CN1368161A - Nano medicine 'Jieyuhegan' and its preparing process - Google Patents
Nano medicine 'Jieyuhegan' and its preparing process Download PDFInfo
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- CN1368161A CN1368161A CN 01102398 CN01102398A CN1368161A CN 1368161 A CN1368161 A CN 1368161A CN 01102398 CN01102398 CN 01102398 CN 01102398 A CN01102398 A CN 01102398A CN 1368161 A CN1368161 A CN 1368161A
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Abstract
A nanometre (0.1-200 nm) medicine for regulating circulation of liver Qi is prepared from the nanometre powders of 20 Chinese medicinal materials including bupleurum root, Chinese angelica root, white peony root, liquorice root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nanometer resolving depression regulating liver-QI preparation medicine of a kind of soothing liver-QI dissipating depression of QI, pleasant relieving distension, the invention still further relates to the method for this medication preparation.
Resolving depression regulating liver-QI ball is a kind of classical Chinese patent medicine, mainly contains effects such as soothing liver-QI dissipating depression of QI, pleasant relieving distension, is used for breast side of body string pain, distension and fullness in the abdomen, acid regurgitation and epigastric upset, anorexia that stagnation of QI due to depression of the liver causes.But traditional resolving depression regulating liver-QI ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer resolving depression regulating liver-QI preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer resolving depression regulating liver-QI preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bupleurum 60-150 part nano Chinese angelica 500-900 part nanometer Radix Paeoniae Alba 350-600 part
Nanometer Rhizoma Atractylodis 150-550 part nano Poria 100-250 part nanometer Radix Glycyrrhizae 50-95 part
Nano cyperus tuber 350-800 part nanometer Radix Aucklandiae 100-200 part nanometer Pericarpium Citri Reticulatae Viride 100-200 part
Nanometer Pericarpium Citri Reticulatae 100-200 part nanometer Fructus Amomi 60-150 part nanometer Cortex Magnoliae Officinalis 100-200 part
Nanometer Fructus Aurantii 100-200 part is received and is fried Radix Curcumae 100-200 part nanometer Rhizoma Chuanxiong 200-400 part
Nanometer Fructus Crataegi 300-650 part nanometer Massa Medicata Fermentata 300-600 part nanometer Rhizoma Pinelliae Preparatum 200-400 part
Nanometer Fructus Gardeniae 500-900 part nanometer Radix Scutellariae 100-200 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano bupleurum 80-120 part nano Chinese angelica 600-800 part nanometer Radix Paeoniae Alba 400-500 part
Nanometer Rhizoma Atractylodis 200-450 part nano Poria 120-180 part nanometer Radix Glycyrrhizae 60-90 part
Nano cyperus tuber 400-600 part nanometer Radix Aucklandiae 120-180 part nanometer Pericarpium Citri Reticulatae Viride 120-180 part
Nanometer Pericarpium Citri Reticulatae 120-180 part nanometer Fructus Amomi 80-120 part nanometer Cortex Magnoliae Officinalis 120-180 part
Nanometer Fructus Aurantii 120-180 part is received and is fried Radix Curcumae 120-180 part nanometer Rhizoma Chuanxiong 250-350 part
Nanometer Fructus Crataegi 350-550 part nanometer Massa Medicata Fermentata 350-550 part nanometer Rhizoma Pinelliae Preparatum 250-350 part
Nanometer Fructus Gardeniae 600-800 part nanometer Radix Scutellariae 120-180 part
The optimum weight proportioning of medicine of the present invention is:
450 parts of 690 parts of nanometer Radix Paeoniae Albas of 97.5 parts of nano Chinese angelicas of nano bupleurum
75 parts in 150 parts of nanometer Radix Glycyrrhizaes of 277.5 parts of nano Porias of nanometer Rhizoma Atractylodis
180 parts on 150 parts of nanometer Pericarpium Citri Reticulatae Virides of 510 parts of nanometer Radix Aucklandiae of nano cyperus tuber
150 parts of 97 5 parts of nanometer Cortex Magnoliae Officinalis of 150 parts of nanometer Fructus Amomis of nanometer Pericarpium Citri Reticulatae
The nanometer Fructus Aurantii receives for 150 parts fries 277 5 parts of 150 parts of nanometer Rhizoma Chuanxiongs of Radix Curcumae
277.5 parts of 450 parts of nanometer Rhizoma Pinelliae Preparatum of 450 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
150 parts of 690 parts of nanometer Radix Scutellariaes of nanometer Fructus Gardeniae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get resolving depression and hepar nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer resolving depression regulating liver-QI preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common resolving depression regulating liver-QI pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer resolving depression regulating liver-QI preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as breast side of body string pain that stagnation of QI due to depression of the liver causes, distension and fullness in the abdomen, acid regurgitation and epigastric upset, anorexia, and clinical efficacy significantly is better than traditional resolving depression regulating liver-QI ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
450 parts of 690 parts of nanometer Radix Paeoniae Albas of 97.5 parts of nano Chinese angelicas of nano bupleurum
75 parts in 150 parts of nanometer Radix Glycyrrhizaes of 277.5 parts of nano Porias of nanometer Rhizoma Atractylodis
180 parts on 150 parts of nanometer Pericarpium Citri Reticulatae Virides of 510 parts of nanometer Radix Aucklandiae of nano cyperus tuber
150 parts of 97.5 parts of nanometer Cortex Magnoliae Officinalis of 150 parts of nanometer Fructus Amomis of nanometer Pericarpium Citri Reticulatae
The nanometer Fructus Aurantii receives for 150 parts fries 277.5 parts of 150 parts of nanometer Rhizoma Chuanxiongs of Radix Curcumae
277.5 parts of 450 parts of nanometer Rhizoma Pinelliae Preparatum of 450 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
150 parts of 690 parts of nanometer Radix Scutellariaes of nanometer Fructus Gardeniae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
450 parts of 690 parts of nanometer Radix Paeoniae Albas of 97.5 parts of nano Chinese angelicas of nano bupleurum
75 parts in 150 parts of nanometer Radix Glycyrrhizaes of 277.5 parts of nano Porias of nanometer Rhizoma Atractylodis
180 parts on 150 parts of nanometer Pericarpium Citri Reticulatae Virides of 510 parts of nanometer Radix Aucklandiae of nano cyperus tuber
150 parts of 97.5 parts of nanometer Cortex Magnoliae Officinalis of 150 parts of nanometer Fructus Amomis of nanometer Pericarpium Citri Reticulatae
The nanometer Fructus Aurantii receives for 150 parts fries 277.5 parts of 150 parts of nanometer Rhizoma Chuanxiongs of Radix Curcumae
277.5 parts of 450 parts of nanometer Rhizoma Pinelliae Preparatum of 450 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
150 parts of 690 parts of nanometer Radix Scutellariaes of nanometer Fructus Gardeniae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer resolving depression regulating liver-QI powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
450 parts of 690 parts of nanometer Radix Paeoniae Albas of 97.5 parts of nano Chinese angelicas of nano bupleurum
75 parts in 150 parts of nanometer Radix Glycyrrhizaes of 277.5 parts of nano Porias of nanometer Rhizoma Atractylodis
180 parts on 150 parts of nanometer Pericarpium Citri Reticulatae Virides of 510 parts of nanometer Radix Aucklandiae of nano cyperus tuber
150 parts of 97.5 parts of nanometer Cortex Magnoliae Officinalis of 150 parts of nanometer Fructus Amomis of nanometer Pericarpium Citri Reticulatae
The nanometer Fructus Aurantii receives for 150 parts fries 277.5 parts of 150 parts of nanometer Rhizoma Chuanxiongs of Radix Curcumae
277.5 parts of 450 parts of nanometer Rhizoma Pinelliae Preparatum of 450 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
150 parts of 690 parts of nanometer Radix Scutellariaes of nanometer Fructus Gardeniae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer resolving depression regulating liver-QI membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer resolving depression regulating liver-QI preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano bupleurum 60-150 part nano Chinese angelica 500-900 part nanometer Radix Paeoniae Alba 350-600 part
Nanometer Rhizoma Atractylodis 150-550 part nano Poria 100-250 part nanometer Radix Glycyrrhizae 50-95 part
Nano cyperus tuber 350-800 part nanometer Radix Aucklandiae 100-200 part nanometer Pericarpium Citri Reticulatae Viride 100-200 part
Nanometer Pericarpium Citri Reticulatae 100-200 part nanometer Fructus Amomi 60-150 part nanometer Cortex Magnoliae Officinalis 100-200 part
Nanometer Fructus Aurantii 100-200 part is received and is fried Radix Curcumae 100-200 part nanometer Rhizoma Chuanxiong 200-400 part
Nanometer Fructus Crataegi 300-650 part nanometer Massa Medicata Fermentata 300-600 part nanometer Rhizoma Pinelliae Preparatum 200-400 part
Nanometer Fructus Gardeniae 500-900 part nanometer Radix Scutellariae 100-200 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, make it do the change in polarity motion with hundred million times/second speed of 20--30, the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour: above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer resolving depression regulating liver-QI preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bupleurum 80-120 part nano Chinese angelica 600-800 part nanometer Radix Paeoniae Alba 400-500 part
Nanometer Rhizoma Atractylodis 200-450 part nano Poria 120-180 part nanometer Radix Glycyrrhizae 60-90 part
Nano cyperus tuber 400-600 part nanometer Radix Aucklandiae 120-180 part nanometer Pericarpium Citri Reticulatae Viride 120-180 part
Nanometer Pericarpium Citri Reticulatae 120-180 part nanometer Fructus Amomi 80-120 part nanometer Cortex Magnoliae Officinalis 120-180 part
Nanometer Fructus Aurantii 120-180 part is received and is fried Radix Curcumae 120-180 part nanometer Rhizoma Chuanxiong 250-350 part
Nanometer Fructus Crataegi 350-550 part nanometer Massa Medicata Fermentata 350-550 part nanometer Rhizoma Pinelliae Preparatum 250-350 part
Nanometer Fructus Gardeniae 600-800 part nanometer Radix Scutellariae 120-180 part
3, nanometer resolving depression regulating liver-QI preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
450 parts of 690 parts of nanometer Radix Paeoniae Albas of 97.5 parts of nano Chinese angelicas of nano bupleurum
75 parts in 150 parts of nanometer Radix Glycyrrhizaes of 277.5 parts of nano Porias of nanometer Rhizoma Atractylodis
180 parts on 150 parts of nanometer Pericarpium Citri Reticulatae Virides of 510 parts of nanometer Radix Aucklandiae of nano cyperus tuber
150 parts of 97.5 parts of nanometer Cortex Magnoliae Officinalis of 150 parts of nanometer Fructus Amomis of nanometer Pericarpium Citri Reticulatae
The nanometer Fructus Aurantii receives for 150 parts fries 277.5 parts of 150 parts of nanometer Rhizoma Chuanxiongs of Radix Curcumae
277.5 parts of 450 parts of nanometer Rhizoma Pinelliae Preparatum of 450 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
150 parts of 690 parts of nanometer Radix Scutellariaes of nanometer Fructus Gardeniae
4, according to claim 1 or 2 or 3 described nanometer resolving depression regulating liver-QI preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer resolving depression regulating liver-QI preparation medicines, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs: place extraction pot, solubilizer also imports microwave extracting, make it do the change in polarity motion with hundred million times/second speed of 20--30, the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102398 CN1368161A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Jieyuhegan' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102398 CN1368161A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Jieyuhegan' and its preparing process |
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| Publication Number | Publication Date |
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| CN1368161A true CN1368161A (en) | 2002-09-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 01102398 Pending CN1368161A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Jieyuhegan' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389519A (en) * | 2011-11-01 | 2012-03-28 | 文登市口腔医院米山路口腔诊所 | Traditional Chinese medicine used for treating abnormal sensations of throat |
| CN103386089A (en) * | 2013-07-24 | 2013-11-13 | 赵世明 | Chinese medicine composition for treating liver-stomach disharmony |
-
2001
- 2001-02-02 CN CN 01102398 patent/CN1368161A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389519A (en) * | 2011-11-01 | 2012-03-28 | 文登市口腔医院米山路口腔诊所 | Traditional Chinese medicine used for treating abnormal sensations of throat |
| CN102389519B (en) * | 2011-11-01 | 2013-10-09 | 刘运波 | Traditional Chinese medicine used for treating abnormal sensations of throat |
| CN103386089A (en) * | 2013-07-24 | 2013-11-13 | 赵世明 | Chinese medicine composition for treating liver-stomach disharmony |
| CN103386089B (en) * | 2013-07-24 | 2015-04-22 | 许高山 | Chinese medicine composition for treating liver-stomach disharmony |
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