CN1366895A - Nano supplement both qi and blood preparation medicine and preparation method thereof - Google Patents
Nano supplement both qi and blood preparation medicine and preparation method thereof Download PDFInfo
- Publication number
- CN1366895A CN1366895A CN 01102034 CN01102034A CN1366895A CN 1366895 A CN1366895 A CN 1366895A CN 01102034 CN01102034 CN 01102034 CN 01102034 A CN01102034 A CN 01102034A CN 1366895 A CN1366895 A CN 1366895A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- chinese
- nanometer radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The present invention discloses a nano supplement both qi and blood preparation medicine. It is made up by using 11 Chinese medicinal materials of nano astragalus, nano tangkuei, nano cooked rehmannia, nano flowery knotweed, nano codonopsis and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of nanometer qi and blood tonifying preparation medicine of benefiting qi and nourishing blood, the invention still further relates to the method for this medication preparation.
The qi and blood tonifying ball is a kind of classical Chinese patent medicine, mainly contains effects such as benefiting qi and nourishing blood, is used for that deficiency of QI with disinclination to talk, language that Qi and blood deficiency causes are humble, shallow complexion, myasthenia of limbs, emaciated physique, irregular menstruation.But traditional qi and blood tonifying ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer qi and blood tonifying preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer qi and blood tonifying preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano astragalus 120-300 nano Chinese angelica 120-300 part nanometer Radix Rehmanniae Preparata 120-300 part
Nanometer Radix Polygoni Multiflori 60-150 part nanometer Radix Codonopsis 60-150 part nanometer Fructus Ligustri Lucidi 35-70 part
Nanometer Radix Paeoniae Alba 60-150 part nanometer Rhizoma Chuanxiong 35-80 part nano red sage 35-80 part
Nanometer Rhizoma Atractylodis Macrocephalae 60-150 part nanometer Radix Glycyrrhizae 35-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano astragalus 160-240 nano Chinese angelica 160-240 part nanometer Radix Rehmanniae Preparata 160-240 part
Nanometer Radix Polygoni Multiflori 80-120 part nanometer Radix Codonopsis 80-120 part nanometer Fructus Ligustri Lucidi 40-60 part
Nanometer Radix Paeoniae Alba 80-120 part nanometer Rhizoma Chuanxiong 40-60 part nano red sage 40-60 part
Nanometer Rhizoma Atractylodis Macrocephalae 80-120 part nanometer Radix Glycyrrhizae 40-60 part
The optimum weight proportioning of medicine of the present invention is:
200 parts of 200 parts of nanometer Radix Rehmanniae Preparata of 200 parts of nano Chinese angelicas of nano astragalus
50 parts of 100 parts of nanometer Fructus Ligustri Lucidi of 100 parts of nanometer Radix Codonopsis of nanometer Radix Polygoni Multiflori
50 parts of 50 parts of nano red sages of 100 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of the nanometer Rhizoma Atractylodis Macrocephalae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get qi and blood tonifying preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer qi and blood tonifying preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common qi and blood tonifying pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer qi and blood tonifying preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as deficiency of QI with disinclination to talk, language that Qi and blood deficiency causes are humble, shallow complexion, myasthenia of limbs, emaciated physique, irregular menstruation, and clinical efficacy significantly is better than traditional qi and blood tonifying ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
200 parts of 200 parts of nanometer Radix Rehmanniae Preparata of 200 parts of nano Chinese angelicas of nano astragalus
50 parts of 100 parts of nanometer Fructus Ligustri Lucidi of 100 parts of nanometer Radix Codonopsis of nanometer Radix Polygoni Multiflori
50 parts of 50 parts of nano red sages of 100 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of the nanometer Rhizoma Atractylodis Macrocephalae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
200 parts of 200 parts of nanometer Radix Rehmanniae Preparata of 200 parts of nano Chinese angelicas of nano astragalus
50 parts of 100 parts of nanometer Fructus Ligustri Lucidi of 100 parts of nanometer Radix Codonopsis of nanometer Radix Polygoni Multiflori
50 parts of 50 parts of nano red sages of 100 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of the nanometer Rhizoma Atractylodis Macrocephalae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer qi and blood tonifying powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
200 parts of 200 parts of nanometer Radix Rehmanniae Preparata of 200 parts of nano Chinese angelicas of nano astragalus
50 parts of 100 parts of nanometer Fructus Ligustri Lucidi of 100 parts of nanometer Radix Codonopsis of nanometer Radix Polygoni Multiflori
50 parts of 50 parts of nano red sages of 100 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of the nanometer Rhizoma Atractylodis Macrocephalae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer qi and blood tonifying membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer qi and blood tonifying preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano astragalus 120-300 nano Chinese angelica 120-300 part nanometer Radix Rehmanniae Preparata 120-300 part
Nanometer Radix Polygoni Multiflori 60-150 part nanometer Radix Codonopsis 60-150 part nanometer Fructus Ligustri Lucidi 35-70 part
Nanometer Radix Paeoniae Alba 60-150 part nanometer Rhizoma Chuanxiong 35-80 part nano red sage 35-80 part
Nanometer Rhizoma Atractylodis Macrocephalae 60-150 part nanometer Radix Glycyrrhizae 35-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer qi and blood tonifying preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano astragalus 160-240 nano Chinese angelica 160-240 part nanometer Radix Rehmanniae Preparata 160-240 part
Nanometer Radix Polygoni Multiflori 80-120 part nanometer Radix Codonopsis 80-120 part nanometer Fructus Ligustri Lucidi 40-60 part
Nanometer Radix Paeoniae Alba 80-120 part nanometer Rhizoma Chuanxiong 40-60 part nano red sage 40-60 part
Nanometer Rhizoma Atractylodis Macrocephalae 80-120 part nanometer Radix Glycyrrhizae 40-60 part
3, nanometer qi and blood tonifying preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
200 parts of 200 parts of nanometer Radix Rehmanniae Preparata of 200 parts of nano Chinese angelicas of nano astragalus
50 parts of 100 parts of nanometer Fructus Ligustri Lucidi of 100 parts of nanometer Radix Codonopsis of nanometer Radix Polygoni Multiflori
50 parts of 50 parts of nano red sages of 100 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of the nanometer Rhizoma Atractylodis Macrocephalae
4, according to claim 1 or 2 or 3 described nanometer qi and blood tonifying preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer qi and blood tonifying preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102034 CN1366895A (en) | 2001-01-22 | 2001-01-22 | Nano supplement both qi and blood preparation medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102034 CN1366895A (en) | 2001-01-22 | 2001-01-22 | Nano supplement both qi and blood preparation medicine and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1366895A true CN1366895A (en) | 2002-09-04 |
Family
ID=4652405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102034 Pending CN1366895A (en) | 2001-01-22 | 2001-01-22 | Nano supplement both qi and blood preparation medicine and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1366895A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512534A (en) * | 2012-01-01 | 2012-06-27 | 徐究竟 | Chinese patent drug for preventing post-telegenesis ectopic pregnancy and preparation process thereof |
| CN104873635A (en) * | 2015-06-19 | 2015-09-02 | 承德御室金丹药业有限公司 | Pill for tonifying both qi and blood as well as preparation method and application of pill |
| CN114306469A (en) * | 2022-01-17 | 2022-04-12 | 杭州师范大学 | Traditional Chinese medicine compound composition for improving sub-health |
-
2001
- 2001-01-22 CN CN 01102034 patent/CN1366895A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512534A (en) * | 2012-01-01 | 2012-06-27 | 徐究竟 | Chinese patent drug for preventing post-telegenesis ectopic pregnancy and preparation process thereof |
| CN104873635A (en) * | 2015-06-19 | 2015-09-02 | 承德御室金丹药业有限公司 | Pill for tonifying both qi and blood as well as preparation method and application of pill |
| CN114306469A (en) * | 2022-01-17 | 2022-04-12 | 杭州师范大学 | Traditional Chinese medicine compound composition for improving sub-health |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1368064A (en) | Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process | |
| CN1368239A (en) | Nano medicine 'Anshenyangxin' and its preparing process | |
| CN1366953A (en) | Nano midday tea preparation medicine and preparation method | |
| CN1362184A (en) | Nano tonic ginsneg medicine and its preparation | |
| CN1368311A (en) | Nano medicine 'Tianma Yuanyunning' and its preparing process | |
| CN1362247A (en) | Nano stomach-nourishing medicine of Aucklandiae and Amino and its preparation | |
| CN1368274A (en) | Nano medicine 'Zhibao Lingzhi' and its preparing process | |
| CN1368184A (en) | Nano medicine 'Shujin Huoluo' and its preparing process | |
| CN1362179A (en) | Nano eight-ingredient medicine and its preparation | |
| CN1368116A (en) | Nano medicine 'Yangxin Dingji' and its preparing process | |
| CN1365717A (en) | Nano medicine 'Jianer Xiaoshi' and its preparing process | |
| CN1368078A (en) | Nano medicine 'Qingshengjianfei' and its preparing process | |
| CN1368356A (en) | Nano medicine 'Tianjingbushen' and its preparing process | |
| CN1368339A (en) | Nano emdicine 'Wubishan' and its preparing process | |
| CN1368241A (en) | Nano medicine 'Tiaojing Zhongzi' and its preparing process | |
| CN1368280A (en) | Nano medicine 'Zhuangyao Jiansheng' and its preparing process | |
| CN1364602A (en) | Nano powerful tonic medicine and its preparing method | |
| CN1368195A (en) | Nano medicine 'Buxuedanggui' and its preparing process | |
| CN1364525A (en) | Nano body strengthening and brain invigorating medicine and its preparing method | |
| CN1365777A (en) | Nano medicine 'Qipi' and its preparing process | |
| CN1366959A (en) | Nano Tiaojing Cuyun preparation medicine and preparation method | |
| CN1362195A (en) | Nano Jinkuishenqi medicine for invigorating kidney essence and its preparation | |
| CN1360917A (en) | Nanoemter alopecia treating medicine and its prepn | |
| CN1364599A (en) | Nano blood tonifying medicine and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Yang Mengjun Document name: Notification before expiration of term |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |