CN1360930A - Nanometer traumatic injury-treating medicine and its prepn - Google Patents
Nanometer traumatic injury-treating medicine and its prepn Download PDFInfo
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- CN1360930A CN1360930A CN 00136926 CN00136926A CN1360930A CN 1360930 A CN1360930 A CN 1360930A CN 00136926 CN00136926 CN 00136926 CN 00136926 A CN00136926 A CN 00136926A CN 1360930 A CN1360930 A CN 1360930A
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Abstract
The nano traumatic injury treating medicine is prepared with nano notoginseng, nano Chinese angelica, nano Radix Paeoniae Alba, nano Radix Paeoniae Rubra, nano peach kernel and other 19 kinds of nano Chinese medicinal materials in certain proportion as material. it has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to the nanometer traumatic injury-treating medicine of a kind of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, the invention still further relates to the method for this medication preparation.
Pill for traumatic injuries is a kind of classical Chinese patent medicine, mainly contains effects such as promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, is used for diseases such as traumatic injury, tendon breaking fracture, congestion swell and ache, lumbar sprain and QI divergeny.But traditional pill for traumatic injuries disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer traumatic injury-treating medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer traumatic injury-treating medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Notoginseng 40-80 part nano Chinese angelica 20-45 part nanometer Radix Paeoniae Alba 30-60 part nanometer Radix Paeoniae Rubra 40-80 part
Nanometer Semen Persicae 20-45 part nano safflower 30-60 part nanometer Sanguis Draxonis 30-60 part nanometer siphonostegia chinensis 20-45 part
Nanometer Rhizoma Drynariae 20-45 part nanometer Radix Dipsaci 200-450 part nanometer Lignum Sappan 30-60 part nanometer Cortex Moutan 20-45 part
Nanometer Olibanum 30-60 part nanometer Myrrha 30-60 part nanometer Rhizoma Curcumae Longae 10-35 part nanometer rhizoma sparganic 30-60 part
Nanometer Radix Saposhnikoviae 20-45 part nanometer Semen Melo 20-45 part nanometer Fructus Aurantii Immaturus 20-45 part nanometer Radix Platycodonis 20-45 part
Nanometer Radix Glycyrrhizae 30-60 part nanometer Caulis Aristolochiae Manshuriensis 20-45 part nanometer Pyritum 20-45 part nanometer Eupolyphaga Seu Steleophaga 20-45 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Notoginseng 50-70 part nano Chinese angelica 25-40 part nanometer Radix Paeoniae Alba 35-55 part nanometer Radix Paeoniae Rubra 50-70 part
Nanometer Semen Persicae 25-40 part nano safflower 35-55 part nanometer Sanguis Draxonis 35-55 part nanometer siphonostegia chinensis 25-40 part
Nanometer Rhizoma Drynariae 25-40 part nanometer Radix Dipsaci 250-400 part nanometer Lignum Sappan 35-55 part nanometer Cortex Moutan 25-40 part
Nanometer Olibanum 35-55 part nanometer Myrrha 35-55 part nanometer Rhizoma Curcumae Longae 15-30 part nanometer rhizoma sparganic 35-55 part
Nanometer Radix Saposhnikoviae 25-40 part nanometer Semen Melo 25-40 part nanometer Fructus Aurantii Immaturus 25-40 part nanometer Radix Platycodonis 25-40 part
Nanometer Radix Glycyrrhizae 35-55 part nanometer Caulis Aristolochiae Manshuriensis 25-40 part nanometer Pyritum 25-40 part nanometer Eupolyphaga Seu Steleophaga 25-40 part
The best important proportioning of medicine of the present invention is:
64 parts of 48 parts of nanometer Radix Paeoniae Rubra of 32 parts of nanometer Radix Paeoniae Albas of 64 parts of nano Chinese angelicas of nanometer Radix Notoginseng
32 parts of 48 parts of nanometer siphonostegia chinensiss of 48 parts of nanometer Sanguis Draxonis of 32 parts of nano safflowers of nanometer Semen Persicae
32 parts of 48 parts of nanometer Cortex Moutans of 320 parts of nanometer Lignum Sappans of 32 parts of nanometer Radix Dipsacis of nanometer Rhizoma Drynariae
48 parts of 24 parts of nanometer rhizoma sparganic of 48 parts of nanometer Rhizoma Curcumae Longaes of 48 parts of nanometer Myrrhas of nanometer Olibanum
32 parts of 32 parts of nanometer Radix Platycodoniss of 32 parts of nanometer Fructus Aurantii Immaturuss of 32 parts of nanometer Semen Melos of nanometer Radix Saposhnikoviae
