CN1368181A - Nano medicine 'Shufeng Dingtong' and its preparing process - Google Patents
Nano medicine 'Shufeng Dingtong' and its preparing process Download PDFInfo
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- CN1368181A CN1368181A CN 01102508 CN01102508A CN1368181A CN 1368181 A CN1368181 A CN 1368181A CN 01102508 CN01102508 CN 01102508 CN 01102508 A CN01102508 A CN 01102508A CN 1368181 A CN1368181 A CN 1368181A
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Abstract
A nanometre (0.1-200 nm) medicine "Shufeng Dingting" for dispelling mild wind and relaxing pain is prepared from the nanometre powders of 15 Chinese medicinal materials including vomica nut, ephedra, liquorice root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of expelling pathogenic wind and eliminating dampness, promoting blood circulation and stopping pain, the nano medicine ' Shufeng Dingtong ' of cure mainly that anemofrigid-damp arthralgia, grain do not relax, numb limbs and tense tendons, lumbago and skelalgia, traumatic injury, blood stasis being had a pain the invention still further relates to the method for this medication preparation.
The dispelling wind Pain-Stopping Pill is a kind of classical Chinese patent medicine, mainly contains effects such as antiinflammatory, antibacterial, analgesia, analgesic, blood vessel dilating, is used for that anemofrigid-damp arthralgia, grain do not relax, numb limbs and tense tendons, lumbago and skelalgia, traumatic injury, blood stasis have a pain.But traditional dispelling wind Pain-Stopping Pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Shufeng Dingtong ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Shufeng Dingtong '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano vomiting nut 60-150 part nanometer Herba Ephedrae 200-450 part nanometer Olibanum 60-150 part
Nanometer Myrrha 60-150 part nanometer Rhizoma Homalomenae 20-45 part nanometer Pyritum 20-45 part
Nanometer Cortex Illicii 20-45 part nanometer Ramulus Cinnamomi 20-45 part nanometer Radix Achyranthis Bidentatae 20-45 part
Nanometer Fructus Chaenomelis 20-45 part nanometer Radix Glycyrrhizae 20..45 part nanometer Cortex Eucommiae 20-45 part
Nanometer Radix Saposhnikoviae 20-45 part nanometer Rhizoma Et Radix Notopterygii 20-45 part nanometer Radix Angelicae Pubescentis 20-45 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano vomiting nut 80-120 part nanometer Herba Ephedrae 250-350 part nanometer Olibanum 80-120 part
Nanometer Myrrha 80-120 part nanometer Rhizoma Homalomenae 25-35 part nanometer Pyritum 25-35 part
Nanometer Cortex Illicii 25-35 part nanometer Ramulus Cinnamomi 25-35 part nanometer Radix Achyranthis Bidentatae 25-35 part
Nanometer Fructus Chaenomelis 25-35 part nanometer Radix Glycyrrhizae 25-35 part nanometer Cortex Eucommiae 25-35 part
Nanometer Radix Saposhnikoviae 25-35 part nanometer Rhizoma Et Radix Notopterygii 25-35 part nanometer Radix Angelicae Pubescentis 25-35 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 300 parts of nanometer Olibanums of 100 parts of nanometer Herba Ephedraes of nano vomiting nut
30 parts of 30 parts of nanometer Pyritums of 100 parts of nanometer Rhizoma Homalomenaes of nanometer Myrrha
30 parts of 30 parts of nanometer Radix Achyranthis Bidentataes of 30 parts of nanometer Ramulus Cinnamomi of nanometer Cortex Illicii
30 parts of 30 parts of nanometer Cortexs Eucommiae of 30 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Chaenomelis
30 parts of 30 parts of nanometer Radix Angelicae Pubescentiss of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Radix Saposhnikoviae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Shufeng Dingtong ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Shufeng Dingtong ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common dispelling wind Pain-Stopping Pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Shufeng Dingtong ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as headache, rheumatic arthritis, rheumatic myositis, rheumatoid arthritis and wound, and clinical efficacy significantly is better than traditional dispelling wind Pain-Stopping Pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 300 parts of nanometer Olibanums of 100 parts of nanometer Herba Ephedraes of nano vomiting nut
30 parts of 30 parts of nanometer Pyritums of 100 parts of nanometer Rhizoma Homalomenaes of nanometer Myrrha
30 parts of 30 parts of nanometer Radix Achyranthis Bidentataes of 30 parts of nanometer Ramulus Cinnamomi of nanometer Cortex Illicii
30 parts of 30 parts of nanometer Cortexs Eucommiae of 30 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Chaenomelis
30 parts of 30 parts of nanometer Radix Angelicae Pubescentiss of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Radix Saposhnikoviae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 300 parts of nanometer Olibanums of 100 parts of nanometer Herba Ephedraes of nano vomiting nut
30 parts of 30 parts of nanometer Pyritums of 100 parts of nanometer Rhizoma Homalomenaes of nanometer Myrrha
30 parts of 30 parts of nanometer Radix Achyranthis Bidentataes of 30 parts of nanometer Ramulus Cinnamomi of nanometer Cortex Illicii
30 parts of 30 parts of nanometer Cortexs Eucommiae of 30 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Chaenomelis
30 parts of 30 parts of nanometer Radix Angelicae Pubescentiss of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Radix Saposhnikoviae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer dispelling wind analgesic therapy powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts of 300 parts of nanometer Olibanums of 100 parts of nanometer Herba Ephedraes of nano vomiting nut
30 parts of 30 parts of nanometer Pyritums of 100 parts of nanometer Rhizoma Homalomenaes of nanometer Myrrha
30 parts of 30 parts of nanometer Radix Achyranthis Bidentataes of 30 parts of nanometer Ramulus Cinnamomi of nanometer Cortex Illicii
30 parts of 30 parts of nanometer Cortexs Eucommiae of 30 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Chaenomelis
30 parts of 30 parts of nanometer Radix Angelicae Pubescentiss of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Radix Saposhnikoviae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer dispelling wind analgesic therapy membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest or affected part.
Claims (6)
1, a kind of nano medicine ' Shufeng Dingtong ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano vomiting nut 60-150 part nanometer Herba Ephedrae 200-450 part nanometer Olibanum 60-150 part
Nanometer Myrrha 60-150 part nanometer Rhizoma Homalomenae 20-45 part nanometer Pyritum 20-45 part
Nanometer Cortex Illicii 20-45 part nanometer Ramulus Cinnamomi 20-45 part nanometer Radix Achyranthis Bidentatae 20-45 part
Nanometer Fructus Chaenomelis 20-45 part nanometer Radix Glycyrrhizae 20-45 part nanometer Cortex Eucommiae 20-45 part
Nanometer Radix Saposhnikoviae 20-45 part nanometer Rhizoma Et Radix Notopterygii 20-45 part nanometer Radix Angelicae Pubescentis 20-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Shufeng Dingtong ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano vomiting nut 80-120 part nanometer Herba Ephedrae 250-350 part nanometer Olibanum 80-120 part
Nanometer Myrrha 80-120 part nanometer Rhizoma Homalomenae 25-35 part nanometer Pyritum 25-35 part
Nanometer Cortex Illicii 25-35 part nanometer Ramulus Cinnamomi 25-35 part nanometer Radix Achyranthis Bidentatae 25-35 part
Nanometer Fructus Chaenomelis 25-35 part nanometer Radix Glycyrrhizae 25-35 part nanometer Cortex Eucommiae 25-35 part
Nanometer Radix Saposhnikoviae 25-35 part nanometer Rhizoma Et Radix Notopterygii 25-35 part nanometer Radix Angelicae Pubescentis 25-35 part
3, nano medicine ' Shufeng Dingtong ' according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 300 parts of nanometer Olibanums of 100 parts of nanometer Herba Ephedraes of nano vomiting nut
30 parts of 30 parts of nanometer Pyritums of 100 parts of nanometer Rhizoma Homalomenaes of nanometer Myrrha
30 parts of 30 parts of nanometer Radix Achyranthis Bidentataes of 30 parts of nanometer Ramulus Cinnamomi of nanometer Cortex Illicii
30 parts of 30 parts of nanometer Cortexs Eucommiae of 30 parts of nanometer Radix Glycyrrhizaes of nanometer Fructus Chaenomelis
30 parts of 30 parts of nanometer Radix Angelicae Pubescentiss of 30 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Radix Saposhnikoviae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Shufeng Dingtong 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Shufeng Dingtong 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102508 CN1368181A (en) | 2001-01-31 | 2001-01-31 | Nano medicine 'Shufeng Dingtong' and its preparing process |
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| CN 01102508 CN1368181A (en) | 2001-01-31 | 2001-01-31 | Nano medicine 'Shufeng Dingtong' and its preparing process |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103082404A (en) * | 2011-11-08 | 2013-05-08 | 江西中烟工业有限责任公司 | Homalomena occulta essential oil and preparation method and application thereof |
| CN104107288A (en) * | 2013-04-20 | 2014-10-22 | 沈阳市骨科医院 | Sinew-relaxing collateral-activating pill |
| CN109528917A (en) * | 2017-09-21 | 2019-03-29 | 延边山宝科技发展有限公司 | A kind of preparation method towards hospital's composition and its cream for treating rheumatoid arthritis |
| CN110693984A (en) * | 2019-12-03 | 2020-01-17 | 杨博 | Traditional Chinese medicine composition for treating lumbar intervertebral disc protrusion |
| CN112107640A (en) * | 2020-09-07 | 2020-12-22 | 杨博 | Externally applied medicine for dispelling wind and eliminating dampness and preparation method thereof |
-
2001
- 2001-01-31 CN CN 01102508 patent/CN1368181A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103082404A (en) * | 2011-11-08 | 2013-05-08 | 江西中烟工业有限责任公司 | Homalomena occulta essential oil and preparation method and application thereof |
| CN104107288A (en) * | 2013-04-20 | 2014-10-22 | 沈阳市骨科医院 | Sinew-relaxing collateral-activating pill |
| CN109528917A (en) * | 2017-09-21 | 2019-03-29 | 延边山宝科技发展有限公司 | A kind of preparation method towards hospital's composition and its cream for treating rheumatoid arthritis |
| CN109528917B (en) * | 2017-09-21 | 2021-08-31 | 延边山宝科技发展有限公司 | Korean medicinal composition for treating rheumatoid arthritis and preparation method of cream thereof |
| CN110693984A (en) * | 2019-12-03 | 2020-01-17 | 杨博 | Traditional Chinese medicine composition for treating lumbar intervertebral disc protrusion |
| CN112107640A (en) * | 2020-09-07 | 2020-12-22 | 杨博 | Externally applied medicine for dispelling wind and eliminating dampness and preparation method thereof |
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