CN1368357A - Nano medicine 'Weitongding' and its preparing process - Google Patents
Nano medicine 'Weitongding' and its preparing process Download PDFInfo
- Publication number
- CN1368357A CN1368357A CN 01103648 CN01103648A CN1368357A CN 1368357 A CN1368357 A CN 1368357A CN 01103648 CN01103648 CN 01103648 CN 01103648 A CN01103648 A CN 01103648A CN 1368357 A CN1368357 A CN 1368357A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- medicine
- weitongding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
A nanometre (0.1-200 nm) medicine "Weitojngding" for treating stomach-ache is prepared from the nanometre powders of 13 Chinese medicinal materials including cinnamon bark, safflower, ginseng, etc, through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of have a respite, change strongly fragrant, by cold pain relieving, cure mainly the nano medicine ' Weitongding ' of stomachache food stagnation, the invention still further relates to the method for this medication preparation.
WEITONGDING is a kind of classical Chinese patent medicine, mainly contain have a respite, change strongly fragrant, by effects such as cold pain relievings, be used to have a respite, change strongly fragrant, by the pain relieving of trembling with fear.But traditional WEITONGDING disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Weitongding ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Weitongding '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Cortex Cinnamomi 12-30 part nano safflower 30-65 part nanometer Lignum Aquilariae Resinatum 40-80 part
Nanometer Oletum Trogopterori 12-30 part nanometer Fructus Amomi Rotundus 12-30 part nanometer-size realgar 12-30 part
Nano ginseng 8-18 part nanometer Radix orixae japonicae 12-30 part nanometer Fructus Aurantii 6-18 part
Nanometer Semen Crotonis Pulveratum 1-5 part nanometer Rhizoma Alpiniae Officinarum 12-30 part nano clove 12-30 part
Nanometer Radix Aucklandiae 12-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Cortex Cinnamomi 15-25 part nano safflower 35-55 part nanometer Lignum Aquilariae Resinatum 50-70 part
Nanometer Oletum Trogopterori 15-25 part nanometer Fructus Amomi Rotundus 15-25 part nanometer-size realgar 15-25 part
Nano ginseng 10-15 part nanometer Radix orixae japonicae 15-25 part nanometer Fructus Aurantii 8-15 part
Nanometer Semen Crotonis Pulveratum 1-3 part nanometer Rhizoma Alpiniae Officinarum 15-25 part nano clove 15-25 part
Nanometer Radix Aucklandiae 15-25 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 42 parts of nanometer Lignum Aquilariae Resinatum of 18 parts of nano safflowers of nanometer Cortex Cinnamomi
18 parts of 18 parts of nanometer-size realgars of 18 parts of nanometer Fructus Amomi Rotunduss of nanometer Oletum Trogopterori
12 parts of 18 parts of nanometer Fructus Aurantiis of 12 parts of nanometer Radix orixae japonicaes of nano ginseng
18 parts of 18 parts of nano cloves of 1.8 portions of nanometer Rhizoma Alpiniae Officinarums of nanometer Semen Crotonis Pulveratum
18 parts of the nanometer Radix Aucklandiae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Weitongding ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Weitongding ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common 'Weitongding ' material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Weitongding ' etc. had no precedent in the past.
That pharmaceutical preparation of the present invention can be used for having a respite, changes is strongly fragrant, by treatment of conditions such as cold pain relievings, clinical efficacy significantly is better than traditional WEITONGDING.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 42 parts of nanometer Lignum Aquilariae Resinatum of 18 parts of nano safflowers of nanometer Cortex Cinnamomi
18 parts of 18 parts of nanometer-size realgars of 18 parts of nanometer Fructus Amomi Rotunduss of nanometer Oletum Trogopterori
12 parts of 18 parts of nanometer Fructus Aurantiis of 12 parts of nanometer Radix orixae japonicaes of nano ginseng
18 parts of 18 parts of nano cloves of 1.8 portions of nanometer Rhizoma Alpiniae Officinarums of nanometer Semen Crotonis Pulveratum
18 parts of the nanometer Radix Aucklandiae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 42 parts of nanometer Lignum Aquilariae Resinatum of 18 parts of nano safflowers of nanometer Cortex Cinnamomi
18 parts of 18 parts of nanometer-size realgars of 18 parts of nanometer Fructus Amomi Rotunduss of nanometer Oletum Trogopterori
12 parts of 18 parts of nanometer Fructus Aurantiis of 12 parts of nanometer Radix orixae japonicaes of nano ginseng
18 parts of 18 parts of nano cloves of 1.8 portions of nanometer Rhizoma Alpiniae Officinarums of nanometer Semen Crotonis Pulveratum
18 parts of the nanometer Radix Aucklandiae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer WEITONGDING powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 42 parts of nanometer Lignum Aquilariae Resinatum of 18 parts of nano safflowers of nanometer Cortex Cinnamomi
18 parts of 18 parts of nanometer-size realgars of 18 parts of nanometer Fructus Amomi Rotunduss of nanometer Oletum Trogopterori
12 parts of 18 parts of nanometer Fructus Aurantiis of 12 parts of nanometer Radix orixae japonicaes of nano ginseng
18 parts of 18 parts of nano cloves of 1.8 portions of nanometer Rhizoma Alpiniae Officinarums of nanometer Semen Crotonis Pulveratum
