CN1362124A - Nano eyesight-improving noble dendrobium medicine and its preparation - Google Patents
Nano eyesight-improving noble dendrobium medicine and its preparation Download PDFInfo
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- CN1362124A CN1362124A CN 01100177 CN01100177A CN1362124A CN 1362124 A CN1362124 A CN 1362124A CN 01100177 CN01100177 CN 01100177 CN 01100177 A CN01100177 A CN 01100177A CN 1362124 A CN1362124 A CN 1362124A
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Abstract
The present invention discloses a nano Shihe-mingmu preparation medicine. It is made up by using 26 Chinese medicinal materials of nano dendrobium, nano celosia, naono fetid cassia, nano tribulus, nano rehmannia and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nano eyesight-improving noble dendrobium preparation medicine of a kind of calming liver and clearing heat, improving kidney and eyes, the invention still further relates to the method for this medication preparation.
Shihu mingmu pills is a kind of classical Chinese patent medicine, mainly contains effects such as calming liver and clearing heat, improving kidney and eyes, is used for both liver and kidney deficiency, the platycoria that depletion fire syndrome going up causes, and nyctalopia is dim-sighted, blurring of vision, the vertigo, mental weariness.But traditional shihu mingmu pills disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano eyesight-improving noble dendrobium preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano eyesight-improving noble dendrobium preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The sub-7-18 part of nanometer Herba Dendrobii 7-18 part nanometer Semen Celosiae 7-18 part nano jueming
Nanometer Fructus Tribuli 7-18 part nanometer Radix Rehmanniae 14-36 part nanometer Radix Rehmanniae Preparata 14-36 part
Nanometer Fructus Lycii 7-18 part nanometer Semen Cuscutae 7-18 part nanometer Herba Cistanches 7-18 part
Nano ginseng 28-72 part nanometer Rhizoma Dioscoreae 7-18 part nanometer Poria 28-72 part
Nanometer Radix Asparagi 28-72 part nanometer 14-36 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 7-18 part
Nanometer Radix Glycyrrhizae 7-18 part nanometer Fructus Aurantii 7-18 part nanometer Flos Chrysanthemi 7-18 part
Nanometer Radix Saposhnikoviae 7-18 part nanometer coptis 7-18 part nanometer Radix Achyranthis Bidentatae 7-18 part
Nanometer Rhizoma Chuanxiong 7-18 part nanometer Semen Armeniacae Amarum 7-18 part nanometer Gypsum Fibrosum 14-36 part
Nano magnetite 5-14 part nanometer Pulvis Cornus Bubali Concentratus 12-32 part
The formula optimization weight proportion scope of medicine of the present invention is:
The sub-10-15 part of nanometer Herba Dendrobii 10-15 part nanometer Semen Celosiae 10-15 part nano jueming
Nanometer Fructus Tribuli 10-15 part nanometer Radix Rehmanniae 20-30 part nanometer Radix Rehmanniae Preparata 20-30 part
Nanometer Fructus Lycii 10-15 part nanometer Semen Cuscutae 10-15 part nanometer Herba Cistanches 10-15 part
Nano ginseng 40-60 part nanometer Rhizoma Dioscoreae 10-15 part nanometer Poria 40-60 part
Nanometer Radix Asparagi 40-60 part nanometer 20-30 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 10-15 part
Nanometer Radix Glycyrrhizae 10-15 part nanometer Fructus Aurantii 10-15 part nanometer Flos Chrysanthemi 10-15 part
Nanometer Radix Saposhnikoviae 10-15 part nanometer coptis 10-15 part nanometer Radix Achyranthis Bidentatae 10-15 part
Nanometer Rhizoma Chuanxiong 10-15 part nanometer Semen Armeniacae Amarum 10-15 part nanometer Gypsum Fibrosum 20-30 part
Nano magnetite 8-12 part nanometer Pulvis Cornus Bubali Concentratus 18-27 part
The optimum weight proportioning of medicine of the present invention is:
12.5 parts of 12.5 parts of nano jueming of 12.5 parts of nanometer Semen Celosiae of nanometer Herba Dendrobii
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 12.5 parts of nanometer Radix Rehmanniae of nanometer Fructus Tribuli
12.5 parts of 12.5 parts of nanometer Herba Cistanches of 12.5 parts of nanometer Semen Cuscutae of nanometer Fructus Lycii
50 parts of 12.5 parts of nanometer Poria of 50 parts of nanometer Rhizoma Dioscoreaes of nano ginseng
12.5 parts of 50 parts of nanometers of nanometer Radix Asparagi, 25 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
12.5 parts of 12.5 parts of nanometer Flos Chrysanthemis of 12.5 parts of nanometer Fructus Aurantiis of nanometer Radix Glycyrrhizae
12.5 parts of 12.5 parts of nanometer Radix Achyranthis Bidentataes of 12.5 parts of nanometer coptis of nanometer Radix Saposhnikoviae
25.5 parts in 12.5 parts of nanometer Gypsum Fibrosum of 12.5 portions of nanometer Semen Armeniacae Amarums of nanometer Rhizoma Chuanxiong
22.625 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano magnetite
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since nano material special construction---the material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa surging,, get eyesight-improving noble dendrobium preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano eyesight-improving noble dendrobium preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common shihu mingmu pills preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano eyesight-improving noble dendrobium preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for both liver and kidney deficiency, the platycoria that depletion fire syndrome going up causes, and nyctalopia is dim-sighted, blurring of vision, the vertigo, treatment of conditions such as mental weariness, clinical efficacy significantly is better than traditional shihu mingmu pills.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
12.5 parts of 12.5 parts of nano jueming of 12.5 parts of nanometer Semen Celosiae of nanometer Herba Dendrobii
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 12.5 parts of nanometer Radix Rehmanniae of nanometer Fructus Tribuli
12.5 parts of 12.5 parts of nanometer Herba Cistanches of 12.5 parts of nanometer Semen Cuscutae of nanometer Fructus Lycii
50 parts of 12.5 parts of nanometer Poria of 50 parts of nanometer Rhizoma Dioscoreaes of nano ginseng
12.5 parts of 50 parts of nanometers of nanometer Radix Asparagi, 25 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
12.5 parts of 12.5 parts of nanometer Flos Chrysanthemis of 12.5 parts of nanometer Fructus Aurantiis of nanometer Radix Glycyrrhizae
12.5 parts of 12.5 parts of nanometer Radix Achyranthis Bidentataes of 12.5 parts of nanometer coptis of nanometer Radix Saposhnikoviae
25.5 parts in 12.5 parts of nanometer Gypsum Fibrosum of 12.5 portions of nanometer Semen Armeniacae Amarums of nanometer Rhizoma Chuanxiong
22.625 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano magnetite
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
12.5 parts of 12.5 parts of nano jueming of 12.5 parts of nanometer Semen Celosiae of nanometer Herba Dendrobii
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 12.5 parts of nanometer Radix Rehmanniae of nanometer Fructus Tribuli
12.5 parts of 12.5 parts of nanometer Herba Cistanches of 12.5 parts of nanometer Semen Cuscutae of nanometer Fructus Lycii
50 parts of 12.5 parts of nanometer Poria of 50 parts of nanometer Rhizoma Dioscoreaes of nano ginseng
12.5 parts of 50 parts of nanometers of nanometer Radix Asparagi, 25 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
12.5 parts of 12.5 parts of nanometer Flos Chrysanthemis of 12.5 parts of nanometer Fructus Aurantiis of nanometer Radix Glycyrrhizae
12.5 parts of 12.5 parts of nanometer Radix Achyranthis Bidentataes of 12.5 parts of nanometer coptis of nanometer Radix Saposhnikoviae
25.5 parts in 12.5 parts of nanometer Gypsum Fibrosum of 12.5 portions of nanometer Semen Armeniacae Amarums of nanometer Rhizoma Chuanxiong
22.625 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano magnetite
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano eyesight-improving noble dendrobium powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
12.5 parts of 12.5 parts of nano jueming of 12.5 parts of nanometer Semen Celosiae of nanometer Herba Dendrobii
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 12.5 parts of nanometer Radix Rehmanniae of nanometer Fructus Tribuli
12.5 parts of 12.5 parts of nanometer Herba Cistanches of 12.5 parts of nanometer Semen Cuscutae of nanometer Fructus Lycii
50 parts of 12.5 parts of nanometer Poria of 50 parts of nanometer Rhizoma Dioscoreaes of nano ginseng
12.5 parts of 50 parts of nanometers of nanometer Radix Asparagi, 25 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
12.5 parts of 12.5 parts of nanometer Flos Chrysanthemis of 12.5 parts of nanometer Fructus Aurantiis of nanometer Radix Glycyrrhizae
12.5 parts of 12.5 parts of nanometer Radix Achyranthis Bidentataes of 12.5 parts of nanometer coptis of nanometer Radix Saposhnikoviae
25.5 parts in 12.5 parts of nanometer Gypsum Fibrosum of 12.5 portions of nanometer Semen Armeniacae Amarums of nanometer Rhizoma Chuanxiong
22.625 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano magnetite
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano eyesight-improving noble dendrobium membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: temple.
Claims (6)
1, a kind of nano eyesight-improving noble dendrobium preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The sub-7-18 part of nanometer Herba Dendrobii 7-18 part nanometer Semen Celosiae 7-18 part nano jueming
Nanometer Fructus Tribuli 7-18 part nanometer Radix Rehmanniae 14-36 part nanometer Radix Rehmanniae Preparata 14-36 part
Nanometer Fructus Lycii 7-18 part nanometer Semen Cuscutae 7-18 part nanometer Herba Cistanches 7-18 part
Nano ginseng 28-72 part nanometer Rhizoma Dioscoreae 7-18 part nanometer Poria 28-72 part
Nanometer Radix Asparagi 28-72 part nanometer 14-36 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 7-18 part
Nanometer Radix Glycyrrhizae 7-18 part nanometer Fructus Aurantii 7-18 part nanometer Flos Chrysanthemi 7-18 part
Nanometer Radix Saposhnikoviae 7-18 part nanometer coptis 7-18 part nanometer Radix Achyranthis Bidentatae 7-18 part
Nanometer Rhizoma Chuanxiong 7-18 part nanometer Semen Armeniacae Amarum 7-18 part nanometer Gypsum Fibrosum 14-36 part
Nano magnetite 5-14 part nanometer Pulvis Cornus Bubali Concentratus 12-32 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano eyesight-improving noble dendrobium preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
The sub-10-15 part of nanometer Herba Dendrobii 10-15 part nanometer Semen Celosiae 10-15 part nano jueming
Nanometer Fructus Tribuli 10-15 part nanometer Radix Rehmanniae 20-30 part nanometer Radix Rehmanniae Preparata 20-30 part
Nanometer Fructus Lycii 10-15 part nanometer Semen Cuscutae 10-15 part nanometer Herba Cistanches 10-15 part
Nano ginseng 40-60 part nanometer Rhizoma Dioscoreae 10-15 part nanometer Poria 40-60 part
Nanometer Radix Asparagi 40-60 part nanometer 20-30 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 10-15 part
Nanometer Radix Glycyrrhizae 10-15 part nanometer Fructus Aurantii 10-15 part nanometer Flos Chrysanthemi 10-15 part
Nanometer Radix Saposhnikoviae 10-15 part nanometer coptis 10-15 part nanometer Radix Achyranthis Bidentatae 10-15 part
Nanometer Rhizoma Chuanxiong 10-15 part nanometer Semen Armeniacae Amarum 10-15 part nanometer Gypsum Fibrosum 20-30 part
Nano magnetite 8-12 part nanometer Pulvis Cornus Bubali Concentratus 18-27 part
3, nano eyesight-improving noble dendrobium preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
12.5 parts of 12.5 parts of nano jueming of 12.5 parts of nanometer Semen Celosiae of nanometer Herba Dendrobii
25 parts of 25 parts of nanometer Radix Rehmanniae Preparata of 12.5 parts of nanometer Radix Rehmanniae of nanometer Fructus Tribuli
12.5 parts of 12.5 parts of nanometer Herba Cistanches of 12.5 parts of nanometer Semen Cuscutae of nanometer Fructus Lycii
50 parts of 12.5 parts of nanometer Poria of 50 parts of nanometer Rhizoma Dioscoreaes of nano ginseng
12.5 parts of 50 parts of nanometers of nanometer Radix Asparagi, 25 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
12.5 parts of 12.5 parts of nanometer Flos Chrysanthemis of 12.5 parts of nanometer Fructus Aurantiis of nanometer Radix Glycyrrhizae
12.5 parts of 12.5 parts of nanometer Radix Achyranthis Bidentataes of 12.5 parts of nanometer coptis of nanometer Radix Saposhnikoviae
25.5 parts in 12.5 parts of nanometer Gypsum Fibrosum of 12.5 portions of nanometer Semen Armeniacae Amarums of nanometer Rhizoma Chuanxiong
22.625 parts of 10 parts of nanometer Pulvis Cornus Bubali Concentratuss of nano magnetite
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano eyesight-improving noble dendrobium preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano eyesight-improving noble dendrobium preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100177 CN1362124A (en) | 2001-01-04 | 2001-01-04 | Nano eyesight-improving noble dendrobium medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100177 CN1362124A (en) | 2001-01-04 | 2001-01-04 | Nano eyesight-improving noble dendrobium medicine and its preparation |
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| CN1362124A true CN1362124A (en) | 2002-08-07 |
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| CN 01100177 Pending CN1362124A (en) | 2001-01-04 | 2001-01-04 | Nano eyesight-improving noble dendrobium medicine and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114193A (en) * | 2011-02-19 | 2011-07-06 | 李彩萍 | Traditional Chinese medicine for treating keratomalacia due to vitamin A deficiency |
| CN102641431A (en) * | 2012-05-21 | 2012-08-22 | 修方伟 | Medicament for treating vitreous opacity |
| CN105748828A (en) * | 2016-04-12 | 2016-07-13 | 崔子扬 | Traditional Chinese medicine pill for treating acquired nyctalopia and preparation method thereof |
-
2001
- 2001-01-04 CN CN 01100177 patent/CN1362124A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114193A (en) * | 2011-02-19 | 2011-07-06 | 李彩萍 | Traditional Chinese medicine for treating keratomalacia due to vitamin A deficiency |
| CN102641431A (en) * | 2012-05-21 | 2012-08-22 | 修方伟 | Medicament for treating vitreous opacity |
| CN102641431B (en) * | 2012-05-21 | 2013-07-10 | 修方伟 | Medicament for treating vitreous opacity |
| CN105748828A (en) * | 2016-04-12 | 2016-07-13 | 崔子扬 | Traditional Chinese medicine pill for treating acquired nyctalopia and preparation method thereof |
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