CN1368145A - Nano medicine 'Gengnianshu' and its preparing process - Google Patents
Nano medicine 'Gengnianshu' and its preparing process Download PDFInfo
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- CN1368145A CN1368145A CN 01102377 CN01102377A CN1368145A CN 1368145 A CN1368145 A CN 1368145A CN 01102377 CN01102377 CN 01102377 CN 01102377 A CN01102377 A CN 01102377A CN 1368145 A CN1368145 A CN 1368145A
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Abstract
A nanometre (0.1-200 nm) medicine "Gengnianshu" for treating climacteric disease is prepared from the nanometre powders of VB6 and 15 Chinese medicinal materials including prepared nehmannia root, tortoise plastron, yam, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of nourishing the liver and kidney, replenishing YIN and blood, cure mainly the nano medicine ' Gengnianshu ' of the climacteric menoxenia that causes of obstacle, giddy, cardiopalmus, insomnia etc., the invention still further relates to the method for this medication preparation.
The climacteric sheet that relaxes is a kind of classical Chinese patent medicine, mainly contains effects such as nourishing the liver and kidney, replenishing YIN and blood, blood stasis dispelling regulating menstruation, regulating QI the kidney warming, trophic nerve, adjusting metabolic function, is used for the climacteric menoxenia that causes of obstacle, giddy, cardiopalmus, insomnia etc.But the easypro sheet disintegrate of traditional climacteric is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Gengnianshu ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Gengnianshu '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Rehmanniae Preparata 120-300 part nano tortoise plastron 120-300 part nanometer Rhizoma Dioscoreae 220-500 part
Nano deerhorn frost 120-300 part nanometer Fructus Schisandrae Chinensis 70-200 part nanometer Cortex Moutan 70-200 part
Nanometer motherwort 220-450 part nanometer Folium Artemisiae Argyi 70-200 part nanometer Rhizoma Alismatis 80-200 part
Nano ass hide glue 40-90 part nano Poria 150-400 part nanometer Fructus Amomi 150-400 part
Nanometer Herba Epimedii 120-300 part nanometer oryzanol 1-5 part nano Chinese angelica 100-300 part
The nanometer vitamin B
60.1-2 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Rehmanniae Preparata 150-250 part nano tortoise plastron 150-250 part nanometer Rhizoma Dioscoreae 250-450 part
Nano deerhorn frost 150-250 part nanometer Fructus Schisandrae Chinensis 90-180 part nanometer Cortex Moutan 90-180 part
Nanometer motherwort 250-400 part nanometer Folium Artemisiae Argyi 90-180 part nanometer Rhizoma Alismatis 90-180 part
Nano ass hide glue 50-80 part nano Poria 200-300 part nanometer Fructus Amomi 200-300 part
Nanometer Herba Epimedii 150-250 part nanometer oryzanol 1-3 part nano Chinese angelica 150-250 part
The nanometer vitamin B
60.5-1 part
The optimum weight proportioning of medicine of the present invention is:
333 parts of 200 parts of nanometer Rhizoma Dioscoreaes of 200 parts of nano tortoise plastrons of nanometer Radix Rehmanniae Preparata
133 parts of 133 parts of nanometer Cortex Moutans of nano deerhorn 200 parts of nanometer Fructus Schisandrae Chinensis of frost
133 parts of 133 parts of nanometer Rhizoma Alismatis of 333 parts of nanometer Folium Artemisiae Argyis of nanometer motherwort
230 parts of 230 parts of nanometer Fructus Amomis of 67 parts of nano Porias of nano ass hide glue
200 parts of 2 parts of nano Chinese angelicas of 200 parts of nanometer oryzanol of nanometer Herba Epimedii
The nanometer vitamin B
60.7 part
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the easypro preparation nano powder of climacteric with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Gengnianshu ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the easypro tablet preparation material of common climacteric is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Gengnianshu ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as the climacteric menoxenia that causes of obstacle, giddy, cardiopalmus, insomnia, and clinical efficacy significantly is better than traditional climacteric sheet that relaxes.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
333 parts of 200 parts of nanometer Rhizoma Dioscoreaes of 200 parts of nano tortoise plastrons of nanometer Radix Rehmanniae Preparata
133 parts of 133 parts of nanometer Cortex Moutans of nano deerhorn 200 parts of nanometer Fructus Schisandrae Chinensis of frost
133 parts of 133 parts of nanometer Rhizoma Alismatis of 333 parts of nanometer Folium Artemisiae Argyis of nanometer motherwort
230 parts of 230 parts of nanometer Fructus Amomis of 67 parts of nano Porias of nano ass hide glue
200 parts of 2 parts of nano Chinese angelicas of 200 parts of nanometer oryzanol of nanometer Herba Epimedii
The nanometer vitamin B
60.7 part
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
333 parts of 200 parts of nanometer Rhizoma Dioscoreaes of 200 parts of nano tortoise plastrons of nanometer Radix Rehmanniae Preparata
133 parts of 133 parts of nanometer Cortex Moutans of nano deerhorn 200 parts of nanometer Fructus Schisandrae Chinensis of frost
133 parts of 133 parts of nanometer Rhizoma Alismatis of 333 parts of nanometer Folium Artemisiae Argyis of nanometer motherwort
230 parts of 230 parts of nanometer Fructus Amomis of 67 parts of nano Porias of nano ass hide glue
200 parts of 2 parts of nano Chinese angelicas of 200 parts of nanometer oryzanol of nanometer Herba Epimedii
The nanometer vitamin B
60.7 part
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making relax powder needle injection, every injection content of nanometer climacteric is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
333 parts of 200 parts of nanometer Rhizoma Dioscoreaes of 200 parts of nano tortoise plastrons of nanometer Radix Rehmanniae Preparata
133 parts of 133 parts of nanometer Cortex Moutans of nano deerhorn 200 parts of nanometer Fructus Schisandrae Chinensis of frost
133 parts of 133 parts of nanometer Rhizoma Alismatis of 333 parts of nanometer Folium Artemisiae Argyis of nanometer motherwort
230 parts of 230 parts of nanometer Fructus Amomis of 67 parts of nano Porias of nano ass hide glue
200 parts of 2 parts of nano Chinese angelicas of 200 parts of nanometer oryzanol of nanometer Herba Epimedii
The nanometer vitamin B
60.7 part
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the easypro membrane of nanometer climacteric, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Gengnianshu ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Rehmanniae Preparata 120-300 part nano tortoise plastron 120-300 part nanometer Rhizoma Dioscoreae 220-500 part
Nano deerhorn frost 120-300 part nanometer Fructus Schisandrae Chinensis 70-200 part nanometer Cortex Moutan 70-200 part
Nanometer motherwort 220-450 part nanometer Folium Artemisiae Argyi 70-200 part nanometer Rhizoma Alismatis 80-200 part
Nano ass hide glue 40-90 part nano Poria 150-400 part nanometer Fructus Amomi 150-400 part
Nanometer Herba Epimedii 120-300 part nanometer oryzanol 1-5 part nano Chinese angelica 100-300 part
The nanometer vitamin B
60.1-2 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Gengnianshu ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Rehmanniae Preparata 150-250 part nano tortoise plastron 150-250 part nanometer Rhizoma Dioscoreae 250-450 part
Nano deerhorn frost 150-250 part nanometer Fructus Schisandrae Chinensis 90-180 part nanometer Cortex Moutan 90-180 part
Nanometer motherwort 250-400 part nanometer Folium Artemisiae Argyi 90-180 part nanometer Rhizoma Alismatis 90-180 part
Nano ass hide glue 50-80 part nano Poria 200-300 part nanometer Fructus Amomi 200-300 part
Nanometer Herba Epimedii 150-250 part nanometer oryzanol 1-3 part nano Chinese angelica 150-250 part
The nanometer vitamin B
60.5-1 part
3, nano medicine ' Gengnianshu ' according to claim 1, wherein the weight proportion of each nano raw material is:
333 parts of 200 parts of nanometer Rhizoma Dioscoreaes of 200 parts of nano tortoise plastrons of nanometer Radix Rehmanniae Preparata
133 parts of 133 parts of nanometer Cortex Moutans of nano deerhorn 200 parts of nanometer Fructus Schisandrae Chinensis of frost
133 parts of 133 parts of nanometer Rhizoma Alismatis of 333 parts of nanometer Folium Artemisiae Argyis of nanometer motherwort
230 parts of 230 parts of nanometer Fructus Amomis of 67 parts of nano Porias of nano ass hide glue
200 parts of 2 parts of nano Chinese angelicas of 200 parts of nanometer oryzanol of nanometer Herba Epimedii
The nanometer vitamin B
60.7 part
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Gengnianshu 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Gengnianshu 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102377 CN1368145A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Gengnianshu' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102377 CN1368145A (en) | 2001-02-02 | 2001-02-02 | Nano medicine 'Gengnianshu' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344308C (en) * | 2003-04-28 | 2007-10-24 | 浙江大学药业有限公司 | Antisenescing and immunoregulating Chinese and Western medicinal mixture |
| CN101143185B (en) * | 2007-07-18 | 2011-05-04 | 广州中医药大学 | Medicinal composition capable of anti-senility during menopausal syndrome |
-
2001
- 2001-02-02 CN CN 01102377 patent/CN1368145A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344308C (en) * | 2003-04-28 | 2007-10-24 | 浙江大学药业有限公司 | Antisenescing and immunoregulating Chinese and Western medicinal mixture |
| CN101143185B (en) * | 2007-07-18 | 2011-05-04 | 广州中医药大学 | Medicinal composition capable of anti-senility during menopausal syndrome |
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