CN1362098A - Nano antiphlogistic forsythiae medicine and its preparation - Google Patents

Nano antiphlogistic forsythiae medicine and its preparation Download PDF

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CN1362098A
CN1362098A CN 01100114 CN01100114A CN1362098A CN 1362098 A CN1362098 A CN 1362098A CN 01100114 CN01100114 CN 01100114 CN 01100114 A CN01100114 A CN 01100114A CN 1362098 A CN1362098 A CN 1362098A
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nanometer
nano
parts
part nanometer
radix
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杨孟君
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Abstract

The present invention discloses a nano forsythia dtoxin-vanquishing preparation medicine. It is made up by using 18 chinese medicinal materials of nano lonicera, nano forsythia, nano rhubarb, nano yedo violet, nano deandelion and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100nm. Said medicine is high in biological utilization, and obvious in therapeutic effect.

Description

Nano antiphlogistic forsythiae preparation medicine and preparation method thereof
The present invention relates to a kind of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cure mainly that furuncle festers, the nano antiphlogistic forsythiae preparation medicine of scorching hot fever, the flowing water of suppurating, erysipelas herpes, scabies sufferings, the invention still further relates to the method for this medication preparation.
The antiphlogistic forsythiae ball is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, is used for diseases such as furuncle festers, scorching hot fever, the flowing water of suppurating, erysipelas herpes, scabies sufferings.But traditional antiphlogistic forsythiae ball absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano antiphlogistic forsythiae preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano antiphlogistic forsythiae preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer gold Flos Lonicerae 10-60 part nanometer Fructus Forsythiae 20-60 part nano rhubarb 20-60 part
Nanometer Herba Violae 10-50 part nanometer Herba Taraxaci 10-50 part nanometer Fructus Gardeniae 10-50 part
Nano angelica root 10-50 part nano astragalus 10-50 part nanometer Radix Paeoniae Rubra 10-50 part
Nanometer Bulbus Fritillariae Thunbergii 10-50 part nanometer Radix Platycodonis 10-50 part nanometer Radix Scrophulariae 10-50 part
Nanometer Caulis Aristolochiae Manshuriensis 10-45 part nanometer Radix Saposhnikoviae 10-50 part nanometer Cortex Dictamni 10-50 part
Nanometer Radix Glycyrrhizae 10-50 part nanometer Periostracum Cicadae 10-40 part nanometer Radix Trichosanthis 10-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer gold Flos Lonicerae 30-50 part nanometer Fructus Forsythiae 30-50 part nano rhubarb 30-50 part
Nanometer Herba Violae 20-40 part nanometer Herba Taraxaci 20-40 part nanometer Fructus Gardeniae 20-40 part
Nano angelica root 20-40 part nano astragalus 20-40 part nanometer Radix Paeoniae Rubra 20-40 part
Nanometer Bulbus Fritillariae Thunbergii 20-40 part nanometer Radix Platycodonis 20-40 part nanometer Radix Scrophulariae 20-40 part
Nanometer Caulis Aristolochiae Manshuriensis 20-40 part nanometer Radix Saposhnikoviae 20-40 part nanometer Cortex Dictamni 20-40 part
Nanometer Radix Glycyrrhizae 20-40 part nanometer Periostracum Cicadae 10-30 part nanometer Radix Trichosanthis 10-30 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 40 parts of nano rhubarbs of 40 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
30 parts of 30 parts of nanometer Fructus Gardeniaes of 30 parts of nanometer Herba Taraxacis of nanometer Herba Violae
30 parts of 30 parts of nanometer Radix Paeoniae Rubra of 30 parts of nano astragalus of nano angelica root
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Platycodoniss of nanometer Bulbus Fritillariae Thunbergii
30 parts of 30 parts of nanometer Cortex Dictamni of 30 parts of nanometer Radix Saposhnikoviaes of nanometer Caulis Aristolochiae Manshuriensis
20 parts of 20 parts of nanometer Radix Trichosanthis of 30 parts of nanometer Periostracum Cicadaes of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition:
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get antiphlogistic forsythiae preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano antiphlogistic forsythiae preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common antiphlogistic forsythiae pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano antiphlogistic forsythiae preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as furuncle festers, scorching hot fever, the flowing water of suppurating, erysipelas herpes, scabies sufferings, and clinical efficacy significantly is better than traditional antiphlogistic forsythiae ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
40 parts of 40 parts of nano rhubarbs of 40 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
30 parts of 30 parts of nanometer Fructus Gardeniaes of 30 parts of nanometer Herba Taraxacis of nanometer Herba Violae
30 parts of 30 parts of nanometer Radix Paeoniae Rubra of 30 parts of nano astragalus of nano angelica root
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Platycodoniss of nanometer Bulbus Fritillariae Thunbergii
30 parts of 30 parts of nanometer Cortex Dictamni of 30 parts of nanometer Radix Saposhnikoviaes of nanometer Caulis Aristolochiae Manshuriensis
20 parts of 20 parts of nanometer Radix Trichosanthis of 30 parts of nanometer Periostracum Cicadaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-5 grain, every day 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts of 40 parts of nano rhubarbs of 40 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
30 parts of 30 parts of nanometer Fructus Gardeniaes of 30 parts of nanometer Herba Taraxacis of nanometer Herba Violae
30 parts of 30 parts of nanometer Radix Paeoniae Rubra of 30 parts of nano astragalus of nano angelica root
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Platycodoniss of nanometer Bulbus Fritillariae Thunbergii
30 parts of 30 parts of nanometer Cortex Dictamni of 30 parts of nanometer Radix Saposhnikoviaes of nanometer Caulis Aristolochiae Manshuriensis
20 parts of 20 parts of nanometer Radix Trichosanthis of 30 parts of nanometer Periostracum Cicadaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nano antiphlogistic forsythiae powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts of 40 parts of nano rhubarbs of 40 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
30 parts of 30 parts of nanometer Fructus Gardeniaes of 30 parts of nanometer Herba Taraxacis of nanometer Herba Violae
30 parts of 30 parts of nanometer Radix Paeoniae Rubra of 30 parts of nano astragalus of nano angelica root
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Platycodoniss of nanometer Bulbus Fritillariae Thunbergii
30 parts of 30 parts of nanometer Cortex Dictamni of 30 parts of nanometer Radix Saposhnikoviaes of nanometer Caulis Aristolochiae Manshuriensis
20 parts of 20 parts of nanometer Radix Trichosanthis of 30 parts of nanometer Periostracum Cicadaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nano antiphlogistic forsythiae membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.

Claims (6)

1, a kind of nano antiphlogistic forsythiae preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer gold Flos Lonicerae 10-60 part nanometer Fructus Forsythiae 20-60 part nano rhubarb 20-60 part
Nanometer Herba Violae 10-50 part nanometer Herba Taraxaci 10-50 part nanometer Fructus Gardeniae 10-50 part
Nano angelica root 10-50 part nano astragalus 10-50 part nanometer Radix Paeoniae Rubra 10-50 part
Nanometer Bulbus Fritillariae Thunbergii 10-50 part nanometer Radix Platycodonis 10-50 part nanometer Radix Scrophulariae 10-50 part
Nanometer Caulis Aristolochiae Manshuriensis 10-45 part nanometer Radix Saposhnikoviae 10-50 part nanometer Cortex Dictamni 10-50 part
Nanometer Radix Glycyrrhizae 10-50 part nanometer Periostracum Cicadae 10-40 part nanometer Radix Trichosanthis 10-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano antiphlogistic forsythiae preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer gold Flos Lonicerae 30-50 part nanometer Fructus Forsythiae 30-50 part nano rhubarb 30-50 part
Nanometer Herba Violae 20-40 part nanometer Herba Taraxaci 20-40 part nanometer Fructus Gardeniae 20-40 part
Nano angelica root 20-40 part nano astragalus 20-40 part nanometer Radix Paeoniae Rubra 20-40 part
Nanometer Bulbus Fritillariae Thunbergii 20-40 part nanometer Radix Platycodonis 20-40 part nanometer Radix Scrophulariae 20-40 part
Nanometer Caulis Aristolochiae Manshuriensis 20-40 part nanometer Radix Saposhnikoviae 20-40 part nanometer Cortex Dictamni 20-40 part
Nanometer Radix Glycyrrhizae 20-40 part nanometer Periostracum Cicadae 10-30 part nanometer Radix Trichosanthis 10-30 part
3, nano antiphlogistic forsythiae preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts of 40 parts of nano rhubarbs of 40 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
30 parts of 30 parts of nanometer Fructus Gardeniaes of 30 parts of nanometer Herba Taraxacis of nanometer Herba Violae
30 parts of 30 parts of nanometer Radix Paeoniae Rubra of 30 parts of nano astragalus of nano angelica root
30 parts of 30 portions of nanometer Radix Scrophulariaes of 30 parts of nanometer Radix Platycodoniss of nanometer Bulbus Fritillariae Thunbergii
30 parts of 30 parts of nanometer Cortex Dictamni of 30 parts of nanometer Radix Saposhnikoviaes of nanometer Caulis Aristolochiae Manshuriensis
20 parts of 20 parts of nanometer Radix Trichosanthis of 30 parts of nanometer Periostracum Cicadaes of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano antiphlogistic forsythiae preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano antiphlogistic forsythiae preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
CN 01100114 2001-01-05 2001-01-05 Nano antiphlogistic forsythiae medicine and its preparation Pending CN1362098A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579696A (en) * 2012-03-26 2012-07-18 中国人民解放军第四军医大学 Chinese herbal compound prescription for treating transfusion phlebophlogosis, method for preparing same and application of Chinese herbal compound prescription
CN104027658A (en) * 2014-07-09 2014-09-10 胡枫 Heat removing and blood cooling beverage for heat-toxin gangrene and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579696A (en) * 2012-03-26 2012-07-18 中国人民解放军第四军医大学 Chinese herbal compound prescription for treating transfusion phlebophlogosis, method for preparing same and application of Chinese herbal compound prescription
CN102579696B (en) * 2012-03-26 2014-12-24 中国人民解放军第四军医大学 Chinese herbal compound prescription for treating transfusion phlebophlogosis, method for preparing same and application of Chinese herbal compound prescription
CN104027658A (en) * 2014-07-09 2014-09-10 胡枫 Heat removing and blood cooling beverage for heat-toxin gangrene and preparation method thereof

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