CN1366953A - Nano midday tea preparation medicine and preparation method - Google Patents

Nano midday tea preparation medicine and preparation method Download PDF

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Publication number
CN1366953A
CN1366953A CN 01102149 CN01102149A CN1366953A CN 1366953 A CN1366953 A CN 1366953A CN 01102149 CN01102149 CN 01102149 CN 01102149 A CN01102149 A CN 01102149A CN 1366953 A CN1366953 A CN 1366953A
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nanometer
parts
nano
part nanometer
radix
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杨孟君
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Abstract

The present invention discloses a nano midday tea preparation medicine. It is made up by using 19 Chinese medicinal materials of nano atractylodes, nano bupleurum, nano notopterygium, nano ledebouriella, nano angelica and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.

Description

Nano midday tea preparation medicine and preparation method thereof
The present invention relates to a kind of separating in the harmony in the exterior, cure mainly be affected by the cold, nano midday tea preparation medicine that internal injury food stagnation, cold and heat are vomited and diarrhoea, the invention still further relates to the method for this medication preparation.
Wushicha granules is a kind of classical Chinese patent medicine, mainly contains to separate the medium effect of harmony in the exterior, be used to be affected by the cold, and the internal injury food stagnation, cold and heat are vomited and diarrhoea.But traditional wushicha granules absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano midday tea preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano midday tea preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Atractylodis 20-45 part nano bupleurum 20-40 part nanometer Rhizoma Et Radix Notopterygii 20-40 part
Nanometer Radix Saposhnikoviae 20-45 part nano angelica root 20-45 part nanometer Rhizoma Chuanxiong 20-45 part
Nanometer Herba Pogostemonis 20-45 part nanometer Radix Peucedani 20-45 part nanometer Fructus Forsythiae 20-45 part
Nanometer Pericarpium Citri Reticulatae 20-45 part nanometer Fructus Crataegi 20-45 part nanometer Fructus Aurantii Immaturus 20-45 part
Nanometer Fructus Hordei Germinatus 25-70 part nanometer Radix Glycyrrhizae 20-45 part nanometer Radix Platycodonis 30-65 part
Nanometer Massa Medicata Fermentata 20-45 part nanometer Folium Perillae 30-60 part nanometer Cortex Magnoliae Officinalis 30-65 part
Nanometer black tea 700-1500 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Atractylodis 25-35 part nano bupleurum 25-35 part nanometer Rhizoma Et Radix Notopterygii 25-35 part
Nanometer Radix Saposhnikoviae 25-35 part nano angelica root 25-35 part nanometer Rhizoma Chuanxiong 25-35 part
Nanometer Herba Pogostemonis 25-35 part nanometer Radix Peucedani 25-35 part nanometer Fructus Forsythiae 25-35 part
Nanometer Pericarpium Citri Reticulatae 25-35 part nanometer Fructus Crataegi 25-35 part nanometer Fructus Aurantii Immaturus 25-35 part
Nanometer Fructus Hordei Germinatus 30-60 part nanometer Radix Glycyrrhizae 25-35 part nanometer Radix Platycodonis 35-55 part
Nanometer Massa Medicata Fermentata 25-35 part nanometer Folium Perillae 35-55 part nanometer Cortex Magnoliae Officinalis 35-55 part
Nanometer black tea 800-1200 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nano bupleurums of nanometer Rhizoma Atractylodis
30 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 30 parts of nano angelica roots of nanometer Radix Saposhnikoviae
30 parts of 30 parts of nanometer Fructus Forsythiaes of 30 parts of nanometer Radix Peucedanis of nanometer Herba Pogostemonis
30 parts of 30 parts of nanometer Fructus Aurantii Immaturuss of 30 parts of nanometer Fructus Crataegis of nanometer Pericarpium Citri Reticulatae
45 parts of 30 parts of nanometer Radix Platycodoniss of 45 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
45 parts of 45 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer Folium Perillaes of nanometer Massa Medicata Fermentata
960 parts of nanometer black tea
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the tea formulation nano powder period of the day from 11 a.m. to 1 p.m with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano midday tea preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common wushicha granules preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano midday tea preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for being affected by the cold, the internal injury food stagnation, and treatment of conditions such as cold and heat vomiting and diarrhoea, clinical efficacy significantly is better than traditional wushicha granules.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nano bupleurums of nanometer Rhizoma Atractylodis
30 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 30 parts of nano angelica roots of nanometer Radix Saposhnikoviae
30 parts of 30 parts of nanometer Fructus Forsythiaes of 30 parts of nanometer Radix Peucedanis of nanometer Herba Pogostemonis
30 parts of 30 parts of nanometer Fructus Aurantii Immaturuss of 30 parts of nanometer Fructus Crataegis of nanometer Pericarpium Citri Reticulatae
45 parts of 30 parts of nanometer Radix Platycodoniss of 45 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
45 parts of 45 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer Folium Perillaes of nanometer Massa Medicata Fermentata
960 parts of nanometer black tea
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nano bupleurums of nanometer Rhizoma Atractylodis
30 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 30 parts of nano angelica roots of nanometer Radix Saposhnikoviae
30 parts of 30 parts of nanometer Fructus Forsythiaes of 30 parts of nanometer Radix Peucedanis of nanometer Herba Pogostemonis
30 parts of 30 parts of nanometer Fructus Aurantii Immaturuss of 30 parts of nanometer Fructus Crataegis of nanometer Pericarpium Citri Reticulatae
45 parts of 30 parts of nanometer Radix Platycodoniss of 45 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
45 parts of 45 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer Folium Perillaes of nanometer Massa Medicata Fermentata
960 parts of nanometer black tea
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano midday tea powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nano bupleurums of nanometer Rhizoma Atractylodis
30 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 30 parts of nano angelica roots of nanometer Radix Saposhnikoviae
30 parts of 30 parts of nanometer Fructus Forsythiaes of 30 parts of nanometer Radix Peucedanis of nanometer Herba Pogostemonis
30 parts of 30 parts of nanometer Fructus Aurantii Immaturuss of 30 parts of nanometer Fructus Crataegis of nanometer Pericarpium Citri Reticulatae
45 parts of 30 parts of nanometer Radix Platycodoniss of 45 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
45 parts of 45 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer Folium Perillaes of nanometer Massa Medicata Fermentata
960 parts of nanometer black tea
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano midday tea membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.

Claims (6)

1, a kind of nano midday tea preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Atractylodis 20-45 part nano bupleurum 20-40 part nanometer Rhizoma Et Radix Notopterygii 20-40 part
Nanometer Radix Saposhnikoviae 20-45 part nano angelica root 20-45 part nanometer Rhizoma Chuanxiong 20-45 part
Nanometer Herba Pogostemonis 20-45 part nanometer Radix Peucedani 20-45 part nanometer Fructus Forsythiae 20-45 part
Nanometer Pericarpium Citri Reticulatae 20-45 part nanometer Fructus Crataegi 20-45 part nanometer Fructus Aurantii Immaturus 20-45 part
Nanometer Fructus Hordei Germinatus 25-70 part nanometer Radix Glycyrrhizae 20-45 part nanometer Radix Platycodonis 30-65 part
Nanometer Massa Medicata Fermentata 20-45 part nanometer Folium Perillae 30-60 part nanometer Cortex Magnoliae Officinalis 30-65 part
Nanometer black tea 700-1500 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano midday tea preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Atractylodis 25-35 part nano bupleurum 25-35 part nanometer Rhizoma Et Radix Notopterygii 25-35 part
Nanometer Radix Saposhnikoviae 25-35 part nano angelica root 25-35 part nanometer Rhizoma Chuanxiong 25-35 part
Nanometer Herba Pogostemonis 25-35 part nanometer Radix Peucedani 25-35 part nanometer Fructus Forsythiae 25-35 part
Nanometer Pericarpium Citri Reticulatae 25-35 part nanometer Fructus Crataegi 25-35 part nanometer Fructus Aurantii Immaturus 25-35 part
Nanometer Fructus Hordei Germinatus 30-60 part nanometer Radix Glycyrrhizae 25-35 part nanometer Radix Platycodonis 35-55 part
Nanometer Massa Medicata Fermentata 25-35 part nanometer Folium Perillae 35-55 part nanometer Cortex Magnoliae Officinalis 35-55 part
Nanometer black tea 800-120 part
3, nano midday tea preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of 30 parts of nano bupleurums of nanometer Rhizoma Atractylodis
30 parts of 30 parts of nanometer Rhizoma Chuanxiongs of 30 parts of nano angelica roots of nanometer Radix Saposhnikoviae
30 parts of 30 parts of nanometer Fructus Forsythiaes of 30 parts of nanometer Radix Peucedanis of nanometer Herba Pogostemonis
30 parts of 30 parts of nanometer Fructus Aurantii Immaturuss of 30 parts of nanometer Fructus Crataegis of nanometer Pericarpium Citri Reticulatae
45 parts of 30 parts of nanometer Radix Platycodoniss of 45 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Hordei Germinatus
45 parts of 45 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer Folium Perillaes of nanometer Massa Medicata Fermentata
960 parts of nanometer black tea
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano midday tea preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano midday tea preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
CN 01102149 2001-01-20 2001-01-20 Nano midday tea preparation medicine and preparation method Pending CN1366953A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314436C (en) * 2004-11-23 2007-05-09 武汉理工大学 Noontime tea volatile oil-beta cyclo dextrin inclusion compound and its preparation technology
CN103315086A (en) * 2013-07-03 2013-09-25 卢桂珍 Health-preserving tea
CN106135516A (en) * 2015-04-07 2016-11-23 王志凤 A kind of purple perilla and ledebouriella root tea

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314436C (en) * 2004-11-23 2007-05-09 武汉理工大学 Noontime tea volatile oil-beta cyclo dextrin inclusion compound and its preparation technology
CN103315086A (en) * 2013-07-03 2013-09-25 卢桂珍 Health-preserving tea
CN103315086B (en) * 2013-07-03 2014-06-25 黄莉莉 Health-preserving tea
CN106135516A (en) * 2015-04-07 2016-11-23 王志凤 A kind of purple perilla and ledebouriella root tea

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