CN108686113A - A kind of composition and preparation method thereof for alleviating three high diseases shape - Google Patents
A kind of composition and preparation method thereof for alleviating three high diseases shape Download PDFInfo
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Abstract
The invention discloses a kind of composition and preparation method thereof for alleviating three high diseases shape, this composition is made of the raw material of following parts by weight:3~7 parts of Cortex Lycii extract, 10~20 parts of brown alga extract, 4~10 parts of cassia seed, 15~20 parts of hawthorn, 5~12 parts of Rhizoma Gastrodiae, 8~16 parts of Rhizoma Chuanxiong, smears 20~40 parts of tea, newborn 1~2 part of mineral salt at 6~15 parts of ginkgo biloba p.e;By with Cortex Lycii extract, ginkgo biloba p.e and newborn mineral salt for main anti-" three high " ingredient, set and algae extract, cassia seed and hawthorn etc. are subject to booster action, so as to get composition have and keep fit and healthy, reinforced immunological function, effectively adjust blood pressure, blood glucose, blood fat balance and other effects.
Description
Technical field
The invention belongs to health medicine preparation fields, and in particular to it is a kind of alleviate three high diseases shape composition and its preparation side
Method.
Background technology
" three high diseases " refer to hypertension, hyperglycemia (diabetes) and hyperlipidemia.They are that modern society is derived from
" rich people's disease ", possible individualism, it is also possible to interrelated.Such as:Diabetes patient is easy to suffer from hypertension or high blood simultaneously
Fat disease, and hyperlipidemia is the principal element of artery sclerosis formation and development, arteriosclerotic's blood vessel elasticity difference aggravates blood pressure
It increases.So there are any one of these three illness, the later stage all easily forms " three high diseases " due to long-time eating habit
Problem, lipid is excessive in diet, and alcohols is excessive.The metabolism for promoting lipid alcohols without reasonably movement again simultaneously, causes in vivo
Lipid alcohols material gradually increases, and doping in blood, makes capillary block, over time, lipid alcohols material
It is easy and mineral ion free in vivo combines, form thrombus.Thrombus is easy the corner in blood vessel or bottleneck heap
Product, calcification.Thrombus is more and more simultaneously, and blood vessel diameter is made to reduce.Heart is increased by blood pressure to keep enough amounts of blood supply,
Cause high blood pressure disease.If hyperpiesia, blood vessel may be caused to burst apart, then generate hemorrhagic cardiovascular and cerebrovascular disease.If
Due to blocking blood supply insufficiency, as ischemic angiocardiopathy and cerebrovascular disease.The three high diseases shape moment jeopardizes people's health even life.
Chinese patent"A kind of Chinese medicine composition for treating three high diseases"(number of patent application:CN201510452472.5) it is related to
Treat the Chinese medicine composition of three high diseases, including following drugs:Scorpio processed, centipede processed, ground beetle, Moschus, Pachyrhizua angulatus, earthworm, artificial ox
Huang, goat's horn, cornu bubali, oldenlandia diffusa, Sculellaria barbata, corn stigma, tabasheer, magnetite, grass leaf sweetflag rhizome, borneol, Rhizoma Gastrodiae, arisaema cum bile,
Chinese yam, semen brassicae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, ginkgo leaf, gynostemma pentaphylla, rheum officinale, hairyvein agrimony, bluish dogbane, summer dry ball, Cassia occidentalis, balsam pear, too
Sub- ginseng, Rhizoma Atractylodis Macrocephalae, Shi Xie, raw Radix Astragali and giant knotweed.This Chinese medicine composition softens blood vessel, heat-clearing solution using natural Chinese herbal medicine as raw material
Poison can exclude human vas and vital organs of the human body rubbish, but material is excessively complicated various, and adjust blood pressure, blood glucose, lipid level
The aspect effect of weighing apparatus is general.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of composition and preparation method thereof for alleviating three high diseases shape, lead to
It crosses with Cortex Lycii extract, ginkgo biloba p.e and newborn mineral salt as main anti-" three high " ingredient, set and algae extract are determined
Pine torch and hawthorn etc. are subject to booster action, so as to get composition have keep fit and healthy, reinforced immunological function, effectively adjust blood
Pressure, blood glucose, blood fat balance and other effects.
The present invention can be achieved through the following technical solutions:
A kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:3~7 parts of Cortex Lycii extract,
6~15 parts of ginkgo biloba p.e, 10~20 parts of brown alga extract, 4~10 parts of cassia seed, 15~20 parts of hawthorn, Rhizoma Gastrodiae 5~12
Part, 8~16 parts of Rhizoma Chuanxiong smear 20~40 parts of tea, newborn 1~2 part of mineral salt.
Preferably, a kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:Cortex Lycii extract
4~6 parts, 8.25~12.75 parts of ginkgo biloba p.e, 12.5~17.5 parts of brown alga extract, 5.5~8.5 parts of cassia seed, hawthorn
16.25~18.75 parts, 6.75~10.25 parts of Rhizoma Gastrodiae, 10~14 parts of Rhizoma Chuanxiong, smear 25~35 parts of tea, newborn mineral salt 1.25~1.75
Part.
It is highly preferred that a kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:The root bark of Chinese wolf-berry extracts
5 parts of object, 10.5 parts of ginkgo biloba p.e, 15 parts of brown alga extract, 7 parts of cassia seed, 17.5 parts of hawthorn, 8.5 parts of Rhizoma Gastrodiae, Rhizoma Chuanxiong 12
Part smears 30 parts of tea, newborn 1.5 parts of mineral salt.
A kind of composition for alleviating three high diseases shape of the present invention, the preparation method of the Cortex Lycii extract are:Take the root bark of Chinese wolf-berry
It crushes, crosses 50~70 mesh sieve, be 1 by solid-liquid ratio:20~30 are added 50~70% ethyl alcohol, the ultrasonic extraction 50 at 50~70 DEG C
~70min, extracting solution filtering, concentration, the absolute ethyl alcohol for adding its 4~5 times amounts carry out alcohol precipitation, stand overnight suction filtration, filter cake
It is washed repeatedly 4~5 times with absolute ethyl alcohol, acetone successively, collects precipitation, vacuum drying is finally dissolved in distilled water, is used
Sevage- enzyme process takes off albumen, centrifugation, concentrated supernatant, alcohol precipitation, collects precipitation, and vacuum drying obtains Cortex Lycii extract.
A kind of composition for alleviating three high diseases shape of the present invention, the preparation method of the ginkgo biloba p.e are:Fresh ginkgo
Leaf dries, and crushed 60~80 mesh sieve, is 1 by solid-liquid ratio:20~25 are added 65~70% ethyl alcohol, and extraction 3 at 50~70 DEG C~
5h is extracted 3 times, merges extracting solution, is filtered, and is concentrated by evaporation, 50 DEG C of dryings are to get ginkgo biloba p.e.
A kind of composition for alleviating three high diseases shape of the present invention, the preparation method of the brown alga extract are:To brown alga by material
Liquor ratio is 1:30~40 addition deionized waters are heated to reflux 20~30min at 45~65 DEG C, filter, obtain filtrate, will be described
Filtrate is concentrated into thick paste, and spray drying just obtains.
A kind of method of composition that alleviating three high diseases shape is prepared, is included the following steps:It determines by weight by what is weighed
Pine torch, hawthorn, Rhizoma Gastrodiae, Rhizoma Chuanxiong, smear tea, newborn mineral salt is crushed, is milled respectively, crosses 50~70 mesh sieve that fine powder is made, in 15
~30MPa, CO 2 supercritical 3~4h of hybrid extraction is carried out under the conditions of 80~130 DEG C, collect the dregs of a decoction, be by solid-liquid ratio
1:2~4 are added the heating of 45~75% ethyl alcohol to the dregs of a decoction decocts 2 times, and 1~2h, filtering every time merges secondary raffinate, be concentrated into
At 50 DEG C relative density be 1.1~1.2, then plus ethyl alcohol to alcohol content up to 60~70% stand 12~for 24 hours, by supernatant liquid filtering
After be recovered under reduced pressure ethyl alcohol, Cortex Lycii extract, ginkgo biloba p.e and brown alga extract is added and continues to be concentrated into thick paste, then does into
Tablet.
The part feature related introduction of technical solution of the present invention is as follows:
Cortex Lycii extract is taken from the conventional Chinese medicine root bark of Chinese wolf-berry, sweet in flavor, cold in nature to have cool blood, except heat and other effects, ground bone
The objects containing organic acid and ester type compound, alkaloid compound, anthracene ketone compounds, flavone compound etc. in bark extract
Matter, these substances have facilitation to beta Cell of islet, are obviously increased to the inhibiting rate of invertase and amylase, can be preferable
Inhibition alpha-glucosidase activity, control the mechanism of blood glucose and inhibit generation, the anti-oxidant energy of enhancing of internal oxygen radical
Power, the removing for accelerating free radical, can restore islet beta cell function, increase insulin secretion, and blood glucose work is reduced to reach
With.
Ginkgo biloba p.e can promote the cycle of brain and body limbs simultaneously, inhibit a kind of and being known as platelet activating factor
(PAF) substance, PAF are a kind of media discharged from cell, can lead to platelet aggregation (being packed together).High-content
PAF can lead to neural cell injury, central nervous system blood flow reduces, inflammation and bronchoconstriction.In addition to inhibiting blood small
Plate adhesion is outer, and ginkgo biloba extract adjusts antiotasis and elastic force, enables vascular circulation effectively.Ginkgo biloba p.e can be with
Mitigate cholesterolemia, triacylglycerol, very low density lipoprotein simultaneously to the adverse effect of human body, mitigate blood fat, improve microcirculation,
Inhibit blood coagulation, these are notable to the therapeutic effect of hypertension.In addition ginkgo biloba p.e is supported to adjusting blood glucose, improving insulin
It is anti-, it is apparent to reduce insulin antibody, the sensitivity effect of enhancing insulin.
Cassia seed, it is sweet, it is bitter, salty, be slightly cold.Return liver, large intestine channel.Function:Heat-clearing improving eyesight relaxes bowel.For the puckery pain of hot eyes,
The more tears of photophobia, dizziness of having a headache, mesh is secretly unknown, constipation.Return liver, kidney, large intestine channel.
Hawthorn, sour, sweet, slightly warm in nature.Effect:Appetite-stimulating and indigestion-relieving changes stagnant disperse accumulation, promoting blood circulation to remove blood stasis, resolving sputum promoting the circulation of qi.For meat
Stagnant product, a lump in the abdomen causing distension and pain, abdominal distension feeling of fullness, stasis blocking abdominal pain, phlegm and retained fluid, diarrhea, discharging fresh blood stool etc..
Rhizoma Gastrodiae has calm, analgesia, anticonvulsant action;Cerebral blood flow (CBF) can be increased, reduce cerebral vascular resistance, light contraction brain blood
Pipe increases coronary vasodilator flow;It can reduce blood pressure, reducing heart rate has protective effect to myocardial ischemia.
Rhizoma Chuanxiong, it is acrid in flavour and warm in nature.Return liver, courage, pericardium channel.Effect:Blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive intermittent headache
Headache, abdominal mass abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Tea is smeared, containing abundant active material such as catechin, tea polysaccharide etc., blood fat, blood glucose level can be reduced, it is fine to increase urine
Molten activity prevents calculi in urinary system to alleviate constipation caused by the insoluble calcium after calcium uptake.
Newborn mineral salt, by coordinating rational 2:1 calcium phosphorus ration composition further includes vitamin D, casein phosphopeptide (CPP)
Equal natural nutrition compositions, both contributing to human body compares the absorption of calcium with other calcium sources, and ingredient is more abundant, and the suction of calcium
Receipts ability is more preferable.And mid-aged population calcium absorptivity is inherently relatively low, calcium loss is more, and companion can be also easier to while calcium deficiency
With symptoms such as hypertension, hyperlipidemia, hyperglycemia, thus it is more important to it to replenish the calcium safely.
Beneficial effects of the present invention are:By intake containing Cortex Lycii extract, ginkgo biloba p.e and brown alga extract etc.
Composition, can effectively improve hyperlipidemia, hypertension and hyperglycemic symptoms, and newborn mineral salt is reached by improving human body calcium component
The case where continuing to increase to prevention blood pressure, blood fat, blood glucose.
Specific implementation mode
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below
Specific embodiment is closed, the present invention is further explained.
Embodiment 1
A kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:5 parts of Cortex Lycii extract, silver
10.5 parts of apricot leaf extract, 7 parts of cassia seed, 17.5 parts of hawthorn, 8.5 parts of Rhizoma Gastrodiae, 12 parts of Rhizoma Chuanxiong, smears tea at 15 parts of brown alga extract
30 parts, newborn 1.5 parts of mineral salt.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the Cortex Lycii extract are:Take ground bone
Skin crushes, and crosses 60 mesh sieve, is 1 by solid-liquid ratio:25 are added 60% ethyl alcohol, the ultrasonic extraction 60min at 60 DEG C, extracting solution mistake
Filter, concentration, the absolute ethyl alcohol for adding its 4.5 times amounts carry out alcohol precipitation, stand overnight suction filtration, and filter cake uses absolute ethyl alcohol, third successively
Ketone washs 4 times repeatedly, collects precipitation, and vacuum drying is finally dissolved in distilled water, takes off albumen with Sevage- enzyme process, centrifugation is dense
Contracting supernatant, alcohol precipitation collect precipitation, and vacuum drying obtains Cortex Lycii extract.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the ginkgo biloba p.e are:Fresh silver
Apricot leaf dries, and crushed 70 mesh sieve, is 1 by solid-liquid ratio:22.5 are added 67.5% ethyl alcohol, and 4h is extracted at 60 DEG C, is extracted 3 times, is closed
And extracting solution, it filters, is concentrated by evaporation, 50 DEG C of dryings are to get ginkgo biloba p.e.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the brown alga extract are:It is pressed to brown alga
Solid-liquid ratio is 1:35 addition deionized waters are heated to reflux 25min at 55 DEG C, filter, obtain filtrate, the filtrate is concentrated into
Thick paste, spray drying just obtain.
A kind of method of composition that alleviating three high diseases shape is prepared, is included the following steps:It determines by weight by what is weighed
Pine torch, hawthorn, Rhizoma Gastrodiae, Rhizoma Chuanxiong, smear tea, newborn mineral salt is crushed, is milled respectively, crosses 60 mesh sieve that fine powder is made, in
22.5MPa, CO 2 supercritical hybrid extraction 3.5h is carried out under the conditions of 105 DEG C, collect the dregs of a decoction, be 1 by solid-liquid ratio:3 to
The dregs of a decoction are added the heating of 60% ethyl alcohol and decoct 2 times, each 1.5h, and filtering merges secondary raffinate, relative density when being concentrated into 50 DEG C
It is 1.15, then plus ethyl alcohol stands 18h to alcohol content up to 65%, and ethyl alcohol will be recovered under reduced pressure after supernatant liquid filtering, the root bark of Chinese wolf-berry is added
Extract, ginkgo biloba p.e and brown alga extract continue to be concentrated into thick paste, then do into tablet.
Embodiment 2
A kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:3 parts of Cortex Lycii extract, silver
6 parts of apricot leaf extract, 4 parts of cassia seed, 15 parts of hawthorn, 5 parts of Rhizoma Gastrodiae, 8 parts of Rhizoma Chuanxiong, smears 20 parts of tea, newborn mine at 10 parts of brown alga extract
1 part of object salt.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the Cortex Lycii extract are:Take ground bone
Skin crushes, and crosses 50 mesh sieve, is 1 by solid-liquid ratio:20 are added 50% ethyl alcohol, the ultrasonic extraction 50min at 50 DEG C, extracting solution mistake
Filter, concentration, the absolute ethyl alcohol for adding its 4 times amounts carry out alcohol precipitation, stand overnight suction filtration, and filter cake uses absolute ethyl alcohol, acetone successively
It washs 4 times repeatedly, collects precipitation, vacuum drying is finally dissolved in distilled water, is taken off albumen with Sevage- enzyme process, is centrifuged, concentration
Supernatant, alcohol precipitation collect precipitation, and vacuum drying obtains Cortex Lycii extract.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the ginkgo biloba p.e are:Fresh silver
Apricot leaf dries, and crushed 60 mesh sieve, is 1 by solid-liquid ratio:20 are added 65% ethyl alcohol, and 3h is extracted at 50 DEG C, is extracted 3 times, merging carries
Liquid is taken, is filtered, is concentrated by evaporation, 50 DEG C of dryings are to get ginkgo biloba p.e.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the brown alga extract are:It is pressed to brown alga
Solid-liquid ratio is 1:30 addition deionized waters are heated to reflux 20min at 45 DEG C, filter, obtain filtrate, the filtrate is concentrated into
Thick paste, spray drying just obtain.
A kind of method of composition that alleviating three high diseases shape is prepared, is included the following steps:It determines by weight by what is weighed
Pine torch, hawthorn, Rhizoma Gastrodiae, Rhizoma Chuanxiong, smear tea, newborn mineral salt is crushed, is milled respectively, crosses 50 mesh sieve that fine powder is made, in 15MPa,
CO 2 supercritical hybrid extraction 3h is carried out under the conditions of 80 DEG C, collects the dregs of a decoction, is being 1 by solid-liquid ratio:2 are added 45% to the dregs of a decoction
Ethyl alcohol, which heats, to be decocted 2 times, each 1h, and filtering merges secondary raffinate, and relative density is 1.1 when being concentrated into 50 DEG C, then adds second
Alcohol stands 12h to alcohol content up to 60%, and ethyl alcohol will be recovered under reduced pressure after supernatant liquid filtering, Cortex Lycii extract is added, ginkgo leaf carries
It takes object and brown alga extract to continue to be concentrated into thick paste, then does into tablet.
Embodiment 3
A kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:7 parts of Cortex Lycii extract, silver
15 parts of apricot leaf extract, 20 parts of brown alga extract, 10 parts of cassia seed, 20 parts of hawthorn, 12 parts of Rhizoma Gastrodiae, 16 parts of Rhizoma Chuanxiong, smear 40 parts of tea,
2 parts of newborn mineral salt.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the Cortex Lycii extract are:Take ground bone
Skin crushes, and crosses 70 mesh sieve, is 1 by solid-liquid ratio:30 are added 70% ethyl alcohol, the ultrasonic extraction 70min at 70 DEG C, extracting solution mistake
Filter, concentration, the absolute ethyl alcohol for adding its 5 times amounts carry out alcohol precipitation, stand overnight suction filtration, and filter cake uses absolute ethyl alcohol, acetone successively
It washs 5 times repeatedly, collects precipitation, vacuum drying is finally dissolved in distilled water, is taken off albumen with Sevage- enzyme process, is centrifuged, concentration
Supernatant, alcohol precipitation collect precipitation, and vacuum drying obtains Cortex Lycii extract.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the ginkgo biloba p.e are:Fresh silver
Apricot leaf dries, and crushed 80 mesh sieve, is 1 by solid-liquid ratio:25 are added 70% ethyl alcohol, and 5h is extracted at 70 DEG C, is extracted 3 times, merging carries
Liquid is taken, is filtered, is concentrated by evaporation, 50 DEG C of dryings are to get ginkgo biloba p.e.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the brown alga extract are:It is pressed to brown alga
Solid-liquid ratio is 1:40 addition deionized waters are heated to reflux 30min at 65 DEG C, filter, obtain filtrate, the filtrate is concentrated into
Thick paste, spray drying just obtain.
A kind of method of composition that alleviating three high diseases shape is prepared, is included the following steps:It determines by weight by what is weighed
Pine torch, hawthorn, Rhizoma Gastrodiae, Rhizoma Chuanxiong, smear tea, newborn mineral salt is crushed, is milled respectively, crosses 70 mesh sieve that fine powder is made, in 30MPa,
CO 2 supercritical hybrid extraction 4h is carried out under the conditions of 130 DEG C, collects the dregs of a decoction, is being 1 by solid-liquid ratio:4 are added to the dregs of a decoction
The heating of 75% ethyl alcohol decocts 2 times, each 2h, and filtering merges secondary raffinate, and relative density is 1.2 when being concentrated into 50 DEG C, then
Add ethyl alcohol to be stood for 24 hours to alcohol content up to 70%, ethyl alcohol will be recovered under reduced pressure after supernatant liquid filtering, Cortex Lycii extract, ginkgo is added
Leaf extract and brown alga extract continue to be concentrated into thick paste, then do into tablet.
Embodiment 4
A kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:4 parts of Cortex Lycii extract, silver
8.25 parts of apricot leaf extract, 12.5 parts of brown alga extract, 5.5 parts of cassia seed, 16.25 parts of hawthorn, 6.75 parts of Rhizoma Gastrodiae, Rhizoma Chuanxiong 10
Part smears 25 parts of tea, newborn 1.25 parts of mineral salt.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the Cortex Lycii extract are:Take ground bone
Skin crushes, and crosses 50 mesh sieve, is 1 by solid-liquid ratio:22.5 are added 55% ethyl alcohol, the ultrasonic extraction 55min at 55 DEG C, extracting solution mistake
Filter, concentration, the absolute ethyl alcohol for adding its 4.25 times amounts carry out alcohol precipitation, stand overnight suction filtration, and filter cake uses absolute ethyl alcohol, third successively
Ketone washs 4 times repeatedly, collects precipitation, and vacuum drying is finally dissolved in distilled water, takes off albumen with Sevage- enzyme process, centrifugation is dense
Contracting supernatant, alcohol precipitation collect precipitation, and vacuum drying obtains Cortex Lycii extract.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the ginkgo biloba p.e are:Fresh silver
Apricot leaf dries, and crushed 60 mesh sieve, is 1 by solid-liquid ratio:21.25 are added 66% ethyl alcohol, and 3.5h is extracted at 55 DEG C, is extracted 3 times, is closed
And extracting solution, it filters, is concentrated by evaporation, 50 DEG C of dryings are to get ginkgo biloba p.e.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the brown alga extract are:It is pressed to brown alga
Solid-liquid ratio is 1:32.5 addition deionized waters are heated to reflux 22.5min at 50 DEG C, filter, obtain filtrate, and the filtrate is dense
It is reduced to thick paste, spray drying just obtains.
A kind of method of composition that alleviating three high diseases shape is prepared, is included the following steps:It determines by weight by what is weighed
Pine torch, hawthorn, Rhizoma Gastrodiae, Rhizoma Chuanxiong, smear tea, newborn mineral salt is crushed, is milled respectively, crosses 50 mesh sieve that fine powder is made, in 20MPa,
CO 2 supercritical hybrid extraction 3h is carried out under the conditions of 90 DEG C, collects the dregs of a decoction, is being 1 by solid-liquid ratio:2.5 are added to the dregs of a decoction
The heating of 55% ethyl alcohol decocts 2 times, each 1h, and filtering merges secondary raffinate, and relative density is 1.1 when being concentrated into 50 DEG C, then
Add ethyl alcohol to stand 15h to alcohol content up to 62.5%, ethyl alcohol will be recovered under reduced pressure after supernatant liquid filtering, Cortex Lycii extract, silver is added
Apricot leaf extract and brown alga extract continue to be concentrated into thick paste, then do into tablet.
Embodiment 5
A kind of composition for alleviating three high diseases shape, is made of the raw material of following parts by weight:6 parts of Cortex Lycii extract, silver
12.75 parts of apricot leaf extract, 17.5 parts of brown alga extract, 8.5 parts of cassia seed, 18.75 parts of hawthorn, 10.25 parts of Rhizoma Gastrodiae, Rhizoma Chuanxiong 14
Part smears 35 parts of tea, newborn 1.75 parts of mineral salt.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the Cortex Lycii extract are:Take ground bone
Skin crushes, and crosses 60 mesh sieve, is 1 by solid-liquid ratio:27.5 are added 65% ethyl alcohol, the ultrasonic extraction 65min at 65 DEG C, extracting solution mistake
Filter, concentration, the absolute ethyl alcohol for adding its 4.75 times amounts carry out alcohol precipitation, stand overnight suction filtration, and filter cake uses absolute ethyl alcohol, third successively
Ketone washs 5 times repeatedly, collects precipitation, and vacuum drying is finally dissolved in distilled water, takes off albumen with Sevage- enzyme process, centrifugation is dense
Contracting supernatant, alcohol precipitation collect precipitation, and vacuum drying obtains Cortex Lycii extract.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the ginkgo biloba p.e are:Fresh silver
Apricot leaf dries, and crushed 70 mesh sieve, is 1 by solid-liquid ratio:23.75 are added 68% ethyl alcohol, and 4.5h is extracted at 65 DEG C, is extracted 3 times, is closed
And extracting solution, it filters, is concentrated by evaporation, 50 DEG C of dryings are to get ginkgo biloba p.e.
A kind of composition for alleviating three high diseases shape of the present embodiment, the preparation method of the brown alga extract are:It is pressed to brown alga
Solid-liquid ratio is 1:37.5 addition deionized waters are heated to reflux 27.5min at 60 DEG C, filter, obtain filtrate, and the filtrate is dense
It is reduced to thick paste, spray drying just obtains.
A kind of method of composition that alleviating three high diseases shape is prepared, is included the following steps:It determines by weight by what is weighed
Pine torch, hawthorn, Rhizoma Gastrodiae, Rhizoma Chuanxiong, smear tea, newborn mineral salt is crushed, is milled respectively, crosses 60 mesh sieve that fine powder is made, in 25MPa,
CO 2 supercritical hybrid extraction 4h is carried out under the conditions of 120 DEG C, collects the dregs of a decoction, is being 1 by solid-liquid ratio:3.5 are added to the dregs of a decoction
The heating of 65% ethyl alcohol decocts 2 times, each 2h, and filtering merges secondary raffinate, and relative density is 1.2 when being concentrated into 50 DEG C, then
Add ethyl alcohol to stand 21h to alcohol content up to 67.5%, ethyl alcohol will be recovered under reduced pressure after supernatant liquid filtering, Cortex Lycii extract, silver is added
Apricot leaf extract and brown alga extract continue to be concentrated into thick paste, then do into tablet.
Comparative example 1
Difference lies in do not add Cortex Lycii extract with embodiment 1 in composition components.
Comparative example 2
Difference lies in do not add ginkgo biloba p.e with embodiment 1 in composition components.
Comparative example 3
With embodiment 1 and difference lies in do not add newborn mineral salt in composition components.
Efficacy validation
Random screening sample:25~80 years old, at least with one of three height, the other situation healthy persons of body, totally 150
Name × 8 groups, it is random to be grouped.
To taking product:In addition to normal diet, each group corresponds to the composition for taking Examples 1 to 5 and comparative example 1~3 respectively,
One day a piece of, is used in conjunction 6 months.
Effect category:
Hypertension symptom point in the present invention:Normal contraction pressure (mm Hg)s <120, diastolic pressure (mm Hg)s <80;Class is slight
Systolic pressure (mm Hg) 140~159, diastolic pressure (mm Hg) 90~99;Moderate systolic pressure (mm Hg) 160~179, diastolic pressure (mm
Hg) 100~109;Severe systolic pressure (mm Hg) >=180, diastolic pressure (mm Hg) >=110.
Hyperlipidemic conditions are classified:Blood fat is primarily referred to as the cholesterol in serum and triglycerides.Either cholesterol level
Increase or the content of triglycerides increases or the two all increases, is referred to as hyperlipidemia.
(1) hypercholesterolemia:Serum total cholesterol is more than 572mmol/L, the normal (< of content of triglyceride;1.7mmol/
L);
(2) hypertriglyceridemia:Xue Qingganyousanzhi >1.70mmol/L, the normal (< of total cholesterol level;5.72mmol/
L);
(3) combined hyperlipidemia familial:Serum total cholesterol and content of triglyceride increase, i.e. Zong Danguchun >
572mmol/L, Gan Yousanzhi >1.7mmol/L;
(4) low hdl mass formed by blood stasis:Serum High-Density Lipoprotein-Cholesterol (HDL- cholesterol) content reduces, i.e. <
9.0mmol/L。
Hyperglycemia classification Symptomatic classification:Normal value:Random blood sugar >=11.1mmol/L, fasting blood-glucose >=7.0mmol/L (one
As at least 8h there is no energy intake), and combine the symptoms such as more drinks, more food, diuresis, weight loss that can be diagnosed as diabetes.
Remarkable result:Symptom rank reduces and effect stability.If former slight clinical symptoms completely disappear, moderate symptoms switch to
Mild, severe symptomatic switch to moderate symptoms.
Effectively:Any symptom rank has reduction, but is not sufficiently stable.
In vain:Main clinic symptoms are unchanged or aggravate, and original three is high and any symptom of diabetes is not improved.
1 curative effect of table compares
| Group | Total number of persons | Effective number | Efficiently individual quantity | Invalid number |
| Embodiment 1 | 150 | 123 | 27 | 0 |
| Embodiment 2 | 150 | 103 | 47 | 0 |
| Embodiment 3 | 150 | 109 | 41 | 0 |
| Embodiment 4 | 150 | 114 | 36 | 0 |
| Embodiment 5 | 150 | 120 | 30 | 0 |
| Comparative example 1 | 150 | 40 | 71 | 39 |
| Comparative example 2 | 150 | 66 | 68 | 16 |
| Comparative example 3 | 150 | 52 | 74 | 24 |
It can be obtained from upper table, compared with comparative example, embodiment has more significant therapeutic effect, and embodiment 1 is better than other
Embodiment group.The effective percentage of comparative example 1~3 is respectively 74%, 89.3% and 84%, compared with Example 1, because certain ingredient
Missing causes effect weakened, illustrates to interact between each ingredient of the present invention indispensable, could more preferably play alleviation " three
The effect of height " symptom.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.
Claims (7)
1. a kind of composition for alleviating three high diseases shape, which is characterized in that be made of the raw material of following parts by weight:The root bark of Chinese wolf-berry extracts
3~7 parts of object, 6~15 parts of ginkgo biloba p.e, 10~20 parts of brown alga extract, 4~10 parts of cassia seed, hawthorn 15~20 part, day
5~12 parts of fiber crops, 8~16 parts of Rhizoma Chuanxiong smear 20~40 parts of tea, newborn 1~2 part of mineral salt.
2. a kind of composition for alleviating three high diseases shape according to claim 1, which is characterized in that by the original of following parts by weight
Material forms:4~6 parts of Cortex Lycii extract, 8.25~12.75 parts of ginkgo biloba p.e, 12.5~17.5 parts of brown alga extract,
5.5~8.5 parts of cassia seed, 6.75~10.25 parts of Rhizoma Gastrodiae, 10~14 parts of Rhizoma Chuanxiong, smears tea 25~35 at 16.25~18.75 parts of hawthorn
Part, newborn 1.25~1.75 parts of mineral salt.
3. a kind of composition for alleviating three high diseases shape according to claim 2, which is characterized in that by the original of following parts by weight
Material forms:5 parts of Cortex Lycii extract, 10.5 parts of ginkgo biloba p.e, 15 parts of brown alga extract, 7 parts of cassia seed, hawthorn 17.5
Part, 8.5 parts of Rhizoma Gastrodiae, 12 parts of Rhizoma Chuanxiong smear 30 parts of tea, newborn 1.5 parts of mineral salt.
4. according to a kind of composition for alleviating three high diseases shape of claims 1 to 3 any one of them, which is characterized in that describedly
The preparation method of bone bark extract is:It takes the root bark of Chinese wolf-berry to crush, crosses 50~70 mesh sieve, be 1 by solid-liquid ratio:20~30 be added 50~
70% ethyl alcohol, 50~70min of ultrasonic extraction at 50~70 DEG C, extracting solution filtering, concentration add the nothing of its 4~5 times amounts
Water-ethanol carries out alcohol precipitation, stands overnight suction filtration, and filter cake is washed 4~5 times with absolute ethyl alcohol, acetone repeatedly successively, collects precipitation, very
Sky is dry, is finally dissolved in distilled water, takes off albumen with Sevage- enzyme process, centrifuges, concentrated supernatant, alcohol precipitation, collects precipitation, very
Sky is dry, obtains Cortex Lycii extract.
5. according to a kind of composition for alleviating three high diseases shape of claims 1 to 3 any one of them, which is characterized in that the silver
The preparation method of apricot leaf extract is:Fresh ginkgo leaf dries, and crushed 60~80 mesh sieve, is 1 by solid-liquid ratio:20~25 are added
65~70% ethyl alcohol extract 3~5h at 50~70 DEG C, extract 3 times, merge extracting solution, filter, and are concentrated by evaporation, 50 DEG C of dryings, i.e.,
Obtain ginkgo biloba p.e.
6. according to a kind of composition for alleviating three high diseases shape of claims 1 to 3 any one of them, which is characterized in that described brown
The preparation method of algae extract is:It is 1 to press solid-liquid ratio to brown alga:30~40 addition deionized waters are heated to reflux at 45~65 DEG C
20~30min, filtering, obtains filtrate, the filtrate is concentrated into thick paste, spray drying just obtains.
7. a kind of prepare such as a kind of method of the composition of alleviation three high diseases shape of claim 1~6 any one of them, feature
It is, includes the following steps:By weight by the cassia seed weighed, hawthorn, Rhizoma Gastrodiae, Rhizoma Chuanxiong, smear tea, newborn mineral salt respectively into
Row crushes, mill, cross 50~70 mesh sieve fine powder is made, under the conditions of 15~30MPa, 80~130 DEG C carry out carbon dioxide surpass faces
Boundary 3~4h of hybrid extraction collects the dregs of a decoction, is being 1 by solid-liquid ratio:2~4 are added the heating of 45~75% ethyl alcohol to the dregs of a decoction decocts 2 times,
1~2h every time, filtering merge secondary raffinate, and relative density is 1.1~1.2 when being concentrated into 50 DEG C, then adds ethyl alcohol to containing alcohol
Amount stands 12 up to 60~70%~for 24 hours, it will be recovered under reduced pressure ethyl alcohol after supernatant liquid filtering, Cortex Lycii extract be added, ginkgo leaf carries
It takes object and brown alga extract to continue to be concentrated into thick paste, then does into tablet.
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