CN1366959A - Nano Tiaojing Cuyun preparation medicine and preparation method - Google Patents
Nano Tiaojing Cuyun preparation medicine and preparation method Download PDFInfo
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- CN1366959A CN1366959A CN 01102155 CN01102155A CN1366959A CN 1366959 A CN1366959 A CN 1366959A CN 01102155 CN01102155 CN 01102155 CN 01102155 A CN01102155 A CN 01102155A CN 1366959 A CN1366959 A CN 1366959A
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Abstract
The present ivnention discloses a nano Tiaojing Cuyun preparation medicine. It is made up by using 18 Chinese medicinal materials of nano velvet deerhorn, nano epimedium, nano curculigo, nano dipsacus, nano mistletoe and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to the nano Tiaojing Cuyun preparation medicine of a kind of kidney and spleen invigorating, nourishing blood for regulating menstruation, the invention still further relates to the method for this medication preparation.
TIAOJING CUYUN WAN is a kind of classical Chinese patent medicine, mainly contains effects such as kidney and spleen invigorating, nourishing blood for regulating menstruation, is used for irregular menstruation, irregular menstrual period, hypomenorrhea that deficiency of spleen-YANG and kidneyYANG causes, fails to be impregnated for a long time; Genus deficiency of spleen-YANG and kidneyYANG syndrome persons such as secondary amenorrhea, luteal function is not good enough, infertility.But traditional TIAOJING CUYUN WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Tiaojing Cuyun preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Tiaojing Cuyun preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano-antler 3-8 part nanometer Herba Epimedii 6-15 part nanometer Rhizoma Curculiginis 6-15 part
Nanometer Radix Dipsaci 6-15 part nanometer Herba Taxilli 6-15 part nanometer Semen Cuscutae 8-25 part
Nanometer Fructus Lycii 6-15 part nanometer Fructus Rubi 6-15 part nanometer Rhizoma Dioscoreae 20-45 part
Nanometer Semen Nelumbinis 6-15 part nano Poria 8-25 part nano astragalus 6-15 part
Nanometer Radix Paeoniae Alba 8-25 part nm acid Semen Ziziphi Spinosae 6-15 part nanometer Ramulus Uncariae Cum Uncis 6-15 part
Nano red sage 8-25 part nanometer Radix Paeoniae Rubra 8-25 part nanometer Caulis Spatholobi 20-45 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano-antler 4-6 part nanometer Herba Epimedii 8-12 part nanometer Rhizoma Curculiginis 8-12 part
Nanometer Radix Dipsaci 8-12 part nanometer Herba Taxilli 8-12 part nanometer Semen Cuscutae 10-20 part
Nanometer Fructus Lycii 8-12 part nanometer Fructus Rubi 8-12 part nanometer Rhizoma Dioscoreae 25-35 part
Nanometer Semen Nelumbinis 8-12 part nano Poria 10-20 part nano astragalus 8-12 part
Nanometer Radix Paeoniae Alba 10-20 part nm acid Semen Ziziphi Spinosae 8-12 part nanometer Ramulus Uncariae Cum Uncis 8-12 part
Nano red sage 10-20 part nanometer Radix Paeoniae Rubra 10-20 part nanometer Caulis Spatholobi 25-35 part
The optimum weight proportioning of medicine of the present invention is:
10 parts of 10 parts of nanometer Rhizoma Curculiginises of 5 parts of nanometer Herba Epimedii of nano-antler
15 parts of 10 parts of nanometer Semen Cuscutae of 10 parts of nanometer Herba Taxillis of nanometer Radix Dipsaci
30 parts of 10 parts of nanometer Rhizoma Dioscoreaes of 10 parts of nanometer Fructus Rubies of nanometer Fructus Lycii
10 parts of 15 parts of nano astragalus of 10 parts of nano Porias of nanometer Semen Nelumbinis
10 parts of 10 parts of nanometer Ramulus Uncariae Cum Uncis of 15 parts of nm acid Semen Ziziphi Spinosaes of the nanometer Radix Paeoniae Alba
30 parts of 15 parts of nanometer Caulis Spatholobis of 15 parts of nanometer Radix Paeoniae Rubra of nano red sage
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the menstruation regulating and pregnancy promoting preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Tiaojing Cuyun preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common TIAOJING CUYUN WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Tiaojing Cuyun preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for irregular menstruation, irregular menstrual period, hypomenorrhea that deficiency of spleen-YANG and kidneyYANG causes, fails to be impregnated for a long time; Treatment of conditions such as genus deficiency of spleen-YANG and kidneyYANG syndrome person such as secondary amenorrhea, luteal function is not good enough, infertility, clinical efficacy significantly is better than traditional TIAOJING CUYUN WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
10 parts of 10 parts of nanometer Rhizoma Curculiginises of 5 parts of nanometer Herba Epimedii of nano-antler
15 parts of 10 parts of nanometer Semen Cuscutae of 10 parts of nanometer Herba Taxillis of nanometer Radix Dipsaci
30 parts of 10 parts of nanometer Rhizoma Dioscoreaes of 10 parts of nanometer Fructus Rubies of nanometer Fructus Lycii
10 parts of 15 parts of nano astragalus of 10 parts of nano Porias of nanometer Semen Nelumbinis
10 parts of 10 parts of nanometer Ramulus Uncariae Cum Uncis of 15 parts of nm acid Semen Ziziphi Spinosaes of the nanometer Radix Paeoniae Alba
30 parts of 15 parts of nanometer Caulis Spatholobis of 15 parts of nanometer Radix Paeoniae Rubra of nano red sage
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
10 parts of 10 parts of nanometer Rhizoma Curculiginises of 5 parts of nanometer Herba Epimedii of nano-antler
15 parts of 10 parts of nanometer Semen Cuscutae of 10 parts of nanometer Herba Taxillis of nanometer Radix Dipsaci
30 parts of 10 parts of nanometer Rhizoma Dioscoreaes of 10 parts of nanometer Fructus Rubies of nanometer Fructus Lycii
10 parts of 15 parts of nano astragalus of 10 parts of nano Porias of nanometer Semen Nelumbinis
10 parts of 10 parts of nanometer Ramulus Uncariae Cum Uncis of 15 parts of nm acid Semen Ziziphi Spinosaes of the nanometer Radix Paeoniae Alba
30 parts of 15 parts of nanometer Caulis Spatholobis of 15 parts of nanometer Radix Paeoniae Rubra of nano red sage
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Tiaojing Cuyun powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
10 parts of 10 parts of nanometer Rhizoma Curculiginises of 5 parts of nanometer Herba Epimedii of nano-antler
15 parts of 10 parts of nanometer Semen Cuscutae of 10 parts of nanometer Herba Taxillis of nanometer Radix Dipsaci
30 parts of 10 parts of nanometer Rhizoma Dioscoreaes of 10 parts of nanometer Fructus Rubies of nanometer Fructus Lycii
10 parts of 15 parts of nano astragalus of 10 parts of nano Porias of nanometer Semen Nelumbinis
10 parts of 10 parts of nanometer Ramulus Uncariae Cum Uncis of 15 parts of nm acid Semen Ziziphi Spinosaes of the nanometer Radix Paeoniae Alba
30 parts of 15 parts of nanometer Caulis Spatholobis of 15 parts of nanometer Radix Paeoniae Rubra of nano red sage
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Tiaojing Cuyun membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano Tiaojing Cuyun preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano-antler 3-8 part nanometer Herba Epimedii 6-15 part nanometer Rhizoma Curculiginis 6-15 part
Nanometer Radix Dipsaci 6-15 part nanometer Herba Taxilli 6-15 part nanometer Semen Cuscutae 8-25 part
Nanometer Fructus Lycii 6-15 part nanometer Fructus Rubi 6-15 part nanometer Rhizoma Dioscoreae 20-45 part
Nanometer Semen Nelumbinis 6-15 part nano Poria 8-25 part nano astragalus 6-15 part
Nanometer Radix Paeoniae Alba 8-25 part nm acid Semen Ziziphi Spinosae 6-15 part nanometer Ramulus Uncariae Cum Uncis 6-15 part
Nano red sage 8-25 part nanometer Radix Paeoniae Rubra 8-25 part nanometer Caulis Spatholobi 20-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Tiaojing Cuyun preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano-antler 4-6 part nanometer Herba Epimedii 8-12 part nanometer Rhizoma Curculiginis 8-12 part
Nanometer Radix Dipsaci 8-12 part nanometer Herba Taxilli 8-12 part nanometer Semen Cuscutae 10-20 part
Nanometer Fructus Lycii 8-12 part nanometer Fructus Rubi 8-12 part nanometer Rhizoma Dioscoreae 25-35 part
Nanometer Semen Nelumbinis 8-12 part nano Poria 10-20 part nano astragalus 8-12 part
Nanometer Radix Paeoniae Alba 10-20 part nm acid Semen Ziziphi Spinosae 8-12 part nanometer Ramulus Uncariae Cum Uncis 8-12 part
Nano red sage 10-20 part nanometer Radix Paeoniae Rubra 10-20 part nanometer Caulis Spatholobi 25-35 part
3, nano Tiaojing Cuyun preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
10 parts of 10 parts of nanometer Rhizoma Curculiginises of 5 parts of nanometer Herba Epimedii of nano-antler
15 parts of 10 parts of nanometer Semen Cuscutae of 10 parts of nanometer Herba Taxillis of nanometer Radix Dipsaci
30 parts of 10 parts of nanometer Rhizoma Dioscoreaes of 10 parts of nanometer Fructus Rubies of nanometer Fructus Lycii
10 parts of 15 parts of nano astragalus of 10 parts of nano Porias of nanometer Semen Nelumbinis
10 parts of 10 parts of nanometer Ramulus Uncariae Cum Uncis of 15 parts of nm acid Semen Ziziphi Spinosaes of the nanometer Radix Paeoniae Alba
30 parts of 15 parts of nanometer Caulis Spatholobis of 15 parts of nanometer Radix Paeoniae Rubra of nano red sage
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Tiaojing Cuyun preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Tiaojing Cuyun preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| CN 01102155 CN1366959A (en) | 2001-01-20 | 2001-01-20 | Nano Tiaojing Cuyun preparation medicine and preparation method |
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| CN 01102155 CN1366959A (en) | 2001-01-20 | 2001-01-20 | Nano Tiaojing Cuyun preparation medicine and preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189356A (en) * | 2014-08-08 | 2014-12-10 | 成都中医药大学附属医院 | Pharmaceutical composition for treating infertility or performing adjuvant therapy on infertility and preparation method and application of pharmaceutical composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189356A (en) * | 2014-08-08 | 2014-12-10 | 成都中医药大学附属医院 | Pharmaceutical composition for treating infertility or performing adjuvant therapy on infertility and preparation method and application of pharmaceutical composition |
| CN104189356B (en) * | 2014-08-08 | 2017-09-08 | 成都中医药大学附属医院 | A kind of pharmaceutical composition for the treatment of or auxiliary treatment infertility and its production and use |
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