CN110710672A - Natural plant active calcium preparation and preparation method thereof - Google Patents
Natural plant active calcium preparation and preparation method thereof Download PDFInfo
- Publication number
- CN110710672A CN110710672A CN201910899710.5A CN201910899710A CN110710672A CN 110710672 A CN110710672 A CN 110710672A CN 201910899710 A CN201910899710 A CN 201910899710A CN 110710672 A CN110710672 A CN 110710672A
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- Prior art keywords
- humilis
- preparation
- calcium
- parts
- prunus
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- 239000011575 calcium Substances 0.000 title claims abstract description 77
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 74
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 51
- 241000057271 Prunus humilis Species 0.000 claims abstract description 101
- 235000008104 Prunus humilis Nutrition 0.000 claims abstract description 101
- 235000005706 Prunus prostrata Nutrition 0.000 claims abstract description 61
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- 241000196324 Embryophyta Species 0.000 claims abstract description 21
- 241000758791 Juglandaceae Species 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 240000007049 Juglans regia Species 0.000 claims description 28
- 235000009496 Juglans regia Nutrition 0.000 claims description 28
- 235000013399 edible fruits Nutrition 0.000 claims description 27
- 238000001035 drying Methods 0.000 claims description 23
- 238000004140 cleaning Methods 0.000 claims description 20
- 235000013305 food Nutrition 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 13
- 238000009835 boiling Methods 0.000 claims description 12
- 238000004537 pulping Methods 0.000 claims description 12
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- 235000003599 food sweetener Nutrition 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
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- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 6
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 6
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Abstract
A natural plant active calcium preparation and its preparation method are provided. The invention provides a natural plant active calcium health food containing cerasus humilis or an extract thereof and walnuts and a preparation method thereof.
Description
Technical field
The invention relates to the field of health care products, in particular to the field of calcium supplement health care products, and specifically provides a natural plant active calcium health care food containing cerasus humilis or an extract thereof and walnuts and a preparation method thereof.
Two background art
9% of calcium exists in the form of phosphate in bones and teeth, and is constructed as a scaffold for the human body, which is called bone calcium, and serves as a reservoir of calcium in the body. The remaining 1% of calcium exists in human blood, extracellular fluid and soft tissue in both bound ion and free states, and we refer to this calcium as a pool of miscible calcium. The two keep dynamic balance and play a crucial role in maintaining normal physiological state and vital activities of cells.
According to the national nutrition survey of the health department, the method comprises the following steps: chinese people are generally lack of calcium, and two large groups (children and middle-aged and old people) lack of calcium in China reach hundreds of millions of people. Wherein, 40% of children need to supplement calcium, and 6 persons of every 10 middle aged and elderly people need to supplement calcium. According to research, more than 9 percent of calcium is lost after entering a human body, and only 1 percent of calcium is absorbed, so that the calcium supplement is not completely equal to the calcium supplement.
The natural calcium supplement preparations on the market at present mainly comprise three types: mineral calcium, animal calcium, and plant calcium. The mineral calcium is mainly inorganic calcium salt, and representative preparations include calcium carbonate, calcium phosphate, calcium oxide, and the like. The calcium supplement preparation has the advantages of convenient production, low price, high calcium content and the defects of extremely poor water solubility and Ca absorbed by organisms2+The calcium salt can be dissociated only after entering the stomach, has large irritation to the stomach, most of the calcium salt is not neutralized, insoluble salt is formed and excreted, the absorption rate is low, and the calcium salt is easy to stay in the kidney to cause kidney stones; animal calcium mainly comprises animal bone calcium and animal milk calcium. The animal bone calcium is divided into natural animal bone calcium (fish bone calcium, yak bone calcium and the like) and a chelated calcium preparation (amino acid chelated calcium), the animal bone is eaten by people from old times, and the animal bone calcium has the characteristics of low price, easy obtaining and high safety, but the animal bone has low calcium content and is not easy to absorb, the chelated calcium preparation has the advantages of quick absorption, high stability and small toxic and side effects, but the preparation condition of the chelated calcium is not easy to control, the process is complex, the yield is low, in addition, the animal milk has poor taste, and is not suitable for people with lactose intolerance to eatUsing; the plant calcium takes plants as main raw materials, takes green olive, cucumber seeds, Chinese yam, soybean, cerasus humilis, walnut and the like as representatives, has the advantages of high solubility, good absorption, no damage to the kidney and no side effect, and is more suitable to be used as a source for supplementing calcium for human bodies. With the improvement of health consciousness of people, more and more people aim at a novel plant calcium source with low price and wide source, develop calcium-rich products which are convenient to eat, good in absorption and free of side effect, can be eaten as general food for a long time, and is one of good ways for solving the increasing calcium supplement demand.
Plant calcium-supplementing food/health product using prunus humilis as calcium source has been precedent, such as calcium tablet prepared from prunus humilis fruit juice powder in CN201910171293, tablet candy prepared from prunus humilis fruit powder in CN201710855038, prunus humilis fruit juice calcium-supplementing beverage in CN201310202825, solid beverage containing prunus humilis fruit juice powder in CN201510649930, etc. The food/health care product has various varieties, but the cerasus humilis is simply used as a calcium source in principle, and the problems of insufficient utilization/absorption of the calcium source and poor/inaccurate calcium supplement effect exist.
Prunus humilis Bunge and semen Juglandis are both medicinal and edible products, and can be used as health food. However, the food for enhancing the bone mineral density, which is prepared by using cerasus humilis and walnuts as raw materials, is not reported at home and abroad at present. The invention takes cerasus humilis as a natural calcium supplement substance and walnuts as a natural calcium absorption promoting substance, and has reasonable collocation and synergistic effect. In addition, the invention does not add lactose and sucrose, has the characteristics of low energy, no decayed tooth and the like, and is particularly suitable for lactose intolerant people, diabetes patients and children.
Disclosure of the invention
Aiming at the problems, the invention provides a natural plant active calcium preparation, which takes cerasus humilis as a natural calcium supplement substance and walnuts as a natural calcium absorption promoting substance, has the characteristics of high solubility, good absorption, no damage to the kidney and no side effect, and realizes synergistic interaction of the cerasus humilis and the walnuts. The cerasus humilis and the walnut kernel are both medicinal and edible products, and the safety is guaranteed; the cerasus humilis and the walnuts also contain rich nutrient substances, and can balance the nutrition of a human body while supplementing calcium. The natural plant active calcium preparation of the invention is made of natural materials, does not add lactose and sucrose, has the characteristics of low energy, no decayed tooth and the like, is particularly suitable for lactose intolerant people, diabetes patients and children to eat, and is helpful for calcium supplement and human nutrition balance.
On one hand, the invention provides a natural plant active calcium preparation which is characterized by comprising the following raw materials, by mass, 20-60 parts of cerasus humilis or an extract thereof and 10-40 parts of walnuts.
Further, the preparation also comprises 0-60 parts of filler, 0-60 parts of prebiotics, 0-25 parts of sweetener and 0-1 part of lubricant.
Further, the preparation comprises the following raw materials in parts by mass: 28.6 parts of cerasus humilis or extract thereof, 11.4 parts of walnut, 54.7 parts of filler, 4 parts of prebiotics, 0.3 part of sweetener and 1 part of lubricant.
Further, the bulking agent is selected from one or more of mannitol, xylitol, fructose-alcohol, sorbitol, maltitol, isomalt, polydextrose, dextrin, maltodextrin, edible corn starch, microcrystalline cellulose or wheat flour.
Further, the prebiotic is selected from the group consisting of: one or more of raffinose, stachyose, soybean oligosaccharide, isomaltooligosaccharide, fructo-oligosaccharide, chitosan oligosaccharide, xylo-oligosaccharide and inulin.
Further, the sweetener is selected from: crystal sugar, brown sugar, high fructose syrup, honey, stevioside, fructus momordicae prasugrel, sucralose, aspartame, sodium cyclamate, acesulfame potassium, saccharin sodium, neotame, alitame, aspartame, glycyrrhizin, monopotassium glycyrrhizinate, tripotassium glycyrrhizinate, polyfructose and polydextrose.
Further, the bulking agent is a combination of mannitol and isomalt.
Further, the prebiotics are isomaltooligosaccharides.
Further, the sweetener is aspartame.
Further, mannitol and isomalt were 10.9% and 43.8% in total mass percentage, respectively.
Further, isomaltooligosaccharides were 4% by total mass.
Further, aspartame accounts for 0.3% by mass of the total composition.
Further, the preparation method of the cerasus humilis or the extract thereof in the preparation comprises the following steps:
(1) selecting Prunus humilis Bunge, cleaning, decocting to protect color, removing core, and drying;
(2) pulverizing or extracting denucleated Prunus humilis Bunge.
Further, the preparation method of the cerasus humilis or the cerasus humilis extract in the preparation comprises the specific operation method in the step (1): selecting fresh cerasus humilis fruits, and removing rotten fruits and wormy fruits; cleaning the surface of the fruit with clear water, soaking in 0.01% potassium permanganate solution for 5-15min, and washing with purified water; placing cleaned fresh Prunus humilis Bunge fruit in stainless steel pot, adding 1-3 times of pure water, adding 0-0.4% citric acid for protecting color, heating and boiling for 1-5 min; after cooling to room temperature, artificial pitting; placing the denucleated cerasus humilis in a forced air drying oven at 50-70 deg.C for drying for 0-40 h; .
Further, the preparation method of the cerasus humilis or the extract thereof in the preparation, wherein the specific operation method for crushing the pitted cerasus humilis in the step (2) is as follows: pulverizing the denucleated Prunus humilis Bunge into powder of 10-120 meshes.
Further, the preparation method of the cerasus humilis or the extract thereof in the preparation comprises the specific steps of extracting the pitted cerasus humilis in the step (2): pulping the denucleated cerasus humilis, wherein the water addition amount is 0.5-2 times, and the pulping time is 3-9 min; carrying out enzymolysis with pectinase at 35-45 deg.C for 0.5-2.5h with the use amount of 0.8-2%; homogenizing at 60 deg.C under 25MPa, and concentrating or concentrating and drying the extractive solution.
Further, the walnuts in the formulation are processed according to conventional methods in the art, and may be processed by optional steps including, but not limited to, sorting, washing, drying, milling, sterilizing, and the like.
On the other hand, the invention provides the application of the preparation in preparing calcium supplement food, health care products or medicines.
The preparation can be prepared into various oral forms, including but not limited to food forms such as solid beverages, biscuits and candies, and health care products/drug formulations such as tablets, granules, pills and capsules.
The raw materials of the prunus humilis bunge and the walnuts in the application can adopt various products of different producing areas and specific varieties which meet the national food/medicine requirements, including but not limited to prunus humilis bunge produced in Heilongjiang, Jilin, Liaoning, inner Mongolia, Hebei, Shandong, Shanxi and the like, and walnuts, juglans sigillata, wild walnuts, Juglans mandshurica, black walnuts and the like produced in various producing areas in south and north.
The formulations of the present application may further comprise various food/pharmaceutical acceptable excipients according to the form/dosage form requirement, including but not limited to coating materials, solvents, solubilizers, binders, stabilizers, antioxidants, pH regulators, flavoring agents, and these excipients may be selected by those skilled in the art according to the common general knowledge in food/pharmaceutical science.
The action mechanism of each raw material in the invention is as follows:
cerasus humilis Bge, also called calcium fruit, is a unique deciduous shrub fruit tree in China. The Prunus humilis Bunge has dual purposes of medicine and food, the kernel of the Prunus humilis Bunge is the main source of Chinese medicine, the fruit is bright red and clear, the fragrance is strong, and the Prunus humilis Bunge contains various nutrient substances such as saccharides, protein, amino acid, mineral substances, vitamins and the like. The edible Prunus humilis Bunge has been recorded as early as 800 years ago, for example, when Yuan Dynasty is long-standing in the army of Mongolia, Prunus humilis Bunge fruits are made into dried fruits which can be carried with the person for eating, so as to balance nutrition. Scientific research shows that the cerasus humilis fruits contain 17 amino acids, the total amount of the amino acids reaches 338.3-451.7 mg/100g, the content of essential amino acids for children to grow reaches 102.7-126.6 mg/100g, particularly the content of lysine, valine, leucine and isoleucine is very high, and the cerasus humilis fruits are high-grade health-care fruits for children, pregnant women and old people. The calcium content can reach 60 mg-100 mg/100g, and the calcium contained in the calcium-rich milk powder is natural active calcium, and has the advantages of easy absorption, high utilization rate, no toxic or side effect and the like. Therefore, the cerasus humilis fruit is not only a natural nutritional health-care fruit, but also an excellent green calcium supplement product. However, the fresh cerasus humilis has sour and astringent taste when being eaten, and is difficult to swallow, and the storage period of the fresh cerasus humilis fruits is short and easy to decay. Therefore, it is necessary to process cerasus humilis to improve its taste and flavor, palatability and utilization. In addition, in the process of harvesting the bunge cherry seeds, the prunus humilis pulp is discarded as a non-medicinal part, so that the waste of traditional Chinese medicine resources is caused. Therefore, the processing and utilization of the prunus humilis pulp are necessary to improve the added value of the prunus humilis products.
The walnut kernel is dry mature seed of Juglans regia L (Juglans regia L.) of Juglandaceae, and is the first of four nuts. Walnut has rich nutrition, fragrant taste, pure flavor, high oil content in kernel, and is reputed by oil depot on trees, wherein the content of unsaturated fatty acid mainly comprising linoleic acid is more than 90%. The nutlet contains rich and complete kinds of amino acids, and the kinds and contents of essential amino acids are very similar to those required by human body and can be comparable with animal protein. The walnut kernel also contains VE, trace elements, mineral substances and other bioactive substances with multiple special functions of reducing blood pressure, blood sugar, blood fat, oxidation resistance, fatigue resistance and the like. Because the walnut kernel has the efficacies of strengthening brain, strengthening body, warming lung, moistening intestines, tonifying kidney, beautifying face and the like, the walnut kernel is regarded as a life-prolonging top-quality product by the medical and health-preserving society of China, and the walnut kernel is called as a fructus alpiniae oxyphyllae, a pecan, a beauty-maintaining fruit and the like by common people. The walnut is rich in nutrients such as protein, vitamins, dietary fibers, carotene, phospholipid, polyphenols, flavonoids, triterpenes, glycosides, calcium, magnesium, phosphorus, iron and the like. Research in recent years shows that protein is hydrolyzed by enzyme in digestive tract of human body to form polypeptide, and the polypeptide has the functions of promoting mineral absorption, resisting oxidation, resisting bacteria, lowering blood pressure, reducing blood fat, protecting liver, etc.
Prebiotics (probiotics) are non-digestible food ingredients that can be used as dietary supplements to improve host health by selectively stimulating the growth and activity of one or a small number of bacteria in a colony to beneficially affect the host. Most importantly, it stimulates the growth of beneficial bacterial flora and not harmful bacteria with potentially pathogenic or putrefactive activity. The prebiotics mainly comprises functional oligosaccharide, including raffinose, stachyose, soybean oligosaccharide, isomaltooligosaccharide, fructo-oligosaccharide, chitosan oligosaccharide, xylo-oligosaccharide, etc., and has effects of promoting calcium absorption, vitamin synthesis, regulating constipation and diarrhea, preventing obesity and dental caries, etc. Functional oligosaccharide (also called bifidus factor) as prebiotics can completely enter the large intestine because of not being digested after eating, but is selectively utilized and fermented by bifidobacterium in the large intestine to generate organic acid, and is indirectly absorbed by human body to be utilized as energy, so blood sugar can not rise after eating, the calorific value is only 40 percent of digestible sugar, and the functional oligosaccharide is not utilized by cariogenic bacteria mutant streptococcus in the oral cavity, the sweetness is 30 to 60 percent of cane sugar, the physicochemical property of some functional oligosaccharides is similar to that of cane sugar, and the functional oligosaccharide can replace the granulated sugar to be used for food manufacture to adjust the sweetness, the viscosity and the freezing point, improve the taste, the moisture retention, the water activity and the like of the food and increase the health-care function of the food.
Detailed description of the invention
Example 1
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting large-fruit and thick-kernel cerasus humilis, cleaning, soaking in 0.01% potassium permanganate solution for 5min, and washing with purified water; adding 1 time of pure water and 0.2% citric acid, heating and boiling for 3 min; after cooling to room temperature, artificial pitting; drying at 50 deg.C for 5 h. The walnut is processed by the following method: selecting and cleaning the raw materials for later use;
(2) weighing 20g of cerasus humilis and 10g of walnuts for standby in the step (1), clamping the walnuts in the stoned cerasus humilis, and fixing the walnut with toothpicks for standby;
(3) weighing 10g of rock sugar, adding 2 times of water to dissolve, boiling with big fire, boiling with small fire until the ice sugar juice turns yellow, wrapping the ice sugar juice on the Prunus humilis Bunge balls to be used in the step (2), cooling to room temperature, and freeze-drying the Prunus humilis Bunge balls in a freeze-drying oven for 24h to obtain Prunus humilis Bunge balls with complete fruit shape, golden yellow and bright color, crisp and tender meat, moderate sour and sweet taste and Prunus humilis Bunge fruit flavor.
Example 2
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting Prunus humilis Bunge, cleaning, soaking in 0.01% potassium permanganate solution for 15min, and washing with purified water; adding 2 times of pure water and 0.4% citric acid, and boiling for 3 min; after cooling to room temperature, artificial pitting; drying at 60 deg.C for 12h, and pulverizing into 10 mesh powder. The walnut is processed by the following method: selecting, cleaning, drying and crushing into 80-mesh fine powder for later use;
(2) weighing 20g of cerasus humilis, 20g of walnut, 30g of wheat flour, 5g of fructo-oligosaccharide and 5g of brown sugar in the step (1), and uniformly mixing for later use;
(3) weighing 15g of butter, melting, adding 5g of honey, and mixing uniformly. Pouring butter honey into the mixture for later use in the step (2), grabbing into dough with the weight of 15g per part, pressing into a round shape with hands, and baking in an oven at 150 ℃ for 15min to obtain the brown biscuit with the flavor of cerasus humilis fruits and walnut.
Example 3
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting Prunus humilis Bunge, cleaning, soaking in 0.01% potassium permanganate solution for 10min, and washing with purified water; adding 3 times of pure water and 0.4% citric acid, and boiling for 1 min; after cooling to room temperature, artificial pitting; drying at 70 deg.C for 19h, and pulverizing into 100 mesh. The walnut is processed by the following method: selecting, cleaning, drying, and pulverizing into 100 mesh powder;
(2) weighing 25g of cerasus humilis, 40g of walnut and 35g of soybean oligosaccharide in the step (1), uniformly mixing, adding a proper amount of honey water, and kneading into pills with the weight of 8g each.
Example 4
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting Prunus humilis Bunge, cleaning, adding 3 times of pure water and 0.2% citric acid, heating and boiling for 5 min; after cooling to room temperature, artificial pitting; pulping the denucleated cerasus humilis, wherein the water addition amount is 1 time, and the pulping time is 6 min; carrying out enzymolysis by using pectinase, wherein the dosage of the pectinase is 1.4%, the enzymolysis temperature is 45 ℃, and the enzymolysis time is 1.5 h; homogenizing at 60 deg.C and 25 MPa. The walnut is processed by the following method: selecting, cleaning, drying, and pulverizing into 14 mesh powder;
(2) weighing 30g of the cerasus humilis extract, 10g of walnuts and 10g of xylo-oligosaccharide in the step (1), and uniformly mixing to obtain the cerasus humilis and walnut compound fruit particle beverage.
Example 5
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting Prunus humilis Bunge, cleaning, adding 1 times of pure water and 0.4% citric acid, heating and boiling for 5 min; after cooling to room temperature, artificial pitting; pulping the denucleated cerasus humilis, wherein the water addition amount is 2 times, and the pulping time is 9 min; carrying out enzymolysis by using pectinase, wherein the use amount of the pectinase is 2%, the enzymolysis temperature is 40 ℃, and the enzymolysis time is 2.5 h; homogenizing at 60 deg.C under 25MPa, concentrating the extractive solution, and drying. The walnut is processed by the following method: selecting, cleaning, drying and crushing into 120 meshes;
(2) weighing 5g of cerasus humilis extract, 4g of walnut and 11g of inulin in the step (1), and uniformly mixing to obtain the powdery solid beverage.
Example 6
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting Prunus humilis Bunge, cleaning, adding 2 times of pure water and 0.2% citric acid, heating and boiling for 1 min; after cooling to room temperature, artificial pitting; pulping the denucleated cerasus humilis, wherein the water addition amount is 1 time, and the pulping time is 3 min; carrying out enzymolysis by using pectinase, wherein the dosage of the pectinase is 0.8 percent, the enzymolysis temperature is 45 ℃, and the enzymolysis time is 2.5 hours; homogenizing at 60 deg.C under 25MPa, and concentrating the extractive solution to obtain soft extract with relative density of 1.5. The walnut is processed by the following method: selecting, cleaning, drying, and pulverizing into 100 mesh powder;
(2) weighing 3g of the cerasus humilis extract, 3g of walnuts, 0.98g of stachyose, 3g of edible corn starch and 0.02g of stevioside in the step (1), uniformly mixing, sieving with a 16-mesh sieve, granulating, drying in a 60-DEG C forced air drying oven for 1h, sieving with a 18-mesh sieve, and grading to obtain the light red granules which are uniform in color, sour, sweet and delicious and have the fragrance of cerasus humilis fruits.
Example 7
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting Prunus humilis Bunge, cleaning, adding 1 times of pure water and 0% citric acid, heating and boiling for 1 min; after cooling to room temperature, artificial pitting; pulping the denucleated cerasus humilis, wherein the water addition amount is 2 times, and the pulping time is 3 min; carrying out enzymolysis by using pectinase, wherein the dosage of the pectinase is 1.4%, the enzymolysis temperature is 35 ℃, and the enzymolysis time is 2.5 h; homogenizing at 60 deg.C under 25MPa, concentrating the extractive solution, and drying. The walnut is processed by the following method: selecting, cleaning, drying and crushing into 80 meshes;
(2) weighing 10g of the cerasus humilis extract, 10g of walnuts, 5g of raffinose, 14.68g of microcrystalline cellulose and 0.12g of saccharin sodium in the step (1), uniformly mixing, sieving with a 12-mesh sieve, granulating, drying in a 60-DEG C forced air drying oven until the water content is less than 3%, sieving with a 14-mesh sieve, granulating, adding 0.2g of magnesium stearate, uniformly mixing, and tabletting to obtain the light red tablet with the cerasus humilis fruit taste.
Example 8
A natural plant active calcium preparation is prepared by the method comprising the following steps:
(1) the cerasus humilis is processed by the following method: selecting Prunus humilis Bunge, cleaning, soaking in 0.01% potassium permanganate solution for 5min, and washing with purified water; adding 2 times of pure water and 0% citric acid, and boiling for 5 min; after cooling to room temperature, artificial pitting; drying at 50 deg.C for 40h, and pulverizing into 100 mesh powder. The walnut is processed by the following method: selecting, cleaning, drying, and pulverizing into 100 mesh powder;
(2) weighing 28.6g of cerasus humilis, 11.4g of walnut, 10.9g of mannitol, 43.8g of isomaltitol, 4g of isomaltooligosaccharide and 0.3g of aspartame in the step (1), uniformly mixing, adding a proper amount of water to prepare a soft material, sieving with a 14-mesh sieve for granulation, drying in a 50-DEG C forced air drying oven until the water content is less than 3%, sieving with a 14-mesh sieve for granulation, adding 1g of magnesium stearate for uniform mixing, and tabletting to obtain tablets with complete shape, uniform color and consistent size.
Example 9
In order to effectively control the quality of the preparation, the content of calcium in the preparation is measured by inductively coupled plasma emission spectrometry (ICP-OES). The calcium concentration detected was well correlated linearly in the range of 0-4.31mg/mL, with the linear equation being Y-611395X +1606.8 (r-1). Precision RSD ═ 1.27%; stability RSD ═ 1.24%; the repeatability RSD is 2.85%; the sample recovery rate RSD was 2.7%, and the average recovery rate was 95.5%. The method has the advantages of simple operation, accurate result and good repeatability. The calcium content of the preparation prepared in example 8 of the present invention was 140mg/100g as determined by this method.
Example 10
Acute toxicity test in mice
By adopting a maximum tolerated dose method, 20 ICR mice with the weight of 18-22g are selected, and the mice are male and female. 13.77g of the preparation prepared in the invention example 8 is dissolved in 30mL of purified water. The mice were subjected to oral gavage for 1 time, the gavage volume was 0.4mL/10g · bw, and the cumulative dose was 40.00mL/kg · bw. Fasting is carried out for 16 hours before the first gavage, and the stomach is continuously observed for two weeks after the first gavage, and the poisoning expression and the death condition are recorded. The experimental results are as follows:
no obvious toxic symptoms are observed after the samples of the invention with the dosage of 18.36 g/kg-bw are used for stomach irrigation of ICR mice of two sexes, and no death is observed for 14 days. At the end of the observation period, the tested animals are sacrificed and subjected to anatomical examination, and no obvious abnormal changes are seen in main organs such as liver, spleen, kidney, stomach, intestine, heart, lung and the like. The maximum tolerance of the invention to ICR male and female mice is more than 18.36g/kg · bw, and the invention belongs to nontoxic grade.
Example 11
Pharmacodynamic test
The experimental scheme is as follows:
1. selection of experimental animals: SPF grade SD rat (purchased from Ningxia medical university animal experiment center), male, weight 60-75 g, SCXK 2015-0001. The fresh-keeping agent is bred in Ningxia Hui drug modernization engineering technology research center (common level), indoor ventilation conditions are good, normal day and night change (8:00 am-8: 00pm), relative humidity is 55 +/-5%, and room temperature is 23 +/-2 ℃.
2. The experimental method comprises the following steps: 40 SD rats were acclimatized for one week during which time water and diet were taken ad libitum. One week later, the groups were randomly divided into 5 groups, a normal group, a model group, a product (example 7) low dose group (2.142 g/kg. BW), a medium dose group (4.284 g/kg. BW), and a high dose group (6.426 g/kg. BW), respectively. The test substance (0.1mL/10g) was administered orally by gavage 1 time per day for 4 weeks. The normal group was given normal feed (calcium content as Ca)2+Calculated as 500mg/100g), the model group, the low dose group, the medium dose group and the high dose group were all given low calcium feed (calcium content as Ca)2+Calculated as 120mg/100g), each group was given purified water to avoid calcium pick up from the drinking water. After the experiment was completed, the animals were sacrificed, the right femurs were peeled off, dried to constant weight in an oven at 105 ℃, and the dry weight of the bones was weighed.
3. Results of the experiment
As shown in table 1, the backbone weight was significantly reduced in the low calcium model group relative to the normal group. The backbone weight of the low-dose group, the medium-dose group and the high-dose group of the product is increased compared with that of the model group, and the high-dose group is increased obviously. The above data indicate that the product prepared in example 7 of the present invention has a certain effect of enhancing bone density.
TABLE 1 Effect of the products on bone Dry weight in Low calcium model rats
In comparison with the normal group,##p<0.01; comparison with model group<0.05，**p<0.01。
Claims (11)
1. A natural plant active calcium preparation is characterized by comprising the following raw materials, by mass, 20-60 parts of cerasus humilis or an extract thereof and 10-40 parts of walnuts.
2. The preparation of claim 1, further comprising 0-60 parts of a filler, 0-60 parts of a prebiotic, 0-25 parts of a sweetener, and 0-1 part of a lubricant.
3. The preparation of claim 2, comprising the following raw materials in parts by mass: 28.6 parts of cerasus humilis or extract thereof, 11.4 parts of walnut, 54.7 parts of filler, 4 parts of prebiotics, 0.3 part of sweetener and 1 part of lubricant.
4. The formulation according to claim 2 or 3, wherein the filler is selected from one or more of mannitol, xylitol, fructose, sorbitol, maltitol, isomalt, polydextrose, dextrin, maltodextrin, edible corn starch, microcrystalline cellulose or wheat flour; the prebiotics are selected from: one or more of raffinose, stachyose, soybean oligosaccharide, isomaltooligosaccharide, fructo-oligosaccharide, chitosan oligosaccharide, xylo-oligosaccharide and inulin; the sweetener is selected from: crystal sugar, brown sugar, high fructose syrup, honey, stevioside, fructus momordicae prasugrel, sucralose, aspartame, sodium cyclamate, acesulfame potassium, saccharin sodium, neotame, alitame, aspartame, glycyrrhizin, monopotassium glycyrrhizinate, tripotassium glycyrrhizinate, polyfructose and polydextrose.
5. The formulation of claim 4, wherein the bulking agent is a combination of mannitol and isomalt, the prebiotic is isomaltooligosaccharide, and the sweetener is aspartame.
6. The formulation of claim 5, wherein the mannitol is 10.9%, the isomalt is 43.8%, the isomaltooligosaccharide is 4%, and the aspartame is 0.3% in total mass percent.
7. The preparation according to any one of claims 1 to 6, wherein the preparation method of Prunus humilis Bunge or its extract comprises the steps of:
(1) selecting Prunus humilis Bunge, cleaning, decocting to protect color, removing core, and drying;
(2) pulverizing or extracting denucleated Prunus humilis Bunge.
8. The method for preparing cerasus humilis or the extract thereof in the preparation according to claim 7, wherein the step (1) comprises the following steps: selecting fresh cerasus humilis fruits, and removing rotten fruits and wormy fruits; cleaning the surface of the fruit with clear water, soaking in 0.01% potassium permanganate solution for 5-15min, and washing with purified water; placing cleaned fresh Prunus humilis Bunge fruit in stainless steel pot, adding 1-3 times of pure water, adding 0-0.4% citric acid for protecting color, heating and boiling for 1-5 min; after cooling to room temperature, artificial pitting; placing the denucleated cerasus humilis in a forced air drying oven at 50-70 deg.C for drying for 0-40 h; .
9. The method for preparing prunus humilis or an extract thereof in the preparation according to claim 7, wherein the specific operation method for pulverizing the denucleated prunus humilis in the step (2) is as follows: pulverizing the denucleated Prunus humilis Bunge into powder of 10-120 meshes.
10. The method for preparing prunus humilis or an extract thereof in the preparation according to claim 7, wherein the specific steps of extracting the denucleated prunus humilis in the step (2) are as follows: pulping the denucleated cerasus humilis, wherein the water addition amount is 0.5-2 times, and the pulping time is 3-9 min; carrying out enzymolysis with pectinase at 35-45 deg.C for 0.5-2.5h with the use amount of 0.8-2%; homogenizing at 60 deg.C under 25MPa, and concentrating or concentrating and drying the extractive solution.
11. Use of a preparation according to any one of claims 1 to 10 for the preparation of a calcium-supplemented food, nutraceutical or pharmaceutical product.
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