CN106266934A - A kind of Chinese medicine composition treating neck, shoulder, waist and leg pain and capsule and preparation method - Google Patents

A kind of Chinese medicine composition treating neck, shoulder, waist and leg pain and capsule and preparation method Download PDF

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Publication number
CN106266934A
CN106266934A CN201610424439.6A CN201610424439A CN106266934A CN 106266934 A CN106266934 A CN 106266934A CN 201610424439 A CN201610424439 A CN 201610424439A CN 106266934 A CN106266934 A CN 106266934A
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grams
radix
rhizoma
chinese medicine
medicine composition
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梁万波
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain and capsule and preparation method, this Chinese medicine composition includes following raw material: Radix Angelicae Sinensis, Flos Carthami, the Radix Angelicae Dahuricae, the Cortex Eucommiae, Rhizoma Chuanxiong, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Clematidis, Rhizoma Drynariae, Radix Dipsaci, Rhizoma Cibotii, Pyritum, Radix Notoginseng, eupolyphaga, Cortex Acanthopancis, Caulis Spatholobi, Olibanum, Myrrha, Resina Draconis, big gun first, Rhizoma Curcumae Longae, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Achyranthis Bidentatae, Scolopendra, Scorpio, Moschus, Herba Asari, Borneolum Syntheticum, Rhizoma Arisaematis (processed), Rhizoma Pinelliae Preparata, Radix Glycyrrhizae.The Chinese medicine composition that the present invention provides is by the collaborative compatibility of plurality of raw materials medicine, and the neck of co-therapy patient, shoulder, waist, have a pain in the leg pain, and this medication effect is notable, performance drug effect is very fast, can the pain of rapid recovery patient, treatment cycle is short, can not only effect a radical cure, and this Chinese medicine is without any side effects, do not damage the internal organs such as patient liver, kidney, additionally, the capsule that the present invention provides, facilitate patient to take and carry, using more safe and reliable.

Description

A kind of Chinese medicine composition treating neck, shoulder, waist and leg pain and capsule and preparation method
Technical field
The present invention relates to technical field of traditional Chinese medicine, treat pain of neck, shoulder, waist and leg particularly to one The Chinese medicine composition of pain and capsule and preparation method.
Background technology
Neck, shoulder, waist, the pain that has a pain in the leg are a kind of commonly encountered diseases, frequently-occurring diseases, as rheumatic cervical syndrome, Rheumatic scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, rheumatic arthritis etc., patient once suffer from neck, Shoulder, waist, lower limb pain disease are the most painful, and even disability be can't take care of oneself. Be presently used for treat neck, shoulder, waist, have a pain in the leg pain medicament categories various, have middle one-tenth for oral administration Medicine class, Western medicine class, also Chinese medicine and western medicine composition of medicine class etc., these class medicines are all oral drugs, Take this kind of medicine for a long time, although neck, shoulder, waist, the pain that has a pain in the leg can be had certain curative effect, But the most also compromise liver, kidney, the long immunity degradation causing health, Other disease is comed one after another, and the time that patient takes medicine is the longest, and disease is the most on the contrary, gives and suffers from Person brings lifelong misery.
For the side effect overcoming existing drugs on patients to bring, existing patent publication No. is The Chinese medicine of CN102293937A disclosed treatment neck, shoulder, waist and leg pain, discloses it in this medicine and joins Fang Wei: Rhizoma Coptidis 40-60g, Rhizoma Corydalis 30-40g, Flos Carthami 20-30g, Radix Angelicae Sinensis 20-30g, Radix Notoginseng 20-30g, Ramulus Uncariae Cum Uncis 20-30g, Rhizoma Et Radix Notopterygii 15-25g, Rhizoma Gastrodiae 10-20g, although this Chinese medicine can play alleviation The effect of pain, but it is cured the symptoms, not the disease, and still there is lumbago and skelalgia symptom after cutting out, Additionally, drug effect is relatively slow after this drug administration, medicine stability is poor, it is impossible to fundamentally remove disease The pain suffered from, being badly in need of exploitation one can conveniently take for this, and the Chinese medicine composition of quick result Thing.
Summary of the invention
In order to solve existing Chinese medicine exist be only capable of play lenitive effect, but it takes stopgap measures Do not effect a permanent cure, after cutting out, still there is lumbago and skelalgia symptom, additionally, medicine after this drug administration Effect is relatively slow, and medicine stability is poor, it is impossible to fundamentally remove the problem such as pain of sufferer, this Bright provide a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain and capsule and preparation method.
The concrete technical scheme of the present invention is as follows:
The invention provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, this Chinese medicine composition Thing includes the raw material of following parts by weight: Radix Angelicae Sinensis 5-10 part, Flos Carthami 15-20 part, Radix Angelicae Dahuricae 10-15 Part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, Ramulus Cinnamomi 10-15 part, Rhizoma Et Radix Notopterygii 10-15 part, solely 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci 15-20 part, Rhizoma Cibotii alive 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 part, eupolyphaga 10-15 part, Cortex Acanthopancis 15-20 Part, Caulis Spatholobi 20-25 part, Olibanum 15-20 part, Myrrha 15-20 part, Resina Draconis 5-10 part, Big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, Radix Aconiti Preparata 10-15 part, Radix Aconiti Kusnezoffii Preparata 10-15 part, cattle Knee joint 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 part, Moschus 0.1-0.5 part, Herba Asari 5-10 Part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 part, Rhizoma Pinelliae Preparata 5-10 part, Radix Glycyrrhizae 5-10 part.
In the Chinese medicine composition that the present invention provides, collaborative compatibility between each composition, complements each other, has Effectiveness in treatment neck, shoulder, waist, have a pain in the leg the diseases such as pain, it is possible to rapid recovery rheumatic cervical syndrome, Neck that rheumatic scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, rheumatic arthritis etc. cause, shoulder, waist, Have a pain in the leg pain etc., it is possible to quickly alleviate the misery of patient, this Chinese medicine composition do not damage patient liver, The internal organs such as kidney, without any side effects.
Further, this Chinese medicine composition also includes the raw material of following parts by weight: Herba Erodii 5-8 Part, Membrana Follicularis ovi 3-5 part.The Chinese medicine composition that the present invention provides adds Herba Erodii further And Membrana Follicularis ovi, Herba Erodii and Membrana Follicularis ovi all can alleviate neck, shoulder, waist, have a pain in the leg pain basis On, also there is exsiccation, effectively treatment patient's shoulder, cervical region, waist and leg causes Pain, the most also has antiinflammation.
Further, this Chinese medicine composition also includes the raw material of following parts by weight: Herba Siegesbeckiae 3-5 Part, Radix seu Caulis Verntilaginis Leiocarpae 4-9 part.The Chinese medicine composition that the present invention provides adds Herba Siegesbeckiae further With Radix seu Caulis Verntilaginis Leiocarpae, Herba Siegesbeckiae and Radix seu Caulis Verntilaginis Leiocarpae can effectively treat between numb limbs and tense tendons, waist shoulder pain, bone The symptoms such as pain, are additionally operable to treat rheumatic Bi syndrome, arthralgia, limb weak unable etc. simultaneously, have Effect reduction of patient is ailing.
Carry for convenience and eat, present invention also offers one and include that described treatment neck takes on waist The capsule of the Chinese medicine composition of the pain that has a pain in the leg, described capsule is by capsule filling and capsule shells group Becoming, described capsule filling includes pharmaceutical composition and the adjuvant that weight part ratio is 1:0.5-2.
Further, described adjuvant includes the composition of following parts by weight: nicotiamide 1-5 part, salt Acid pyridoxol 1-3 part, monoethanolamine 1-5 part.By adding nicotiamide, hydrochloric acid in capsule Pyridoxol, monoethanolamine use primarily as solubilizing agent, and Chinese medicine composition plays hydrotropy effect Really, improve the stability of crude drug in Chinese medicine composition, the effect of slow release can be played simultaneously, Make crude drug that drug effect fully to occur.
Further, described adjuvant also includes the composition of following parts by weight: sodium starch glycol 1-4 part, sucrose monolaurate 1-3 part.By in capsule increase sodium starch glycol and Sucrose monolaurate, uses primarily as disintegrating agent, and this disintegrating agent can make Chinese medicine composition Thing formed capsule can whole disintegrates in 10 minutes, raising disintegration, shorten and control The treatment time, it is possible to make capsule quickly realize drug effect, alleviate patient pain.
Preferably, described capsule shells includes the composition of following parts by weight: Pullulan 2-6 part, sea Calcium alginate 4-8 part.By select the capsule shells made of above material have good sun-proof, Thermal protective performance, further ensures quality and the stability of capsule filling, further increases The stability of capsule so that it is drug effect can be played fully.
The present invention further provides the system of a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain Preparation Method, the method comprises the following steps:
S1, weigh following raw material respectively according to parts by weight: Radix Angelicae Sinensis 5-10 part, Flos Carthami 15-20 Part, Radix Angelicae Dahuricae 10-15 part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, Ramulus Cinnamomi 10-15 part, Qiang 10-15 part, Radix Angelicae Pubescentis 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci alive 15-20 part, Rhizoma Cibotii 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 part, eupolyphaga 10-15 Part, Cortex Acanthopancis 15-20 part, Caulis Spatholobi 20-25 part, Olibanum 15-20 part, Myrrha 15-20 part, Resina Draconis 5-10 part, big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, Radix Aconiti Preparata 10-15 part, system grass Crow 10-15 part, Radix Achyranthis Bidentatae 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 part, Moschus 0.1-0.5 Part, Herba Asari 5-10 part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 part, Rhizoma Pinelliae Preparata 5-10 part, sweet Grass 5-10 part, and carry out the crude drug weighed respectively pulverizing, mill, sieve and make fine powder, The mesh number of described screen cloth is 10-30 mesh；
S2, extraction: the powder after pulverizing in step S1 is at 20～40MPa, 30～60 DEG C of bars Carry out CO 2 supercritical hybrid extraction 3-4 hour under part, collect medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating decoction 2 of 5-9 times of 60%-80% ethanol Secondary, each 1～2 hour, filter, merge secondary raffinate, be concentrated into during 50 DEG C of surveys the closeest Degree is 1.15～1.20, adds ethanol to alcohol content and reaches 60～70%, stands 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continues to concentrate, the neck that i.e. obtains medical treatment shoulder waist The Chinese medicine composition extractum of the pain that has a pain in the leg.
The Chinese medicine composition prepared by said method, it does not affect the active ingredient of crude drug, The active ingredient that will not make crude drug loses, and by extraction, alcohol extraction, the method energy of concentration Enough the active ingredient of crude drug is sufficiently mixed collection, additionally, this preparation method is simple to operate, Preparation is convenient, it is possible to use of large-scale production.
Further, in step S1, weigh following raw material respectively according to parts by weight: Radix Angelicae Sinensis 5-10 Part, Flos Carthami 15-20 part, Radix Angelicae Dahuricae 10-15 part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, osmanthus Branch 10-15 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Angelicae Pubescentis 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci 15-20 part, Rhizoma Cibotii 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 Part, eupolyphaga 10-15 part, Cortex Acanthopancis 15-20 part, Caulis Spatholobi 20-25 part, Olibanum 15-20 part, Myrrha 15-20 part, Resina Draconis 5-10 part, big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, Radix Aconiti Preparata 10-15 part, Radix Aconiti Kusnezoffii Preparata 10-15 part, Radix Achyranthis Bidentatae 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 Part, Moschus 0.1-0.5 part, Herba Asari 5-10 part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 part, system Rhizoma Pinelliae 5-10 part, Radix Glycyrrhizae 5-10 part, Herba Erodii 5-8 part, Membrana Follicularis ovi 3-5 part, and will weigh Crude drug carry out respectively pulverizing, mill, sieve and make fine powder, the mesh number of described screen cloth is 10-30 Mesh；
Preferably, in step S1, weigh following raw material respectively according to parts by weight: Radix Angelicae Sinensis 5-10 Part, Flos Carthami 15-20 part, Radix Angelicae Dahuricae 10-15 part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, osmanthus Branch 10-15 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Angelicae Pubescentis 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci 15-20 part, Rhizoma Cibotii 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 Part, eupolyphaga 10-15 part, Cortex Acanthopancis 15-20 part, Caulis Spatholobi 20-25 part, Olibanum 15-20 part, Myrrha 15-20 part, Resina Draconis 5-10 part, big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, Radix Aconiti Preparata 10-15 part, Radix Aconiti Kusnezoffii Preparata 10-15 part, Radix Achyranthis Bidentatae 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 Part, Moschus 0.1-0.5 part, Herba Asari 5-10 part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 part, system Rhizoma Pinelliae 5-10 part, Radix Glycyrrhizae 5-10 part, Herba Erodii 5-8 part, Membrana Follicularis ovi 3-5 part, Herba Siegesbeckiae 3-5 Part, Radix seu Caulis Verntilaginis Leiocarpae 4-9 part, and carry out the crude drug weighed respectively pulverizing, mill, cross sieve series Becoming fine powder, the mesh number of described screen cloth is 10-30 mesh.
Preferably, described Chinese medicine composition is at preparation treatment neck, shoulder, waist or the medicine of the pain that has a pain in the leg Application in thing.
Beneficial effects of the present invention is as follows: the Chinese medicine composition that the present invention provides passes through plurality of raw materials The collaborative compatibility of medicine, the neck of co-therapy patient, shoulder, waist, have a pain in the leg pain, this Drug therapy imitate Fruit is notable, plays drug effect very fast, it is possible to the pain of rapid recovery patient, and treatment cycle is short, Can not only effect a radical cure, and this Chinese medicine is without any side effects, not damage in patient liver, kidney etc. Dirty, that the present invention provides in addition capsule, facilitates patient to take and carries, using safer Reliably.
Detailed description of the invention
Below in conjunction with following example, the present invention is described in further detail.
Embodiment 1
The embodiment of the present invention 1 provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 5 grams, 15 grams of Flos Carthami, the Radix Angelicae Dahuricae 10 Gram, the Cortex Eucommiae 15 grams, Rhizoma Chuanxiong 15 grams, Ramulus Cinnamomi 10 grams, Rhizoma Et Radix Notopterygii 10 grams, Radix Angelicae Pubescentis 10 grams, prestige Radix Clematidis 15 grams, Rhizoma Drynariae 15 grams, Radix Dipsaci 15 grams, Rhizoma Cibotii 15 grams, Pyritum 10 grams, three 75 grams, eupolyphaga 10 grams, Cortex Acanthopancis 15 grams, Caulis Spatholobi 20 grams, Olibanum 15 grams, Myrrha 15 grams, Resina Draconis 5 grams, big gun first 10 grams, 10 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 10 grams, Radix Aconiti Kusnezoffii Preparata 10 Gram, Radix Achyranthis Bidentatae 15 grams, Scolopendra 7 grams, Scorpio 5 grams, 0.1 gram of Moschus, Herba Asari 5 grams, Borneolum Syntheticum 5 grams, Rhizoma Arisaematis (processed) 5 grams, Rhizoma Pinelliae Preparata 5 grams, 5 grams of Radix Glycyrrhizae.
Embodiment 2
The embodiment of the present invention 2 provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 8 grams, 18 grams of Flos Carthami, the Radix Angelicae Dahuricae 13 Gram, the Cortex Eucommiae 18 grams, Rhizoma Chuanxiong 18 grams, Ramulus Cinnamomi 13 grams, Rhizoma Et Radix Notopterygii 13 grams, Radix Angelicae Pubescentis 12 grams, prestige Radix Clematidis 17 grams, Rhizoma Drynariae 17 grams, Radix Dipsaci 17 grams, Rhizoma Cibotii 18 grams, Pyritum 13 grams, three 78 grams, eupolyphaga 13 grams, Cortex Acanthopancis 13 grams, Caulis Spatholobi 23 grams, Olibanum 18 grams, Myrrha 18 grams, Resina Draconis 8 grams, big gun first 13 grams, 13 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 13 grams, Radix Aconiti Kusnezoffii Preparata 13 Gram, Radix Achyranthis Bidentatae 18 grams, Scolopendra 10 grams, Scorpio 8 grams, 0.3 gram of Moschus, Herba Asari 8 grams, Borneolum Syntheticum 8 grams, Rhizoma Arisaematis (processed) 8 grams, Rhizoma Pinelliae Preparata 8 grams, 8 grams of Radix Glycyrrhizae.
The embodiment of the present invention 2 further provides a kind of Chinese drug-treated group treating neck, shoulder, waist and leg pain The preparation method of compound, the method comprises the following steps:
S1, weigh following raw material respectively according to weight grams: Radix Angelicae Sinensis 8 grams, 18 grams of Flos Carthami, white The root of Dahurian angelica 13 grams, the Cortex Eucommiae 18 grams, Rhizoma Chuanxiong 18 grams, Ramulus Cinnamomi 13 grams, Rhizoma Et Radix Notopterygii 13 grams, Radix Angelicae Pubescentis 12 Gram, Radix Clematidis 17 grams, Rhizoma Drynariae 17 grams, Radix Dipsaci 17 grams, Rhizoma Cibotii 18 grams, Pyritum 13 Gram, Radix Notoginseng 8 grams, eupolyphaga 13 grams, Cortex Acanthopancis 13 grams, Caulis Spatholobi 23 grams, Olibanum 18 grams, Myrrha 18 grams, Resina Draconis 8 grams, big gun first 13 grams, 13 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 13 grams, system grass Crow 13 grams, Radix Achyranthis Bidentatae 18 grams, Scolopendra 10 grams, Scorpio 8 grams, 0.3 gram of Moschus, Herba Asari 8 grams, Borneolum Syntheticum 8 grams, Rhizoma Arisaematis (processed) 8 grams, Rhizoma Pinelliae Preparata 8 grams, 8 grams of Radix Glycyrrhizae, and the crude drug that will weigh Carrying out respectively pulverizing, mill, sieve and make fine powder, the mesh number of described screen cloth is 10 mesh；
S2, extraction: the powder after pulverizing in step S1 is carried out at 20MPa, under the conditions of 30 DEG C CO 2 supercritical hybrid extraction 3 hours, collects medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating of 5 times of 60% ethanol decoct 2 times, every time 1～2 hour, filtering, merge secondary raffinate, when being concentrated into 50 DEG C of surveys, relative density is 1.15, Add ethanol to alcohol content and reach 60～70%, stand 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continues to concentrate, the neck that i.e. obtains medical treatment shoulder waist The Chinese medicine composition extractum of the pain that has a pain in the leg.
Embodiment 3
The embodiment of the present invention 3 provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 10 grams, 20 grams of Flos Carthami, the Radix Angelicae Dahuricae 15 grams, the Cortex Eucommiae 20 grams, Rhizoma Chuanxiong 20 grams, Ramulus Cinnamomi 15 grams, Rhizoma Et Radix Notopterygii 15 grams, Radix Angelicae Pubescentis 15 grams, Radix Clematidis 20 grams, Rhizoma Drynariae 20 grams, Radix Dipsaci 20 grams, Rhizoma Cibotii 20 grams, Pyritum 15 grams, Radix Notoginseng 10 grams, eupolyphaga 15 grams, Cortex Acanthopancis 20 grams, Caulis Spatholobi 25 grams, Olibanum 20 grams, do not have Medicine 20 grams, Resina Draconis 10 grams, big gun first 15 grams, 15 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 15 grams, Radix Aconiti Kusnezoffii Preparata 15 grams, Radix Achyranthis Bidentatae 20 grams, Scolopendra 13 grams, Scorpio 10 grams, 0.5 gram of Moschus, Herba Asari 10 grams, Borneolum Syntheticum 10 grams, Rhizoma Arisaematis (processed) 10 grams, Rhizoma Pinelliae Preparata 10 grams, 10 grams of Radix Glycyrrhizae, Herba Erodii 5 grams, Membrana Follicularis ovi 3 grams.
The embodiment of the present invention 3 further provides a kind of Chinese drug-treated group treating neck, shoulder, waist and leg pain The preparation method of compound, the method comprises the following steps:
S1, weigh following raw material respectively according to weight grams: Radix Angelicae Sinensis 10 grams, 20 grams of Flos Carthami, The Radix Angelicae Dahuricae 15 grams, the Cortex Eucommiae 20 grams, Rhizoma Chuanxiong 20 grams, Ramulus Cinnamomi 15 grams, Rhizoma Et Radix Notopterygii 15 grams, Radix Angelicae Pubescentis 15 Gram, Radix Clematidis 20 grams, Rhizoma Drynariae 20 grams, Radix Dipsaci 20 grams, Rhizoma Cibotii 20 grams, Pyritum 15 Gram, Radix Notoginseng 10 grams, eupolyphaga 15 grams, Cortex Acanthopancis 20 grams, Caulis Spatholobi 25 grams, Olibanum 20 grams, Myrrha 20 grams, Resina Draconis 10 grams, big gun first 15 grams, 15 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 15 grams, system grass Crow 15 grams, Radix Achyranthis Bidentatae 20 grams, Scolopendra 13 grams, Scorpio 10 grams, 0.5 gram of Moschus, Herba Asari 10 Gram, Borneolum Syntheticum 10 grams, Rhizoma Arisaematis (processed) 10 grams, Rhizoma Pinelliae Preparata 10 grams, 10 grams of Radix Glycyrrhizae, Herba Erodii 5 Gram, Membrana Follicularis ovi 3 grams, and carry out the crude drug weighed respectively pulverizing, mill, sieve and make Fine powder, the mesh number of described screen cloth is 20 mesh；
S2, extraction: the powder after pulverizing in step S1 is carried out at 30MPa, under the conditions of 45 DEG C CO 2 supercritical hybrid extraction 3.5 hours, collects medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating of 7 times of 70% ethanol decoct 2 times, every time 1～2 hour, filtering, merge secondary raffinate, when being concentrated into 50 DEG C of surveys, relative density is 1.17, Add ethanol to alcohol content and reach 60～70%, stand 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continues to concentrate, the neck that i.e. obtains medical treatment shoulder waist The Chinese medicine composition extractum of the pain that has a pain in the leg.
Embodiment 4
The embodiment of the present invention 4 provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 5 grams, 15 grams of Flos Carthami, the Radix Angelicae Dahuricae 10 Gram, the Cortex Eucommiae 15 grams, Rhizoma Chuanxiong 15 grams, Ramulus Cinnamomi 10 grams, Rhizoma Et Radix Notopterygii 10 grams, Radix Angelicae Pubescentis 10 grams, prestige Radix Clematidis 15 grams, Rhizoma Drynariae 15 grams, Radix Dipsaci 15 grams, Rhizoma Cibotii 15 grams, Pyritum 10 grams, three 75 grams, eupolyphaga 10 grams, Cortex Acanthopancis 15 grams, Caulis Spatholobi 20 grams, Olibanum 15 grams, Myrrha 15 grams, Resina Draconis 5 grams, big gun first 10 grams, 10 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 10 grams, Radix Aconiti Kusnezoffii Preparata 10 Gram, Radix Achyranthis Bidentatae 15 grams, Scolopendra 7 grams, Scorpio 5 grams, 0.1 gram of Moschus, Herba Asari 5 grams, Borneolum Syntheticum 5 grams, Rhizoma Arisaematis (processed) 5 grams, Rhizoma Pinelliae Preparata 5 grams, 5 grams of Radix Glycyrrhizae, Herba Erodii 8 grams, Membrana Follicularis ovi 5 Gram.
The embodiment of the present invention 4 further provides a kind of Chinese drug-treated group treating neck, shoulder, waist and leg pain The preparation method of compound, the method comprises the following steps:
S1, weigh following raw material respectively according to weight grams: Radix Angelicae Sinensis 5 grams, 15 grams of Flos Carthami, white The root of Dahurian angelica 10 grams, the Cortex Eucommiae 15 grams, Rhizoma Chuanxiong 15 grams, Ramulus Cinnamomi 10 grams, Rhizoma Et Radix Notopterygii 10 grams, Radix Angelicae Pubescentis 10 Gram, Radix Clematidis 15 grams, Rhizoma Drynariae 15 grams, Radix Dipsaci 15 grams, Rhizoma Cibotii 15 grams, Pyritum 10 Gram, Radix Notoginseng 5 grams, eupolyphaga 10 grams, Cortex Acanthopancis 15 grams, Caulis Spatholobi 20 grams, Olibanum 15 grams, Myrrha 15 grams, Resina Draconis 5 grams, big gun first 10 grams, 10 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 10 grams, system grass Crow 10 grams, Radix Achyranthis Bidentatae 15 grams, Scolopendra 7 grams, Scorpio 5 grams, 0.1 gram of Moschus, Herba Asari 5 grams, Borneolum Syntheticum 5 grams, Rhizoma Arisaematis (processed) 5 grams, Rhizoma Pinelliae Preparata 5 grams, 5 grams of Radix Glycyrrhizae, Herba Erodii 8 grams, phoenix 5 grams of clothing, and carry out the crude drug weighed respectively pulverizing, mill, sieve and make fine powder, institute The mesh number stating screen cloth is 30 mesh；
S2, extraction: the powder after pulverizing in step S1 is carried out at 40MPa, under the conditions of 60 DEG C CO 2 supercritical hybrid extraction 4 hours, collects medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating of 9 times of 80% ethanol decoct 2 times, every time 1～2 hour, filtering, merge secondary raffinate, when being concentrated into 50 DEG C of surveys, relative density is 1.20, Add ethanol to alcohol content and reach 60～70%, stand 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continues to concentrate, the neck that i.e. obtains medical treatment shoulder waist The Chinese medicine composition extractum of the pain that has a pain in the leg.
Embodiment 5
The embodiment of the present invention 5 provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 8 grams, 18 grams of Flos Carthami, the Radix Angelicae Dahuricae 13 Gram, the Cortex Eucommiae 18 grams, Rhizoma Chuanxiong 18 grams, Ramulus Cinnamomi 13 grams, Rhizoma Et Radix Notopterygii 13 grams, Radix Angelicae Pubescentis 12 grams, prestige Radix Clematidis 17 grams, Rhizoma Drynariae 17 grams, Radix Dipsaci 17 grams, Rhizoma Cibotii 18 grams, Pyritum 13 grams, three 78 grams, eupolyphaga 13 grams, Cortex Acanthopancis 13 grams, Caulis Spatholobi 23 grams, Olibanum 18 grams, Myrrha 18 grams, Resina Draconis 8 grams, big gun first 13 grams, 13 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 13 grams, Radix Aconiti Kusnezoffii Preparata 13 Gram, Radix Achyranthis Bidentatae 18 grams, Scolopendra 10 grams, Scorpio 8 grams, 0.3 gram of Moschus, Herba Asari 8 grams, Borneolum Syntheticum 8 grams, Rhizoma Arisaematis (processed) 8 grams, Rhizoma Pinelliae Preparata 8 grams, 8 grams of Radix Glycyrrhizae, Herba Erodii 7 grams, Membrana Follicularis ovi 4 Gram, Herba Siegesbeckiae 3 grams, Radix seu Caulis Verntilaginis Leiocarpae 4 grams.
The embodiment of the present invention 5 further provides a kind of Chinese drug-treated group treating neck, shoulder, waist and leg pain The preparation method of compound, the method comprises the following steps:
S1, weigh following raw material respectively according to weight grams: Radix Angelicae Sinensis 8 grams, 18 grams of Flos Carthami, white The root of Dahurian angelica 13 grams, the Cortex Eucommiae 18 grams, Rhizoma Chuanxiong 18 grams, Ramulus Cinnamomi 13 grams, Rhizoma Et Radix Notopterygii 13 grams, Radix Angelicae Pubescentis 12 Gram, Radix Clematidis 17 grams, Rhizoma Drynariae 17 grams, Radix Dipsaci 17 grams, Rhizoma Cibotii 18 grams, Pyritum 13 Gram, Radix Notoginseng 8 grams, eupolyphaga 13 grams, Cortex Acanthopancis 13 grams, Caulis Spatholobi 23 grams, Olibanum 18 grams, Myrrha 18 grams, Resina Draconis 8 grams, big gun first 13 grams, 13 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 13 grams, system grass Crow 13 grams, Radix Achyranthis Bidentatae 18 grams, Scolopendra 10 grams, Scorpio 8 grams, 0.3 gram of Moschus, Herba Asari 8 grams, Borneolum Syntheticum 8 grams, Rhizoma Arisaematis (processed) 8 grams, Rhizoma Pinelliae Preparata 8 grams, 8 grams of Radix Glycyrrhizae, Herba Erodii 7 grams, phoenix 4 grams of clothing, Herba Siegesbeckiae 3 grams, Radix seu Caulis Verntilaginis Leiocarpae 4 grams, and carry out the crude drug weighed respectively pulverizing, Milling, sieve and make fine powder, the mesh number of described screen cloth is 15 mesh；
S2, extraction: the powder after pulverizing in step S1 is carried out at 30MPa, under the conditions of 48 DEG C CO 2 supercritical hybrid extraction 3.5 hours, collects medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating of 6 times of 75% ethanol decoct 2 times, every time 1～2 hour, filtering, merge secondary raffinate, when being concentrated into 50 DEG C of surveys, relative density is 1.16, Add ethanol to alcohol content and reach 60～70%, stand 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continues to concentrate, the neck that i.e. obtains medical treatment shoulder waist The Chinese medicine composition extractum of the pain that has a pain in the leg.
Embodiment 6
The embodiment of the present invention 6 provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 5 grams, 15 grams of Flos Carthami, the Radix Angelicae Dahuricae 10 Gram, the Cortex Eucommiae 15 grams, Rhizoma Chuanxiong 15 grams, Ramulus Cinnamomi 10 grams, Rhizoma Et Radix Notopterygii 10 grams, Radix Angelicae Pubescentis 10 grams, prestige Radix Clematidis 15 grams, Rhizoma Drynariae 15 grams, Radix Dipsaci 15 grams, Rhizoma Cibotii 15 grams, Pyritum 10 grams, three 75 grams, eupolyphaga 10 grams, Cortex Acanthopancis 15 grams, Caulis Spatholobi 20 grams, Olibanum 15 grams, Myrrha 15 grams, Resina Draconis 5 grams, big gun first 10 grams, 10 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 10 grams, Radix Aconiti Kusnezoffii Preparata 10 Gram, Radix Achyranthis Bidentatae 15 grams, Scolopendra 7 grams, Scorpio 5 grams, 0.1 gram of Moschus, Herba Asari 5 grams, Borneolum Syntheticum 5 grams, Rhizoma Arisaematis (processed) 5 grams, Rhizoma Pinelliae Preparata 5 grams, 5 grams of Radix Glycyrrhizae, Herba Erodii 8 grams, Membrana Follicularis ovi 5 Gram, Herba Siegesbeckiae 4 grams, Radix seu Caulis Verntilaginis Leiocarpae 7 grams.
The embodiment of the present invention 6 further provides a kind of Chinese drug-treated group treating neck, shoulder, waist and leg pain The preparation method of compound, the method comprises the following steps:
S1, weigh following raw material respectively according to weight grams: Radix Angelicae Sinensis 5 grams, 15 grams of Flos Carthami, white The root of Dahurian angelica 10 grams, the Cortex Eucommiae 15 grams, Rhizoma Chuanxiong 15 grams, Ramulus Cinnamomi 10 grams, Rhizoma Et Radix Notopterygii 10 grams, Radix Angelicae Pubescentis 10 Gram, Radix Clematidis 15 grams, Rhizoma Drynariae 15 grams, Radix Dipsaci 15 grams, Rhizoma Cibotii 15 grams, Pyritum 10 Gram, Radix Notoginseng 5 grams, eupolyphaga 10 grams, Cortex Acanthopancis 15 grams, Caulis Spatholobi 20 grams, Olibanum 15 grams, Myrrha 15 grams, Resina Draconis 5 grams, big gun first 10 grams, 10 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 10 grams, system grass Crow 10 grams, Radix Achyranthis Bidentatae 15 grams, Scolopendra 7 grams, Scorpio 5 grams, 0.1 gram of Moschus, Herba Asari 5 grams, Borneolum Syntheticum 5 grams, Rhizoma Arisaematis (processed) 5 grams, Rhizoma Pinelliae Preparata 5 grams, 5 grams of Radix Glycyrrhizae, Herba Erodii 8 grams, phoenix 5 grams of clothing, Herba Siegesbeckiae 4 grams, Radix seu Caulis Verntilaginis Leiocarpae 7 grams, and carry out the crude drug weighed respectively pulverizing, Milling, sieve and make fine powder, the mesh number of described screen cloth is 10 mesh；
S2, extraction: the powder after pulverizing in step S1 is carried out at 20MPa, under the conditions of 30 DEG C CO 2 supercritical hybrid extraction 3 hours, collects medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating of 5 times of 60% ethanol decoct 2 times, every time 1～2 hour, filtering, merge secondary raffinate, when being concentrated into 50 DEG C of surveys, relative density is 1.15, Add ethanol to alcohol content and reach 60～70%, stand 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continues to concentrate, the neck that i.e. obtains medical treatment shoulder waist The Chinese medicine composition extractum of the pain that has a pain in the leg.
Embodiment 7
The embodiment of the present invention 7 provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 10 grams, 20 grams of Flos Carthami, the Radix Angelicae Dahuricae 15 grams, the Cortex Eucommiae 20 grams, Rhizoma Chuanxiong 20 grams, Ramulus Cinnamomi 15 grams, Rhizoma Et Radix Notopterygii 15 grams, Radix Angelicae Pubescentis 15 grams, Radix Clematidis 20 grams, Rhizoma Drynariae 20 grams, Radix Dipsaci 20 grams, Rhizoma Cibotii 20 grams, Pyritum 15 grams, Radix Notoginseng 10 grams, eupolyphaga 15 grams, Cortex Acanthopancis 20 grams, Caulis Spatholobi 25 grams, Olibanum 20 grams, do not have Medicine 20 grams, Resina Draconis 10 grams, big gun first 15 grams, 15 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 15 grams, Radix Aconiti Kusnezoffii Preparata 15 grams, Radix Achyranthis Bidentatae 20 grams, Scolopendra 13 grams, Scorpio 10 grams, 0.5 gram of Moschus, Herba Asari 10 grams, Borneolum Syntheticum 10 grams, Rhizoma Arisaematis (processed) 10 grams, Rhizoma Pinelliae Preparata 10 grams, 10 grams of Radix Glycyrrhizae, Herba Erodii 5 grams, Membrana Follicularis ovi 3 grams, Herba Siegesbeckiae 5 grams, Radix seu Caulis Verntilaginis Leiocarpae 9 grams.
The embodiment of the present invention 7 further provides a kind of Chinese drug-treated group treating neck, shoulder, waist and leg pain The preparation method of compound, the method comprises the following steps:
S1, weigh following raw material respectively according to weight grams: Radix Angelicae Sinensis 10 grams, 20 grams of Flos Carthami, The Radix Angelicae Dahuricae 15 grams, the Cortex Eucommiae 20 grams, Rhizoma Chuanxiong 20 grams, Ramulus Cinnamomi 15 grams, Rhizoma Et Radix Notopterygii 15 grams, Radix Angelicae Pubescentis 15 Gram, Radix Clematidis 20 grams, Rhizoma Drynariae 20 grams, Radix Dipsaci 20 grams, Rhizoma Cibotii 20 grams, Pyritum 15 Gram, Radix Notoginseng 10 grams, eupolyphaga 15 grams, Cortex Acanthopancis 20 grams, Caulis Spatholobi 25 grams, Olibanum 20 grams, Myrrha 20 grams, Resina Draconis 10 grams, big gun first 15 grams, 15 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 15 grams, system grass Crow 15 grams, Radix Achyranthis Bidentatae 20 grams, Scolopendra 13 grams, Scorpio 10 grams, 0.5 gram of Moschus, Herba Asari 10 Gram, Borneolum Syntheticum 10 grams, Rhizoma Arisaematis (processed) 10 grams, Rhizoma Pinelliae Preparata 10 grams, 10 grams of Radix Glycyrrhizae, Herba Erodii 5 Gram, Membrana Follicularis ovi 3 grams, Herba Siegesbeckiae 5 grams, Radix seu Caulis Verntilaginis Leiocarpae 9 grams, and will the crude drug that weigh respectively Carrying out pulverizing, mill, sieve and make fine powder, the mesh number of described screen cloth is 30 mesh；
S2, extraction: the powder after pulverizing in step S1 is carried out at 40MPa, under the conditions of 60 DEG C CO 2 supercritical hybrid extraction 4 hours, collects medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating of 9 times of 80% ethanol decoct 2 times, every time 1～2 hour, filtering, merge secondary raffinate, when being concentrated into 50 DEG C of surveys, relative density is 1.20, Add ethanol to alcohol content and reach 60～70%, stand 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continues to concentrate, the neck that i.e. obtains medical treatment shoulder waist The Chinese medicine composition extractum of the pain that has a pain in the leg.
Embodiment 8
The invention provides the glue of the Chinese medicine composition including a kind of described treatment neck, shoulder, waist and leg pain Wafer, described capsule is made up of capsule filling and capsule shells, and described capsule filling includes Weight in grams is than for the pharmaceutical composition of 2:1 and adjuvant, and concrete content is as follows:
Embodiment 9
The invention provides the glue of the Chinese medicine composition including a kind of described treatment neck, shoulder, waist and leg pain Wafer, described capsule is made up of capsule filling and capsule shells, and described capsule filling includes Weight in grams is than for the pharmaceutical composition of 1:1 and adjuvant, and concrete content is as follows:
Embodiment 10
The invention provides the glue of the Chinese medicine composition including a kind of described treatment neck, shoulder, waist and leg pain Wafer, described capsule is made up of capsule filling and capsule shells, and described capsule filling includes Weight in grams is than for the pharmaceutical composition of 1:2 and adjuvant, and concrete content is as follows:
Preferably, described capsule shells includes the composition of following weight grams: Pullulan 2 grams, sea Calcium alginate 4 grams.
Embodiment 11
The invention provides the glue of the Chinese medicine composition including a kind of described treatment neck, shoulder, waist and leg pain Wafer, described capsule is made up of capsule filling and capsule shells, and described capsule filling includes Weight in grams is than for the pharmaceutical composition of 1:1 and adjuvant, and concrete content is as follows:
Preferably, described capsule shells includes the composition of following weight grams: Pullulan 4 grams, sea Calcium alginate 6 grams.
Embodiment 12
The invention provides the glue of the Chinese medicine composition including a kind of described treatment neck, shoulder, waist and leg pain Wafer, described capsule is made up of capsule filling and capsule shells, and described capsule filling includes Weight in grams is than for the pharmaceutical composition of 2:1 and adjuvant, and concrete content is as follows:
Preferably, described capsule shells includes the composition of following weight grams: Pullulan 6 grams, sea Calcium alginate 8 grams.
Embodiment 13
Preferably, the present invention provide described Chinese medicine composition preparation treatment neck, shoulder, waist or Have a pain in the leg the application in the medicine of pain.
Reference examples 1
Reference examples 1 of the present invention provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Pubescentis 12 grams, Radix Clematidis 14 grams, bone Broken benefit 15 grams, Radix Dipsaci 17 grams, Rhizoma Cibotii 15 grams, Radix Notoginseng 5 grams, Resina Draconis 8 grams, big gun first 11 Gram, 10 grams of Rhizoma Curcumae Longae.
Reference examples 2
Reference examples 2 of the present invention provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Radix Angelicae Sinensis 7 grams, 17 grams of Flos Carthami, the Radix Angelicae Dahuricae 13 Gram, the Cortex Eucommiae 18 grams, Rhizoma Chuanxiong 21 grams, Ramulus Cinnamomi 9 grams, Rhizoma Et Radix Notopterygii 13 grams, Caulis Spatholobi 21 grams, Olibanum 20 grams, Myrrha 22 grams, Resina Draconis 18 grams, big gun first 12 grams, 18 grams of Rhizoma Curcumae Longae, Radix Aconiti Preparata 19 grams, Radix Aconiti Kusnezoffii Preparata 14 grams, Radix Achyranthis Bidentatae 20 grams, Scolopendra 15 grams, 12 grams of Radix Glycyrrhizae, Herba Erodii 6 Gram.
Reference examples 3
Reference examples 3 of the present invention provides a kind of Chinese medicine composition treating neck, shoulder, waist and leg pain, should Chinese medicine composition includes the raw material of following weight grams: Ramulus Cinnamomi 13 grams, Rhizoma Et Radix Notopterygii 13 grams, Radix Angelicae Pubescentis 12 grams, Radix Clematidis 17 grams, Rhizoma Drynariae 17 grams, Radix Dipsaci 17 grams, Caulis Spatholobi 23 grams, Olibanum 18 grams, big gun first 13 grams, 13 grams of Rhizoma Curcumae Longae, Scorpio 8 grams, 0.3 gram of Moschus, Borneolum Syntheticum 8 grams, Rhizoma Arisaematis (processed) 8 grams, Rhizoma Pinelliae Preparata 8 grams, 8 grams of Radix Glycyrrhizae, Membrana Follicularis ovi 4 grams, Radix seu Caulis Verntilaginis Leiocarpae 4 grams.
Reference examples 4
Reference examples 4 of the present invention provides the Chinese drug-treated group including a kind of described treatment neck, shoulder, waist and leg pain The capsule of compound, described capsule is made up of capsule filling and capsule shells, and described capsule is filled out Fill thing include weight in grams than for the pharmaceutical composition of 2:1 and adjuvant, concrete content is as follows:
Chinese medicine composition 10 grams
Nicotiamide 2.5 grams
Monoethanolamine 2.5 grams.
Reference examples 5
The invention provides the glue of the Chinese medicine composition including a kind of described treatment neck, shoulder, waist and leg pain Wafer, described capsule is made up of capsule filling and capsule shells, and described capsule filling includes Weight in grams is than for the pharmaceutical composition of 1:1 and adjuvant, and concrete content is as follows:
The vitro release of the capsule including Chinese medicine composition that experiment 1, the present invention provide measures Test
The release detection of pharmaceutical composition: with reference to 2010 editions version " Chinese Pharmacopoeia " annex XIXD bodies Outer drug release rate inspection.
Take the capsule that above example 8, embodiment 9 and reference examples 4 provide respectively, and will take The capsule gone out is respectively implanted in digestion instrument, in 1h, 2h, 4h, 6h, 12h, 16h, 24h Separately sampled, and the sample high performance liquid chromatography taken out is detected dissolution percentage rate, and count Calculate the cumulative release percentage rate of medicine.
Dissolution (%) result of the test of inventive samples
The pharmaceutical composition of embodiment 8 all discharges in 12h as can be seen from the table, implements The pharmaceutical composition of example 9 all discharges in 4h, and there is serious peak valley phenomenon, right The capsule of the pharmaceutical composition of 4 only released 75%, therefore, basis within 24 hours as usual In inventive embodiments 8 and 9 provide pharmaceutical composition add nicotiamide, pyridoxine hydrochloride and After monoethanolamine, it is possible to significantly improve the stability of drug regimen raw material, play slow release effect, Promote the absorption of active component in Chinese medicine major ingredient, it is preferred that along with hydroquinone, polyvidone and hexamethylene The content of amino sulphur increases, and releasing effect is more preferably obvious, lacks any one, its release Effect is the most poor.
Effect disintegration of the capsule including Chinese medicine composition that experiment 2, the present invention provide is surveyed Fixed
According to the regulation in Chinese Pharmacopoeia, the disintegration surveying capsule surveys it to pharmaceutical composition Emulsifying effectiveness.
Take what above example 10, embodiment 11, embodiment 12 and reference examples 5 provided respectively Capsule, tests disintegration respectively, and test data result is as follows:
The different auxiliary material impact on capsule disintegration
As can be seen from the table, the embodiment of the present invention 10,11,12 provide capsule and reference examples 5 capsules provided are compared, the present invention contain sodium starch glycol that weight grams is 1-4 gram and The sucrose monolaurate of 1-3 gram, can be effectively improved pharmaceutical composition disintegrate in capsule In the time limit, lacking any one, disintegrate effect is the most bad, thus may certify that, the present invention The capsule provided can fater disintegration, it is possible to make active ingredient the most quickly arrive pathogenic site, Thus alleviate the pain of sufferer.
The stability test of the capsule including Chinese medicine composition that test example 3 present invention provides 1. accelerated test
Take capsule and patent document Publication No. that above example 10 provides respectively The neck, shoulder, waist and leg pain capsule that CN1435245A provides, all at temperature 40 DEG C ± 2 DEG C, relatively Humidity is to place 6 months under conditions of 75% ± 5%, test 1 month period, 2 months, 3 Individual month, 6 the end of month separately sampled once, detect the character of capsule, color and luster, abnormal smells from the patient, main one-tenth Divide content (labelled amount %), moisture, it was found that the indices of embodiment 10 is all without substantially Change；And the neck, shoulder, waist and leg pain capsule face that patent document Publication No. CN1435245A provides Color substantially deepens, and the labelled amount of main constituent significantly reduces, and moisture increases.
2. long term test
Take capsule and patent document Publication No. that above example 10 provides respectively The neck, shoulder, waist and leg pain capsule that CN1435245A provides, all at temperature 25 DEG C ± 2 DEG C, relatively Humidity is to place 12 months under conditions of 60% ± 10%, test 0 month period, 3 months, 6 Individual month, 9 months, 12 the end of month separately sampled once, detection the character of capsule, color and luster, Main constituent content (labelled amount %), moisture, it was found that the equal nothing of the indices of embodiment 10 Significant change；And the neck, shoulder, waist and leg pain glue that patent document Publication No. CN1435245A provides Capsule color substantially deepens, and the labelled amount of main constituent significantly reduces, and moisture increases.
It can be seen that Pullulan and the mixture of calcium alginate from accelerated test and long term test Being remarkably improved the stability of capsule, the capsule shells being simultaneously made up of heterogeneity is to capsule Stability also have certain contribution.
The Chinese medicine that experiment 4, the present invention the provide therapeutic effect to patient's neck, shoulder, waist and leg pain
1, test crowd
Select patient 120 example of neck, shoulder, waist and leg pain, male 80 example, women 40 example, 100 examples Patient all suffers from the neck, shoulder, waist and leg pain of more than at least 2 months.
2, packet
120 example patients are randomly divided into 6 test group, each test group 20 people, wherein 3 The patient of test group takes in the embodiment of the present invention 1, embodiment 3 and embodiment 5 offer respectively Capsule prepared by drug composition, the patient of remaining 3 test group takes the present invention couple respectively Capsule prepared by the Chinese medicine composition that 1, reference examples 2 and reference examples 3 provide as usual, one day 3 Secondary, after taking 30 days, observe clinical symptoms.
3, criterion of therapeutical effect
Cure: pain disappears, without any rebound phenomenon；
Effective: pain relief, it is possible to normal activity, pain relief；
Invalid: symptom is without any improvement, hurt like hell, limitation of activity.
4, statistical standard
Using SPSS forWindows 10.0.7 statistical package, enumeration data uses x2 inspection, Ranked data employing Ridit analyzes, and measurement data uses t inspection, and the interior different time points of group compare to be adopted With one factor analysis of variance, P ＜ 0.05 is variant, and test result is as with following table:
Group Case load Cure Effectively Invalid Effectively (%)
Embodiment 1 20 12 4 4 80
Embodiment 3 20 15 3 2 90
Embodiment 5 20 17 2 1 95
Reference examples 1 20 2 5 13 35
Reference examples 2 20 3 6 11 45
Reference examples 3 20 4 7 9 55
By above-mentioned statistical result it can be seen that the Chinese medicine composition of present invention offer is to neck, shoulder, waist and leg The treatment effectiveness of pain has reached more than 80%, with reference examples 1, reference examples 2 and reference examples 3 Comparing, therapeutic effect is notable, and the effective percentage of the Chinese medicine composition that embodiment 5 provides has reached 95%, And find in clinic, patient pain is violent, it is difficult to stand, and effect is more significantly.
Clinical trial, the clinical observation on the therapeutic effect of the capsule that the present invention provides:
1, Yin, man, 34 years old, office worker, sitting waist cervical vertebra ache unbearably, caused headache, sits Osteoneuralgia, long pain 5 months, increase the weight of, hospitalize is invalid, and taking the present invention provides Capsule after 1 month, waist cervical vertebra ache disappears, and leg numbness disappears.
2, Liu, female, 55 years old, peasant, 2 years front right knee joints swelled and ache, movable unfavorable, add Weighing 20 days, take the capsule 20 days that the present invention provides, oral, three times a day, right knee joint closes Joint pain is swollen to disappear.
3, Zhang, female, shoulder joints pain, limitation of activity, long-term bed, increases the weight of 1 month After, take the capsule 10 days that the present invention provides, pain relief, continue to take 20 days, pain Pain disappears, it is possible to out-of-bed activity.
4, Zheng, man, 45 years old, foreneck napex pain was uncomfortable, and joint stuffiness increases the weight of 50 days, Being difficult to night fall asleep, take the capsule 1 month that the present invention provides, pain disappears, bend and stretch as Often.
5, Lee, female, leg traumatic injury, after skeleton is replied, in 2 years, bone joint pain is unbearably, Paralysis phenomenon often occurs, increases the weight of 2 months, it is difficult to walking, take the capsule that the present invention provides After agent 1 month, pain relief, it is possible to normally walk.
The present invention is not limited to above-mentioned preferred forms, anyone under the enlightenment of the present invention all Other various forms of products can be drawn, no matter but in its shape or structure, make any change, Every have same as the present application or akin technical scheme, all falls within the protection model of the present invention Within enclosing.

Claims (10)

1. the Chinese medicine composition treating neck, shoulder, waist and leg pain, it is characterised in that this Chinese medicine composition Raw material including following parts by weight: Radix Angelicae Sinensis 5-10 part, Flos Carthami 15-20 part, Radix Angelicae Dahuricae 10-15 Part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, Ramulus Cinnamomi 10-15 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Angelicae Pubescentis 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci 15-20 part, Rhizoma Cibotii 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 part, eupolyphaga 10-15 part, slender acanthopanax Skin 15-20 part, Caulis Spatholobi 20-25 part, Olibanum 15-20 part, Myrrha 15-20 part, Resina Draconis 5-10 part, big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, Radix Aconiti Preparata 10-15 part, Radix Aconiti Kusnezoffii Preparata 10-15 Part, Radix Achyranthis Bidentatae 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 part, Moschus 0.1-0.5 part, Herba Asari 5-10 part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 part, Rhizoma Pinelliae Preparata 5-10 part, Radix Glycyrrhizae 5-10 part.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that this Chinese medicine composition also wraps Include the raw material of following parts by weight: Herba Erodii 5-8 part, Membrana Follicularis ovi 3-5 part.
3. Chinese medicine composition as claimed in claim 2, it is characterised in that this Chinese medicine composition also wraps Include the raw material of following parts by weight: Herba Siegesbeckiae 3-5 part, Radix seu Caulis Verntilaginis Leiocarpae 4-9 part.
4. include the Chinese medicine composition for the treatment of neck, shoulder, waist and leg pain described in any one of claim 1-3 Capsule, it is characterised in that described capsule is made up of capsule filling and capsule shells, described Capsule filling includes pharmaceutical composition and the adjuvant that weight part ratio is 1:0.5-2.
5. capsule as claimed in claim 4, it is characterised in that described adjuvant includes following weight The composition of number: nicotiamide 1-5 part, pyridoxine hydrochloride 1-3 part, monoethanolamine 1-5 part.
6. capsule as claimed in claim 4, it is characterised in that described adjuvant also includes following heavy The composition of amount number: sodium starch glycol 1-4 part, sucrose monolaurate 1-3 part.
7. capsule as claimed in claim 4, it is characterised in that described capsule shells includes following heavy The composition of amount number: Pullulan 2-6 part, calcium alginate 4-8 part.
8. the preparation method of the Chinese medicine composition treating neck, shoulder, waist and leg pain, it is characterised in that should Method comprises the following steps:
S1, weigh following raw material respectively according to parts by weight: Radix Angelicae Sinensis 5-10 part, Flos Carthami 15-20 part, Radix Angelicae Dahuricae 10-15 part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, Ramulus Cinnamomi 10-15 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Angelicae Pubescentis 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci 15-20 part, Rhizoma Cibotii 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 part, eupolyphaga 10-15 Part, Cortex Acanthopancis 15-20 part, Caulis Spatholobi 20-25 part, Olibanum 15-20 part, Myrrha 15-20 Part, Resina Draconis 5-10 part, big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, Radix Aconiti Preparata 10-15 part, Radix Aconiti Kusnezoffii Preparata 10-15 part, Radix Achyranthis Bidentatae 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 part, Moschus 0.1-0.5 part, Herba Asari 5-10 part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 part, Rhizoma Pinelliae Preparata 5-10 Part, Radix Glycyrrhizae 5-10 part, and carry out the crude drug weighed respectively pulverizing, mill, sieve and make Fine powder, the mesh number of described screen cloth is 10-30 mesh；
S2, extraction: the powder after pulverizing in step S1 is under the conditions of 20～40MPa, 30～60 DEG C Carry out CO 2 supercritical hybrid extraction 3-4 hour, collect medicinal residues, standby；
S3, the medicinal residues in step S2 will add the heating of 5-9 times of 60%-80% ethanol decoct 2 times, Each 1～2 hour, filtering, merge secondary raffinate, when being concentrated into 50 DEG C of surveys, relative density is 1.15～1.20, add ethanol to alcohol content and reach 60～70%, stand 12 hours；
S4, leaching supernatant, decompression recycling ethanol, continue to concentrate, i.e. obtain medical treatment pain of neck, shoulder, waist and leg The Chinese medicine composition extractum of pain.
9. preparation method as claimed in claim 8, it is characterised in that in step S1, according to weight Amount number weighs following raw material respectively: Radix Angelicae Sinensis 5-10 part, Flos Carthami 15-20 part, Radix Angelicae Dahuricae 10-15 Part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, Ramulus Cinnamomi 10-15 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Angelicae Pubescentis 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci 15-20 part, Rhizoma Cibotii 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 part, eupolyphaga 10-15 part, slender acanthopanax Skin 15-20 part, Caulis Spatholobi 20-25 part, Olibanum 15-20 part, Myrrha 15-20 part, Resina Draconis 5-10 part, big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, Radix Aconiti Preparata 10-15 part, Radix Aconiti Kusnezoffii Preparata 10-15 Part, Radix Achyranthis Bidentatae 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 part, Moschus 0.1-0.5 part, Herba Asari 5-10 part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 part, Rhizoma Pinelliae Preparata 5-10 part, Radix Glycyrrhizae 5-10 part, Herba Erodii 5-8 part, Membrana Follicularis ovi 3-5 part, and the crude drug weighed is carried out respectively Pulverizing, mill, sieve and make fine powder, the mesh number of described screen cloth is 10-30 mesh；
Preferably, in step S1, weigh following raw material respectively according to parts by weight: Radix Angelicae Sinensis 5-10 part, Flos Carthami 15-20 part, Radix Angelicae Dahuricae 10-15 part, Cortex Eucommiae 15-20 part, Rhizoma Chuanxiong 15-20 part, Ramulus Cinnamomi 10-15 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Angelicae Pubescentis 10-15 part, Radix Clematidis 15-20 part, Rhizoma Drynariae 15-20 part, Radix Dipsaci 15-20 part, Rhizoma Cibotii 15-20 part, Pyritum 10-15 part, Radix Notoginseng 5-10 Part, eupolyphaga 10-15 part, Cortex Acanthopancis 15-20 part, Caulis Spatholobi 20-25 part, Olibanum 15-20 Part, Myrrha 15-20 part, Resina Draconis 5-10 part, big gun first 10-15 part, Rhizoma Curcumae Longae 10-15 part, system Radix Aconiti 10-15 part, Radix Aconiti Kusnezoffii Preparata 10-15 part, Radix Achyranthis Bidentatae 15-20 part, Scolopendra 7-13 part, Scorpio 5-10 part, Moschus 0.1-0.5 part, Herba Asari 5-10 part, Borneolum Syntheticum 5-10 part, Rhizoma Arisaematis (processed) 5-10 Part, Rhizoma Pinelliae Preparata 5-10 part, Radix Glycyrrhizae 5-10 part, Herba Erodii 5-8 part, Membrana Follicularis ovi 3-5 part, Herba Siegesbeckiae 3-5 part, Radix seu Caulis Verntilaginis Leiocarpae 4-9 part, and carry out the crude drug weighed respectively pulverizing, grinding Grinding, sieve and make fine powder, the mesh number of described screen cloth is 10-30 mesh.
10. the Chinese medicine composition as described in any one of claim 1-3 preparation treatment neck, shoulder, waist or Have a pain in the leg the application in the medicine of pain.
CN201610424439.6A 2016-06-14 2016-06-14 A kind of Chinese medicine composition treating neck, shoulder, waist and leg pain and capsule and preparation method Pending CN106266934A (en)

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CN108686113A (en) * 2018-08-15 2018-10-23 佛山市三水区嘉华化学研究院（普通合伙） A kind of composition and preparation method thereof for alleviating three high diseases shape

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