CN1360917A - Nanoemter alopecia treating medicine and its prepn - Google Patents
Nanoemter alopecia treating medicine and its prepn Download PDFInfo
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- CN1360917A CN1360917A CN 00136679 CN00136679A CN1360917A CN 1360917 A CN1360917 A CN 1360917A CN 00136679 CN00136679 CN 00136679 CN 00136679 A CN00136679 A CN 00136679A CN 1360917 A CN1360917 A CN 1360917A
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Abstract
The nano alopecia treating medicine is prepared with nano rehmannia root, nano prepared remannia rhizome, nano Radix Polygoni Multiflori, nano Chinese angelica, nano red sage and other four kinds of nano Chinese medicinal materials in certain proportion as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to the nanometer alopecia areata preparation medicine of a kind of nourishing the liver and kidney, beneficial intensive culture blood, the hair growth promoting of dispeling the wind, the invention still further relates to the method for this medication preparation.
Alopecia Pill is a kind of classical Chinese patent medicine, mainly contains effects such as nourishing the liver and kidney, beneficial intensive culture blood, the hair growth promoting of dispeling the wind, and is used for alopecia areata, alopecia totalis, alopecia universalis.But traditional Alopecia Pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer alopecia areata preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer alopecia areata preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Rehmanniae 41-106 part nanometer Radix Rehmanniae Preparata 41-106 part nanometer Radix Polygoni Multiflori Preparata 41-106 part
Nano Chinese angelica 27-70 part nano red sage 27-70 part nanometer Radix Paeoniae Alba 27-70 part
Nanometer Fructus Schisandrae Chinensis 27-70 part nanometer Rhizoma Et Radix Notopterygii 14-36 part nanometer Fructus Chaenomelis 14-36 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Rehmanniae 59-88 part nanometer Radix Rehmanniae Preparata 59-88 part nanometer Radix Polygoni Multiflori Preparata 59-88 part
Nano Chinese angelica 39-58 part nano red sage 39-58 part nanometer Radix Paeoniae Alba 39-58 part
Nanometer Fructus Schisandrae Chinensis 39-58 part nanometer Rhizoma Et Radix Notopterygii 20-30 part nanometer Fructus Chaenomelis 20-30 part
The best important proportioning of medicine of the present invention is:
74 parts of 74 parts of nanometer Radix Polygoni Multiflori Preparatas of 74 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Rehmanniae
49 parts of 49 parts of nanometer Radix Paeoniae Albas of 49 parts of nano red sages of nano Chinese angelica
25 parts of 25 parts of nanometer Fructus Chaenomeliss of 49 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Fructus Schisandrae Chinensis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the special construction of nano material--------material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get alopecia areata preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer alopecia areata preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common Alopecia Pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, traditional Alopecia Pill disintegrate is slow, absorption is incomplete, bioavailability is not high, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer alopecia areata preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as alopecia areata, alopecia totalis, alopecia universalis, and clinical efficacy significantly is better than traditional Alopecia Pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
74 parts of 74 parts of nanometer Radix Polygoni Multiflori Preparatas of 74 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Rehmanniae
49 parts of 49 parts of nanometer Radix Paeoniae Albas of 49 parts of nano red sages of nano Chinese angelica
25 parts of 25 parts of nanometer Fructus Chaenomeliss of 49 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Fructus Schisandrae Chinensis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
74 parts of 74 parts of nanometer Radix Polygoni Multiflori Preparatas of 74 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Rehmanniae
49 parts of 49 parts of nanometer Radix Paeoniae Albas of 49 parts of nano red sages of nano Chinese angelica
25 parts of 25 parts of nanometer Fructus Chaenomeliss of 49 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Fructus Schisandrae Chinensis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer alopecia areata powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
74 parts of 74 parts of nanometer Radix Polygoni Multiflori Preparatas of 74 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Rehmanniae
49 parts of 49 parts of nanometer Radix Paeoniae Albas of 49 parts of nano red sages of nano Chinese angelica
25 parts of 25 parts of nanometer Fructus Chaenomeliss of 49 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Fructus Schisandrae Chinensis
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer alopecia areata membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, and paste the medicine position: back, chest, cervical region etc. are located.
Claims (6)
1, a kind of nanometer alopecia areata preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Rehmanniae 41-106 part nanometer Radix Rehmanniae Preparata 41-106 part nanometer Radix Polygoni Multiflori Preparata 41-106 part
Nano Chinese angelica 27-70 part nano red sage 27-70 part nanometer Radix Paeoniae Alba 27-70 part
Nanometer Fructus Schisandrae Chinensis 27-70 part nanometer Rhizoma Et Radix Notopterygii 14-36 part nanometer Fructus Chaenomelis 14-36 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05 surging, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer alopecia areata preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Rehmanniae 59-88 part nanometer Radix Rehmanniae Preparata 59-88 part nanometer Radix Polygoni Multiflori Preparata 59-88 part
Nano Chinese angelica 39-58 part nano red sage 39-58 part nanometer Radix Paeoniae Alba 39-58 part
Nanometer Fructus Schisandrae Chinensis 39-58 part nanometer Rhizoma Et Radix Notopterygii 20-30 part nanometer Fructus Chaenomelis 20-30 part
3, nanometer alopecia areata preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
74 parts of 74 parts of nanometer Radix Polygoni Multiflori Preparatas of 74 parts of nanometer Radix Rehmanniae Preparata of nanometer Radix Rehmanniae
49 parts of 49 parts of nanometer Radix Paeoniae Albas of 49 parts of nano red sages of nano Chinese angelica
25 parts of 25 parts of nanometer Fructus Chaenomeliss of 49 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Fructus Schisandrae Chinensis
4, according to claim 1 or 2 or 3 described nanometer alopecia areata preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer alopecia areata preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05Mpa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136679 CN1360917A (en) | 2000-12-29 | 2000-12-29 | Nanoemter alopecia treating medicine and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136679 CN1360917A (en) | 2000-12-29 | 2000-12-29 | Nanoemter alopecia treating medicine and its prepn |
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| Publication Number | Publication Date |
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| CN1360917A true CN1360917A (en) | 2002-07-31 |
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| CN 00136679 Pending CN1360917A (en) | 2000-12-29 | 2000-12-29 | Nanoemter alopecia treating medicine and its prepn |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100333748C (en) * | 2005-02-23 | 2007-08-29 | 广州固志医药科技开发有限公司 | Chinese medicine composition for treating baldness and its preparing method |
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2000
- 2000-12-29 CN CN 00136679 patent/CN1360917A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100333748C (en) * | 2005-02-23 | 2007-08-29 | 广州固志医药科技开发有限公司 | Chinese medicine composition for treating baldness and its preparing method |
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