KR0137897B1 - Health food containing leaf of eucommia ulmoides oliver - Google Patents

Abstract

The present invention relates to a health food composition containing the two young leaves as a main raw material, more specifically, the two young leaves containing the main raw material, and here, one or more herbal medicines such as persimmon leaf, mountain lion, moon dog, gyeolja, golden, Donggyuja By containing two or more kinds, not only an excellent weight loss effect can be obtained, but also a significant decrease in the concentration of cholesterol and triglycerides in the blood, thereby imparting a preventive effect on adult diseases such as arteriosclerosis and high sciatic cancer caused by obesity. The present invention relates to a health food composition.

Description

Health Food Composition Containing Tobacco Leaf as Main Ingredient

The present invention relates to a health food composition containing the two young leaves as a main raw material, more specifically, the two young leaves containing the main raw material, and here, one or more herbal medicines such as persimmon leaf, mountain lion, moon dog, gyeolja, golden, Donggyuja By containing two or more kinds, not only an excellent weight loss effect can be obtained, but also a significant decrease in the concentration of blood cholesterol and triglycerides, which can impart prophylactic effects such as arteriosclerosis and hypertension caused by obesity. It relates to a health food composition.

People living in modern times are rapidly increasing obesity due to body fat increase due to changes in living environment due to economic abundance, excessive intake of calories due to westernization of diet and lack of exercise, and such obesity is diabetes or artery It is a very dangerous factor to breast or worsen complications such as hardening and hypertension.

Since obesity is directly linked to health, prevention and resolution of obesity are now pointed out as a necessity for protecting the health of everyone, not just the wishes of young women.

Currently, there are methods for weight loss, such as taking meal therapy, exercise therapy, and weight loss supplements.However, in the case of meal therapy, reducing the amount of meal or eating a calorie of the calculated calories is temporary effect, but if you resume normal eating There is a disadvantage in that the weight increases again, and exercise therapy can gain weight by burning fat in the body by vigorous exercise, which can be obtained only by steady exercise, and requires extra time for exercise. There is a problem, and it usually involves a lot of pain. The most common methods of taking weight loss supplements include diuretics, diarrhea, appetite suppressants, and fibrous medications. Diuretics and diarrhea have temporary effects of weight loss by reducing moisture in the body. It is irrelevant to the elimination and cannot be treated fundamentally.In the case of an appetite suppressant that has the effect of suppressing appetite by stimulating the satiety central nerve in the brain, phenyl propanolamine is mainly composed of side effects such as increased pressure, nervousness and insomnia. May come. In addition, fibrous materials processed with fiber that gives only a feeling of satiety and little nutritional value may cause nutritional deficiency in long-term overdose.

Thus, the present inventors can give a weight loss effect without pain, such as diet restrictions or vigorous exercise associated with the above-described diet therapy or exercise therapy, unlike the conventional weight loss supplements are excellent in human safety and fear of side effects In order to provide a healthy food composition that does not have a long history of research, focusing on herbal medicines that have been taken for a long time and have proven their safety, we have selected herbal medicines that are expected to be effective in weight loss through various experiments. Thus, the present invention has been completed.

The present invention has been used as a medicine for a variety of diseases, such as high blood pressure, stress, arthritis, hangover, etc., and the health food composition containing soybean tea as a main ingredient, which has recently been proven attention in preventing clinical obesity through clinical experiments To provide.

On the other hand, according to a recently published document, the activity of digestive enzymes, such as a-amylase, which breaks down starch from the human digestive enzymes to produce maltose and glucose, and liase, which breaks down fat. Inhibition of digestion of carbohydrates or fats can slow down or slow down digestion, which can ultimately reduce the amount of calories ingested and reduce the amount of fat stored in the body, resulting in a dietary effect. lost.

(Reference: Japanese Food Co., Ltd. Vol. 41, No. 8, p561, 1994;

日本 食品 工業 會 誌 Vol. 40, no. 3, p214, 1993;

New Food Industry Vol. 36, No. 9, p 1, 1994;

New Food Industry Vol. 35, No. 12, pi, 1993;

生 樂 學 雜誌 Vol. 39, No. 4, p261, 19953;

Food Industry, p23, Oct. 30, 1994)

Therefore, the present inventors conducted an extensive search for natural herbal medicines that inhibit the enzymatic activity of a-amylase and lipase. It has been found to have excellent ability, and when herbal medicines with the ability to inhibit these digestive enzymes are added to and mixed with the two lobe leaves, the weight loss effect, as well as the effect of reducing the blood fat and cholesterol concentrations of the two lobe leaves alone When taken as found to show a superior synergistic effect, the present invention was completed.

In other words, the object of the present invention contains the two main leaves, which are known to have a weight loss effect, selected from persimmon leaves, hawthorn, moon dogs, deficiencies, gold and sage By containing one or more herbal medicines, not only can an excellent weight loss effect be obtained, but also a significant decrease in the concentration of cholesterol and triglycerides in the blood, thereby imparting the prevention of adult diseases such as arteriosclerosis and hypertension caused by obesity. It is to provide a health food composition that can be.

The health food composition according to the present invention has no pain such as dietary restrictions or vigorous exercise accompanying dietary therapy or exercise therapy, and unlike conventional weight loss supplements, it is excellent in human safety and gives weight loss effects without fear of side effects. Can be.

EMBODIMENT OF THE INVENTION Hereinafter, the active ingredient of the composition of this invention is demonstrated.

In the present invention, the worm (Eucommia ulmoides oliver) is a deciduous tree belonging to the Eucommiaceae, and it is native to Sichuan Province in China and has been drinking as a tea from stems and leaves since ancient times. Containing a lot of functions to increase the function of the adrenal gland is effective in preventing heart disease, diabetes, arteriosclerosis.

Moonflower is a seed of evening primrose (Oenothera lamarckiana Seringe), which has been used for antipyretic and anti-inflammatory purposes in Korea, and contains unsaturated terrestrial acid such as linoleic acid and linolenic acid as main components. It is effective in hypertension.

The hawthorn refers to the seeds of the hawthorn (Crataegus pinnatifiad Bumge), and is known to act as an antibacterial action and dilate the blood vessels and lower blood pressure, and is used in the treatment of postpartum care and hypertension, arteriosclerosis and myocardial system in oriental medicine.

Cassia tora Linne not only stimulates metabolism and blood circulation in the body, but also opens the eyes and promotes intestinal peristalsis. Oriental medicine is used for the treatment of heart disease, diabetes, high blood pressure and chronic constipation.

Golden (Sutellaria baicalensis Georgi) uses the root as a plant belonging to the family Naples, and in the present invention, the root color is faithful to yellow and has a bitter taste.

It is mainly used for the purpose of lowering blood pressure, fever, diuresis and antibacterial medicine.

Dong Kyuja (Malva verticillata Linne) refers to the seeds of the jade, diuretic and intestinal peristalsis is active to the effect of oriental medicine is used for the treatment of constipation and diuresis.

Addition and mixing of these herbal medicines on the larvae will increase the weight loss effect. However, the mechanism of weight loss of the larvae and the inhibitory effects of the digestive enzymes in vivo of each medicinal herb on the metabolism process are not yet clear. It is believed to produce a complex synergistic effect, resulting in an excellent weight loss effect and a reduction in blood fat and cholesterol.

The composition of the present invention contains a two-leaf lobe excellent in weight loss effect, and one or more herbal medicines selected from persimmon leaves, hawthorn, walnuts, gwanjakja, golden and Donggyuja that can give the anti-obesity effect by the inhibitory action of digestive enzymes The form of the preparation may be tea, beverages, granules, tablets, hard capsules, and the like, and is not particularly limited. At this time, the herbal medicine is preferably contained in an amount of 30% by weight or less based on the combined weight of the two young leaves and the herbal medicine in terms of the effect. When the herbal medicine is contained in an amount exceeding the above 30% by weight, no clear effect can be obtained in the weight loss effect, which is demonstrated by the following experimental example.

When preparing the composition of the present invention as a tea, well-dried two-leaf lobe may be roasted by a conventional distributor, but in order to minimize loss of nutrients and to improve palatability of taste and aroma, a far-infrared drum distributor is used. Far-infrared roasting treatment is performed at a wavelength of 10 to 100 µm for 5 to 30 minutes at 100 to 130 ° C.

Even in the case of persimmon leaves, hawthorn, woldogja, gwanjaja, golden and copper medicinal herbs, to minimize the loss of nutrients and to improve the palatability of taste and aroma, each far infrared drum distributor for 5-30 minutes at 80 ~ 110 ℃ Far-infrared distribution is performed at a wavelength of 10 to 100 µm. These herbal medicines retain their own odor when they are roasted at temperatures below 80 ° C, which reduces their palatability when blended into two lobes. Loss of flavor reduces the preference.

The composition of the present invention is one or more herbal medicines selected from the group consisting of persimmon leaves, hawthorn, moon dog, gwanjaja, golden and copper gyubu in roasted two-leafed leaves as described above so that the blending amount is 30% by weight or less, preferably 10 It can be blended and contained in an amount of -20% by weight, and can be used as it is or as a tea bag, which can be easily converted to tea bag after pulverizing to 0.15 to 1 mm.

In addition, when the composition of the present invention is prepared as a beverage, the two leaves and each herbal medicine is extracted with drinking water or edible alcohol by a conventional herbal medicine extraction method, the present invention is not limited by these extraction methods. At this time, the two-leaf lobe extract based on the solid content of 0.2% by weight, persimmon leaf, hawthorn, moon dog, gwanjaja, gold and copper extract, one or two or more herbal extracts of 0.02 to 0.05% by weight It is preferable to contain in quantity from an effect point.

The beverage according to the present invention may contain additives added to conventional beverages, in addition to the above-mentioned two-leaf extract and herbal extracts, but is not particularly limited. That is, the beverage according to the present invention further comprises a low-calorie sweetener such as oligosaccharide, fructooligosaccharide, malto oligosaccharide, galactooligosaccharide, maltitol, lactitol, and at least one sweetener selected from high sweetener such as aspartame and stevia. It may contain one or more acidulants selected from citric acid, malic acid, ascorbic acid, and other organic components such as vitamin B group (B1, B2, B6, B12), nicotinic acid amide, niacin, and various amino acids. .

When the composition of the present invention is prepared in granules, tablets, hard capsules, the cedar leaf and each herbal medicine is prepared as an extract dry powder, using a conventional extract lyophilization method, and is not limited by these methods.

The efficacy of the composition of the present invention was demonstrated through the following experimental example.

Experimental Example 1 Experiment of Inhibiting Activity of α-amylase

Dissolve α-amylase (Sigma VI-B Type) in a concentration of 0.02% in 0.2M acetic acid buffer solution (pH5.5) containing 0.02M calcium acetate and use it as an enzyme solution.

As a substrate, swimming starch is dissolved in 0.1 M acetic acid buffer solution (pH 5.5) at a concentration of 1.5% and used. 0.5 ml of each herbal extract extracted with drinking water (based on 0.1% solids) and 0.5 ml of enzyme solution were used as treatment, and the mixture of 0.5 ml of distilled water and 0.5 ml of enzyme solution was used instead of the crude herb extract. The mixed solution of 0.5 ml of distilled water and 0.5 ml of acetic acid buffer solution was used as Control 1 (Blank), and each experiment was used after standing at 37 ° C. for 10 minutes.

2 ml of substrate solution was added to each experimental section for 10 minutes at 37 ° C, and 5 ml of a solution containing 0.5 N hydrochloric acid and 0.5 N acetic acid at a ratio of 1: 5 was added to stop the enzymatic reaction. After the reaction, 5 ml of a mixture of 0.002% of iodine (I) and 0.5% of potassium iodide (KI) was added to 0.1 ml of each reaction solution and allowed to react for 20 minutes. The absorbance was measured at 660 nm, and the enzyme inhibition rate was expressed as the ratio of the absorbance difference between the control and control 2 to the difference in absorbance between the control 1 and the control 2. Table 1 shows the inhibition rate of α-amylase of each herbal extract.

Table 1. Inhibition rate of α-amylase of each herbal

As shown in Table 1, the inhibitory effect of the a-amylase of each herbal medicine was excellent in the order of hawthorn, moon dog, persimmon leaf, gold, copper sequential.

Experimental Example 2 Inhibition of Lipase Activity

In a McIlvian buffer solution (pH7.4) prepared by mixing 9.15 ml of 0.1 M citric acid solution and 90.85 ml of 0.2 M sodium hydrogen phosphate solution, dissolved in a concentration of 0.71 mg / ml lipase (sigma Type II) extracted from porcine pancreas. This is used as enzyme solution.

As a substrate, 1 ml of triolein is placed in a test tube, and 7 ml of McIlvain buffer is added thereto. 1 ml of herbal medicine extract extracted with THF (Tetrahydrofuran) is added thereto to obtain a treatment tool. The solution obtained by adding 1 ml of THF solution to the substrate solution instead of the herbal extract was used as Control 2, and 1 ml of the buffer solution without adding the enzyme solution was used as Control 1 (Blank). Fatty acid was measured.

1 ml of the enzyme solution prepared in advance was added to each experimental section, followed by shaking for 1 hour at 37 ° C. After 7 ml of ethanol was poured out to stop the reaction, the fatty acid decomposed with 0.05 N sodium hydroxide was titrated. Inhibition rate (%) of the lipase was expressed as the ratio of the appropriate ml number of sodium hydride solution of Control 1 and Control 2. Table 2 shows the activity inhibition rate of the lipase of each herbal medicine.

Table 2. Inhibition rate of lipase activity of each herbal

As shown in Table 2 above, the inhibitory effect of the lipase of each herbal medicine was excellent in the order of persimmon leaf, Cultivator, moon dog, hawthorn.

Through the above Experimental Example 1 and Experimental Example 2, persimmon leaf, hawthorn, wolseulja, Cultivator, golden larvae selected as a herbal medicine contained in the composition of the present invention is a digestive enzyme in the human body, and inhibits the activity of a-amylase and lipase It is understood that this is an excellent herbal medicine.

In addition, the following animal experiments demonstrated the weight loss effects, blood cholesterol and triglyceride lowering effects of these herbal medicines.

[Experimental Example 3] Measurement of body weight change when administering both larvae and each medicinal herb Animal experiments After extracting the larvae with water in a conventional manner, and concentrated to 10% solids to prepare a chungchung salt extract. In addition, persimmon leaves, mountain lions, moon dogs, crystals, golden and Donggyuja were also extracted with water in the same manner and concentrated to 10% solids to prepare each extract.

As experimental animals, four-week-old Sucker Rada (Sqrague-Dawoey) rats were freely fed with water and normal feed for 10 days to complete the acclimatization period, and then placed in 6 wire mesh cages per experimental group to adjust their average weight to 200 ± 5g. . From this time, 0.5% of Uji (animal oil) and 0.5% of soybean oil (vegetable oil) were mixed and administered to the feed, and a control group to feed only oil-containing feed was prepared separately. One dose of 200 mg / kg body weight was administered orally.

Experimental group 1: oral administration of cedar leaf extract 200mg / weight kg

Experimental group 2: oral administration of persimmon leaf extract 200mg / weight kg

Experimental group 3: oral administration of hawthorn extract 200mg / weight kg

Experimental group 4: 200 mg / weight kg oral administration of moon dog extract

Experimental group 5: 200 mg / kg body weight oral administration

Experimental group 6: oral administration of golden extract 200mg / weight kg

Experimental group 7: oral administration of Donggyuja extract 200 mg / weight kg

After 2 weeks, the weight was measured using a digital scale, and the average value of the weight of each group was obtained, and the results are shown in Table 3 below.

Table 3. Changes in body weight according to the administration of cedar leaf extract and each herbal extract

As shown in Table 3 above, the weight loss effect of the two leaf lobe extract and each wild vegetable extract in the rats in the same amount was found to be the most excellent.

Therefore, the present inventors measured the increased effect of the weight loss effect when the two main lobe containing as a main ingredient, and further contains one or more herbal medicines through the animal experiment of Experimental Example 4 below.

[Experimental Example 4] Measurement of the weight change during the administration of the mixture of the two loaves and each herbal medicine To measure the weight loss effect of adding the herbal medicine extract to the two-leaf extract of the animal extract and mixed, the two-leaf extract of 10% solids of Experimental Example 3 Each herbal extract with a solid content of 10% was mixed at a ratio of 9: 1 to prepare the following experimental groups.

As the experimental animals, male SD rats of 4 weeks old were freely ingested with water and general feed for 10 days, and after completion of the acclimation period, 6 animals per experimental group were placed in a wire cage to adjust the average weight to 200 ± 5g. From this time, Uji (animal oil) 0.5% and soybean oil (vegetable oil) 0.5% were mixed and administered to the feed, and a control group to feed only the oil-containing feed was prepared separately. The mixture was administered orally once a day 200 mg / kg body weight.

Experimental group 1: oral administration of cedar leaf extract 200mg / weight kg

Experimental group 2: two leaf lobe extract + persimmon leaf extract (9: 1) 200mg / weight kg oral administration

Experimental group 3: two leaf lobe extract + mountain lion extract (9: 1) 200mg / weight kg oral administration

Experimental group 4: two leaf lobe extract + moon dog extract (9: 1) 200mg / weight kg oral administration

Experimental group 5: two leaf lobe extract + deficiency extract (9: 1) 200mg / weight kg oral administration

Experimental group 6: two leaf lobe extract + golden extract (9: 1) 200mg / weight kg oral administration

Experimental group 7: two leaf lobe extract + Donggyuja extract (9: 1) 200mg / weight kg oral administration

The weight of each group was measured by the digital scale every two weeks, and the average value of the weight of each group was obtained, and the results are shown in Table 4 below.

Table 4. Changes in body weight according to the mixed administration of cedar leaf extract and herbal extract

As shown in Table 4 above, in the experimental groups 2 to 7 administered by adding and mixing each herbal medicine to the two larvae extract than the experimental group 1 administered the two larvae extract alone showed a synergistic effect of weight loss over winter It is proved that by combining and containing a herbal medicine having an inhibitory effect on digestive enzyme activity in the leaves, it is possible to give an even higher weight loss effect.

Experimental Example 5 below is to search the weight loss effect according to the mixing ratio of the two lobe and the herbal medicine through an animal experiment, to determine the mixing ratio of the two lobe and herbal medicine of the present invention.

Experimental Example 5 Mixing Ratio Determination of Tobacco Leaf and Herbal Medicine

The cedar leaf extract was extracted with water by a conventional method, and concentrated to 10% solids to prepare a cedar leaf extract.

In addition, persimmon leaf, gentleman, moon dog, crystallization, golden and Donggyugwa were mixed in the same weight ratio, water was extracted by a conventional method, and then concentrated to 10% solids to prepare a mixed extract.

As the experimental animals, male SD rats of 4 weeks old were freely ingested with water and general feed for 10 days, and after completion of the acclimation period, 6 rats per experimental group were placed in a wire cage to adjust the average weight to 200 ± 5g. At this time, 0.5% of Uji (animal oil) and 0.5% of soybean oil (vegetable oil) were mixed and administered to the feed, and a control group to feed only oil-containing feed was prepared separately. 200 mg / kg body weight was administered orally once daily.

Experimental group 1: two leaf lobe extract + herbal medicine mixed extract (9: 1) 200mg / weight kg oral administration

Experimental group 2: two leaf lobe extract + herbal medicine mixed extract (8: 2) 200mg / weight kg oral administration

Experimental group 3: two leaf lobe extract + herbal medicine mixed extract (7: 3) 200mg / weight kg oral administration

Experimental group 4: two leaf lobe extract + herbal medicine mixed extract (6: 4) 200mg / weight kg oral administration

Experimental group 5: two leaf lobe extract + herbal medicine mixed extract (5: 5) 200mg / weight kg oral administration

Experimental group 6: two leaf lobe extract + herbal medicine mixed extract (4: 6) 200mg / weight kg oral administration

The weight of each group was measured with a digital balance every two weeks, and the average value of each group's weight was calculated. The results are shown in Table 5 below.

Table 5. Changes in weight of each experimental group according to the mixing ratio of the two leaf extracts and herbal remix extract

As shown in Table 5, in the weight loss effect according to the mixing ratio of the two leaf extract and the herbal medicine mixture extract, when the content of the herbal medicine extract exceeds 30% by weight of the total dose (experimental group 4, 5, 6) It can be seen that there is no effect. Therefore, the content of the herbal medicines added to the two leaves is preferably 30% by weight or less.

Experimental Example 6 Measurement of Total Cholesterol in Blood Animal Experimental Animal SD rats of 4 weeks of age were ingested freely with water and general feed for 10 days, and after completion of the acclimation period, 6 animals per group were placed in a wire cage and the average weight was 200 ±. Adjusted to 5 g. At this time, the mixture was administered with 1% of cholesterol in the feed, and a control group was fed to feed only 1% cholesterol, and a control group was fed to feed only 1% cholesterol, and 2% to 2% cholesterol-containing feed. The following experimental group was prepared by mixing and adding the extract dry powder alone or the two young leaves and the dry powder of each herbal extract.

Experimental group 1: two leaf extract extract powder 0.3%

Experimental Group 2: Two leaf extract extract powder 0.25% + persimmon leaf extract powder 0.05%

Experimental group 3: two leaf extract extract powder 0.25% + mountain lion extract dry powder 0.05%

Experimental group 4: two-leaf extract extract powder 0.25% + moon dog extract dry powder 0.05%

Experimental group 5: two leaf extract extract powder 0.25% + deficiency extract dry powder 0.05%

Experimental Group 6: Two leaf extract powder 0.25% + golden extract dry powder 0.05%

Experimental group 7: two leaf extract extract powder 0.25% + Donggyuja extract dry powder 0.05%

Rats were reared by feeding the experimental groups, and blood was collected from the tail vein after 2 and 4 weeks, but fasted for 12 hours before blood collection. After serum was obtained by centrifuging the blood at 3000 rpm for 15 minutes, the total cholesterol content in the serum was measured using a diagnostic kit (No. 352) from Sigma (Singna) using an enzymatic method. In Table 6, the total serum cholesterol level (mg / dl) of each experimental group was compared, and the total cholesterol concentration drop rate (5) of the experimental group compared to the control group was shown.

Table 6. Comparison of Serum Total Cholesterol Concentration in Each Experimental Group

Experimental Example 7 Triglyceride Measurement Animal Test

As a test animal, male SD rats of 4 weeks of age were freely ingested with water and general feed for 10 days to complete the acclimatization period. Then, 6 rats per experimental group were placed in a wire cage to adjust the average body weight to 200 ± 5g. At this time, 0.5% Uji (animal fat) and 0.5% soybean oil (vegetable fat) were mixed and administered to the feed, and a control group for feeding only fat-containing feed was prepared separately. The following experimental group was prepared by mixing and adding the leaves and the dry powder of each herbal extract.

Experimental group 1: two leaf extract extract powder 0.3%

Experimental Group 2: Two leaf extract extract powder 0.25% + persimmon leaf extract powder 0.05%

Experimental group 3: two leaf extract extract powder 0.25% + mountain lion extract dry powder 0.05%

Experimental group 4: two-leaf extract extract powder 0.25% + moon dog extract dry powder 0.05%

Experimental group 5: two leaf extract extract powder 0.25% + deficiency extract dry powder 0.05%

Experimental Group 6: Two leaf extract powder 0.25% + golden extract dry powder 0.05%

Experimental group 7: two leaf extract extract powder 0.25% + Donggyuja extract dry powder 0.05%

Rats were reared by feeding the experimental groups, and blood was collected from the tail vein after 2 and 4 weeks, but fasted for 12 hours before blood collection. After serum was obtained by centrifuging the blood at 3000 rpm for 15 minutes, the amount of lipid in the serum was quantified using a diagnostic kit (No. 337-B) from Sigma. That is, the amount of serum triglyceride (triglyceride) was measured by measuring the absorbance of quinoneimine produced by the enzymatic reaction at 540 nm. In Table 7, the amount of sperm fat of each experimental group (mg / dl) was compared, and the percentage of decrease in serum fat concentration of the experimental group compared to the control group was shown.

Table 7. Comparison of Serum Triglyceride Concentration in Each Experimental Group

As shown in the results of the animal experiments of Experimental Example 6 and Experimental Example 7, weight-loss effect when administered by adding persimmon leaf, hawthorn, moon dog, deficiency, golden, Donggyuja, etc. Of course, the amount of cholesterol and triglycerides in the blood was proved to be superior to the administration of cedar lobe alone.

Therefore, the health food composition according to the present invention is characterized by containing the two leaf lobes as the main raw material, and further contains at least one herbal medicine selected from persimmon leaf, mountain lion, moon dog, gyeolja, golden and Donggyuja In addition, by lowering the concentration of cholesterol and triglycerides in the blood significantly, it can also impart an adult disease prevention effect such as arteriosclerosis and hypertension caused by obesity.

Hereinafter, the present invention will be described in more detail with reference to examples of the present invention. The present invention is not limited only to these examples.

Example 1

The well-dried two-leaf lobe was subjected to uninfrared ray roasting at a wavelength of 30 μm for 30 minutes at 110 ° C. with a far-infrared drum distributor. In addition, herbal medicines such as persimmon leaves, hawthorn, moon dogs, crystals, gold, and Donggyuja were far-infrared roasted at 30 占 폚 for 30 minutes at 80 占 폚.

The roasted cedar leaf and each herbal medicine were ground to 0.15-2 mm using a cutter.

Example 2

The cedar leaf, persimmon leaf, hawthorn, and moon dog, which were prepared in Example 1, were mixed at a ratio of 7: 1: 1: 1 to obtain tea.

Example 3

Tofu was prepared in Example 1 was mixed with the two leaves, the crystallization, the golden, copper qualities in the ratio of 7: 1: 1: 1.

Example 4

The cedar leaf, persimmon leaf, hawthorn, and Cultivator prepared in Example 1 were mixed in a ratio of 7: 1: 1: 1 to 1.5-2 g teabags.

Example 5

The cedar leaf, hawthorn, hawthorn, and sperm prepared in Example 1 were mixed at a ratio of 7: 1: 1: 1 to 1.5-2 g teabags.

Example 6

After adding 10 kg of purified water to 1 kg each of the head, leaf, persimmon leaf, mountain lion, moon dog, gwanjaja, golden, Donggyuja, extracted three times at 80 ℃ for 8 hours. The extracts were combined three times, filtered through 400 mesh, depressurized and concentrated to obtain each extract having a solid content of 60%.

Example 7

The two-leaf lobe extract prepared in Example 6 was mixed by adding 0.2% by weight, persimmon leaf extract, Cultivator extract, and sperm extract in 0.02% by weight, 0.02% by weight, and 0.01% by weight, respectively. After adding 8% by weight maltooligosaccharide, 0.12% by weight citric acid and 0.003% by weight stevioside, a small amount of vitamin B ₁ , B ₂ , B ₃ nicotinic acid amide and the like were added thereto, and purified water was added as a beverage.

Example 8

The same procedure as in Example 7 was carried out, except that 0.02% by weight, 0.02% by weight, and 0.01% by weight, respectively, were prepared as beverages.

Example 9

It was carried out in the same manner as in Example 7, but was prepared as a beverage by adding 0.01% by weight of persimmon leaf extract, hawthorn extract, moon dog extract, gyeoljaja extract in herbal medicine.

Example 10

It was carried out in the same manner as in Example 7, but was prepared as a beverage by adding 0.01% by weight of persimmon leaf extract, mountain lion extract, golden extract, Donggyuja extract in herbal medicine.

Example 11

The two larvae and each herbal extract prepared in Example 6 were rapidly frozen at -20 to -30 ° C so that the blending ratio of the extract and the crystal cellulose was 10: 2. The frozen two leaf lobe and each herbal extract was transferred to a freeze dryer, and subjected to freeze-drying until the water content was 5% or less while applying a reduced pressure of 0.5 to 0.05 mmHg and keeping the condenser at -50 ° C or less.

The dried product was ground by a micropulverizer in which cooling water was circulated to obtain a dry leaf powder and a medicinal herb extract having a particle size of 0.04-0.3 mm.

Example 12

7 kg of the two-leaf extract extract powder prepared in Example 11, 1 kg persimmon leaf extract powder, 1 kg of mountain lion extract dry powder, 1 kg moon dog extract dry powder was put into a high speed rotary mixer and mixed. 3.5 kg of sterile purified water was added thereto and mixed again to form granules having a diameter of 1 to 2 mm. The molded granules are dried in a vacuum dryer at 40 to 50 ° C., and then passed through 12 to 14 mesh to prepare uniform granules.

Example 13

In the same manner as in Example 12, 1kg persimmon leaf extract dry powder, 1kg gyeongja extract dry powder, 0.5kg golden extract dry powder, 0.5kg Dongguja extract dry powder was prepared as granules.

Example 14

In the same manner as in Example 12, 1kg of walnut extract extract powder, 1 kg of hawthorn extract dry powder, 0.5kg extract ginseng extract powder 0.5kg, 0.5kg Dongjaja extract dry powder was prepared as granules.

Example 15

7 kg of the two-leaf extract extract powder prepared in Example 11 and 1 kg of persimmon leaf extract powder, herbal extract extract powder 1kg, Dongjak extract extract powder 1kg in herbal medicine was mixed in a high speed rotary mixer. 3.5 kg of sterile purified water was added thereto and mixed again to form granules having a diameter of 1 to 2 mm. The molded granules were dried in a vacuum dryer at 40 to 50 ° C., and then compression molded in appropriate amounts to prepare tablets.

Example 16

In the same manner as in Example 15, 1kg of geunja extract dry powder, geunja extract dry powder, 1kg of golden extract dry powder, 0.5kg of golden extract powder dry powder 0.5kg, was prepared as a tablet.

Example 17

In the same manner as in Example 15, 1kg persimmon leaf extract dry powder, hawthorn extract dry powder 1kg, moon dog extract dry powder 0.5kg, 0.5kg extract geunja extract dry powder was prepared as a tablet.

Example 18

7 kg of the two-leaf extract extract powder prepared in Example 11 and 1 kg of persimmon leaf extract powder, 1 kg of moon dog extract dry powder, 1 kg deflector extract dry powder in the herbal medicine was mixed in a high speed rotary mixer. 3.5 kg of sterile purified water was added thereto and mixed again to form granules having a diameter of 0.5 to 1 mm. The molded granules were dried in a vacuum dryer at 40 to 50 ° C., homogenized by passing through 14 to 16 mesh, and then filled into empty hard capsules to prepare as hard capsules.

Example 19

In the same manner as in Example 18, 1kg of golden dog extract dry powder, golden extract dry powder 1kg, 1kg of copper gyuja extract dry powder was prepared as a hard capsule.

Example 20

In the same manner as in Example 18, 1kg persimmon leaf extract dry powder, hawthorn extract dry powder, 1kg Dongjaja extract dry powder of the herbal medicine was prepared as a hard capsule.

Experimental Example 8 Weight Loss Effect Animal Experiment

As the experimental animals, male SD rats of 4 weeks old were freely ingested with water and general feed for 10 days, and after completion of the acclimation period, 6 rats per experimental group were placed in a wire cage to adjust the average weight to 200 ± 5g. At this time, 0.5% of Uji (animal oil) and 0.5% of soybean oil (vegetable oil) were mixed and administered to the feed, and a control group to feed only the fat-containing feed was prepared separately. The composition of the extracts was varied, mixed and orally administered 200 mg / kg body weight once a day.

Experimental group 1: two leaf extract + persimmon leaf + mountain lion + moon dog extract (7: 1: 1: 1)

Experimental group 2: two leaf extract + persimmon leaf + hawthorn + deficiency extract (7: 1: 1: 1)

Experimental group 3: two leaf extract + persimmon leaf + golden + missing extract (7: 1: 1: 1)

Experimental group 4: two leaf extract + Donggyuja + mountain lion + gyeolja extract (7: 1: 1: 1)

Experimental group 5: two leaf extract + deficiency + golden + copper rule extract (7: 1: 1: 1)

Experimental group 6: two leaf extract + moon dog + mountain lion + Donggyuja extract (7: 1: 1: 1)

Experimental group 7: two leaf extract + moon dog + mountain lion + golden extract (7: 1: 1: 1)

The weight of each group was measured with a digital balance every two weeks, and the average value of the weight of each group was obtained. The results are shown in Table 8 below.

Table 8. Changes in body weight of each group following the mixing of the two leaf extracts and the herbal extracts

Claims (2)

Two main leaves were treated as main raw materials; A health food composition, characterized in that it contains at least 30% by weight of the total weight of the two leaves and herbal medicines selected from the group consisting of persimmon leaves, moon dogs, hawthorn, clarifiers, golden and copper gyubu. The health food composition of claim 1, wherein the health food composition is a formulation of tea, beverage, granules, tablets or hard capsules.