CN1362122A - Nano fracture-setting traumatic medicine and its preparation - Google Patents
Nano fracture-setting traumatic medicine and its preparation Download PDFInfo
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- CN1362122A CN1362122A CN 01100175 CN01100175A CN1362122A CN 1362122 A CN1362122 A CN 1362122A CN 01100175 CN01100175 CN 01100175 CN 01100175 A CN01100175 A CN 01100175A CN 1362122 A CN1362122 A CN 1362122A
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Abstract
The present invention discloses a nano bone-setting preparation medicine. It is made up by using 12 Chinese medicinal materials of nano carthamus, nano wingless cockroach, nano cinnabar, nano nux vomica powder, nano myrrh and others as raw material through the process of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nano fracture-setting traumatic preparation medicine of a kind of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, Shujin bone strengthening, the invention still further relates to the method for this medication preparation.
Bone setting tablet is a kind of classical Chinese patent medicine, mainly contains effects such as blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, Shujin bone strengthening, is used for traumatic injury, and lumbar sprain and QI divergeny is injured in the sinews or bones, swelling and pain due to blood stasis, diseases such as damage redness.Fracture patient is needed to be used after resetting.But traditional bone setting tablet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano fracture-setting traumatic preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano fracture-setting traumatic preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano safflower 50-500 part nanometer Eupolyphaga Seu Steleophaga 50-500 part nanometer Cinnabaris 50-400 part
Nano vomiting nut powder 30-400 part nanometer Myrrha 50-500 part nanometer Radix Notoginseng 50-500 part
Nanometer Asterias amurensis Lutken 50-500 part nanometer Os Gallus domesticus 50-500 part nanometer Borneolum Syntheticum 1-10 part
Nanometer Pyritum 30-300 part nanometer Olibanum 50-500 part nanometer Semen Melo 50-500 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano safflower 100-300 part nanometer Eupolyphaga Seu Steleophaga 100-350 part nanometer Cinnabaris 100-250 part
Nano vomiting nut powder 50-300 part nanometer Myrrha 100-300 part nanometer Radix Notoginseng 100-400 part
Nanometer Asterias amurensis Lutken 100-300 part nanometer Os Gallus domesticus 100-300 part nanometer Borneolum Syntheticum 3-8 part
Nanometer Pyritum 50-200 part nanometer Olibanum 100-300 part nanometer Semen Melo 100-300 part
The optimum weight proportioning of medicine of the present invention is:
150 parts in 200 parts of nanometer Cinnabaris of 150 parts of nanometer Eupolyphaga Seu Steleophagas of nano safflower
200 parts of 150 parts of nanometer Radix Notoginseng of 100 parts of nanometer Myrrhas of nano vomiting nut powder
5 parts of 150 parts of nanometer Borneolum Syntheticums of 200 parts of nanometer Os Gallus domesticus of nanometer Asterias amurensis Lutken
200 parts of 150 parts of nanometer Semen Melos of 100 parts of nanometer Olibanums of nanometer Pyritum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the material grains size of the special construction nano fracture-setting traumatic preparation medicine of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Shangke bone-knitting preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano fracture-setting traumatic preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common bone setting tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: traditional bone setting tablet disintegrate is slow, absorption is incomplete, bioavailability is not high, solid preparation of the present invention disintegrate rapidly, solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano fracture-setting traumatic preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for traumatic injury, and lumbar sprain and QI divergeny is injured in the sinews or bones, swelling and pain due to blood stasis, and treatment of conditions such as damage redness, clinical efficacy significantly is better than traditional bone setting tablet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
150 parts in 200 parts of nanometer Cinnabaris of 150 parts of nanometer Eupolyphaga Seu Steleophagas of nano safflower
200 parts of 150 parts of nanometer Radix Notoginseng of 100 parts of nanometer Myrrhas of nano vomiting nut powder
5 parts of 150 parts of nanometer Borneolum Syntheticums of 200 parts of nanometer Os Gallus domesticus of nanometer Asterias amurensis Lutken
200 parts of 150 parts of nanometer Semen Melos of 100 parts of nanometer Olibanums of nanometer Pyritum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
150 parts in 200 parts of nanometer Cinnabaris of 150 parts of nanometer Eupolyphaga Seu Steleophagas of nano safflower
200 parts of 150 parts of nanometer Radix Notoginseng of 100 parts of nanometer Myrrhas of nano vomiting nut powder
5 parts of 150 parts of nanometer Borneolum Syntheticums of 200 parts of nanometer Os Gallus domesticus of nanometer Asterias amurensis Lutken
200 parts of 150 parts of nanometer Semen Melos of 100 parts of nanometer Olibanums of nanometer Pyritum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano fracture-setting traumatic powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
150 parts in 200 parts of nanometer Cinnabaris of 150 parts of nanometer Eupolyphaga Seu Steleophagas of nano safflower
200 parts of 150 parts of nanometer Radix Notoginseng of 100 parts of nanometer Myrrhas of nano vomiting nut powder
5 parts of 150 parts of nanometer Borneolum Syntheticums of 200 parts of nanometer Os Gallus domesticus of nanometer Asterias amurensis Lutken
200 parts of 150 parts of nanometer Semen Melos of 100 parts of nanometer Olibanums of nanometer Pyritum
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano fracture-setting traumatic membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano fracture-setting traumatic preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano safflower 50-500 part nanometer Eupolyphaga Seu Steleophaga 50-500 part nanometer Cinnabaris 50-400 part
Nano vomiting nut powder 30-400 part nanometer Myrrha 50-500 part nanometer Radix Notoginseng 50-500 part
Nanometer Asterias amurensis Lutken 50-500 part nanometer Os Gallus domesticus 50-500 part nanometer Borneolum Syntheticum 1-10 part
Nanometer Pyritum 30-300 part nanometer Olibanum 50-500 part nanometer Semen Melo 50-500 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano fracture-setting traumatic preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano safflower 100-300 part nanometer Eupolyphaga Seu Steleophaga 100-350 part nanometer Cinnabaris 100-250 part
Nano vomiting nut powder 50-300 part nanometer Myrrha 100-300 part nanometer Radix Notoginseng 100-400 part
Nanometer Asterias amurensis Lutken 100-300 part nanometer Os Gallus domesticus 100-300 part nanometer Borneolum Syntheticum 3-8 part
Nanometer Pyritum 50-200 part nanometer Olibanum 100-300 part nanometer Semen Melo 100-300 part
3, nano fracture-setting traumatic preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
150 parts in 200 parts of nanometer Cinnabaris of 150 parts of nanometer Eupolyphaga Seu Steleophagas of nano safflower
200 parts of 150 parts of nanometer Radix Notoginseng of 100 parts of nanometer Myrrhas of nano vomiting nut powder
5 parts of 150 parts of nanometer Borneolum Syntheticums of 200 parts of nanometer Os Gallus domesticus of nanometer Asterias amurensis Lutken
200 parts of 150 parts of nanometer Semen Melos of 100 parts of nanometer Olibanums of nanometer Pyritum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano fracture-setting traumatic preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano fracture-setting traumatic preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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CN 01100175 CN1362122A (en) | 2001-01-04 | 2001-01-04 | Nano fracture-setting traumatic medicine and its preparation |
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CN 01100175 CN1362122A (en) | 2001-01-04 | 2001-01-04 | Nano fracture-setting traumatic medicine and its preparation |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1316990C (en) * | 2005-01-18 | 2007-05-23 | 北京凯瑞创新医药科技有限公司 | Chinese medicinal composition, preparation method and quality control method thereof |
CN100361667C (en) * | 2005-07-08 | 2008-01-16 | 大连美罗中药厂有限公司 | Medicine for treating traumatology diseases, and its preparing method |
CN1935192B (en) * | 2005-09-22 | 2010-12-01 | 北京凯瑞创新医药科技有限公司 | Chinese medicine composition, and its preparing method and quality control method |
-
2001
- 2001-01-04 CN CN 01100175 patent/CN1362122A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1316990C (en) * | 2005-01-18 | 2007-05-23 | 北京凯瑞创新医药科技有限公司 | Chinese medicinal composition, preparation method and quality control method thereof |
CN100361667C (en) * | 2005-07-08 | 2008-01-16 | 大连美罗中药厂有限公司 | Medicine for treating traumatology diseases, and its preparing method |
CN1935192B (en) * | 2005-09-22 | 2010-12-01 | 北京凯瑞创新医药科技有限公司 | Chinese medicine composition, and its preparing method and quality control method |
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