CN1362091A - Nano antiphlogistic bezoar medicine and its preparation - Google Patents
Nano antiphlogistic bezoar medicine and its preparation Download PDFInfo
- Publication number
- CN1362091A CN1362091A CN 01100079 CN01100079A CN1362091A CN 1362091 A CN1362091 A CN 1362091A CN 01100079 CN01100079 CN 01100079 CN 01100079 A CN01100079 A CN 01100079A CN 1362091 A CN1362091 A CN 1362091A
- Authority
- CN
- China
- Prior art keywords
- nano
- nanometer
- parts
- part nanometer
- bezoar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a kind of nano bezoar antidote pill. It comprises materials such as nano coptis, nano golden cypress, nano gyp, nano field mint, nano radix platycodi, nano capsule of weeping forsythia, nano rheum officinale, nano Radix scutellariae, nano Cape jasmine, nano chrysanthemum, nano tenuifolia, nano radix sileris, nano inula flower, nano Angelica dehurica, nano ligusticum wallichii, nano fructus viticis, nano silkworm excrement, nano liquorice, nano bezoar, and nano borneol. Making up in proportion and to be fabricated into new dmedicine drug. Its particle fineness is 1200-1500 mesh and particle size 0.1-200nm and most of the particle size is shorter than 100nm and has new material properties. It is fabricated through steps such as microwave extraction, decompression and concentration, supersonic jet and spray drying.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, the nano antiphlogistic bezoar preparation medicine of reducing swelling and alleviating pain the invention still further relates to the method for this medication preparation.
Cow-bezoar anti-toxic bolus is a kind of Chinese patent medicine of classics, mainly contain analgesic, antiinflammatory, the analgesia, antibiotic; effects such as convulsion are used for laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue, diseases such as dizziness and red eyes; but traditional cow-bezoar anti-toxic bolus disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano antiphlogistic bezoar preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano antiphlogistic bezoar preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer coptis 25-45 part nano phellodendron bark 25-45 part nanometer Gypsum Fibrosum 15-35 part
Nanometer money flower 40-70 part nanometer Herba Menthae 10-30 part nanometer Radix Platycodonis 15-35 part
Nanometer Fructus Forsythiae 40-70 part nano rhubarb 25-45 part nanometer Radix Scutellariae 25-45 part
Nanometer Fructus Gardeniae 15-35 part nanometer Flos Chrysanthemi 25-45 part nanometer Herba Schizonepetae 10-30 part
Nanometer Radix Saposhnikoviae 5-20 part nanometer Flos Inulae 15-35 part nano angelica root 15-30 part
Nanometer Rhizoma Chuanxiong 10-30 part nanometer Fructus Viticis 5-20 part nanometer silkworm excrement 15-35 part
Nanometer Radix Glycyrrhizae 10-30 part nano bezoar 5-15 part nanometer Borneolum Syntheticum 25-45 part
The formula optimization weight proportion scope of medicine of the present invention is;
Nanometer coptis 30-40 part nano phellodendron bark 30-40 part nanometer Gypsum Fibrosum 20-30 part
Nanometer money flower 50-60 part nanometer Herba Menthae 15-20 part nanometer Radix Platycodonis 20-30 part
Nanometer Fructus Forsythiae 50-60 part nano rhubarb 30-40 part nanometer Radix Scutellariae 30-40 part
Nanometer Fructus Gardeniae 20-30 part nanometer Flos Chrysanthemi 30-40 part nanometer Herba Schizonepetae 15-20 part
Nanometer Radix Saposhnikoviae 15-20 part nanometer Flos Inulae 20-30 part nano angelica root 20-30 part
Nanometer Rhizoma Chuanxiong 15-20 part nanometer Fructus Viticis 10-15 part nanometer silkworm excrement 20-30 part
Nanometer Radix Glycyrrhizae 15-20 part nano bezoar 8-12 part nanometer Borneolum Syntheticum 30-40
The optimum weight proportioning of medicine of the present invention is:
26 parts in 35 parts of nanometer Gypsum Fibrosum of 35 parts of nano phellodendron barks of nanometer coptis
Nanometer money is spent 26 parts of 18 parts of nanometer Radix Platycodoniss of 53 parts of nanometer Herba Menthaes
35 parts of 35 parts of nanometer Radix Scutellariaes of 53 parts of nano rhubarbs of nanometer Fructus Forsythiae
18 parts of 35 parts of nanometer Herba Schizonepetaes of 26 parts of nanometer Flos Chrysanthemis of nanometer Fructus Gardeniae
22 parts of 26 parts of nano angelica roots of 13 parts of nanometer Flos Inulae of nanometer Radix Saposhnikoviae
26 parts of 13 parts of nanometer silkworm excrements of 18 parts of nanometer Fructus Viticises of nanometer Rhizoma Chuanxiong
10 parts of nanometer Borneolum Syntheticums 33 of 18 parts of nano bezoars of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05Mpa under the pressure,, get the antiphlogistic bezoar nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano antiphlogistic bezoar preparation medicine is identical.
A kind of important feature of the present invention is; the made drug material of the present invention has reached nanoscale; common cow-bezoar anti-toxic bolus preparation material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano antiphlogistic bezoar preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for pharyngolaryngitis, gingivitis, and glossitis, tonsillitis, treatments such as gnathitis, clinical efficacy is significantly because traditional cow-bezoar anti-toxic bolus.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method;
26 parts in 35 parts of nanometer Gypsum Fibrosum of 35 parts of nano phellodendron barks of nanometer coptis
Nanometer money is spent 26 parts of 18 parts of nanometer Radix Platycodoniss of 53 parts of nanometer Herba Menthaes
35 parts of 35 parts of nanometer Radix Scutellariaes of 53 parts of nano rhubarbs of nanometer Fructus Forsythiae
18 parts of 35 parts of nanometer Herba Schizonepetaes of 26 parts of nanometer Flos Chrysanthemis of nanometer Fructus Gardeniae
22 parts of 26 parts of nano angelica roots of 13 parts of nanometer Flos Inulae of nanometer Radix Saposhnikoviae
26 parts of 13 parts of nanometer silkworm excrements of 18 parts of nanometer Fructus Viticises of nanometer Rhizoma Chuanxiong
10 parts of nanometer Borneolum Syntheticums 33 of 18 parts of nano bezoars of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
26 parts in 35 parts of nanometer Gypsum Fibrosum of 35 parts of nano phellodendron barks of nanometer coptis
Nanometer money is spent 26 parts of 18 parts of nanometer Radix Platycodoniss of 53 parts of nanometer Herba Menthaes
35 parts of 35 parts of nanometer Radix Scutellariaes of 53 parts of nano rhubarbs of nanometer Fructus Forsythiae
18 parts of 35 parts of nanometer Herba Schizonepetaes of 26 parts of nanometer Flos Chrysanthemis of nanometer Fructus Gardeniae
22 parts of 26 parts of nano angelica roots of 13 parts of nanometer Flos Inulae of nanometer Radix Saposhnikoviae
26 parts of 13 parts of nanometer silkworm excrements of 18 parts of nanometer Fructus Viticises of nanometer Rhizoma Chuanxiong
10 parts of nanometer Borneolum Syntheticums 33 of 18 parts of nano bezoars of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard; do not add any adjuvant; make the nano antiphlogistic bezoar powder needle injection; every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
26 parts in 35 parts of nanometer Gypsum Fibrosum of 35 parts of nano phellodendron barks of nanometer coptis
Nanometer money is spent 26 parts of 18 parts of nanometer Radix Platycodoniss of 53 parts of nanometer Herba Menthaes
35 parts of 35 parts of nanometer Radix Scutellariaes of 53 parts of nano rhubarbs of nanometer Fructus Forsythiae
18 parts of 35 parts of nanometer Herba Schizonepetaes of 26 parts of nanometer Flos Chrysanthemis of nanometer Fructus Gardeniae
22 parts of 26 parts of nano angelica roots of 13 parts of nanometer Flos Inulae of nanometer Radix Saposhnikoviae
26 parts of 13 parts of nanometer silkworm excrements of 18 parts of nanometer Fructus Viticises of nanometer Rhizoma Chuanxiong
10 parts of nanometer Borneolum Syntheticums 33 of 18 parts of nano bezoars of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard; filmogen adopts polyvinyl alcohol; make the nano antiphlogistic bezoar membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano antiphlogistic bezoar preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nanometer coptis 25-45 part nano phellodendron bark 25-45 part nanometer Gypsum Fibrosum 15-35 part
Nanometer money flower 40-70 part nanometer Herba Menthae 10-30 part nanometer Radix Platycodonis 15-35 part
Nanometer Fructus Forsythiae 40-70 part nano rhubarb 25-45 part nanometer Radix Scutellariae 25-45 part
Nanometer Fructus Gardeniae 15-35 part nanometer Flos Chrysanthemi 25-45 part nanometer Herba Schizonepetae 10-30 part
Nanometer Radix Saposhnikoviae 5-20 part nanometer Flos Inulae 15-35 part nano angelica root 15-30 part
Nanometer Rhizoma Chuanxiong 10-30 part nanometer Fructus Viticis 5-20 part nanometer silkworm excrement 15-35 part
Nanometer Radix Glycyrrhizae 10-30 part nano bezoar 5-15 part nanometer Borneolum Syntheticum 25-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05Mpa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano antiphlogistic bezoar preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer coptis 30-40 part nano phellodendron bark 30-40 part nanometer Gypsum Fibrosum 20-30 part
Nanometer money flower 50-60 part nanometer Herba Menthae 15-20 part nanometer Radix Platycodonis 20-30 part
Nanometer Fructus Forsythiae 50-60 part nano rhubarb 30-40 part nanometer Radix Scutellariae 30-40 part
Nanometer Fructus Gardeniae 20-30 part nanometer Flos Chrysanthemi 30-40 part nanometer Herba Schizonepetae 15-20 part
Nanometer Radix Saposhnikoviae 15-20 part nanometer Flos Inulae 20-30 part nano angelica root 20-30 part
Nanometer Rhizoma Chuanxiong 15-20 part nanometer Fructus Viticis 10-15 part nanometer silkworm excrement 20-30 part
Nanometer Radix Glycyrrhizae 15-20 part nano bezoar 8-12 part nanometer Borneolum Syntheticum 30-40
3, nano antiphlogistic bezoar preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
26 parts in 35 parts of nanometer Gypsum Fibrosum of 35 parts of nano phellodendron barks of nanometer coptis
Nanometer money is spent 26 parts of 18 parts of nanometer Radix Platycodoniss of 53 parts of nanometer Herba Menthaes
35 parts of 35 parts of nanometer Radix Scutellariaes of 53 parts of nano rhubarbs of nanometer Fructus Forsythiae
18 parts of 35 parts of nanometer Herba Schizonepetaes of 26 parts of nanometer Flos Chrysanthemis of nanometer Fructus Gardeniae
22 parts of 26 parts of nano angelica roots of 13 parts of nanometer Flos Inulae of nanometer Radix Saposhnikoviae
26 parts of 13 parts of nanometer silkworm excrements of 18 parts of nanometer Fructus Viticises of nanometer Rhizoma Chuanxiong
10 parts of nanometer Borneolum Syntheticums 33 of 18 parts of nano bezoars of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano antiphlogistic bezoar preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano antiphlogistic bezoar preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05Mpa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100079 CN1362091A (en) | 2001-01-08 | 2001-01-08 | Nano antiphlogistic bezoar medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100079 CN1362091A (en) | 2001-01-08 | 2001-01-08 | Nano antiphlogistic bezoar medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362091A true CN1362091A (en) | 2002-08-07 |
Family
ID=4651280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100079 Pending CN1362091A (en) | 2001-01-08 | 2001-01-08 | Nano antiphlogistic bezoar medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362091A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376179C (en) * | 2005-10-21 | 2008-03-26 | 黎雪如 | Tobacco substitute and its production method |
| CN104435193A (en) * | 2014-11-13 | 2015-03-25 | 王佳丽 | Medicament for treating pharyngitis and preparation method of medicament |
| CN104740281A (en) * | 2015-04-07 | 2015-07-01 | 范永启 | Essential oil for treating gingivitis and preparation method thereof |
-
2001
- 2001-01-08 CN CN 01100079 patent/CN1362091A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376179C (en) * | 2005-10-21 | 2008-03-26 | 黎雪如 | Tobacco substitute and its production method |
| CN104435193A (en) * | 2014-11-13 | 2015-03-25 | 王佳丽 | Medicament for treating pharyngitis and preparation method of medicament |
| CN104740281A (en) * | 2015-04-07 | 2015-07-01 | 范永启 | Essential oil for treating gingivitis and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1362115A (en) | Nano Guilin water melon medicine and its preparation | |
| CN1365781A (en) | Nano medicine 'Ruyi Jinhuang' and its preparing process | |
| CN1360916A (en) | Nanometer zhangyanming medicine for treating eye disease and its prepn | |
| CN1362091A (en) | Nano antiphlogistic bezoar medicine and its preparation | |
| CN1362209A (en) | Nano bezoar medicine for treating upper respiratory tract infection and its preparation | |
| CN1368353A (en) | Nano medicine 'Zibushengfa' and its preparing process | |
| CN1360931A (en) | Nanometer luminous Dendrobium nobil medicine and its prepn | |
| CN1366936A (en) | Nano antelope lung-clearing preparation medicine and preparation method | |
| CN1360939A (en) | Nanometer eyesight-improving and health-clearing medicine and its prepn | |
| CN1365749A (en) | Nano medicine 'Xiongju Shangqing' and its preparing process | |
| CN1362142A (en) | Nano Niaosaitong medicine for dredging urethra and its preparation | |
| CN1368235A (en) | Nano medicine for treating leukoderma and its preparing process | |
| CN1365774A (en) | Nano medicine 'Niuhuang Shangqing' and its preparing process | |
| CN1362126A (en) | Nano wind-evil dispelling and itch stopping medicine and its preparation | |
| CN1360920A (en) | Nanometer antiphlogistic Lonicerae and Forsythiae medicine and its prepn | |
| CN1362124A (en) | Nano eyesight-improving noble dendrobium medicine and its preparation | |
| CN1365688A (en) | Nano medicine 'Ertong Qingfei' and its preparing process | |
| CN1363341A (en) | Nano medicine 'Jiuwei Qianghuo' and its preparing process | |
| CN1368187A (en) | Nano medicine 'Tongqiaobiyan' and its preparing process | |
| CN1365703A (en) | Nano medicine for child to induce diaphoresis and its preparing process | |
| CN1366953A (en) | Nano midday tea preparation medicine and preparation method | |
| CN1366925A (en) | Nano stomach-clearing coptis preparation medicine and preparation method | |
| CN1362247A (en) | Nano stomach-nourishing medicine of Aucklandiae and Amino and its preparation | |
| CN1362098A (en) | Nano antiphlogistic forsythiae medicine and its preparation | |
| CN1362121A (en) | Nano Shangqing medicine and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |