CN1366888A - Nano quicken the blood and disperse welling abscess preparation medicine and preparation method thereof - Google Patents
Nano quicken the blood and disperse welling abscess preparation medicine and preparation method thereof Download PDFInfo
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- CN1366888A CN1366888A CN 01102027 CN01102027A CN1366888A CN 1366888 A CN1366888 A CN 1366888A CN 01102027 CN01102027 CN 01102027 CN 01102027 A CN01102027 A CN 01102027A CN 1366888 A CN1366888 A CN 1366888A
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Abstract
The present ivnention discloses a nano quicken the blood and disperse welling abscess preparation medicine. It is made up by using the Chinese medicinal materials of nano tangkuei, nano notoginseng, nano frankincense, nano borneol, nano wingless cockroach and nano pyrite as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to the nanometer promoting blood circulation and stopping pain preparation medicine of a kind of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, the invention still further relates to the method for this medication preparation.
HUOXUE ZHIRONG JIAONANG is a kind of classical Chinese patent medicine, mainly contains promoting blood circulation to remove blood stasis, and effects such as reducing swelling and alleviating pain are used for traumatic injury, swelling and pain due to blood stasis. but traditional HUOXUE ZHIRONG JIAONANG absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer promoting blood circulation and stopping pain preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer promoting blood circulation and stopping pain preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
300-500 part nanometer Radix Notoginseng 60-100 part nanometer Olibanum 60-100 part in the nano Chinese angelica
Nanometer Borneolum Syntheticum 10-30 part nanometer Eupolyphaga Seu Steleophaga 120-280 part nanometer Pyritum 80-160 part
The formula optimization weight proportion scope of medicine of the present invention is:
350-450 part nanometer Radix Notoginseng 70-90 part nanometer Olibanum 70-90 part in the nano Chinese angelica
Nanometer Borneolum Syntheticum 15-25 part nanometer Eupolyphaga Seu Steleophaga 160-240 part nanometer Pyritum 100-140 part
The optimum weight proportioning of medicine of the present invention is:
80 parts of 80 parts of nanometer Olibanums of 400 parts of nanometer Radix Notoginseng of nano Chinese angelica
120 parts of 200 parts of nanometer Pyritums of 20 parts of nanometer Eupolyphaga Seu Steleophagas of nanometer Borneolum Syntheticum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, get promoting blood circulation and stopping pain preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer promoting blood circulation and stopping pain preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common HUOXUE ZHIRONG JIAONANG preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, syrup, oral solution of nanometer promoting blood circulation and stopping pain preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for traumatic injury, treatment of conditions such as swelling and pain due to blood stasis, and clinical efficacy significantly is better than traditional HUOXUE ZHIRONG JIAONANG.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
80 parts of 80 parts of nanometer Olibanums of 400 parts of nanometer Radix Notoginseng of nano Chinese angelica
120 parts of 200 parts of nanometer Pyritums of 20 parts of nanometer Eupolyphaga Seu Steleophagas of nanometer Borneolum Syntheticum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
80 parts of 80 parts of nanometer Olibanums of 400 parts of nanometer Radix Notoginseng of nano Chinese angelica
120 parts of 200 parts of nanometer Pyritums of 20 parts of nanometer Eupolyphaga Seu Steleophagas of nanometer Borneolum Syntheticum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make nanometer promoting blood circulation and stopping pain powder needle injection, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method
80 parts of 80 parts of nanometer Olibanums of 400 parts of nanometer Radix Notoginseng of nano Chinese angelica
120 parts of 200 parts of nanometer Pyritums of 20 parts of nanometer Eupolyphaga Seu Steleophagas of nanometer Borneolum Syntheticum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make nanometer promoting blood circulation and stopping pain membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest, cervical region and affected part.
Claims (6)
1, a kind of nanometer promoting blood circulation and stopping pain preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
300-500 part nanometer Radix Notoginseng 60-100 part nanometer Olibanum 60-100 part in the nano Chinese angelica
Nanometer Borneolum Syntheticum 10-30 part nanometer Eupolyphaga Seu Steleophaga 120-280 part nanometer Pyritum 80-160 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer promoting blood circulation and stopping pain preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
350-450 part nanometer Radix Notoginseng 70-90 part nanometer Olibanum 70-90 part in the nano Chinese angelica
Nanometer Borneolum Syntheticum 15-25 part nanometer Eupolyphaga Seu Steleophaga 160-240 part nanometer Pyritum 100-140 part
3, nanometer promoting blood circulation and stopping pain preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
80 parts of 80 parts of nanometer Olibanums of 400 parts of nanometer Radix Notoginseng of nano Chinese angelica
120 parts of 200 parts of nanometer Pyritums of 20 parts of nanometer Eupolyphaga Seu Steleophagas of nanometer Borneolum Syntheticum
4, according to claim 1 or 2 or 3 described nanometer promoting blood circulation and stopping pain preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer promoting blood circulation and stopping pain preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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CN 01102027 CN1366888A (en) | 2001-01-22 | 2001-01-22 | Nano quicken the blood and disperse welling abscess preparation medicine and preparation method thereof |
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CN 01102027 CN1366888A (en) | 2001-01-22 | 2001-01-22 | Nano quicken the blood and disperse welling abscess preparation medicine and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100482214C (en) * | 2003-05-24 | 2009-04-29 | 毛友昌 | Blood circulation promoting and pain relieving bolus and its prepn |
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2001
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100482214C (en) * | 2003-05-24 | 2009-04-29 | 毛友昌 | Blood circulation promoting and pain relieving bolus and its prepn |
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