CN1364482A - Nano wild jujube seed mecicine and its preparing method - Google Patents
Nano wild jujube seed mecicine and its preparing method Download PDFInfo
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- CN1364482A CN1364482A CN 01100256 CN01100256A CN1364482A CN 1364482 A CN1364482 A CN 1364482A CN 01100256 CN01100256 CN 01100256 CN 01100256 A CN01100256 A CN 01100256A CN 1364482 A CN1364482 A CN 1364482A
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Abstract
The nano wild jujube seed medicine is prepared with nano wild jujube seed, nano anemarrhena rhizome, nano tuckahoe, nano Rhizoma Ligustici chuanxiong and nano licorice in certai proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompression concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to the nano wild jujube seed mecicine of a kind of clearing away heat-fire, nourishing blood to tranquillize the mind, the invention still further relates to the method for this medication preparation.
The Semen Ziziphi Spinosae syrup is a kind of classical Chinese patent medicine, mainly contains effects such as clearing away heat-fire, nourishing blood to tranquillize the mind, disease such as be used for restlessness of asrhenia type and insomnia, palpitation and uneasiness, have a dizzy spell.But traditional Semen Ziziphi Spinosae syrup absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano wild jujube seed mecicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano wild jujube seed mecicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nm acid Semen Ziziphi Spinosae 200-400 part nanometer Rhizoma Anemarrhenae 80-180 part nano Poria 120-250 part
Nanometer Rhizoma Chuanxiong 80-180 part nanometer Radix Glycyrrhizae 40-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nm acid Semen Ziziphi Spinosae 250-350 part nanometer Rhizoma Anemarrhenae 100-150 part nano Poria 150-200 part
Nanometer Rhizoma Chuanxiong 100-150 part nanometer Radix Glycyrrhizae 50-70 part
The optimum weight proportioning of medicine of the present invention is:
180 parts of 120 parts of nano Porias of 300 parts of nanometer Rhizoma Anemarrhenaes of nm acid Semen Ziziphi Spinosae
60 parts in 120 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Chuanxiong
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Semen Ziziphi Spinosae preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano wild jujube seed mecicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common acids Semen Ziziphi Spinosae syrup preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano wild jujube seed mecicine etc. had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for restlessness of asrhenia type and insomnia, palpitation and uneasiness, have a dizzy spell, clinical efficacy significantly is better than traditional Semen Ziziphi Spinosae syrup.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
180 parts of 120 parts of nano Porias of 300 parts of nanometer Rhizoma Anemarrhenaes of nm acid Semen Ziziphi Spinosae
60 parts in 120 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Chuanxiong
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
180 parts of 120 parts of nano Porias of 300 parts of nanometer Rhizoma Anemarrhenaes of nm acid Semen Ziziphi Spinosae
60 parts in 120 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Chuanxiong
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nm acid Semen Ziziphi Spinosae powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
180 parts of 120 parts of nano Porias of 300 parts of nanometer Rhizoma Anemarrhenaes of nm acid Semen Ziziphi Spinosae
60 parts in 120 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Chuanxiong
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nm acid Semen Ziziphi Spinosae membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano wild jujube seed mecicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nm acid Semen Ziziphi Spinosae 200-400 part nanometer Rhizoma Anemarrhenae 80-180 part nano Poria 120-250 part
Nanometer Rhizoma Chuanxiong 80-180 part nanometer Radix Glycyrrhizae 40-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano wild jujube seed mecicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nm acid Semen Ziziphi Spinosae 250-350 part nanometer Rhizoma Anemarrhenae 100-150 part nano Poria 150-200 part
Nanometer Rhizoma Chuanxiong 100-150 part nanometer Radix Glycyrrhizae 50-70 part
3, nano wild jujube seed mecicine according to claim 1, wherein the weight proportion of each nano raw material is:
180 parts of 120 parts of nano Porias of 300 parts of nanometer Rhizoma Anemarrhenaes of nm acid Semen Ziziphi Spinosae
60 parts in 120 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Chuanxiong
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano wild jujube seed mecicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano wild jujube seed mecicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100256 CN1364482A (en) | 2001-01-12 | 2001-01-12 | Nano wild jujube seed mecicine and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100256 CN1364482A (en) | 2001-01-12 | 2001-01-12 | Nano wild jujube seed mecicine and its preparing method |
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| CN1364482A true CN1364482A (en) | 2002-08-21 |
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| CN 01100256 Pending CN1364482A (en) | 2001-01-12 | 2001-01-12 | Nano wild jujube seed mecicine and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308321C (en) * | 2003-09-17 | 2007-04-04 | 浙江海正药业股份有限公司 | Jujube kernel saponin derivative and its preparation method and use |
| CN102895482A (en) * | 2011-07-29 | 2013-01-30 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for integrated new formulation of sour jujube decoction |
| CN116370530A (en) * | 2023-04-21 | 2023-07-04 | 吉林大学第一医院 | Nanometer medicinal preparation comprising semen Ziziphi Spinosae, and its preparation method and application |
-
2001
- 2001-01-12 CN CN 01100256 patent/CN1364482A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308321C (en) * | 2003-09-17 | 2007-04-04 | 浙江海正药业股份有限公司 | Jujube kernel saponin derivative and its preparation method and use |
| CN102895482A (en) * | 2011-07-29 | 2013-01-30 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for integrated new formulation of sour jujube decoction |
| CN116370530A (en) * | 2023-04-21 | 2023-07-04 | 吉林大学第一医院 | Nanometer medicinal preparation comprising semen Ziziphi Spinosae, and its preparation method and application |
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