18 parts of the nanometer Radix Aucklandiae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer WEITONGDING membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Weitongding ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Cortex Cinnamomi 12-30 part nano safflower 30-65 part nanometer Lignum Aquilariae Resinatum 40-80 part
Nanometer Oletum Trogopterori 12-30 part nanometer Fructus Amomi Rotundus 12-30 part nanometer-size realgar 12-30 part
Nano ginseng 8-18 part nanometer Radix orixae japonicae 12-30 part nanometer Fructus Aurantii 6-18 part
Nanometer Semen Crotonis Pulveratum 1-5 part nanometer Rhizoma Alpiniae Officinarum 12-30 part nano clove 12-30 part
Nanometer Radix Aucklandiae 12-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Weitongding ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Cortex Cinnamomi 15-25 part nano safflower 35-55 part nanometer Lignum Aquilariae Resinatum 50-70 part
Nanometer Oletum Trogopterori 15-25 part nanometer Fructus Amomi Rotundus 15-25 part nanometer-size realgar 15-25 part
Nano ginseng 10-15 part nanometer Radix orixae japonicae 15-25 part nanometer Fructus Aurantii 8-15 part
Nanometer Semen Crotonis Pulveratum 1-3 part nanometer Rhizoma Alpiniae Officinarum 15-25 part nano clove 15-25 part
Nanometer Radix Aucklandiae 15-25 part
3, nano medicine ' Weitongding ' according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 42 parts of nanometer Lignum Aquilariae Resinatum of 18 parts of nano safflowers of nanometer Cortex Cinnamomi
18 parts of 18 parts of nanometer-size realgars of 18 parts of nanometer Fructus Amomi Rotunduss of nanometer Oletum Trogopterori
12 parts of 18 parts of nanometer Fructus Aurantiis of 12 parts of nanometer Radix orixae japonicaes of nano ginseng
18 parts of 18 parts of nano cloves of 1.8 portions of nanometer Rhizoma Alpiniae Officinarums of nanometer Semen Crotonis Pulveratum
18 parts of the nanometer Radix Aucklandiae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Weitongding 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Weitongding 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103648 CN1368357A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Weitongding' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103648 CN1368357A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Weitongding' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368357A true CN1368357A (en) | 2002-09-11 |
Family
ID=4653393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01103648 Pending CN1368357A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Weitongding' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368357A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301726C (en) * | 2004-10-28 | 2007-02-28 | 金恭春 | Chinese medicinal capsule for treating asthenic cold type prolonged diarrhea |
| CN105435067A (en) * | 2015-12-21 | 2016-03-30 | 贵州瑞和制药有限公司龙里药厂 | Manufacturing method for stomachache-relieving preparation |
-
2001
- 2001-02-05 CN CN 01103648 patent/CN1368357A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301726C (en) * | 2004-10-28 | 2007-02-28 | 金恭春 | Chinese medicinal capsule for treating asthenic cold type prolonged diarrhea |
| CN105435067A (en) * | 2015-12-21 | 2016-03-30 | 贵州瑞和制药有限公司龙里药厂 | Manufacturing method for stomachache-relieving preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1366915A (en) | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method | |
| CN1368063A (en) | Nano medicine 'Yushangling' and its preparing process | |
| CN1368357A (en) | Nano medicine 'Weitongding' and its preparing process | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1360912A (en) | Nanometer spur treating medicine and its prepn | |
| CN1365697A (en) | Nano medicine 'Naoling' and its preparing process | |
| CN1368318A (en) | Nano medicine 'Shugantiaoqi' and its preparing process | |
| CN1368263A (en) | Nano medicine for treating infantile intractable cough and its preparing process | |
| CN1364505A (en) | Nano seven ingredient iron filing medicine and its prepairng method | |
| CN1362126A (en) | Nano wind-evil dispelling and itch stopping medicine and its preparation | |
| CN1368087A (en) | Nano medicine for treating cerebral thrombus and its preparing process | |
| CN1364534A (en) | Nano eight ingredient ingredient and eagled wood medicine for clearing away pericardium heat and its preparing method | |
| CN1366916A (en) | Nano plum blossom tongue preparation medicine and preparation method | |
| CN1368165A (en) | Nano medicine 'Shudan' and its preparing process | |
| CN1368099A (en) | Nano medicine 'Xiaoyin' and its preparing process | |
| CN1368155A (en) | Nano medicine 'Huanshao' and its preparing process | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1366923A (en) | Nano kindey-benefiting preparation medicine and preparation method | |
| CN1368191A (en) | Nano medicine 'Qufengshujin' and its preparing process | |
| CN1368324A (en) | Nano medicine 'Zhike' for relieving cough and its preparing process | |
| CN1365709A (en) | Nano medicine for child to relieve cough and its preparing process | |
| CN1368170A (en) | Nano medicine 'Shenshu' and its preparing process | |
| CN1368314A (en) | Nano medicine 'Weiqitong' and its preparing process | |
| CN1365715A (en) | Nano medicine 'Jiuqi Niantong' and its preparing process | |
| CN1368252A (en) | Nano medicine 'Banfenghe' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |