CN1362220A - Nano Anemarrhenae, phellodendri and Rehmanniae medicine and its preparation - Google Patents
Nano Anemarrhenae, phellodendri and Rehmanniae medicine and its preparation Download PDFInfo
- Publication number
- CN1362220A CN1362220A CN 01100719 CN01100719A CN1362220A CN 1362220 A CN1362220 A CN 1362220A CN 01100719 CN01100719 CN 01100719 CN 01100719 A CN01100719 A CN 01100719A CN 1362220 A CN1362220 A CN 1362220A
- Authority
- CN
- China
- Prior art keywords
- nano
- nanometer
- parts
- anemarrhenae
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The present invention discloses a nano Zhibai-dihuang preparation medicine. It is made up by uisng usig 8 Chinese medicinal materials of nano anemarrhena, nano cooked rehmannia, nano phellodendron, nano cornus, nano dioscorea and others as raw material through the processes of microwave extraction, reduced pressure concentration, and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biologicla utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of nourishing YIN to lower pathogenic fire, cure mainly the excess of YIN hyperactivity of fire and the nano Anemarrhenae cypress rehmannia preparation medicine of the hectic fever due to YIN-deficiency consumptive fever that causes, fidgets due to deficiency night sweat ache of the spinal column, seminal emission, the invention still further relates to the method for this medication preparation.
ZHIBAI DIHUANG WAN is a kind of classical Chinese patent medicine, mainly contains effects such as antibiotic, antiinflammatory, calmness, blood sugar lowering, blood pressure lowering, is used for the excess of YIN hyperactivity of fire and the hectic fever due to YIN-deficiency consumptive fever, fidgets due to deficiency night sweat ache of the spinal column, the seminal emission that cause.But traditional ZHIBAI DIHUANG WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Anemarrhenae cypress rehmannia preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Anemarrhenae cypress rehmannia preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Anemarrhenae 20-60 part nanometer Radix Rehmanniae Preparata 100-220 part nano phellodendron bark 20-60 part
Nanometer Fructus Corni 40-120 part nanometer Rhizoma Dioscoreae 40-120 part nanometer Cortex Moutan 30-90 part
Nano Poria 30-90 part nanometer Rhizoma Alismatis 30-90 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Anemarrhenae 30-50 part nanometer Radix Rehmanniae Preparata 130-190 part nano phellodendron bark 30-50 part
Nanometer Fructus Corni 60-100 part nanometer Rhizoma Dioscoreae 60-100 part nanometer Cortex Moutan 50-70 part
Nano Poria 50-70 part nanometer Rhizoma Alismatis 50-70 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 160 parts of nano phellodendron barks of 40 parts of nanometer Radix Rehmanniae Preparata of the nanometer Rhizoma Anemarrhenae
60 parts of 80 parts of nanometer Cortex Moutans of 80 parts of nanometer Rhizoma Dioscoreaes of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of nano Poria
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, learn cypress rehmannia preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Anemarrhenae cypress rehmannia preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common ZHIBAI DIHUANG WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano Anemarrhenae cypress rehmannia preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as acute retinal pigment epithelitis due to the hyperactivity of fire caused by deficiency of YIN, infertility, seminal emission, neurasthenia, diabetes, hypertension, hyperthyroidism, and clinical efficacy significantly is better than traditional ZHIBAI DIHUANG WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
40 parts of 160 parts of nano phellodendron barks of 40 parts of nanometer Radix Rehmanniae Preparata of the nanometer Rhizoma Anemarrhenae
60 parts of 80 parts of nanometer Cortex Moutans of 80 parts of nanometer Rhizoma Dioscoreaes of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of nano Poria
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts of 160 parts of nano phellodendron barks of 40 parts of nanometer Radix Rehmanniae Preparata of the nanometer Rhizoma Anemarrhenae
60 parts of 80 parts of nanometer Cortex Moutans of 80 parts of nanometer Rhizoma Dioscoreaes of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of nano Poria
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer ZHIBAIDIHUANG powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts of 160 parts of nano phellodendron barks of 40 parts of nanometer Radix Rehmanniae Preparata of the nanometer Rhizoma Anemarrhenae
60 parts of 80 parts of nanometer Cortex Moutans of 80 parts of nanometer Rhizoma Dioscoreaes of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of nano Poria
