CN100353971C - Wind-repellent itching-relieving granules and preparing method - Google Patents
Wind-repellent itching-relieving granules and preparing method Download PDFInfo
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- CN100353971C CN100353971C CNB2005102007222A CN200510200722A CN100353971C CN 100353971 C CN100353971 C CN 100353971C CN B2005102007222 A CNB2005102007222 A CN B2005102007222A CN 200510200722 A CN200510200722 A CN 200510200722A CN 100353971 C CN100353971 C CN 100353971C
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Abstract
The present invention provides wind-repelling itch-relieving granules and a preparation method thereof. The wind-repelling itch-relieving granules are prepared from 125g of ledebouriella root, 125g of cicada slough, 225g of Chinese wolfberry root-bark, 150g of sauted swordlike atractylodes rhizome, 225g of flaxseed, 225g of angelica, 375g of rehmannia root, 75g of akebia stem, 125g of herba schizonepetae, 75g of plaster, 75g of glycyrrhiza and 960g of dextrine. Compared with the prior art, the wind-repelling itch-relieving granules provided by the present invention have the advantages of reasonable manufacturing technique, stable product quality, conspicuous curative effect and convenient storage, and a scientific proof is provided for large-scale industrial production.
Description
Technical field:
The present invention relates to a kind of wind-repellent itching-relieving granules and preparation method thereof, belong to technical field of Chinese medicine.
Background technology:
Urticaria belongs to categories such as Chinese medicine " urticaria ", " rubella wheal ", and its cause of disease is mainly not anti-, the plain body weakness of plain body natural endowment, and wind, wet, pathogenic heat are soaked or affection of exogenous wind-cold, wind heat mechanical equivalent or stimulations such as fish and shrimp or malnutrition due to parasitic infestation, abnormal flavour, or feelings body will is hindered outward in addition.The etiology and pathogenesis key of primary disease is positive QI-insufficiency, defends gas and loses admittedly, and abnormally climatic pathogens is invaded due to the skin space between skin and muscles.The urticaria of modern medicine, surely belong to Chinese medicine " categories such as medical science " urticaria ", " rubella wheal "; be characterized in that red or white rash piece appear in skin; break out; skin lesion appearing without definite location, flickering, pruritus is immoderate; disappear and do not stay any vestige, sends out in any age, season and position by its clinical manifestation.Existing wind-repellent itching-relieving granules has the pathogenic wind expelling heat clearing away, the effect of removing damp to relieve itching.For safety and the effectiveness that improves this preparation,, need technological parameter and adjuvant are carried out preferably for industrialized great production provides scientific basis.
Summary of the invention:
The objective of the invention is to: a kind of wind-repellent itching-relieving granules and preparation method thereof is provided, the present invention is directed to prior art, the preparation process that provides is reasonable, and steady quality is evident in efficacy, and it is convenient to store, and helps industrialized great production.
The present invention is achieved in that according to weight and calculates that it is made with Radix Saposhnikoviae 125g, Periostracum Cicadae 125g, Cortex Lycii 225g, Rhizoma Atractylodis (parched) 150g, Semen Lini 225g, Radix Angelicae Sinensis 225g, Radix Rehmanniae 375g, Caulis Akebiae 75g, Herba Schizonepetae 125g, Gypsum Fibrosum 75g, Radix Glycyrrhizae 75g and dextrin 960g.
The preparation method of wind-repellent itching-relieving granules is: get Gypsum Fibrosum and smash and added water boil 2 hours, adding Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae and Radix Glycyrrhizae continues to decoct twice, adding for the first time 10 times of water gagings decocted 3 hours, adding for the second time 8 times of water gagings decocted 2 hours, collecting decoction, filter, filtrate is concentrated into every 1ml and contains 0.5 g medical material; Add ethanol and make and contain the alcohol amount and reach 70%, stir evenly, leave standstill, filter, filtrate is concentrated into the clear paste of 20 ℃ of relative densities 1.36; Every 100g clear paste adds dextrin 213g, makes granule, cold drying, promptly.
Among the we, Radix Saposhnikoviae has inducing diaphoresis to dispel wind, wins and wets, the effect of relieving convulsion; Periostracum Cicadae has diffusing wind heat extraction, sore-throat relieving, rash, nebula removing, the effect of infantile convulsion; The Cortex Lycii removing heat from blood removes and steams, and the lung pathogenic fire reducing disappears; Rhizoma Atractylodis are drying damp and strengthening spleen, and expelling wind and cold makes eye bright; The Semen Lini function is moisturized, and dispels the wind; The Radix Angelicae Sinensis function is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; The Radix Rehmanniae clearing away heat and promoting production of body fluid; The Caulis Akebiae clearing away heart-fire, diuresis, the stimulating milk secretion of stimulating the menstrual flow; The Herba Schizonepetae diffusing wind that induces sweat, rash; Gypsum Fibrosum has clearing away heat-fire, the function that relieving restlessness is quenched the thirst; Radix Glycyrrhizae function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share, and play the pathogenic wind expelling heat clearing away altogether, the effect of removing damp to relieve itching
Compared with prior art, preparation production technique provided by the present invention is reasonable, and constant product quality is evident in efficacy, and it is convenient to store, for industrialized great production provides scientific basis.
Experimental example:
1. water boiling and extraction technology is investigated
In extraction process, extracting method, extraction time, extraction time and extraction solvent amount are the principal elements that influences extraction ratio, and former technology has the technological parameter of extraction time, extraction time, and we only investigate amount of water.
Method: press the prescribed dose dispensing, get Radix Saposhnikoviae 50g, Periostracum Cicadae 50g, Cortex Lycii 90g, Rhizoma Atractylodis (stir-fry) 60g, Semen Lini 90g, Radix Angelicae Sinensis 90g, Radix Rehmanniae 150g, Caulis Akebiae 30g, Herba Schizonepetae 50g, Gypsum Fibrosum 30g and Radix Glycyrrhizae 30g, be total to 720g, totally three parts.Gypsum Fibrosum 30g smashes and boils 2 hours, adds ten flavor continuation decoction secondaries such as all the other Radix Saposhnikoviaes, and 3 hours for the first time, 2 hours for the second time, merging filtrate filtered, and filtrate is concentrated in right amount (every 1ml contains medical material 0.5g).Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, filtrate is concentrated into the clear paste of relative density about 1.36 (20 ℃).The results are shown in Table 1.
The different amount of water of table 1 are to the influence of decocting technology
| Method | Dosage (g) | Extraction time each (h) | Extraction time (inferior) | Amount of water (doubly) | Clear paste heavy (g) | Clear paste yield (%) |
| 1 | 720 | 3,2 | 2 | 6,4 | 170.6 | 23.69 |
| 2 | 720 | 3,2 | 2 | 8,6 | 158.1 | 21.95 |
| 3 | 720 | 3,2 | 2 | 10,8 | 182.3 | 25.32 |
Table 1 is the result show, method 1,2 clear paste yield are lower, and method 3 clear paste yield are higher, so think that method 3 is comparatively suitable, through ten batches of pilot scale checkings, the result is with above-mentioned consistent, so determine that the amount of water of this prescription is 10 times, 8 times.
2. the investigation of adjuvant
(1) selection of supplementary product kind
The adjuvant of the former technology of wind-repellent itching-relieving granules is a sucrose, now makes sugar type granules, so do not get sucrose, we investigate dextrin, soluble starch, lactose, can both better granulate for three kinds as a result, but the dextrin low price, and yield is slightly high, so select dextrin.
(2) selection of supplementary product consumption
By the ratio of extractum consumption and dextrin consumption, serve as to investigate index with granulation complexity and particulate yield, supplementary product consumption is investigated, the results are shown in Table 2.
Table 2 supplementary product consumption selection
| Method | Extractum amount: dextrin amount | The granulation complexity | Qualified granule yield (%) |
| 1 | 1∶4 | Easier | 58.5 |
| 2 | 1∶3 | Easier | 62.3 |
| 3 | 1∶2.5 | Easier | 70.5 |
| 4 | 1∶2.13 | Easier | 80.5 |
| 5 | 1∶1.5 | Difficult | 52 |
By table 2 as can be seen, the ratio of extractum and dextrin is that 1: 2.13 o'clock yield is the highest, and more easily granulates, so system of selection 4.The ratio of primary standard prescription extractum and dextrin is 1: 8, makes every packed 15g, and every bag contains crude drug 7.2g, and existing ratio in extractum and dextrin is 1: 2.13, is distributed into every bag of 4.0g, and is consistent with the contained crude drug of the every packed 15g of primary standard.So determine that packing specification is every packed 4.0g.Through ten batches of pilot scale checkings, the result is with above-mentioned consistent.
In sum, concrete preparation technology is: above ten simply, getting Gypsum Fibrosum smashes and added water boil 2 hours, add ten flavor continuation decoction secondaries such as all the other Radix Saposhnikoviaes, add for the first time 10 times of water gagings and decocted 3 hours, add 8 times of water gagings for the second time and decocted collecting decoction 2 hours, filter, filtrate is concentrated into the clear paste of relative density about 1.36 (20 ℃).Every 100g clear paste adds dextrin 213g, makes granule, and 1000g is made in cold drying, promptly.
3. pilot plant test data
According to the technical study result, amplify 10 times by former prescription respectively and feed intake, carry out the pilot scale scale-up, ten batches of trial-production pilot products, test data and intermediate parameters see Table 3.
Ten batches of pilot scale data of table 3
| Lot number | The total amount that feeds intake (kg) | Clear paste amount (kg) | Relative density (20 ℃) | Clear paste yield (%) | Semi-finished product (kg) | Theoretical output (bag) | The real finished product (bag) that gets | Yield rate (%) |
| 20050201 | 14.4 | 3.65 | 1.36 | 25.35 | 7.98 | 2000 | 1968 | 98.4 |
| 20050202 | 14.4 | 3.60 | 1.36 | 25.0 | 7.92 | 2000 | 1960 | 98.0 |
| 20050203 | 14.4 | 3.62 | 1.36 | 25.14 | 7.9 | 2000 | 1964 | 98.2 |
| 20050204 | 14.4 | 3.58 | 1.36 | 24.86 | 7.9 | 2000 | 1956 | 97.8 |
| 20050301 | 14.4 | 3.63 | 1.36 | 25.21 | 7.94 | 2000 | 1960 | 98.0 |
| 20050302 | 14.4 | 3.64 | 1.36 | 25.28 | 7.94 | 2000 | 1961 | 98.05 |
| 20050303 | 14.4 | 3.65 | 1.36 | 25.35 | 7.96 | 2000 | 1969 | 98.45 |
| 20050304 | 72 | 18.1 | 1.36 | 25.14 | 40 | 10000 | 9956 | 99.56 |
| 20050305 | 72 | 18.05 | 1.36 | 25.07 | 39.5 | 10000 | 9800 | 98.0 |
| 20050306 | 72 | 18.2 | 1.36 | 25.28 | 40.5 | 10000 | 9911 | 99.11 |
4. stability test
Through three batches of wind-repellent itching-relieving granules are carried out 6 months the accelerated stability test and the investigation that kept sample in 6 months, projects such as character, discriminating, inspection and assay with sample serve as to investigate index, the result all meets wind-repellent itching-relieving granules quality standard draft specifies, show that this constant product quality property is better, effect duration is tentative to be 24 months.
The specific embodiment:
Embodiments of the invention: Radix Saposhnikoviae 125g, Periostracum Cicadae 125g, Cortex Lycii 225g, Rhizoma Atractylodis (parched) 150g, Semen Lini 225g, Radix Angelicae Sinensis 225g, Radix Rehmanniae 375g, Caulis Akebiae 75g, Herba Schizonepetae 125g, Gypsum Fibrosum 75g, Radix Glycyrrhizae 75g, dextrin 960g
Getting Gypsum Fibrosum smashes and added water boil 2 hours, adding Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae and Radix Glycyrrhizae continues to decoct twice, adding for the first time 10 times of water gagings decocted 3 hours, adding for the second time 8 times of water gagings decocted 2 hours, collecting decoction, filter, filtrate is concentrated into every 1ml and contains the 0.5g medical material; Add ethanol and make and contain the alcohol amount and reach 70%, stir evenly, leave standstill, filter, filtrate is concentrated into the clear paste of 20 ℃ of relative densities 1.36; Every 100g clear paste adds dextrin 213g, makes granule, and 1000g is made in cold drying, promptly.
Claims (1)
1. wind-repellent itching-relieving granules, it is characterized in that: calculate according to weight, it is to be prepared as follows with Radix Saposhnikoviae 125g, Periostracum Cicadae 125g, Cortex Lycii 225g, Rhizoma Atractylodis (parched) 150g, Semen Lini 225g, Radix Angelicae Sinensis 225g, Radix Rehmanniae 375g, Caulis Akebiae 75g, Herba Schizonepetae 125g, Gypsum Fibrosum 75g, Radix Glycyrrhizae 75g and dextrin 960g to form:
Getting Gypsum Fibrosum smashes and added water boil 2 hours, adding Radix Saposhnikoviae, Periostracum Cicadae, Cortex Lycii, Rhizoma Atractylodis (parched), Semen Lini, Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Akebiae, Herba Schizonepetae and Radix Glycyrrhizae continues to decoct twice, adding for the first time 10 times of water gagings decocted 3 hours, adding for the second time 8 times of water gagings decocted 2 hours, collecting decoction, filter, filtrate is concentrated into every 1ml and contains the 0.5g medical material; Add ethanol and make and contain the alcohol amount and reach 70%, stir evenly, leave standstill, filter, filtrate is concentrated into the clear paste of 20 ℃ of relative densities 1.36; Every 100g clear paste adds dextrin 213g, makes granule, cold drying, promptly.
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| CNB2005102007222A CN100353971C (en) | 2005-11-21 | 2005-11-21 | Wind-repellent itching-relieving granules and preparing method |
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| CN102078442A (en) * | 2010-12-26 | 2011-06-01 | 烟台大洋制药有限公司 | Wind expelling and itching relieving granule with improved taste |
| CN114931604B (en) * | 2022-06-17 | 2023-12-19 | 烟台东诚大洋制药有限公司 | Wind-dispelling itching-relieving granule and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362126A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano wind-evil dispelling and itch stopping medicine and its preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362126A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano wind-evil dispelling and itch stopping medicine and its preparation |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂第十五册 中华人民共和国卫生部药典委员会，173 1998 * |
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