32 parts of 32 parts of nanometer Eupolyphaga Seu Steleophagas of 32 parts of nanometer Pyritums of 48 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of special construction-----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05Mpa under the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05Mpa under the pressure,, get traumatic injury preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer traumatic injury-treating medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common traumatic injury preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, syrup, oral solution of nanometer traumatic injury-treating medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as traumatic injury, tendon breaking fracture, congestion swell and ache, lumbar sprain and QI divergeny, and clinical efficacy significantly is better than traditional pill for traumatic injuries.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
64 parts of 48 parts of nanometer Radix Paeoniae Rubra of 32 parts of nanometer Radix Paeoniae Albas of 64 parts of nano Chinese angelicas of nanometer Radix Notoginseng
32 parts of 48 parts of nanometer siphonostegia chinensiss of 48 parts of nanometer Sanguis Draxonis of 32 parts of nano safflowers of nanometer Semen Persicae
32 parts of 48 parts of nanometer Cortex Moutans of 320 parts of nanometer Lignum Sappans of 32 parts of nanometer Radix Dipsacis of nanometer Rhizoma Drynariae
48 parts of 24 parts of nanometer rhizoma sparganic of 48 parts of nanometer Rhizoma Curcumae Longaes of 48 parts of nanometer Myrrhas of nanometer Olibanum
32 parts of 32 parts of nanometer Radix Platycodoniss of 32 parts of nanometer Fructus Aurantii Immaturuss of 32 parts of nanometer Semen Melos of nanometer Radix Saposhnikoviae
32 parts of 32 parts of nanometer Eupolyphaga Seu Steleophagas of 32 parts of nanometer Pyritums of 48 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
64 parts of 48 parts of nanometer Radix Paeoniae Rubra of 32 parts of nanometer Radix Paeoniae Albas of 64 parts of nano Chinese angelicas of nanometer Radix Notoginseng
32 parts of 48 parts of nanometer siphonostegia chinensiss of 48 parts of nanometer Sanguis Draxonis of 32 parts of nano safflowers of nanometer Semen Persicae
32 parts of 48 parts of nanometer Cortex Moutans of 320 parts of nanometer Lignum Sappans of 32 parts of nanometer Radix Dipsacis of nanometer Rhizoma Drynariae
48 parts of 24 parts of nanometer rhizoma sparganic of 48 parts of nanometer Rhizoma Curcumae Longaes of 48 parts of nanometer Myrrhas of nanometer Olibanum
32 parts of 32 parts of nanometer Radix Platycodoniss of 32 parts of nanometer Fructus Aurantii Immaturuss of 32 parts of nanometer Semen Melos of nanometer Radix Saposhnikoviae
32 parts of 32 parts of nanometer Eupolyphaga Seu Steleophagas of 32 parts of nanometer Pyritums of 48 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer traumatic injury powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
64 parts of 48 parts of nanometer Radix Paeoniae Rubra of 32 parts of nanometer Radix Paeoniae Albas of 64 parts of nano Chinese angelicas of nanometer Radix Notoginseng
32 parts of 48 parts of nanometer siphonostegia chinensiss of 48 parts of nanometer Sanguis Draxonis of 32 parts of nano safflowers of nanometer Semen Persicae
32 parts of 48 parts of nanometer Cortex Moutans of 320 parts of nanometer Lignum Sappans of 32 parts of nanometer Radix Dipsacis of nanometer Rhizoma Drynariae
48 parts of 24 parts of nanometer rhizoma sparganic of 48 parts of nanometer Rhizoma Curcumae Longaes of 48 parts of nanometer Myrrhas of nanometer Olibanum
32 parts of 32 parts of nanometer Radix Platycodoniss of 32 parts of nanometer Fructus Aurantii Immaturuss of 32 parts of nanometer Semen Melos of nanometer Radix Saposhnikoviae
32 parts of 32 parts of nanometer Eupolyphaga Seu Steleophagas of 32 parts of nanometer Pyritums of 48 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Glycyrrhizae
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer traumatic injury membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nanometer traumatic injury-treating medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Notoginseng 40-80 part nano Chinese angelica 20-45 part nanometer Radix Paeoniae Alba 30-60 part nanometer Radix Paeoniae Rubra 40-80 part
Nanometer Semen Persicae 20-45 part nano safflower 30-60 part nanometer Sanguis Draxonis 30-60 part nanometer siphonostegia chinensis 20-45 part
Nanometer Rhizoma Drynariae 20-45 part nanometer Radix Dipsaci 200-450 part nanometer Lignum Sappan 30-60 part nanometer Cortex Moutan 20-45 part
Nanometer Olibanum 30-60 part nanometer Myrrha 30-60 part nanometer Rhizoma Curcumae Longae 10-35 part nanometer rhizoma sparganic 30-60 part
Nanometer Radix Saposhnikoviae 20-45 part nanometer Semen Melo 20-45 part nanometer Fructus Aurantii Immaturus 20-45 part nanometer Radix Platycodonis 20-45 part
Nanometer Radix Glycyrrhizae 30-60 part nanometer Caulis Aristolochiae Manshuriensis 20-45 part nanometer Pyritum 20-45 part nanometer Eupolyphaga Seu Steleophaga 20-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer traumatic injury-treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Notoginseng 50-70 part nano Chinese angelica 25-40 part nanometer Radix Paeoniae Alba 35-55 part nanometer Radix Paeoniae Rubra 50-70 part
Nanometer Semen Persicae 25-40 part nano safflower 35-55 part nanometer Sanguis Draxonis 35-55 part nanometer siphonostegia chinensis 25-40 part
Nanometer Rhizoma Drynariae 25-40 part nanometer Radix Dipsaci 250-400 part nanometer Lignum Sappan 35-55 part nanometer Cortex Moutan 25-40 part
Nanometer Olibanum 35-55 part nanometer Myrrha 35-55 part nanometer Rhizoma Curcumae Longae 15-30 part nanometer rhizoma sparganic 35-55 part
Nanometer Radix Saposhnikoviae 25-40 part nanometer Semen Melo 25-40 part nanometer Fructus Aurantii Immaturus 25-40 part nanometer Radix Platycodonis 25-40 part
Nanometer Radix Glycyrrhizae 35-55 part nanometer Caulis Aristolochiae Manshuriensis 25-40 part nanometer Pyritum 25-40 part nanometer Eupolyphaga Seu Steleophaga 25-40 part
3, nanometer traumatic injury-treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
64 parts of 48 parts of nanometer Radix Paeoniae Rubra of 32 parts of nanometer Radix Paeoniae Albas of 64 parts of nano Chinese angelicas of nanometer Radix Notoginseng
32 parts of 48 parts of nanometer siphonostegia chinensiss of 48 parts of nanometer Sanguis Draxonis of 32 parts of nano safflowers of nanometer Semen Persicae
32 parts of 48 parts of nanometer Cortex Moutans of 320 parts of nanometer Lignum Sappans of 32 parts of nanometer Radix Dipsacis of nanometer Rhizoma Drynariae
48 parts of 24 parts of nanometer rhizoma sparganic of 48 parts of nanometer Rhizoma Curcumae Longaes of 48 parts of nanometer Myrrhas of nanometer Olibanum
32 parts of 32 parts of nanometer Radix Platycodoniss of 32 parts of nanometer Fructus Aurantii Immaturuss of 32 parts of nanometer Semen Melos of nanometer Radix Saposhnikoviae
32 parts of 32 parts of nanometer Eupolyphaga Seu Steleophagas of 32 parts of nanometer Pyritums of 48 parts of nanometer Caulis Aristolochiae Manshuriensis of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nanometer traumatic injury-treating medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer traumatic injury-treating medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136926 CN1360930A (en) | 2000-12-29 | 2000-12-29 | Nanometer traumatic injury-treating medicine and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136926 CN1360930A (en) | 2000-12-29 | 2000-12-29 | Nanometer traumatic injury-treating medicine and its prepn |
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| CN1360930A true CN1360930A (en) | 2002-07-31 |
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| CN 00136926 Pending CN1360930A (en) | 2000-12-29 | 2000-12-29 | Nanometer traumatic injury-treating medicine and its prepn |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361702C (en) * | 2006-03-09 | 2008-01-16 | 张海峰 | Bone fracture treating medicine and its preparing method |
| CN101524450B (en) * | 2009-04-13 | 2011-11-16 | 王宝岭 | Oral traditional Chinese medicine for setting bones and relieving rigidity of muscles and preparation method thereof |
| CN104491762A (en) * | 2015-01-19 | 2015-04-08 | 李宏良 | Medicine composition for treating traumatic injury and preparation method |
-
2000
- 2000-12-29 CN CN 00136926 patent/CN1360930A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361702C (en) * | 2006-03-09 | 2008-01-16 | 张海峰 | Bone fracture treating medicine and its preparing method |
| CN101524450B (en) * | 2009-04-13 | 2011-11-16 | 王宝岭 | Oral traditional Chinese medicine for setting bones and relieving rigidity of muscles and preparation method thereof |
| CN104491762A (en) * | 2015-01-19 | 2015-04-08 | 李宏良 | Medicine composition for treating traumatic injury and preparation method |
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