CN1362178A - Nano rehmannia medicine with six ingredients and its preparation - Google Patents
Nano rehmannia medicine with six ingredients and its preparation Download PDFInfo
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- CN1362178A CN1362178A CN 01100333 CN01100333A CN1362178A CN 1362178 A CN1362178 A CN 1362178A CN 01100333 CN01100333 CN 01100333 CN 01100333 A CN01100333 A CN 01100333A CN 1362178 A CN1362178 A CN 1362178A
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Abstract
The present invention discloses a nano six-ingredient rehmannia preparation medicine. It is made up by using the Chinese medicinal materials of nano cornus, nano cooked rehmannia, nano poutan, nano dioscorea, nano poria and nano alisma as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of enriching yin and nourishing kidney, cure mainly the nanometer Liuwei Dihuang preparation medicine of deficiency of the kidney yin, the invention still further relates to the method for this medication preparation.
LIUWEI DIHUANG WAN is a kind of classical Chinese patent medicine, mainly contains effects such as enriching yin and nourishing kidney, is used for dizziness and tinnitus, damage of kidney-YIN, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, quenches one's thirst.But traditional LIUWEI DIHUANG WAN disintegrate is slower, absorbs not exclusively bioavailability, not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer Liuwei Dihuang preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer Liuwei Dihuang preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Corni 60-100 part nanometer Radix Rehmanniae Preparata 100-220 part nanometer Cortex Moutan 40-80 part
Nanometer Rhizoma Dioscoreae 60-100 part nano Poria 40-80 part nanometer Rhizoma Alismatis 40-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Corni 70-90 part nanometer Radix Rehmanniae Preparata 130-190 part nanometer Cortex Moutan 50-70 part
Nanometer Rhizoma Dioscoreae 70-90 part nano Poria 50-70 part nanometer Rhizoma Alismatis 50-70 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 160 parts of nanometer Cortex Moutans of 80 parts of nanometer Radix Rehmanniae Preparata of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of 80 parts of nano Porias of nanometer Rhizoma Dioscoreae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get the Liuwei Dihuang preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer Liuwei Dihuang preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common LIUWEI DIHUANG WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine of nanometer Liuwei Dihuang preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for esophageal epithelial proliferation, prevents canceration, nephritis, and climacteric syndrome, diabetes, hypertension, arrhythmia, chronic prostatitis, treatment of conditions such as neurasthenia, clinical efficacy significantly is better than traditional LIUWEI DIHUANG WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 160 parts of nanometer Cortex Moutans of 80 parts of nanometer Radix Rehmanniae Preparata of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of 80 parts of nano Porias of nanometer Rhizoma Dioscoreae
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 160 parts of nanometer Cortex Moutans of 80 parts of nanometer Radix Rehmanniae Preparata of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of 80 parts of nano Porias of nanometer Rhizoma Dioscoreae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make nanometer six drugs containing rehmanniae powder needle injection, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 160 parts of nanometer Cortex Moutans of 80 parts of nanometer Radix Rehmanniae Preparata of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of 80 parts of nano Porias of nanometer Rhizoma Dioscoreae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make nanometer six drugs containing rehmanniae membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back.
Claims (6)
1, a kind of nanometer Liuwei Dihuang preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Corni 60-100 part nanometer Radix Rehmanniae Preparata 100-220 part nanometer Cortex Moutan 40-80 part
Nanometer Rhizoma Dioscoreae 60-100 part nano Poria 40-80 part nanometer Rhizoma Alismatis 40-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer Liuwei Dihuang preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Corni 70-90 part nanometer Radix Rehmanniae Preparata 130-190 part nanometer Cortex Moutan 50-70 part
Nanometer Rhizoma Dioscoreae 70-90 part nano Poria 50-70 part nanometer Rhizoma Alismatis 50-70 part
3, nanometer Liuwei Dihuang preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 160 parts of nanometer Cortex Moutans of 80 parts of nanometer Radix Rehmanniae Preparata of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of 80 parts of nano Porias of nanometer Rhizoma Dioscoreae
4, according to claim 1 or 2 or 3 described nanometer Liuwei Dihuang preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer Liuwei Dihuang preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100333 CN1362178A (en) | 2001-01-02 | 2001-01-02 | Nano rehmannia medicine with six ingredients and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100333 CN1362178A (en) | 2001-01-02 | 2001-01-02 | Nano rehmannia medicine with six ingredients and its preparation |
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| CN1362178A true CN1362178A (en) | 2002-08-07 |
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| CN 01100333 Pending CN1362178A (en) | 2001-01-02 | 2001-01-02 | Nano rehmannia medicine with six ingredients and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430029A (en) * | 2011-11-25 | 2012-05-02 | 河南工业大学 | Nano microcapsule for six ingredients with rehmannia and preparation process thereof |
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2001
- 2001-01-02 CN CN 01100333 patent/CN1362178A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430029A (en) * | 2011-11-25 | 2012-05-02 | 河南工业大学 | Nano microcapsule for six ingredients with rehmannia and preparation process thereof |
| CN102430029B (en) * | 2011-11-25 | 2015-08-19 | 河南工业大学 | A kind of nano microcapsule for six ingredients with rehmannia and preparation technology thereof |
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