CN1365774A - Nano medicine 'Niuhuang Shangqing' and its preparing process - Google Patents
Nano medicine 'Niuhuang Shangqing' and its preparing process Download PDFInfo
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- CN1365774A CN1365774A CN 01100875 CN01100875A CN1365774A CN 1365774 A CN1365774 A CN 1365774A CN 01100875 CN01100875 CN 01100875 CN 01100875 A CN01100875 A CN 01100875A CN 1365774 A CN1365774 A CN 1365774A
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Abstract
A nanometre medicine "Niuhuang Shangqing" is prepared from the nanometre powders of 19 Chinese medicinal materials including bezoar, mint, Chuan-xiong rhizome, red peony root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of clearing away heat-fire, diffusing wind analgesic nano medicine ' Niuhuang Shangqing ', the invention still further relates to the method for this medication preparation.
Cow-bezoar bolus for clearing away heat of the upper part of the body is a kind of classical Chinese patent medicine, mainly contains effects such as clearing away heat-fire, diffusing wind pain relieving, and it is dizzy to be used to have a headache, conjunctival congestion tinnitus, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain, constipation due to dry stool.But traditional cow-bezoar bolus for clearing away heat of the upper part of the body disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Niuhuang Shangqing ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Niuhuang Shangqing '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bezoar 1-5 part nanometer Herba Menthae 20-45 part nanometer Flos Chrysanthemi 30-60 part
Nanometer Herba Schizonepetae 10-25 part nano angelica root 10-25 part nanometer Rhizoma Chuanxiong 10-25 part
Nanometer Fructus Gardeniae 30-80 part nanometer coptis 10-25 part nano phellodendron bark 6-15 part
Nanometer Radix Scutellariae 30-80 part nano rhubarb 60-95 part nanometer Fructus Forsythiae 30-80 part
Nanometer Radix Paeoniae Rubra 10-25 part nano Chinese angelica 30-80 part nanometer Radix Rehmanniae 40-90 part
Nanometer Radix Platycodonis 10-25 part nanometer Radix Glycyrrhizae 6-14 part nanometer Gypsum Fibrosum 60-94 part
Nanometer Borneolum Syntheticum 6-15 part
The formula optimization weight proportion scope of medicine of the present invention is;
Nano bezoar 1-3 part nanometer Herba Menthae 25-35 part nanometer Flos Chrysanthemi 35-50 part
Nanometer Herba Schizonepetae 12-20 part nano angelica root 12-20 part nanometer Rhizoma Chuanxiong 12-20 part
Nanometer Fructus Gardeniae 40-60 part nanometer coptis 12-20 part nano phellodendron bark 8-12 part
Nanometer Radix Scutellariae 40-60 part nano rhubarb 70-90 part nanometer Fructus Forsythiae 40-60 part
Nanometer Radix Paeoniae Rubra 12-20 part nano Chinese angelica 40-60 part nanometer Radix Rehmanniae 50-80 part
Nanometer Radix Platycodonis 12-20 part nanometer Radix Glycyrrhizae 8-12 part nanometer Gypsum Fibrosum 70-90 part
Nanometer Borneolum Syntheticum 8-12 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 30 parts of nanometer Flos Chrysanthemis of 2 parts of nanometer Herba Menthaes of nano bezoar
16 parts of 16 parts of nanometer Rhizoma Chuanxiongs of 16 parts of nano angelica roots of nanometer Herba Schizonepetae
10 parts of 16 parts of nano phellodendron barks of 50 parts of nanometer coptis of nanometer Fructus Gardeniae
50 parts of 80 parts of nanometer Fructus Forsythiaes of 50 parts of nano rhubarbs of nanometer Radix Scutellariae
64 parts of 50 parts of nanometer Radix Rehmanniae of 16 parts of nano Chinese angelicas of nanometer Radix Paeoniae Rubra
80 parts in 10 parts of nanometer Gypsum Fibrosum of 16 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
10 parts of nanometer Borneolum Syntheticums
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Niuhuang Shangqing ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Niuhuang Shangqing ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale; common cow-bezoar bolus for clearing away heat of the upper part of the body preparation material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1--200nm; the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Niuhuang Shangqing ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for having a headache dizzy, conjunctival congestion tinnitus, and laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain, treatment of conditions such as constipation due to dry stool, clinical efficacy significantly is better than traditional cow-bezoar bolus for clearing away heat of the upper part of the body.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
40 parts of 30 parts of nanometer Flos Chrysanthemis of 2 parts of nanometer Herba Menthaes of nano bezoar
16 parts of 16 parts of nanometer Rhizoma Chuanxiongs of 16 parts of nano angelica roots of nanometer Herba Schizonepetae
10 parts of 16 parts of nano phellodendron barks of 50 parts of nanometer coptis of nanometer Fructus Gardeniae
50 parts of 80 parts of nanometer Fructus Forsythiaes of 50 parts of nano rhubarbs of nanometer Radix Scutellariae
64 parts of 50 parts of nanometer Radix Rehmanniae of 16 parts of nano Chinese angelicas of nanometer Radix Paeoniae Rubra
80 parts in 10 parts of nanometer Gypsum Fibrosum of 16 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
10 parts of nanometer Borneolum Syntheticums
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts of 30 parts of nanometer Flos Chrysanthemis of 2 parts of nanometer Herba Menthaes of nano bezoar
16 parts of 16 parts of nanometer Rhizoma Chuanxiongs of 16 parts of nano angelica roots of nanometer Herba Schizonepetae
10 parts of 16 parts of nano phellodendron barks of 50 parts of nanometer coptis of nanometer Fructus Gardeniae
50 parts of 80 parts of nanometer Fructus Forsythiaes of 50 parts of nano rhubarbs of nanometer Radix Scutellariae
64 parts of 50 parts of nanometer Radix Rehmanniae of 16 parts of nano Chinese angelicas of nanometer Radix Paeoniae Rubra
80 parts in 10 parts of nanometer Gypsum Fibrosum of 16 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
10 parts of nanometer Borneolum Syntheticums
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard; do not add any adjuvant; make nano bezoar supernatant powder needle injection, every injection content is the 5-20 milligram; each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts of 30 parts of nanometer Flos Chrysanthemis of 2 parts of nanometer Herba Menthaes of nano bezoar
16 parts of 16 parts of nanometer Rhizoma Chuanxiongs of 16 parts of nano angelica roots of nanometer Herba Schizonepetae
10 parts of 16 parts of nano phellodendron barks of 50 parts of nanometer coptis of nanometer Fructus Gardeniae
50 parts of 80 parts of nanometer Fructus Forsythiaes of 50 parts of nano rhubarbs of nanometer Radix Scutellariae
64 parts of 50 parts of nanometer Radix Rehmanniae of 16 parts of nano Chinese angelicas of nanometer Radix Paeoniae Rubra
80 parts in 10 parts of nanometer Gypsum Fibrosum of 16 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
10 parts of nanometer Borneolum Syntheticums
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard; filmogen adopts polyvinyl alcohol; make nano bezoar supernatant membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Niuhuang Shangqing ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano bezoar 1-5 part nanometer Herba Menthae 20-45 part nanometer Flos Chrysanthemi 30-60 part
Nanometer Herba Schizonepetae 10-25 part nano angelica root 10-25 part nanometer Rhizoma Chuanxiong 10-25 part
Nanometer Fructus Gardeniae 30-80 part nanometer coptis 10-25 part nano phellodendron bark 6-15 part
Nanometer Radix Scutellariae 30-80 part nano rhubarb 60-95 part nanometer Fructus Forsythiae 30-80 part
Nanometer Radix Paeoniae Rubra 10-25 part nano Chinese angelica 30-80 part nanometer Radix Rehmanniae 40-90 part
Nanometer Radix Platycodonis 10-25 part nanometer Radix Glycyrrhizae 6-14 part nanometer Gypsum Fibrosum 60-94 part
Nanometer Borneolum Syntheticum 6-15 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Niuhuang Shangqing ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bezoar 1-3 part nanometer Herba Menthae 25-35 part nanometer Flos Chrysanthemi 35-50 part
Nanometer Herba Schizonepetae 12-20 part nano angelica root 12-20 part nanometer Rhizoma Chuanxiong 12-20 part
Nanometer Fructus Gardeniae 40-60 part nanometer coptis 12-20 part nano phellodendron bark 8-12 part
Nanometer Radix Scutellariae 40-60 part nano rhubarb 70-90 part nanometer Fructus Forsythiae 40-60 part
Nanometer Radix Paeoniae Rubra 12-20 part nano Chinese angelica 40-60 part nanometer Radix Rehmanniae 50-80 part
Nanometer Radix Platycodonis 12-20 part nanometer Radix Glycyrrhizae 8-12 part nanometer Gypsum Fibrosum 70-90 part
Nanometer Borneolum Syntheticum 8-12 part
3, nano medicine ' Niuhuang Shangqing ' according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts of 30 parts of nanometer Flos Chrysanthemis of 2 parts of nanometer Herba Menthaes of nano bezoar
16 parts of 16 parts of nanometer Rhizoma Chuanxiongs of 16 parts of nano angelica roots of nanometer Herba Schizonepetae
10 parts of 16 parts of nano phellodendron barks of 50 parts of nanometer coptis of nanometer Fructus Gardeniae
50 parts of 80 parts of nanometer Fructus Forsythiaes of 50 parts of nano rhubarbs of nanometer Radix Scutellariae
64 parts of 50 parts of nanometer Radix Rehmanniae of 16 parts of nano Chinese angelicas of nanometer Radix Paeoniae Rubra
80 parts in 10 parts of nanometer Gypsum Fibrosum of 16 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
10 parts of nanometer Borneolum Syntheticums
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Niuhuang Shangqing 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Niuhuang Shangqing 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100875 CN1365774A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Niuhuang Shangqing' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100875 CN1365774A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Niuhuang Shangqing' and its preparing process |
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| CN1365774A true CN1365774A (en) | 2002-08-28 |
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| CN 01100875 Pending CN1365774A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Niuhuang Shangqing' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366858B (en) * | 2008-09-12 | 2011-08-24 | 江西天施康中药股份有限公司 | Preparation method of medicament for clearing heat, discharging fire, dispelling wind and relieving pain |
| CN101444570B (en) * | 2008-12-31 | 2012-06-06 | 太极集团有限公司 | Niuhuangshangqing soft capsule and preparation method thereof |
-
2001
- 2001-01-19 CN CN 01100875 patent/CN1365774A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366858B (en) * | 2008-09-12 | 2011-08-24 | 江西天施康中药股份有限公司 | Preparation method of medicament for clearing heat, discharging fire, dispelling wind and relieving pain |
| CN101444570B (en) * | 2008-12-31 | 2012-06-06 | 太极集团有限公司 | Niuhuangshangqing soft capsule and preparation method thereof |
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