CN111480840A

CN111480840A - Composition for preventing and treating hyperuricemia and gout and application thereof

Info

Publication number: CN111480840A
Application number: CN202010304578.1A
Authority: CN
Inventors: 刘扬; 龙秀红; 王炎冰; 潘建文
Original assignee: Guangdong Shinyee Marine Biology Engineering Corp
Current assignee: Guangdong Shinyee Marine Biology Engineering Corp
Priority date: 2020-04-17
Filing date: 2020-04-17
Publication date: 2020-08-04

Abstract

The invention relates to the technical field of health care products, and particularly provides a composition for preventing and treating hyperuricemia and gout and application thereof. The composition for preventing and treating hyperuricemia and gout provided by the invention can effectively improve the sleep quality; synergistically eliminate the endotoxin in the intestinal tract and repair the cell tissues of the gastrointestinal mucosa; the synergistic antioxidation promotes the uric acid metabolism; the composition for preventing and treating hyperuricemia and gout has the advantages of strengthening an immune system, improving renal function and the like, preventing and treating hyperuricemia and ventilating, having an obvious deacidification effect, and being stable in performance and beneficial to storage.

Description

Composition for preventing and treating hyperuricemia and gout and application thereof

Technical Field

The invention relates to the technical field of health care products, and particularly provides a composition for preventing and treating hyperuricemia and gout and application thereof.

Background

With the improvement of living standard and the change of eating habits of people, the incidence of hyperuricemia and gout in China is on a rising trend year by year in recent years. Hyperuricemia is a disease in which blood uric acid exceeds normal values due to purine metabolic disorder and/or uric acid excretion disorder, and does not show any symptoms clinically. When a human body is in hyperuricemia for a long time, uric acid is precipitated in joints, soft tissues, cartilages and kidneys in the form of sodium salt, so that organ and tissue diseases of the human body are caused, gout is caused, serious complications are caused, the symptoms comprise gouty arthritis, gouty kidney diseases, gouty kidney stones, gouty heart diseases, gouty hypertension and the like, and patients have symptoms of arthralgia, renal colic or hematuria and the like. Therefore, how to effectively reduce uric acid is a major problem for patients with hyperuricemia and gout.

Although many products adopt food raw materials to achieve the effect of reducing uric acid at present, when the products are clinically applied, the defects of long treatment period, low overall efficiency, poor absorption and metabolism and the like generally exist, so that how to improve the treatment efficiency and the nutrient absorption condition of the products for reducing uric acid becomes a problem to be solved urgently at present. In addition, many products have the problems of being incapable of long-term storage, low stability and the like.

Disclosure of Invention

In order to solve the technical problems, the invention provides a composition for preventing and treating hyperuricemia and gout, which comprises, by weight, 120-220 parts of tuna peptide powder, 35-60 parts of aminobutyric acid, 18-50 parts of chitosan oligosaccharide, 20-50 parts of fruit powder, 100-230 parts of plant powder and 1.4-3.5 parts of vitamins; the molecular weight of the chitosan oligosaccharide is 600-1200 Da.

According to a preferable technical scheme, the tuna peptide powder comprises low-molecular-weight tuna peptide powder and high-molecular-weight tuna peptide powder in percentage by weight.

As a preferred technical scheme of the present invention, the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is 1: (0.6 to 0.8)

As a preferred technical scheme, the plant powder is selected from one or a combination of more of inulin, lotus leaf powder, tuckahoe powder, pearl barley powder, medlar powder, yellow fine powder, moringa leaf powder, cassia seed powder, lemon powder, sweet orange powder, passion fruit powder and acerola powder.

As a preferable embodiment of the present invention, the inulin includes short-chain inulin and long-chain inulin.

As a preferable technical scheme of the invention, the weight ratio of the short-chain inulin to the long-chain inulin is (0.3-0.5): 1.

as a preferable technical scheme of the invention, the composition also contains edible auxiliary materials.

As a preferred technical scheme of the invention, the edible auxiliary materials are one or a combination of more of excipient, stabilizer, flavoring agent and color fixative.

The third aspect of the invention provides an application of the composition for preventing and treating hyperuricemia and gout in preparing products and/or product additives for reducing uric acid and enhancing body immunity.

As a preferable technical scheme of the invention, the product comprises one or more of solid beverage, liquid beverage, dairy product, seasoning powder, cold drink, health nutriment and medical health care product.

Has the advantages that: the composition for preventing and treating hyperuricemia and gout, which is disclosed by the invention, has the synergistic effect of the low-molecular-weight tuna peptide powder and the high-molecular-weight tuna peptide powder and gamma-aminobutyric acid, lemon powder and sucralose in a system, can obviously improve the sleep quality, and can prevent the excessive formation of uric acid; in the composition for preventing and treating high uric acid and gout, the low molecular weight tuna peptide powder, fructo-oligosaccharide, inulin in plant powder, lotus leaf powder and cassia seed powder can be well compatible, so that intestinal endotoxin can be synergistically eliminated, gastrointestinal mucosa cell tissues can be repaired, and the blockage of a discharge channel of uric acid of 1/3 of a human body caused by intestinal dysfunction is improved, so that the uric acid can be quickly discharged out of the body, and the uric acid in blood can be safely, efficiently and healthily reduced; in the composition for preventing and treating hyperuricemia and gout, tuna peptide powder and chitosan oligosaccharide are scientifically compounded to interact with vitamins, sugar alcohol, sucralose in a system, tuckahoe powder and pearl barley powder in plant powder, and the composition is matched with each other and reasonably compatible, so that the effects of promoting the increase of hypoxanthine-guanine phosphoribosyl transferase activity, inhibiting the activity of hypoxanthine/xanthine oxidase, reducing the formation of uric acid, promoting the increase of lactic dehydrogenase activity, accelerating the metabolism of lactic acid, reducing the competitiveness of lactic acid on the excretion of uric acid, promoting the excretion of uric acid, balancing the content of uric acid in a body and safely, efficiently and healthily reducing uric acid in blood can be achieved; the composition for preventing and treating hyperuricemia and gout, which is disclosed by the invention, contains the biological zinc tuna peptide powder, and the gamma-aminobutyric acid, the sweet orange powder, the sucralose and the vitamins in the system interact with each other to strengthen an immune system, improve the kidney function and facilitate the discharge of uric acid; in addition, the fruit powder and the plant powder added into the system can make the composition more comfortable in taste, the components are matched with each other, and the compatibility is reasonable, so that the composition which is safe, stable, high-efficiency and capable of preventing and treating hyperuricemia and gout, has no side effect, can be brewed and has good taste is prepared.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

In order to solve the technical problems, the invention provides a composition for preventing and treating hyperuricemia and gout, which comprises, by weight, 120-220 parts of tuna peptide powder, 35-60 parts of aminobutyric acid, 18-50 parts of chitosan oligosaccharide, 20-50 parts of fruit powder, 100-222 parts of plant powder and 1.4-3.5 parts of vitamins; the molecular weight of the chitosan oligosaccharide is 600-1200 Da.

In a preferred embodiment, the components comprise 170 parts of tuna peptide powder, 47 parts of aminobutyric acid, 34 parts of chitosan oligosaccharide, 35 parts of fruit powder, 161 parts of plant powder and 2.5 parts of vitamins in parts by weight.

The composition also contains edible auxiliary materials.

Tuna peptide powder

The tuna is a marine warm water migratory fish, is red in meat color, is one of marine animals with the fastest swimming speed, and is reputable to the world due to delicious taste and high nutritional value. Compared with other meats, the meat is rich in unsaturated fatty acid, vitamins and proteins, wherein the protein content is the highest, the protein content of abdominal meat and back meat exceeds 21%, and the biological value is as high as 90%. Researches show that tuna contains abundant branched chain amino acids (leucine, isoleucine and valine), the content of which is up to 16.7 percent through detection, and the tuna has various physiological effects on human bodies.

In one embodiment, the tuna peptide powder comprises a low molecular weight tuna peptide powder and a high molecular weight tuna peptide powder.

In a preferred embodiment, the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is 1: (0.6-0.8); more preferably, the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is 1: 0.7.

in a more preferred embodiment, the low molecular weight tuna peptide powder has a molecular weight of 200 to 400 Da; the molecular weight of the high molecular weight tuna peptide powder is 500-1000 Da.

In some embodiments, the low molecular weight tuna peptide powder and the high molecular weight tuna peptide powder are available from commercial sources, including but not limited to from tokenized celebration marine bioengineering, ltd.

Aminobutyric acid

The aminobutyric acid is one or more selected from α -aminobutyric acid, D-2-aminobutyric acid, L-2-aminobutyric acid and gamma-aminobutyric acid.

In a preferred embodiment, the aminobutyric acid is gamma aminobutyric acid.

The gamma-aminobutyric acid (CAS number 56-12-2) is also called 4-aminobutyric acid (GABA for short) with a relative molecular weight of 103.1, is a four-carbon non-protein amino acid and widely exists in vertebrates, plants and microorganisms.

In some embodiments, the gamma-aminobutyric acid is commercially available, including but not limited to, from Tianjin century Tianlong Biotech, Inc

Chitosan oligosaccharide

The chitosan oligosaccharide is called chitosan oligosaccharide and oligomeric chitosan, and is an oligosaccharide product with the polymerization degree of 2-20, which is obtained by degrading chitosan by a special biological enzyme technology (reports of using chemical degradation and microwave degradation technologies).

In one embodiment, the chitosan oligosaccharide has a molecular weight of 600-1200 Da; preferably, the molecular weight of the chitosan oligosaccharide is 1000 Da.

In some embodiments, the chitosan oligosaccharide is commercially available, including but not limited to from Qingdao Bozhihui Biotech, Inc. model dp 3-7.

The tuna peptide powder added into the system by the applicant can be compounded with chitosan oligosaccharide and aminobutyric acid to bring a good uric acid reduction effect, but sometimes the effect is not particularly ideal, and the problem can be solved by simultaneously selecting low-molecular-weight tuna peptide powder with the molecular weight of 200-400 Da, high-molecular-weight tuna peptide powder with the molecular weight of 500-1000 Da and chitosan oligosaccharide with the molecular weight of 600-1200 Da. Meanwhile, as uric acid and lactic acid in vivo have a competitive discharge mechanism, and the lactic acid is prior to the uric acid, the anserine has the function of promoting the activity of lactate dehydrogenase, so that the lactic acid is rapidly decomposed into pyruvic acid, further converted into carbon dioxide and water, discharged out of the body, and more discharge channels are reserved for the uric acid, thereby reducing the concentration of uric acid in blood; and meanwhile, the low-molecular-weight tuna peptide powder is transported quickly, so that the gamma-aminobutyric acid can rapidly penetrate through a blood brain barrier and enter brain tissues, the smooth absorption of the gamma-aminobutyric acid is promoted, the gamma-aminobutyric acid is converted into the gamma-hydroxybutyric acid under the action of the gamma-aminobutyric acid transaminase, the sleep waves are increased, the gamma-aminobutyric acid is ascended through an intestine-brain axis information bidirectional communication system and acts on a central nervous system, the sleep quality is improved, and the formation of excessive uric acid can be prevented.

Meanwhile, the high molecular weight tuna peptide powder contains more abundant branched chain amino acids, can bring more selenium into human cells, strengthens the immune system, improves the kidney function and is beneficial to discharge of uric acid. However, when the amount of the high molecular weight tuna peptide powder added is too much, the steric hindrance of the long chain is large, which hinders the absorption of the active components gamma-aminobutyric acid and tuna peptide powder, and when the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is controlled to be 1: (0.6-0.8), the absorption effect is relatively good, and a relatively ideal uric acid reducing effect can be achieved.

Fruit powder

The fruit powder is a food prepared from apple powder, citric acid, malic acid, white granulated sugar powder, glucose powder, vitamin C, DHA powder, arachidonic acid powder and the like according to a certain proportion through pretreatment, mixing, tabletting, inspection and packaging, has health care and treatment effects of promoting digestion, preventing and treating diseases, enhancing immunity, resisting aging and the like, well retains effective components in vinegar powder, DHA powder and arachidonic acid powder, and has the effects of better promoting metabolism of a human body and reducing occurrence of cardiovascular diseases.

In some embodiments, the fruit powder is available from commercial sources, including but not limited to from huangshan fukuku trading ltd.

Vitamin preparation

The vitamins of the present invention include vitamin complex and vitamin C.

In a preferred embodiment, the weight ratio of the multivitamin and the vitamin C is 1: (1-15); more preferably, the weight ratio of the vitamin complex to the vitamin C is 1: 8.

in some embodiments, the multivitamins and vitamin C can be obtained from commercially available sources, including, but not limited to, multivitamins from guangzhou major food technology, inc; vitamin C was purchased from north china biotechnology limited.

Plant powder

The plant powder is selected from one or a combination of more of inulin, lotus leaf powder, tuckahoe powder, pearl barley powder, medlar powder, fine yellow powder, moringa leaf powder, cassia seed powder, lemon powder, sweet orange powder, passion fruit powder and acerola powder.

In a preferred embodiment, the plant powder comprises inulin, lotus leaf powder, poria cocos powder, coix seed powder, wolfberry powder, polygonatum powder, cassia seed powder, lemon powder, sweet orange powder, passion fruit powder and acerola powder.

In a more preferred embodiment, the plant powder comprises, by weight, 32-50 parts of inulin, 1-5 parts of lotus leaf powder, 18-50 parts of poria cocos powder, 10-25 parts of coix seed powder, 3-12 parts of medlar powder, 3-12 parts of rhizoma polygonati powder, 1-4 parts of cassia seed powder, 15-30 parts of lemon powder, 15-25 parts of sweet orange powder, 3-8 parts of passion fruit powder and 25-35 parts of acerola powder.

In a more preferred embodiment, the plant powder comprises, by weight, 41 parts of inulin, 3 parts of lotus leaf powder, 34 parts of poria cocos powder, 18 parts of coix seed powder, 7 parts of medlar powder, 7 parts of fine yellow powder, 2 parts of cassia seed powder, 23 parts of lemon powder, 20 parts of sweet orange powder, 6 parts of passion fruit powder and 28 parts of acerola powder.

Inulin powder

The inulin is reserve polysaccharide in plants, mainly comes from the plants, has more than 36000, comprises 11 families such as Compositae, Campanulaceae and Gentianaceae in dicotyledonous plants and 11 families such as Liliaceae and gramineae in monocotyledonous plants, is also called inulin, is linear straight-chain polysaccharide formed by connecting D-fructose through β (1 → 2) bonds, has a glucose residue at the end, has a polymerization Degree (DP) of 2-60, wherein the inulin with the average polymerization degree less than or equal to 10 is called short-chain inulin, and the inulin with the average polymerization degree more than or equal to 23 is called long-chain inulin.

In one embodiment, the inulin includes short-chain inulin and long-chain inulin.

In a more preferred embodiment, the weight ratio of the short-chain inulin to the long-chain inulin is (0.3-0.5): 1; more preferably, the weight ratio of the short-chain inulin to the long-chain inulin is 0.4: 1.

the applicant finds that the lemon powder and the sweet orange powder added into the system can improve sleep and prevent and treat hyperuricemia, but the taste is bitter, and the eating mouthfeel is influenced. When long-chain inulin and short-chain inulin are simultaneously selected, the bitter and astringent feeling of the composition can be reduced, probably because the inulin, particularly the long-chain inulin, contains abundant branched chain amino acids, and has strong affinity for furan ring and triterpene structures in limonin in lemon powder and sweet orange powder in a system, and a layer of protective film can be formed on the surface of the limonin; the short-chain inulin contains more monosaccharide and disaccharide, and the two components cooperate with each other to reduce the bitter taste of the limonin without influencing the effect of reducing uric acid. However, the applicant found that when too much short-chain inulin is added, free water is easy to combine with each other to cause moisture absorption and agglomeration of the composition, and when the weight ratio of the short-chain inulin to the long-chain inulin is controlled to be (0.3-0.5): at 1, the system is relatively stable.

Lotus leaf powder

The lotus leaf powder is powder obtained by grinding lotus leaves, and the chemical components of the lotus leaf powder mainly comprise nuciferine, citric acid, malic acid, gluconic acid, oxalic acid, succinic acid and other alkaline components with antimitotic effect. Pharmacological research finds that the traditional Chinese medicine composition has the effects of clearing heart fire, calming liver fire, purging spleen fire, reducing lung fire, clearing heat, nourishing spirit, assisting in reducing blood pressure, promoting urination, astringing liquid, arresting sweating, stopping bleeding, controlling nocturnal emission and the like.

Poria cocos powder

The poria cocos powder is powder of traditional Chinese medicine poria cocos, which is white and light grey in color and is dark grey after being brewed, the sclerotium contains β -pachyman accounting for 93% of dry weight and triterpenoid compounds of acetylpachymic acid, pachymic acid and 3 β -hydroxylanostane trienoic acid, and in addition, the sclerotium also contains gum, chitin, protein, fat, sterol, lecithin, glucose, adenine, histidine, choline, β -pachyman resolvase, lipase, protease and the like.

Coix seed powder

The coix seed powder is powder prepared by grinding coix seeds serving as raw materials, and has extremely high beauty and health care values. Also called coix seed, coix seed and coix seed, ancient name is "coix seed", which is called Xiandan for natural beauty therapist, angel for treatment, cancer killer and longevity. Coix seeds are herbaceous plants of Coix genus of Gramineae, and recent researches show that the Coix seeds have the effects of resisting oxidation, allergy, obesity, hyperlipidemia, tumors and the like. The active ingredients found in the composition mainly comprise coix polysaccharide A, B and C (Coixana, B and C), neutral glucan 1-7, acidic polysaccharides CA-1 and CA-2, coix ester (Coixolide), Coixol (Coixol), lignans, phenols, various unsaturated fatty acids, benzoxazinone, oxazepinone and triterpenes ring-opening compounds such as squalene, sterols, adenosine and various amino acids. Has effects in clearing away heat, promoting diuresis, benefiting lung, expelling pus, invigorating spleen and stomach, and strengthening muscle and bone.

Chinese wolfberry powder

The fructus Lycii powder is prepared by grinding fructus Lycii, contains carotene, betaine, vitamin A, vitamin B1, vitamin B2, vitamin C, calcium, phosphorus, ferrum, etc., and has pharmacological effects of increasing leukocyte activity and promoting hepatocyte regeneration. The medlar has rich nutrient components and is a natural raw material with comprehensive nutrition at present. The medlar contains a large amount of proteins, amino acids, vitamins and nutrient components such as iron, zinc, phosphorus, calcium and the like which are necessary for human bodies, the medlar tonifies the kidney and benefits the essence, nourishes the liver and improves the eyesight, is commonly called as Viagra in fruits, can repair the damage of the kidney caused by medicines and the like, enhances the excretion mechanism of the kidney to uric acid and promotes the excretion of uric acid.

Rhizoma Polygonati powder

The rhizoma Polygonati powder is prepared by grinding rhizoma Polygonati, wherein rhizome of rhizoma Polygonati contains steroid saponin, and 2 furostanol type saponins and 2 spirostanol type saponins are separated. Rhizoma Polygonati has effects of invigorating qi, nourishing yin, invigorating spleen, invigorating kidney, enhancing superoxide dismutase (SOD) activity in liver, enhancing oxidation resistance, regulating uric acid generation mechanism, and inhibiting excessive uric acid formation.

Cassia seed powder

The semen Cassiae powder is obtained by grinding dried mature seed of Cassia tora or Cassia tora L of Leguminosae, and has bitter taste and therapeutic and health promoting effects. Contains chrysophanol, emodin, aloe-emodin, rhein, emodin glucoside, emodin anthrone, physcion, obtusin, aurantio-obtusin, and neospora rosea pigment, obtusin, and toralactone. Firming skin, losing weight, expelling toxin, reducing pathogenic fire, clearing liver, improving eyesight, promoting diuresis, relaxing bowel.

Lemon powder

The lemon is called as the king of whitening, contains a large amount of vitamin C, Vc is one of important elements widely accepted by the beauty cosmetics field, and can effectively inhibit the activity of the neuraminidase and reduce the oxidative melanin into colorless reductive melanin, thereby achieving the effects of whitening and removing freckles. The lemon is rich in vitamins and trace elements, and has effects of promoting digestion, improving appetite, reducing fat and uric acid, and burning fat.

Sweet orange powder

The sweet orange is a fruit of citrus sinensis (L.) Osbeck of Rutaceae, has the efficacies of soothing liver and promoting qi, eliminating stagnation and promoting lactation, and relieving alcoholism, and is mainly used for treating hypochondriac pain caused by stagnation of liver qi, abdominal fullness, puerperal galactostasis, breast caking and gall, drunkenness, and the fruit contains flavonoid glycoside, lactone, alkaloid, organic acid and the like, wherein the flavonoid glycoside comprises hesperidin, narirutin, isosakuranetin-7-rutinoside, naringenin-4' -glucoside-7-rutinoside, naringin, 3-3 β -D-glucoside and O-D-xylosylvitexin, the lactone comprises a dilactone bitter component, namely phellodendron lactone and a derivative thereof, namely limonic acid A-cyclic lactone, the alkaloid is narcotine, the organic acid mainly comprises citric acid and malic acid, and the organic acid also comprises phloroglucinol- β -D-glucoside, calcium, vitamin, calcium, vitamin and the like.

Passion fruit powder

The passion fruit (also known as Passiflora edulis Sims) contains 17 amino acids, rich protein, fat, sugar, vitamin, calcium, phosphorus, iron, potassium, SOD enzyme, super fiber and other 165 substances beneficial to human body, more called as the king of VC (vitamin) in fruits, and has unique taste. The passion fruit contains rich nutrient components, is rich in vitamin C, also contains seventeen amino acids, multiple vitamins, carotenoids and various trace elements required by a human body, can enhance the resistance of the human body and improve the immunity, and is particularly beneficial to the development and growth of the body when being eaten by children and pregnant women. And the passion fruit has the effects of helping digestion, reducing phlegm, treating kidney deficiency, refreshing, restoring consciousness, promoting blood circulation, strengthening body, tranquilizing, relieving pain, reducing pressure, reducing fat and the like.

Acerola cherry powder

The acerola powder is extracted from natural acerola. German scientists find that cherry pit extract, cherry pit flavone essence and large cherry essence can neutralize the enzymes producing uric acid and effectively promote the excretion of uric acid from the far end of renal tubule to reduce uric acid. Research of the university of Michigan in America shows that anthocyanin in cherry has the effect of reducing inflammation probability. Anthocyanidin, vitamin E and the like contained in acerola cherry are effective antioxidants, and can promote blood circulation, accelerate uric acid excretion and quickly relieve discomfort caused by gout and arthritis.

In some embodiments, the inulin, lotus leaf powder, poria cocos powder, coix seed powder, wolfberry powder, polygonatum powder, cassia seed powder, lemon powder, sweet orange powder and passion fruit powder are commercially available, including but not limited to inulin from Qingdao Renuo food ingredients, Inc.; lotus leaf powder and cassia seed powder are purchased from Hao Chen biology ltd; poria powder and Coicis semen powder are purchased from Nanjing Zelang Biotechnology GmbH; fructus Lycii powder and rhizoma Polygonati powder are purchased from Shaanxi Huiyac plant development Co., Ltd; lemon powder was purchased from Shanghai hong Gehen food science and technology, Inc.; the sweet orange powder is purchased from Zhenguoa food industry Co., Ltd in Tianjin; passion fruit powder was purchased from Huangshan Fukuwa Henshu, Inc., and acerola cherry powder was purchased from Tianjin Xiugu, Inc., Biotech development Co.

Edible auxiliary material

The edible auxiliary materials are selected from one or a combination of a plurality of excipients, stabilizers, flavoring agents and color retention agents.

In a preferred embodiment, the dietary supplement is a flavoring agent.

In a more preferred embodiment, the flavoring agent is selected from one or more of halogenated sucrose derivatives, oligosaccharides, sugar alcohols, and polysaccharides.

In a more preferred embodiment, the odorant comprises a halogenated sucrose derivative, an oligosaccharide and a sugar alcohol.

In a more preferred embodiment, the odorant comprises 0.6 to 4 parts by weight of a halogenated sucrose derivative, 30 to 48 parts by weight of an oligosaccharide, and 32 to 68 parts by weight of a sugar alcohol.

In a more preferred embodiment, the odorant comprises 2.3 parts of a halogenated sucrose derivative, 39 parts of an oligosaccharide and 50 parts of a sugar alcohol, in parts by weight.

Halogenated sucrose derivatives

The halogenated sucrose derivative is sucralose and/or tetrachlorosucrose.

In a preferred embodiment, the halogenated sucrose derivative is sucralose.

In some embodiments, the sucralose may be obtained from commercial sources, including but not limited to from Henan Jinrun food additives, Inc.

Oligosaccharides

The oligosaccharide is selected from one or a combination of several of isomaltooligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide and galacto-oligosaccharide.

In a preferred embodiment, the oligosaccharide is a fructooligosaccharide.

In some embodiments, the fructooligosaccharides are commercially available, including but not limited to from bowling bio-shares, inc.

The applicant finds that the addition of fructo-oligosaccharide can make the uric acid reducing effect more ideal. The reason for this is probably that the polymerization degree of fructo-oligosaccharide is small, and the fructo-oligosaccharide is easily decomposed completely in the front 1/3 segment of colon, but the fructo-oligosaccharide with higher polymerization degree contained in inulin can reach the rear half segment of colon, and the fructo-oligosaccharide and inulin are mutually coordinated to regulate intestinal flora, enhance gastrointestinal peristalsis, improve gastrointestinal function, increase digestion and appetite, and improve the blockage of the discharge channel of uric acid in 1/3 of human body caused by intestinal dysfunction, so that uric acid can be rapidly discharged out of body, safely, efficiently and healthily reduce uric acid in blood.

Sugar alcohols

The sugar alcohol is selected from one or a combination of more of sorbitol, mannitol, erythritol, maltitol, lactitol, xylitol and isomaltitol.

Sorbitol

Sorbitol is a hexahydric alcohol obtained by hydrogenating glucose in the presence of a catalyst, and reducing an unsaturated carbonyl group at the 1-position of glucose to generate a hydroxyl group. The sorbitol has the performances and effects of low calorie, low sugar, low temperature oxidation resistance, cooling effect, compressibility, moisture retention, caries prevention and the like.

Mannitol

Mannitol, also known as mannitol, is a polyol or sugar alcohol, the natural product of which is widely found in plants, algae, edible fungi, lichens and other organisms. Mannitol is a six-carbon sugar alcohol, can be prepared from fructose by catalytic hydrogenation, has low hygroscopicity, is often used as a dusting agent in the manufacture of gum to avoid adhesion to manufacturing equipment and packaging machinery, and is also used as a component of a plasticizing system to keep the softness of the gum. It can also be used as a diluent or filler for sugar tablets and chocolate-flavored coating for ice cream and candy. Has pleasant flavor, no discoloration at high temperature, and no chemical activity. Its pleasant flavor and taste can mask the odor of vitamins, minerals and herbs. Is a good anti-sticking agent, nutritional supplement, tissue modifier and humectant for low calorie sweetener, chewing gum and candy.

Erythritol and its preparation method

Erythritol is a natural substance with a chemical name of 1, 2, 3, 4-butanetetraol, and is widely distributed in nature, and is contained in seaweed, mushroom, melon, grape, peach and other fruits, and also exists in fruit wine, beer, soy sauce and other foods. The sweetness of the erythritol is 60% to 70% of the sweetness of a 10% sucrose aqueous solution, the erythritol can be quickly absorbed by a human body after being taken, the discomfort of the stomach and the intestine can not be caused, 80% of the absorbed erythritol is discharged along with urine, and 20% of the absorbed erythritol enters the large intestine, and the blood sugar level and the insulin level can not be improved. Erythritol is identified by japan's thick birth province as the sole non-caloric sweetener. In addition, the erythritol absorbs a large amount of heat when dissolved, so that cool mouthfeel enjoyment is brought to people, and the erythritol is not utilized by the oral cavity mutant streptococcus and is anti-dental caries.

Maltitol

Maltitol is a sugar alcohol obtained by hydrogenation of maltose, which has both liquid and crystalline products. Important characteristics include: (1) maltitol has the same sweetness as sucrose, and is mild in sweetness and free of foreign flavor; (2) maltitol has remarkable hygroscopicity, and can be used as a humectant for various foods or for preventing crystallization of sucrose; (3) maltitol is not easily utilized by mold, yeast and lactobacillus, and can prevent dental caries; (4) maltitol is very difficult to be digested and metabolized in animals and is a good low-energy sweetener; (5) when a human body takes in maltitol, the blood sugar can not rise rapidly, and the insulin secretion is not stimulated; (6) the effect of maltitol in diet is not only low calorie, but also it inhibits fat storage in the human body when taken with high fat foods.

Lactitol

Lactitol is 12 carbon sugar alcohol, can be prepared by catalytic hydrogenation of lactose, has 2 products of anhydrous type and containing a piece of bound water, is sweet and tasty, is usually combined with a high-sweetness sweetener for use, has no aftertaste, low hygroscopicity and high solubility, has the relative molecular mass similar to that of cane sugar, has the influence on water activity similar to that of cane sugar, is stable under both acidic and alkaline conditions, and is very stable under the high-temperature condition of food processing. Lactitol is suitable for use in many food products, such as baked goods, sugar coated confectionery, frozen dairy desserts and the like.

Xylitol, its preparation method and use

Xylitol, also known as pentanol, is a five carbon sugar alcohol. Xylitol has the sweetness equivalent to that of sucrose, can permeate cell membranes and is absorbed and utilized by tissues without being promoted by insulin. Xylitol has excellent anti-caries properties, and chewing gums and confections using xylitol as the primary sweetener have received formal approval from six national dental health associations. Notably, excessive xylitol intake is prone to osmotic diarrhea.

Isomalt

Isomalt is also known as hydrogenated palatinose (hydrogenated isomaltulose), also known as palatinol (Palatinitol), also known as isomalt. The isomaltitol heat value is about half of that of sucrose, has no obvious influence on the levels of plasma glucose and insulin, can be eaten by diabetics, does not cause caries and has no browning reaction. The FDA in the united states places it on a GRAS (generally recognized as safe) status and does not limit its daily intake. In addition, isomalt is an excellent bifidobacteria-proliferating factor.

In a preferred embodiment, the sugar alcohol is sorbitol.

In some embodiments, the sorbitol is available from commercially available sources, including but not limited to from Shandong Jianjian Life technologies, Inc.

The preparation method of the composition comprises the following steps: and (3) uniformly mixing the components in parts by weight and weight ratio, and sterilizing to obtain the composition.

The composition of the present invention is any one of tablets, powders, granules and capsules, and is not particularly limited herein, and may be determined according to the actual production needs and the needs of consumers.

The second aspect of the invention provides application of a composition for preventing and treating hyperuricemia and gout in preparing products and/or product additives for reducing uric acid and enhancing body immunity.

In one embodiment, the product comprises one or more of a solid beverage, a liquid beverage, a dairy product, a seasoning powder, a cold drink, a health nutrient and a health care product.

Examples

In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the starting materials used are all commercially available, unless otherwise specified.

Example 1

The embodiment 1 of the invention provides a composition for preventing and treating hyperuricemia and gout, which comprises, by weight, 120 parts of tuna peptide powder, 35 parts of aminobutyric acid, 18 parts of chitosan oligosaccharide, 20 parts of fruit powder, 100 parts of plant powder and 1.4 parts of vitamins.

The molecular weight of the chitosan oligosaccharide is 1000Da, and the chitosan oligosaccharide is purchased from Qingdao Bozhi Virginian Biotech Co., Ltd, and the model is dp 3-7.

The tuna peptide powder comprises low-molecular weight tuna peptide powder and high-molecular weight tuna peptide powder; the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is 1: 0.6; the molecular weight of the low molecular weight tuna peptide powder is 200-400 Da; the molecular weight of the high molecular weight tuna peptide powder is 500-1000 Da.

The aminobutyric acid is gamma-aminobutyric acid.

The vitamins include vitamin complex and vitamin C; the weight ratio of the compound vitamin to the vitamin C is 1: 1.

the plant powder comprises inulin, lotus leaf powder, tuckahoe powder, pearl barley powder, medlar powder, rhizoma polygonati powder, cassia seed powder, lemon powder, sweet orange powder, passion fruit powder and acerola powder.

The plant powder comprises, by weight, 32 parts of inulin, 1 part of lotus leaf powder, 18 parts of poria cocos powder, 10 parts of coix seed powder, 3 parts of medlar powder, 3 parts of fine yellow powder, 1 part of cassia seed powder, 15 parts of lemon powder, 15 parts of sweet orange powder, 3 parts of passion fruit powder and 25 parts of acerola powder.

The inulin includes short-chain inulin and long-chain inulin; the weight ratio of the short-chain inulin to the long-chain inulin is 0.3: 1.

the composition also contains edible auxiliary materials.

The edible auxiliary material is a flavoring agent; the odorants include halogenated sucrose derivatives, oligosaccharides and sugar alcohols;

the odorant comprises 0.6 parts of a halogenated sucrose derivative, 30 parts of an oligosaccharide and 32 parts of a sugar alcohol, in parts by weight;

the halogenated sucrose derivative is sucralose; the oligosaccharide is fructo-oligosaccharide; the sugar alcohol is sorbitol.

The low molecular weight tuna peptide powder and the high molecular weight tuna peptide powder were purchased from Zhaoqing Xingyi oceanic bioengineering Co., Ltd.

The gamma-aminobutyric acid was purchased from Tianjin century Tianlong Biotech Co., Ltd.

The vitamin complex is purchased from Guangzhou Shuowei food technology, Inc.; the vitamin C was purchased from hebeihuaheng biotechnology limited.

The fruit powder is purchased from Huangshan Fukun trading Co.

The inulin was purchased from Qingdao Reno food ingredients, Inc.; the lotus leaf powder and the cassia seed powder are purchased from Hao Chen biology GmbH; the tuckahoe powder and the pearl barley powder are purchased from Nanjing Zelang biological technology Limited; the medlar powder and the sealwort powder are purchased from Shaanxi comedy plant development Limited company; the lemon powder is purchased from Shanghai hong Gem food science and technology Limited; the sweet orange powder is purchased from Zhenguoa food industry Co., Ltd in Tianjin; the passion fruit powder is purchased from Huangshan Fukuwa trade company, Inc.; the acerola cherry powder was purchased from Tianjin Xiugu Biotech development Co., Ltd.

The sucralose was purchased from jinrun food additives limited, henna.

The fructooligosaccharides were purchased from bowling bio-incorporated.

The sorbitol was purchased from Shandong Jianyi Life technologies, Inc.

Example 2

The embodiment 2 of the invention provides a composition for preventing and treating hyperuricemia and gout, which is the same as the embodiment 1 in specific implementation mode, and is characterized in that the composition comprises 170 parts of tuna peptide powder, 47 parts of aminobutyric acid, 34 parts of chitosan oligosaccharide, 35 parts of fruit powder, 161 parts of plant powder and 2.5 parts of vitamins in parts by weight; the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is 1: 0.7; the weight ratio of the compound vitamin to the vitamin C is 1: 8; the plant powder comprises, by weight, 41 parts of inulin, 3 parts of lotus leaf powder, 34 parts of poria cocos powder, 18 parts of coix seed powder, 7 parts of medlar powder, 7 parts of fine yellow powder, 2 parts of cassia seed powder, 23 parts of lemon powder, 20 parts of sweet orange powder, 6 parts of passion fruit powder and 28 parts of acerola powder; the weight ratio of the short-chain inulin to the long-chain inulin is 0.4: 1; the odorant comprises, by weight, 2.3 parts of a halogenated sucrose derivative, 39 parts of an oligosaccharide, and 50 parts of a sugar alcohol.

Example 3

The embodiment 3 of the invention provides a composition for preventing and treating hyperuricemia and gout, which is the same as the embodiment 1 in specific implementation mode, and is characterized in that the composition comprises 220 parts of tuna peptide powder, 60 parts of aminobutyric acid, 50 parts of chitosan oligosaccharide, 50 parts of fruit powder, 222 parts of plant powder and 3.5 parts of vitamins in parts by weight; the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is 1: 0.8; the weight ratio of the compound vitamin to the vitamin C is 1: 15; the plant powder comprises, by weight, 50 parts of inulin, 5 parts of lotus leaf powder, 50 parts of poria cocos powder, 25 parts of coix seed powder, 12 parts of medlar powder, 12 parts of fine yellow powder, 4 parts of cassia seed powder, 30 parts of lemon powder, 25 parts of sweet orange powder, 8 parts of passion fruit powder and 33 parts of acerola powder; the weight ratio of the short-chain inulin to the long-chain inulin is 0.5: 1; the odorant comprises 4 parts of a halogenated sucrose derivative, 48 parts of an oligosaccharide, and 68 parts of a sugar alcohol, in parts by weight.

Example 4

Example 4 of the present invention provides a composition for the prevention and treatment of hyperuricemia and gout, which is specifically implemented in the same manner as in example 2, except that the weight ratio of short-chain inulin to long-chain inulin is replaced with 1: 1.

example 5

Example 5 of the present invention provides a composition for preventing and treating hyperuricemia and gout, which is specifically embodied in the same manner as example 2, except that short-chain inulin is not present.

Example 6

Example 6 of the present invention provides a composition for preventing and treating hyperuricemia and gout, which is specifically embodied in the same manner as example 2, except that no long-chain inulin is present.

Performance testing

1. Storage stability test and bitterness test

After the composition prepared in the embodiments 1-6 is placed at room temperature for 2 weeks, observing whether flocculation and caking phenomena exist, respectively setting 100 parallel samples in each embodiment, and recording the probability of flocculation and caking, namely the percentage of the number of flocculation and caking to the total number of the composition to be tested;

the compositions prepared in examples 1-6 were eaten by volunteers, 120 volunteers were selected and divided into 10 groups of 12 persons, the bitterness was scored at 0-10 points, 0 points representing very bitter and 10 points representing no bitterness, and finally the average score was taken.

TABLE 1 stability and bitterness

2. Animal experiment testing

Selecting 63 healthy male rats with the weight of 190.9-230.9 g, randomly and averagely dividing the rats into a normal control group, a model control group, a positive control group, a uric acid reduction control group and a treatment group, and respectively trying the compositions prepared in the embodiments 1-3. Except for the normal control group, animals in each group were gavaged with adenine solution at a dose of 250mg/kg body weight daily for 30 consecutive days to establish a hyperuricemia model. The composition with the weight dose of 1.6g/kg is respectively gavaged every day in a treatment group, the positive control group is gavaged with a purine tablet liquid medicine, the souring-reducing group is gavaged with a souring-reducing liquid medicine, the level changes of blood uric acid and serum urea nitrogen of each group of mice after 30 days are observed and recorded for 30 days continuously, and the specific data are shown in table 2.

Table 2 animal test data tabulation

	Blood uric acid (mu mol/L)	Serum urea nitrogen (mu mol/L)
			Normal control group	71.74±11.48	5.51±0.67
Model control group	111.19±56.39	43.28±13.91
			Positive control group	72.77±16.07	46.27±9.87
Uric acid-lowering control group	100.53±14.54	41.04±6.99
			Example 1	112.49±42.90	38.55±13.11
Example 2	111.77±23.99	38.82±13.41
			Example 3	82.49±8.18	47.30±8.02

3. Clinical trial

30 gout patients (male-female ratio is 1: 1) with the age of 30-80 years are collected. Specifically, the patients were divided into 3 groups of 10 patients each, and the compositions of examples 1 to 3 were tried on the first to third groups, 0.2g each time, once a day, morning and evening. The administration of each example was carried out for 4 weeks, and then the change in uric acid content was measured and averaged for each patient.

TABLE 3 clinical trial data

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. The composition for preventing and treating hyperuricemia and gout is characterized by comprising, by weight, 120-220 parts of tuna peptide powder, 35-60 parts of aminobutyric acid, 18-50 parts of chitosan oligosaccharide, 20-50 parts of fruit powder, 100-230 parts of plant powder and 1.4-3.5 parts of vitamins;

the molecular weight of the chitosan oligosaccharide is 600-1200 Da.

2. The composition for preventing and treating hyperuricemia and gout according to claim 1, wherein the tuna peptide powder comprises low molecular weight tuna peptide powder and high molecular weight tuna peptide powder.

3. The composition for preventing and treating hyperuricemia and gout according to claim 2, wherein the weight ratio of the low molecular weight tuna peptide powder to the high molecular weight tuna peptide powder is 1: (0.6-0.8).

4. The composition for preventing and treating hyperuricemia and gout according to claim 1 or 2, wherein the plant powder is selected from one or a combination of inulin, lotus leaf powder, tuckahoe powder, pearl barley powder, medlar powder, rhizoma polygonati powder, moringa oleifera leaf powder, cassia seed powder, lemon powder, sweet orange powder, passion fruit powder and acerola powder.

5. Composition for the control of hyperuricemia and gout according to claim 4, wherein the inulin comprises short-chain inulin and long-chain inulin.

6. The composition for preventing and treating hyperuricemia and gout according to claim 5, wherein the weight ratio of the short-chain inulin to the long-chain inulin is (0.3-0.5): 1.

7. the composition for preventing and treating hyperuricemia and gout according to claim 1, wherein the composition further comprises edible auxiliary materials.

8. The composition for preventing and treating hyperuricemia and gout according to claim 7, wherein the edible auxiliary materials are one or a combination of excipients, stabilizers, flavoring agents and color fixatives.

9. Use of the composition for preventing and treating hyperuricemia and gout according to any one of claims 1 to 8 in preparation of products and/or product additives for reducing uric acid and enhancing body immunity.

10. The use according to claim 9, wherein the product comprises one or more of a solid beverage, a liquid beverage, a dairy product, a seasoning powder, a cold drink, a health nutriment and a health care product.