CN1364525A - Nano body strengthening and brain invigorating medicine and its preparing method - Google Patents
Nano body strengthening and brain invigorating medicine and its preparing method Download PDFInfo
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- CN1364525A CN1364525A CN 01100685 CN01100685A CN1364525A CN 1364525 A CN1364525 A CN 1364525A CN 01100685 CN01100685 CN 01100685 CN 01100685 A CN01100685 A CN 01100685A CN 1364525 A CN1364525 A CN 1364525A
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Abstract
The nano body strengthening and brain invigorating medicine is prepared with nano ginseng, nano pilose antler, nano arboruitae seed, nano Chinese angelica, nano Radix Paeoniae Alba and other nine kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The nano body strengthening and brain invigorating medicine of the present invention relates to a kind of calmness, calming the nerves the invention still further relates to the method for this medication preparation.
Keeping fit the brain-strengthening sheet is a kind of classical Chinese patent medicine, and effect such as mainly contain calmness, calm the nerves is used for neurasthenia, insomnia forgetfulness, Light-headedness, susceptible fatigue, malnutrition, physical weakness.But traditional to keep fit the disintegrate of brain-strengthening sheet slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano body strengthening and brain invigorating medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano body strengthening and brain invigorating medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ginseng 6-14 part nano-antler 1-5 part nanometer Semen Platycladi 40-120 part
Nano Chinese angelica 40-120 part nanometer Radix Paeoniae Alba 40-120 part nanometer Fructus Schisandrae Chinensis 140-340 part
Nano Poria 20-60 part nanometer Radix Glycyrrhizae 10-30 part nanometer Herba Cistanches 20-60 part
Nanometer Radix Rehmanniae 40-120 part nanometer Rhizoma Chuanxiong 10-30 part nm acid Semen Ziziphi Spinosae 140-340 part
Nanometer Radix Rehmanniae Preparata 40-120 part nanometer Medulla sus domestica extract 10-25 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ginseng 8-12 part nano-antler 2-4 part nanometer Semen Platycladi 60-100 part
Nano Chinese angelica 60-100 part nanometer Radix Paeoniae Alba 60-100 part nanometer Fructus Schisandrae Chinensis 190-290 part
Nano Poria 30-50 part nanometer Radix Glycyrrhizae 15-25 part nanometer Herba Cistanches 30-50 part
Nanometer Radix Rehmanniae 60-100 part nanometer Rhizoma Chuanxiong 15-25 part nm acid Semen Ziziphi Spinosae 190-290 part
Nanometer Radix Rehmanniae Preparata 60-100 part nanometer Medulla sus domestica extract 13-21 part
The optimum weight proportioning of medicine of the present invention is:
80 parts of 3 parts of nanometer Semen Platycladi of 10 parts of nano-antlers of nano ginseng
240 parts of 80 parts of nanometer Fructus Schisandrae Chinensis of 80 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
40 parts of 20 parts of nanometer Herba Cistanches of 40 parts of nanometer Radix Glycyrrhizaes of nano Poria
240 parts of 20 parts of nm acid Semen Ziziphi Spinosaes of 80 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Rehmanniae
17 parts of 80 parts of nanometer Medulla sus domestica extract of nanometer Radix Rehmanniae Preparata
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the body strengthening and brain invigorating nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano body strengthening and brain invigorating medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the common brain-strengthening tablet preparation material of keeping fit is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano body strengthening and brain invigorating medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as neurasthenia, insomnia forgetfulness, Light-headedness, susceptible fatigue, malnutrition, physical weakness, and clinical efficacy significantly is better than traditional brain-strengthening sheet of keeping fit.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
80 parts of 3 parts of nanometer Semen Platycladi of 10 parts of nano-antlers of nano ginseng
240 parts of 80 parts of nanometer Fructus Schisandrae Chinensis of 80 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
40 parts of 20 parts of nanometer Herba Cistanches of 40 parts of nanometer Radix Glycyrrhizaes of nano Poria
240 parts of 20 parts of nm acid Semen Ziziphi Spinosaes of 80 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Rehmanniae
17 parts of 80 parts of nanometer Medulla sus domestica extract of nanometer Radix Rehmanniae Preparata
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
80 parts of 3 parts of nanometer Semen Platycladi of 10 parts of nano-antlers of nano ginseng
240 parts of 80 parts of nanometer Fructus Schisandrae Chinensis of 80 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
40 parts of 20 parts of nanometer Herba Cistanches of 40 parts of nanometer Radix Glycyrrhizaes of nano Poria
240 parts of 20 parts of nm acid Semen Ziziphi Spinosaes of 80 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Rehmanniae
17 parts of 80 parts of nanometer Medulla sus domestica extract of nanometer Radix Rehmanniae Preparata
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano body strengthening brain-strengthening powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
80 parts of 3 parts of nanometer Semen Platycladi of 10 parts of nano-antlers of nano ginseng
240 parts of 80 parts of nanometer Fructus Schisandrae Chinensis of 80 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
40 parts of 20 parts of nanometer Herba Cistanches of 40 parts of nanometer Radix Glycyrrhizaes of nano Poria
240 parts of 20 parts of nm acid Semen Ziziphi Spinosaes of 80 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Rehmanniae
17 parts of 80 parts of nanometer Medulla sus domestica extract of nanometer Radix Rehmanniae Preparata
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano body strengthening brain-strengthening membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano body strengthening and brain invigorating medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ginseng 6-14 part nano-antler 1-5 part nanometer Semen Platycladi 40-120 part
Nano Chinese angelica 40-120 part nanometer Radix Paeoniae Alba 40-120 part nanometer Fructus Schisandrae Chinensis 140-340 part
Nano Poria 20-60 part nanometer Radix Glycyrrhizae 10-30 part nanometer Herba Cistanches 20-60 part
Nanometer Radix Rehmanniae 40-120 part nanometer Rhizoma Chuanxiong 10-30 part nm acid Semen Ziziphi Spinosae 140-340 part
Nanometer Radix Rehmanniae Preparata 40-120 part nanometer Medulla sus domestica extract 10-25 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano body strengthening and brain invigorating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ginseng 8-12 part nano-antler 2-4 part nanometer Semen Platycladi 60-100 part
Nano Chinese angelica 60-100 part nanometer Radix Paeoniae Alba 60-100 part nanometer Fructus Schisandrae Chinensis 190-290 part
Nano Poria 30-50 part nanometer Radix Glycyrrhizae 15-25 part nanometer Herba Cistanches 30-50 part
Nanometer Radix Rehmanniae 60-100 part nanometer Rhizoma Chuanxiong 15-25 part nm acid Semen Ziziphi Spinosae 190-290 part
Nanometer Radix Rehmanniae Preparata 60-100 part nanometer Medulla sus domestica extract 13-21 part
3, nano body strengthening and brain invigorating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
80 parts of 3 parts of nanometer Semen Platycladi of 10 parts of nano-antlers of nano ginseng
240 parts of 80 parts of nanometer Fructus Schisandrae Chinensis of 80 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
40 parts of 20 parts of nanometer Herba Cistanches of 40 parts of nanometer Radix Glycyrrhizaes of nano Poria
240 parts of 20 parts of nm acid Semen Ziziphi Spinosaes of 80 parts of nanometer Rhizoma Chuanxiongs of nanometer Radix Rehmanniae
17 parts of 80 parts of nanometer Medulla sus domestica extract of nanometer Radix Rehmanniae Preparata
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano body strengthening and brain invigorating medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano body strengthening and brain invigorating medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100685 CN1364525A (en) | 2001-01-17 | 2001-01-17 | Nano body strengthening and brain invigorating medicine and its preparing method |
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| CN 01100685 CN1364525A (en) | 2001-01-17 | 2001-01-17 | Nano body strengthening and brain invigorating medicine and its preparing method |
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| CN1364525A true CN1364525A (en) | 2002-08-21 |
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| CN 01100685 Pending CN1364525A (en) | 2001-01-17 | 2001-01-17 | Nano body strengthening and brain invigorating medicine and its preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178778A (en) * | 2011-04-21 | 2011-09-14 | 通化斯威药业股份有限公司 | Medicament for treating neurasthenia and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178778A (en) * | 2011-04-21 | 2011-09-14 | 通化斯威药业股份有限公司 | Medicament for treating neurasthenia and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |