nanometer Rhizoma Bistortae 50-95 part nanometer Fructus Piperis Longi 30-80 part
Nanometer Semen Myristicae 30-80 part nano safflower 30-80 part nanometer Fructus Choerospondiatis 30-80 part
Sea, nanometer side 30-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano sixteen ingredient Dongqingque medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Folium Ilicis Purpureae 120-180 part nanometer Punica granatum L. 20-30 part nanometer Gypsum Fibrosum 60-90 part
Nanometer Cortex Cinnamomi 40-60 part nanometer Fructus Amomi Rotundus 40-60 part nanometer Radix Aucklandiae 40-60 part
Nano clove 40-60 part nanometer Radix Glycyrrhizae 40-60 part nanometer Fructus Vins is done 100-150 part
Nanometer Lignum Aquilariae Resinatum 60-90 part nanometer Rhizoma Bistortae 60-90 part nanometer Fructus Piperis Longi 40-60 part
Nanometer Semen Myristicae 40-60 part nano safflower 40-60 part nanometer Fructus Choerospondiatis 40-60 part
Sea, nanometer side 40-60 part
3, nano sixteen ingredient Dongqingque medicine according to claim 1, wherein the weight proportion of each nano raw material is:
75 parts in 25 parts of nanometer Gypsum Fibrosum of 150 parts of nanometer Punica granatum L.s of nanometer Folium Ilicis Purpureae
50 parts of 50 parts of nanometer Radix Aucklandiae of 50 parts of nanometer Fructus Amomi Rotunduss of nanometer Cortex Cinnamomi
50 parts of nanometer Fructus Vins of 50 parts of nanometer Radix Glycyrrhizaes of nano clove are done 125 parts
50 parts of 75 parts of nanometer Fructus Piperis Longi of 75 parts of nanometer Rhizoma Bistortaes of nanometer Lignum Aquilariae Resinatum
50 parts of 50 parts of nanometer Fructus Choerospondiatis of 50 parts of nano safflowers of nanometer Semen Myristicae
50 parts in sea, nanometer side
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano sixteen ingredient Dongqingque medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano sixteen ingredient Dongqingque medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100264 CN1364490A (en) | 2001-01-12 | 2001-01-12 | Nano sixteen ingredient Dongqingque medicine and its preparing method |
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| CN 01100264 CN1364490A (en) | 2001-01-12 | 2001-01-12 | Nano sixteen ingredient Dongqingque medicine and its preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307978C (en) * | 2004-12-13 | 2007-04-04 | 北京正大绿洲医药科技有限公司 | Drop pill for diminishing inflammation in four seasons and its preparation method |
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2001
- 2001-01-12 CN CN 01100264 patent/CN1364490A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307978C (en) * | 2004-12-13 | 2007-04-04 | 北京正大绿洲医药科技有限公司 | Drop pill for diminishing inflammation in four seasons and its preparation method |
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