CN1362126A - Nano wind-evil dispelling and itch stopping medicine and its preparation - Google Patents
Nano wind-evil dispelling and itch stopping medicine and its preparation Download PDFInfo
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- CN1362126A CN1362126A CN 01100179 CN01100179A CN1362126A CN 1362126 A CN1362126 A CN 1362126A CN 01100179 CN01100179 CN 01100179 CN 01100179 A CN01100179 A CN 01100179A CN 1362126 A CN1362126 A CN 1362126A
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Abstract
The present invention discloses a nano wind-dispersing itch-relieving preparation medicine. It is made up by using 11 Chinese medicinal materials of nano ledebourille, nano cicada molting, nano lycium root bark, nano atractylodes, nano flax seed and others as raw material through the processes of microwave extraction, reduced pressure concentration and dsupersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of pathogenic wind expelling heat clearing away, removing damp to relieve itching, cure mainly papular urticaria, also be used for the nanometer wind-repellent itching-relieving preparation medicine of eczema, skin pruritus, the invention still further relates to the method for this medication preparation.
Wind-repellent itching-relieving granules is a kind of classical Chinese patent medicine, mainly contains effects such as pathogenic wind expelling heat clearing away, removing damp to relieve itching, is used for papular urticaria, also is used for eczema, skin pruritus.But traditional wind-repellent itching-relieving granules disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer wind-repellent itching-relieving preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer wind-repellent itching-relieving preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Saposhnikoviae 28-72 part nanometer Periostracum Cicadae 28-72 part nanometer Cortex Lycii 50.4-129.6 part
Nanometer Rhizoma Atractylodis (stir-fry) 33-86 part nanometer Semen Lini 50-129 part nano Chinese angelica 50-129 part
Nanometer Radix Rehmanniae 84-216 part nanometer Caulis Aristolochiae Manshuriensis 16-43 part nanometer Herba Schizonepetae 28-72 part
Nanometer Gypsum Fibrosum 16-43 part nanometer Radix Glycyrrhizae 16-43 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Saposhnikoviae 40-60 part nanometer Periostracum Cicadae 40-60 part nanometer Cortex Lycii 72-108 part
Nanometer Rhizoma Atractylodis (stir-fry) 48-72 part nanometer Semen Lini 72-108 part nano Chinese angelica 72-108 part
Nanometer Radix Rehmanniae 120-180 part nanometer Caulis Aristolochiae Manshuriensis 24-36 part nanometer Herba Schizonepetae 40-60 part
Nanometer Gypsum Fibrosum 24-36 part nanometer Radix Glycyrrhizae 24-36 part
The optimum weight proportioning of medicine of the present invention is:
90 parts of 50 parts of nanometer Cortex Lycii of 50 parts of nanometer Periostracum Cicadaes of nanometer Radix Saposhnikoviae
90 parts of 90 parts of nano Chinese angelicas of 60 parts of nanometer Semen Linis of nanometer Rhizoma Atractylodis (stir-fry)
50 parts of 30 parts of nanometer Herba Schizonepetae of 150 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Rehmanniae
30 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Gypsum Fibrosum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get wind-repellent itching-relieving preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer wind-repellent itching-relieving preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common wind-repellent itching-relieving granules preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200mm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer wind-repellent itching-relieving preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as papular urticaria, eczema, skin pruritus, and clinical efficacy significantly is better than traditional wind-repellent itching-relieving granules.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
90 parts of 50 parts of nanometer Cortex Lycii of 50 parts of nanometer Periostracum Cicadaes of nanometer Radix Saposhnikoviae
90 parts of 90 parts of nano Chinese angelicas of 60 parts of nanometer Semen Linis of nanometer Rhizoma Atractylodis (stir-fry)
50 parts of 30 parts of nanometer Herba Schizonepetae of 150 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Rehmanniae
30 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Gypsum Fibrosum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, the every capsules content of dispersion 0.1-0.6 of descendants of the Yellow gram, the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
90 parts of 50 parts of nanometer Cortex Lycii of 50 parts of nanometer Periostracum Cicadaes of nanometer Radix Saposhnikoviae
90 parts of 90 parts of nano Chinese angelicas of 60 parts of nanometer Semen Linis of nanometer Rhizoma Atractylodis (stir-fry)
50 parts of 30 parts of nanometer Herba Schizonepetae of 150 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Rehmanniae
30 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Gypsum Fibrosum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer wind-repellent itching-relieving powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
90 parts of 50 parts of nanometer Cortex Lycii of 50 parts of nanometer Periostracum Cicadaes of nanometer Radix Saposhnikoviae
90 parts of 90 parts of nano Chinese angelicas of 60 parts of nanometer Semen Linis of nanometer Rhizoma Atractylodis (stir-fry)
50 parts of 30 parts of nanometer Herba Schizonepetae of 150 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Rehmanniae
30 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Gypsum Fibrosum
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer wind-repellent itching-relieving membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, affected part.
Claims (6)
1, a kind of nanometer wind-repellent itching-relieving preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Saposhnikoviae 28-72 part nanometer Periostracum Cicadae 28-72 part nanometer Cortex Lycii 50-129 part
Nanometer Rhizoma Atractylodis (stir-fry) 33-86 part nanometer Semen Lini 50-129 part nano Chinese angelica 50-129 part
Nanometer Radix Rehmanniae 84-216 part nanometer Caulis Aristolochiae Manshuriensis 16-43 part nanometer Herba Schizonepetae 28-72 part
Nanometer Gypsum Fibrosum 16-43 part nanometer Radix Glycyrrhizae 16-43 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer wind-repellent itching-relieving preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Saposhnikoviae 40-60 part nanometer Periostracum Cicadae 40-60 part nanometer Cortex Lycii 72-108 part
Nanometer Rhizoma Atractylodis (stir-fry) 48-72 part nanometer Semen Lini 72-108 part nano Chinese angelica 72-108 part
Nanometer Radix Rehmanniae 120-180 part nanometer Caulis Aristolochiae Manshuriensis 24-36 part nanometer Herba Schizonepetae 40-60 part
Nanometer Gypsum Fibrosum 24-36 part nanometer Radix Glycyrrhizae 24-36 part
3, nanometer wind-repellent itching-relieving preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
90 parts of 50 parts of nanometer Cortex Lycii of 50 parts of nanometer Periostracum Cicadaes of nanometer Radix Saposhnikoviae
90 parts of 90 parts of nano Chinese angelicas of 60 parts of nanometer Semen Linis of nanometer Rhizoma Atractylodis (stir-fry)
50 parts of 30 parts of nanometer Herba Schizonepetae of 150 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Rehmanniae
30 parts in 30 parts of nanometer Radix Glycyrrhizaes of nanometer Gypsum Fibrosum
4, according to claim 1 or 2 or 3 described nanometer wind-repellent itching-relieving preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer wind-repellent itching-relieving preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100179 CN1362126A (en) | 2001-01-04 | 2001-01-04 | Nano wind-evil dispelling and itch stopping medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100179 CN1362126A (en) | 2001-01-04 | 2001-01-04 | Nano wind-evil dispelling and itch stopping medicine and its preparation |
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| Publication Number | Publication Date |
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| CN1362126A true CN1362126A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100179 Pending CN1362126A (en) | 2001-01-04 | 2001-01-04 | Nano wind-evil dispelling and itch stopping medicine and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100353971C (en) * | 2005-11-21 | 2007-12-12 | 贵州宏奇药业有限公司 | Wind-repellent itching-relieving granules and preparing method |
| CN1895451B (en) * | 2006-06-23 | 2010-05-12 | 徐新盛 | Medicinal composition for treating hives and eczema and its preparation |
| CN101612253B (en) * | 2009-07-17 | 2012-02-01 | 吉林紫鑫药业股份有限公司 | Medicine composition used for treating pimple type urticaria |
-
2001
- 2001-01-04 CN CN 01100179 patent/CN1362126A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100353971C (en) * | 2005-11-21 | 2007-12-12 | 贵州宏奇药业有限公司 | Wind-repellent itching-relieving granules and preparing method |
| CN1895451B (en) * | 2006-06-23 | 2010-05-12 | 徐新盛 | Medicinal composition for treating hives and eczema and its preparation |
| CN101612253B (en) * | 2009-07-17 | 2012-02-01 | 吉林紫鑫药业股份有限公司 | Medicine composition used for treating pimple type urticaria |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |