CN100344308C - Antisenescing and immunoregulating Chinese and Western medicinal mixture - Google Patents
Antisenescing and immunoregulating Chinese and Western medicinal mixture Download PDFInfo
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- CN100344308C CN100344308C CNB031167225A CN03116722A CN100344308C CN 100344308 C CN100344308 C CN 100344308C CN B031167225 A CNB031167225 A CN B031167225A CN 03116722 A CN03116722 A CN 03116722A CN 100344308 C CN100344308 C CN 100344308C
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- vitamin
- rhizoma dioscoreae
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- oryzanol
- herba epimedii
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a mixed preparation of traditional Chinese medicine and western medicine for resisting senility and adjusting immunity, which is prepared from the following raw medicine materials (wt. %): 8 to 15 wt. % of glossy privet fruit, 6 to 13 wt. % of epimedium herb and 3 to 5 wt. % of Chinese yam, wherein the raw medicine materials also contain western medicine oryzanol, vitamin B6 and vitamin B1. The present invention has the preparation method: after the glossy privet fruit, the epimedium herb, part of Chinese yam are proportionally mixed, purified water is added; by the heat preservation extraction of vapor, aqueous extract extractum is prepared into a solid substance through spray drying; the residual Chinese yam is pulverized, sieved and baked into Chinese yam powder; the solid substance, the Chinese yam powder and the dried fine powder of the oryzanol, the vitamin B6 the vitamin B1 are processed by even mixing and sterilization and are prepared into a preparation. The mixed preparation of traditional Chinese medicine and western medicine of the present invention has health care function for delay aging, immunological regulation and the relief of climacteric syndromes of women.
Description
(1) technical field: the present invention relates to a kind of is the Pharmaceutical composition that is used for slow down aging, immunomodulating and alleviation climacteric syndrome that raw material is made with Chinese herbal medicine and vitamin.
(2) background technology: modern Chinese medicine research is thought, senilism or old and feeble various crowds are because factor affecting such as body constitution, environment, life, spirit, diseases, kidney qi fails gradually, essence and blood is obviously not enough, the imbalance of YIN and YANG that causes kidney, then cause each function to be degenerated or disorder, cause geromorphism or aging.Motherland's medical science is thought, kidney controlling essence storage, and liver storing blood, The liver and the kidney have a common source, and essence and blood sharing the same origin grows mutually.
The research of the traditional Chinese medical science aspect slow down aging is with a long history, thinks that the prosperity and decline of kidney qi plays a decisive role to it.Kidney be internal organs this, Source of life has the title of " root of life ".Kidney qi fills the person, and is slowly old and feeble; The short person of kidney qi, the old and feeble acceleration.The agent of Chinese medicine the kidney invigorating, but tonification human body kidney qi keep the human body kidney qi full, slow down aging.
The present invention is that primary raw material is equipped with Western medicine oryzanol, vitamin B by liver and kidney tonifying, nourishing YIN and benefiting blood, defying age, immunoregulatory Chinese herbal medicine extract
6, vitamin B
1Refining forming.Fructus Ligustri Lucidi is the dry mature fruit of sweet-scented osmanthus plant Fructus Ligustri Lucidi Ligustrum Iucidum Ait in the prescription.Nature and flavor are sweet, bitter, cool, have nourishing the liver and kidney, a function of the black hair that makes eye bright, and modern pharmacological research shows the activity that can significantly improve mouse liver SOD at advanced age, suppress the formation of brain malonaldehyde (MDA), have anti-aging effects and strengthen humoral immune function.
Herba Epimedii is Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim.; arrow leaf Herba Epimedii Epimedium Sagittatum (sieb.et Zuce.); Maxim.; pubescence Herba Epimedii Epimediumpubescens maxim.; the dry aerial parts of Epimedium wushanense Epmedium wusbanebse T.S.Ying or Herba Epimedii Epimedium koreanum Nakai; the nature and flavor suffering; sweet; temperature; has kidney-replenishing; bone and muscle strengthening; the effect of wind-damp dispelling; main component is an icariine; flavone etc.; modern pharmacological research shows to have immunomodulating; antioxidation and delaying senility function; Herba Epimedii has the activity that improves body liver superoxide dismutase; reduce the formation of liver lipid peroxide; and the minimizing heart; the fat brown pigment of tissue such as liver forms; eliminated free radical; protect cell to exempt from the oxygen-derived free radicals infringement, and then delayed the aging of organ and whole machine body.
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Dioscorea opposita Thunb., and nature and flavor are sweet, flat, has the spleen reinforcing nourishing the stomach, a lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission function.Compositions such as mainly starch-containing, phlegmatic temperament, choline, glycoprotein, polysaccharide.Modern pharmacological research shows that it has adjusting and raise immunity, improves body erythrocyte superoxide dismutase and hemase vigor, has anti-aging effects.
Oryzanol is a ferulic acid and the fat that combines of plant sterol, has lipotropism matter Oxidation.
Vitamin B
1Contain sulfur and an amido in its chemical constitution, thus claim thiamine again, its physiological function be involved in sugar metabolism, promote energy metabolism, safeguard nerve and digestive system normal function, promote growth promoter.
Vitamin B
6Its physiological function mainly is as coenzyme, participates in the metabolism of protein, fat and carbohydrate usually with the form of phosphorus 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine. or phosphopyridoxamine, vitamin B
6Be requisite a kind of important substance such as energy generation, aminoacid and lipid metabolism, central nervous system and hemoglobin production, the immunity of energy enhancing body.
(3) summary of the invention: task of the present invention is to have developed the Pharmaceutical composition of slow down aging, immunomodulating and alleviation climacteric syndrome by the method for liver and kidney tonifying, nourishing YIN and benefiting blood, mind tranquilizing and the heart calming.
Technical scheme of the present invention:
Pharmaceutical composition of the present invention is by Chinese medicine Fructus Ligustri Lucidi, Herba Epimedii, Rhizoma Dioscoreae and Western medicine oryzanol, vitamin B
6And vitamin B
1Form, the weight ratio of raw material of Chinese medicine is: Fructus Ligustri Lucidi: Herba Epimedii: Rhizoma Dioscoreae=8～15: 6～13: 3～5.
Preparation method is, Fructus Ligustri Lucidi, Herba Epimedii, the adding of 7/8 Rhizoma Dioscoreae of aforementioned proportion are purified waste water, logical steam also is incubated lixiviate twice, and each 2h merges lixiviating solution twice, filter, vacuum concentration is made solid content, and solid content is about 20%, carry out spray drying at hothouse, make the spray drying extract; Get 1/8 Rhizoma Dioscoreae raw material of aforementioned proportion amount, pulverize, sieve, dry to moisture below 7%, make Rhizoma Dioscoreae powder; With above-mentioned spray-dried extract, Rhizoma Dioscoreae powder and oryzanol, vitamin B
6, vitamin B
1Dry fine powder mix homogeneously, the sterilization, packing.
The present invention is a kind of Chinese and Western medicine mixture, and based on liver and kidney tonifying, nourishing YIN and benefiting blood, Fructus Ligustri Lucidi, Herba Epimedii, Rhizoma Dioscoreae are monarch in the side, the formation of wherein Fructus Ligustri Lucidi nourishing the liver and kidney, and inhibition interior free yl; Herba Epimedii benefit vital essence, hard muscles and bones is mended the waist knee joint, and heart tonifying power can increase the cardiovascular and cerebrovascular vessel blood flow, promotes hemopoietic function, immunologic function and bone metabolism, has effects such as defying age, antitumor; Rhizoma Dioscoreae kidney tonifying gas, strengthening the spleen and stomach, can YIN nourishing again can dampness removing, can be lubricious again can astringent therapy, the tonifying the spleen and stomach of can the tonifying the lung the kidney invigorating holding concurrently; Three medicines share the soothing liver-QI the kidney invigorating, spleen reinforcing nourishing the stomach, the foster lung that promotes the production of body fluid, nourishing YIN and benefiting blood, the kidney invigorating reinforcing YIN-essence benefit marrow; Be aided with the oryzanol of ministerial drug lipotropism matter Oxidation, the vitamin B of promotion energy metabolism
1With participate in lipid metabolism, Conversion of energy, improve the vitamin B of immunologic function
6, monarch, the effect of playing liver and kidney tonifying, taste kidney tonifying the moon, nourishing YIN and benefiting blood and mind tranquilizing and the heart calming is altogether taken Pharmaceutical composition of the present invention, has enhancing human body immunity power, and delaying senility function also has the effect of alleviating climacteric syndrome simultaneously.
(4) specific embodiments:
Pharmaceutical composition according to the present invention's preparation is by Chinese medicine Fructus Ligustri Lucidi, Herba Epimedii, Rhizoma Dioscoreae and Western medicine oryzanol, vitamin B
6, vitamin B
1Form:
Prescription one: Chinese medicine: Fructus Ligustri Lucidi: Herba Epimedii: Rhizoma Dioscoreae=10: 10: 5, that is:
Fructus Ligustri Lucidi 1800g Herba Epimedii 1800g Rhizoma Dioscoreae 900g
Western medicine: oryzanol 70g vitamin B
61.5g vitamin B
11.35g
Prescription two: Chinese medicine: Fructus Ligustri Lucidi: Herba Epimedii: Rhizoma Dioscoreae=15: 9.3: 3, that is:
Fructus Ligustri Lucidi 2500g Herba Epimedii 1550g Rhizoma Dioscoreae 500g
Western medicine: oryzanol 35g vitamin B
60.7g vitamin B
10.65g
Prescription three: Chinese medicine: Fructus Ligustri Lucidi: Herba Epimedii: Rhizoma Dioscoreae=8.2: 5.8: 3, that is:
Fructus Ligustri Lucidi 2200g Herba Epimedii 1550g Rhizoma Dioscoreae 800g
Western medicine: oryzanol 55g vitamin B
61.0g vitamin B
10.8g
Prescription four: Chinese medicine: Fructus Ligustri Lucidi: Herba Epimedii: Rhizoma Dioscoreae=11.1: 12.9: 3, that is:
Fructus Ligustri Lucidi 1850g Herba Epimedii 2150g Rhizoma Dioscoreae 500g
Western medicine: oryzanol 60g vitamin B
61.65g vitamin B
11.2g
Prescription five: Chinese medicine: Fructus Ligustri Lucidi: Herba Epimedii: Rhizoma Dioscoreae=10.5: 8: 4, that is:
Fructus Ligustri Lucidi 2100g Herba Epimedii 1600g Rhizoma Dioscoreae 800g
Western medicine: oryzanol 50g vitamin B
61.2g vitamin B
11.0g
Wherein fill a prescription five for most preferred embodiment,, the preparation method of Pharmaceutical composition of the present invention is described below with the most preferred embodiment proportioning.
Preparation method is: get exsiccant 2100g Fructus Ligustri Lucidi, 1600g Herba Epimedii and 700g Rhizoma Dioscoreae by above-mentioned prescription and mix, add purifying waste water of 10 times of weight, feed Steam Heating, control temperature in 90 ℃～95 ℃ scopes, and be incubated lixiviate 2 hours, filter to get filtrate; Filtering residue adds purifying waste water of 8 times of weight again, and under equal conditions lixiviate is 2 hours, filters to get filtrate, and merges filtrate twice; Above-mentioned gained lixiviating solution is carried out vacuum concentration, and evaporating temperature is controlled at 70 ℃, vacuum degree control about 83Kpa, and being concentrated into solid content is about 20%, carries out spray drying at hothouse in about 110 ℃, the spray drying extract;
Get above-mentioned remaining 100g Rhizoma Dioscoreae raw material, pulverize, cross 100 mesh sieves through pulverizer, under 90 ℃, dry to moisture below 7%, make Rhizoma Dioscoreae powder;
With above-mentioned spray drying extract, Rhizoma Dioscoreae powder and 50g oryzanol, 1.2g vitamin B
6, the 1.0g vitamin B
1Dry fine powder place stirrer for mixing even, make the 1000g dry mash;
Above-mentioned deployed 1000g dry mash is carried out irradiation sterilization, and the irradiation total absorbed dose is 8KGy; At cleanliness factor is 100,000 grades capsule workshop filled capsules, and the capsule that installs moves after the buffing machine polishing, rejects damaged capsule, makes the capsule-type Pharmaceutical composition with slow down aging, immunomodulating and alleviation climacteric syndrome of the present invention.
In the capsule-type Pharmaceutical composition of making by above-mentioned prescription, every 100g contains icariine 〉=240mg (separate through chromatographic column, detect at wavelength 270nm place, quantitative with external standard method according to retention time, the content of calculating icariine), vitamin B
6Be 68mg～163mg, vitamin B
1Be 60mg～135mg.
Pharmaceutical composition of the present invention is named to growing capsule, every day 2 times, each 3 (every pastille 0.3g), 24 months shelf-lifves.
The antioxidation zoopery of Pharmaceutical composition of the present invention: undertaken by Ministry of Public Health promulgation " the health product function assessment assessment process and the method for inspection ".
Measured product Pharmaceutical composition of the present invention to the rat function in delaying senility with lipid peroxide (MDA, lipofuscin) content, antioxidase activity (SOD, GSH-Px): Pharmaceutical composition of the present invention gives SD senile rat (distilled water is a matched group) with 150mg/kg, 300mg/kg, 900mg/kg, after irritating stomach in continuous 30 days, measure lipofuscin content in rat blood serum SOD (superoxide dismutase), MDA (malonaldehyde), GSH-Px (glutathion peroxidase) and the liver organization.The result shows that the Pharmaceutical composition of this invention can obviously improve the content that rat blood serum SOD, GSH-Px vigor also can reduce rat blood serum MDA.Conclusion: think that this product has antioxidation, and point out it may have delaying senility function.
The immunoregulation effect zoopery of Pharmaceutical composition of the present invention: undertaken by the immunomodulating method of inspection in the Ministry of Public Health promulgation " the health product function assessment assessment process and the method for inspection ".
With the reaction of tardy paraphilia, serum hemolysin measure, carbon clearance test and dirty/body ratio estimated Pharmaceutical composition of the present invention to effect of immunologic function: Pharmaceutical composition of the present invention is given sample 30d continuously with 150mg/kg, 300mg/kg, 900mg/kg, and the result shows that the Pharmaceutical composition of this invention has the formation that promotes the mice hemolysin, strengthens the ability that mouse DTH (ear swelling method) and carbon are cleaned up.Conclusion: think that this product has immunoregulation effect.
The toxicity animal experiment of Pharmaceutical composition of the present invention: undertaken by " toxicological evaluation of food safety procedure and method ".
30 days feeding trials of Pharmaceutical composition rat of the present invention are established 0.75g/kg, 2.25g/kg, 3.0g/kg body weight group, are equivalent to 25 times, 75 times, 100 times of human body recommended amounts approximately.Experimental result does not see that poisoning symptom appears in animal, and gross anatomy and histological observation be the no abnormality seen pathological change also, and rat body weight, food-intake, food utilization, hemogram, blood biochemistry are not all had obvious influence.30 days feeding trial action-less doses of rat that this experiment draws Pharmaceutical composition of the present invention are the 3.0g/kg body weight.
The acute toxicity animal experiment of Pharmaceutical composition of the present invention: undertaken by " toxicological evaluation of food safety procedure and method ".
Pharmaceutical composition of the present invention is to large and small Mus per os LD
50Male and female are all greater than the 10g/kg body weight, and true border is nontoxic.Acute toxinology experiment confirms also that product of the present invention is taken for a long time and has no side effect, and is safe and reliable.
Claims (2)
1. a defying age and immunoregulatory Pharmaceutical composition is characterized in that it is by Chinese medicine Fructus Ligustri Lucidi, Herba Epimedii, Rhizoma Dioscoreae and Western medicine oryzanol, vitamin B
6And vitamin B
1Form, the weight ratio of raw material of Chinese medicine is: Fructus Ligustri Lucidi: Herba Epimedii: Rhizoma Dioscoreae=8～15: 6～13: 3～5.
2. the preparation method of Pharmaceutical composition according to claim 1 is characterized in that finishing according to the following steps: above-mentioned Fructus Ligustri Lucidi, Herba Epimedii, part Rhizoma Dioscoreae are added purify waste water twice of logical steam insulation lixiviate, merge lixiviating solution twice, filter vacuum concentration, the spray-dried extract of making; The Rhizoma Dioscoreae of remainder is made Rhizoma Dioscoreae powder through pulverizing, sieve, drying; With above-mentioned spray-dried extract, Rhizoma Dioscoreae powder and Western medicine oryzanol, vitamin B
6, vitamin B
1Dry fine powder mix homogeneously, the sterilization, make preparation.
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| CNB031167225A CN100344308C (en) | 2003-04-28 | 2003-04-28 | Antisenescing and immunoregulating Chinese and Western medicinal mixture |
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| CNB031167225A CN100344308C (en) | 2003-04-28 | 2003-04-28 | Antisenescing and immunoregulating Chinese and Western medicinal mixture |
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| CN100344308C true CN100344308C (en) | 2007-10-24 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100335104C (en) * | 2004-12-30 | 2007-09-05 | 贵州恒霸药业有限责任公司 | Health protection capsule suitable for climateric woman |
| CN100374132C (en) * | 2005-10-08 | 2008-03-12 | 贵州神奇集团控股有限公司 | Compound Chinese and Western medicine prepn for treating women's climacteric syndrome and its prepn |
| CN105769790A (en) * | 2016-03-15 | 2016-07-20 | 山东仁和堂药业有限公司 | Oryznol tablets for treating premenstrual tension and climacteric syndromes and preparation process thereof |
| CN105769879A (en) * | 2016-03-15 | 2016-07-20 | 山东仁和堂药业有限公司 | Medicinal preparation for calming and helping sleep and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079396A (en) * | 1992-12-20 | 1993-12-15 | 淄博市淄川区第二制药厂 | Intelligence-enhancing pharmaceutical preparation |
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for invigorating kidney and strengthening the spleen and stomach |
| CN1368145A (en) * | 2001-02-02 | 2002-09-11 | 杨孟君 | Nano medicine 'Gengnianshu' and its preparing process |
-
2003
- 2003-04-28 CN CNB031167225A patent/CN100344308C/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079396A (en) * | 1992-12-20 | 1993-12-15 | 淄博市淄川区第二制药厂 | Intelligence-enhancing pharmaceutical preparation |
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for invigorating kidney and strengthening the spleen and stomach |
| CN1368145A (en) * | 2001-02-02 | 2002-09-11 | 杨孟君 | Nano medicine 'Gengnianshu' and its preparing process |
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