CN1362094A - Nano reinforced loquet medicine and its preparation - Google Patents
Nano reinforced loquet medicine and its preparation Download PDFInfo
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- CN1362094A CN1362094A CN 01100110 CN01100110A CN1362094A CN 1362094 A CN1362094 A CN 1362094A CN 01100110 CN01100110 CN 01100110 CN 01100110 A CN01100110 A CN 01100110A CN 1362094 A CN1362094 A CN 1362094A
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Abstract
The present invention discloses a nano strong liquat preparation medicine. It is made up by using the Chinese medicinal materials of nano loquat leaf, nano mulberry root bark, nano cyanachum and nano platycodon as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of antitussive, eliminate the phlegm, cure mainly the nanometer intensified loquet preparation medicine of cough, the invention still further relates to the method for this medication preparation.
The intensified loquet capsule is a kind of classical Chinese patent medicine, mainly contains antitussive, eliminates the phlegm, antiinflammatory, effect such as antibiotic, be used for the cough due to common cold, bronchitis etc., but traditional intensified loquet capsule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer intensified loquet preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer intensified loquet preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Folium Eriobotryae 10-60 part nanometer Cortex Mori 10-50 part nanometer Rhizoma Cynanchi Stauntonii 5-50 part
Nanometer Radix Platycodonis 10-60 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Folium Eriobotryae 15-50 part nanometer Cortex Mori 20-40 part nanometer Rhizoma Cynanchi Stauntonii 10-30 part
Nanometer Radix Platycodonis 15-50 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 30 parts of nanometer Rhizoma Cynanchi Stauntoniis of 25 parts of nanometer Cortex Mori of nanometer Folium Eriobotryae
25 parts of nanometer Radix Platycodoniss
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get intensified loquet preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer intensified loquet preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common intensified loquet capsule preparations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum of intensified loquet capsule preparations medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as the cough due to common cold, bronchitis, and clinical efficacy significantly is better than traditional intensified loquet capsule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 30 parts of nanometer Rhizoma Cynanchi Stauntoniis of 25 parts of nanometer Cortex Mori of nanometer Folium Eriobotryae
25 parts of nanometer Radix Platycodoniss
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 30 parts of nanometer Rhizoma Cynanchi Stauntoniis of 25 parts of nanometer Cortex Mori of nanometer Folium Eriobotryae
25 parts of nanometer Radix Platycodoniss
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer intensified loquet powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
20 parts of 30 parts of nanometer Rhizoma Cynanchi Stauntoniis of 25 parts of nanometer Cortex Mori of nanometer Folium Eriobotryae
25 parts of nanometer Radix Platycodoniss
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer intensified loquet membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest, cervical region.
Claims (6)
1, a kind of nanometer intensified loquet preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Folium Eriobotryae 10-60 part nanometer Cortex Mori 10-50 part nanometer Rhizoma Cynanchi Stauntonii 5-50 part
Nanometer Radix Platycodonis 10-60 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nanometer intensified loquet preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Folium Eriobotryae 15-50 part nanometer Cortex Mori 20-40 part nanometer Rhizoma Cynanchi Stauntonii 10-30 part
Nanometer Radix Platycodonis 15-50 part
3, nanometer intensified loquet preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 30 parts of nanometer Rhizoma Cynanchi Stauntoniis of 25 parts of nanometer Cortex Mori of nanometer Folium Eriobotryae
25 parts of nanometer Radix Platycodoniss
4, according to claim 1 or 2 or 3 described nanometer intensified loquet preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer intensified loquet preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100110 CN1362094A (en) | 2001-01-05 | 2001-01-05 | Nano reinforced loquet medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100110 CN1362094A (en) | 2001-01-05 | 2001-01-05 | Nano reinforced loquet medicine and its preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1362094A true CN1362094A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100110 Pending CN1362094A (en) | 2001-01-05 | 2001-01-05 | Nano reinforced loquet medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524154A (en) * | 2014-12-29 | 2015-04-22 | 河南天纳图生物科技有限公司 | Compound fermented traditional Chinese medicine for relieving cough and asthma of livestock and poultry and preparation method of compound fermented traditional Chinese medicine |
-
2001
- 2001-01-05 CN CN 01100110 patent/CN1362094A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524154A (en) * | 2014-12-29 | 2015-04-22 | 河南天纳图生物科技有限公司 | Compound fermented traditional Chinese medicine for relieving cough and asthma of livestock and poultry and preparation method of compound fermented traditional Chinese medicine |
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