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer ZHIBAIDIHUANG membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano Anemarrhenae cypress rehmannia preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Anemarrhenae 20-60 part nanometer Radix Rehmanniae Preparata 100-220 part nano phellodendron bark 20-60 part
Nanometer Fructus Corni 40-120 part nanometer Rhizoma Dioscoreae 40-120 part nanometer Cortex Moutan 30-90 part
Nano Poria 30-90 part nanometer Rhizoma Alismatis 30-90 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Anemarrhenae cypress rehmannia preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Anemarrhenae 30-50 part nanometer Radix Rehmanniae Preparata 130-190 part nano phellodendron bark 30-50 part
Nanometer Fructus Corni 60-100 part nanometer Rhizoma Dioscoreae 60-100 part nanometer Cortex Moutan 50-70 part
Nano Poria 50-70 part nanometer Rhizoma Alismatis 50-70 part
3, nano Anemarrhenae cypress rehmannia preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts of 160 parts of nano phellodendron barks of 40 parts of nanometer Radix Rehmanniae Preparata of the nanometer Rhizoma Anemarrhenae
60 parts of 80 parts of nanometer Cortex Moutans of 80 parts of nanometer Rhizoma Dioscoreaes of nanometer Fructus Corni
60 parts of 60 parts of nanometer Rhizoma Alismatis of nano Poria
4, according to claim 1 or 2 or 3 described nano Anemarrhenae cypress rehmannia preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Anemarrhenae cypress rehmannia preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, make it do the change in polarity motion with hundred million times/second speed of 20--30, the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour: above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100719 CN1362220A (en) | 2001-01-08 | 2001-01-08 | Nano Anemarrhenae, phellodendri and Rehmanniae medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100719 CN1362220A (en) | 2001-01-08 | 2001-01-08 | Nano Anemarrhenae, phellodendri and Rehmanniae medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362220A true CN1362220A (en) | 2002-08-07 |
Family
ID=4651826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100719 Pending CN1362220A (en) | 2001-01-08 | 2001-01-08 | Nano Anemarrhenae, phellodendri and Rehmanniae medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362220A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148212A (en) * | 2015-10-28 | 2015-12-16 | 蒋玉群 | Traditional Chinese medicine composition for treating diabetes and hypertension combined disease |
-
2001
- 2001-01-08 CN CN 01100719 patent/CN1362220A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148212A (en) * | 2015-10-28 | 2015-12-16 | 蒋玉群 | Traditional Chinese medicine composition for treating diabetes and hypertension combined disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1362183A (en) | Nano Lycii-chrysanthemia-rhemanniae medicine and its preparation | |
| CN1366915A (en) | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method | |
| CN1362220A (en) | Nano Anemarrhenae, phellodendri and Rehmanniae medicine and its preparation | |
| CN1366966A (en) | Nano pinellia preparation medicine and preparation method | |
| CN1362081A (en) | Nano tranquilizing cinnabar medicine and its preparation | |
| CN1362184A (en) | Nano tonic ginsneg medicine and its preparation | |
| CN1362232A (en) | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation | |
| CN1362246A (en) | Nano Bupleuric medicine for regulating Shaoyang and it spreparation | |
| CN1362248A (en) | Nano stomach-calming medicine of Aucklandiae and Amomi and its preparation | |
| CN1362178A (en) | Nano rehmannia medicine with six ingredients and its preparation | |
| CN1362229A (en) | Nano Maiwei Rehmannine Praeparatae medicine and its preparation | |
| CN1362247A (en) | Nano stomach-nourishing medicine of Aucklandiae and Amino and its preparation | |
| CN1362179A (en) | Nano eight-ingredient medicine and its preparation | |
| CN1364514A (en) | Nano eight ingredient motherwort medicine and its preparing method | |
| CN1362182A (en) | Nano spleen-invigorating medicine and its preparation | |
| CN1362146A (en) | Nano Qingkailing medicine and its preparation | |
| CN1362128A (en) | Nano tranquilizing and brain nourishing medicine and its preparation | |
| CN1362223A (en) | Nano Xinmaitong medicine and its preparation | |
| CN1362222A (en) | Nanometer blood-nourishing and transquilizing medicine and its preparation | |
| CN1368078A (en) | Nano medicine 'Qingshengjianfei' and its preparing process | |
| CN1365680A (en) | Nano medicine 'Suzi Jingqi' and its preparing process | |
| CN1362195A (en) | Nano Jinkuishenqi medicine for invigorating kidney essence and its preparation | |
| CN1364525A (en) | Nano body strengthening and brain invigorating medicine and its preparing method | |
| CN1368324A (en) | Nano medicine 'Zhike' for relieving cough and its preparing process | |
| CN1362157A (en) | Nano Sanjiuweitai medicine and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |