CN1368274A - Nano medicine 'Zhibao Lingzhi' and its preparing process - Google Patents
Nano medicine 'Zhibao Lingzhi' and its preparing process Download PDFInfo
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- CN1368274A CN1368274A CN 01102628 CN01102628A CN1368274A CN 1368274 A CN1368274 A CN 1368274A CN 01102628 CN01102628 CN 01102628 CN 01102628 A CN01102628 A CN 01102628A CN 1368274 A CN1368274 A CN 1368274A
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Abstract
A nanometre (0.1-200 nm) medicine "Zhibao lingzhi" is prepared from the nanometre powders of 13 Chinese medicinal materials including ganoderma, ginseng, tangerine peel, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of benefiting qi and nourishing blood, the nano medicine ' Zhibao Lingzhi ' of the cough-relieving of calming the nerves, the invention still further relates to the method for this medication preparation.
The most valuable treasure Lucid Ganoderma wine is a kind of classical Chinese patent medicine, mainly contains benefiting qi and nourishing blood, effect such as the cough-relieving of calming the nerves, be used for deficiency of both QI and blood, pale or sallow complexion, the cough with asthma of breathing hard has expectorant, extremity asthenia, inappetence, severe palpitation, have a dizzy spell, weak after being ill.But traditional most valuable treasure Lucid Ganoderma wine disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Zhibao Lingzhi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Zhibao Lingzhi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ganoderma 80-180 part nano ginseng 40-80 part nanometer Rhizoma Atractylodis Macrocephalae 70-150 part
Nano Poria 70-150 part nanometer Cortex Cinnamomi 40-80 part nanometer Pericarpium Citri Reticulatae 20-45 part
Nano Chinese angelica 70-150 part nanometer Radix Paeoniae Alba 70-150 part nanometer Radix Rehmanniae Preparata 100-200 part
Nano astragalus 100-200 part nanometer Fructus Schisandrae Chinensis 20-45 part nanometer Radix Polygalae 20-45 part
Nanometer Radix Glycyrrhizae 20-45 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ganoderma 100-150 part nano ginseng 50-70 part nanometer Rhizoma Atractylodis Macrocephalae 80-120 part
Nano Poria 80-120 part nanometer Cortex Cinnamomi 50-70 part nanometer Pericarpium Citri Reticulatae 25-35 part
Nano Chinese angelica 80-120 part nanometer Radix Paeoniae Alba 80-120 part nanometer Radix Rehmanniae Preparata 120-180 part
Nano astragalus 120-180 part nanometer Fructus Schisandrae Chinensis 24-35 part nanometer Radix Polygalae 25-35 part
Nanometer Radix Glycyrrhizae 25-35 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 120 parts of nano ginsengs of nano ganoderma
30 parts of 60 parts of nanometer Pericarpium Citri Reticulataes of 100 parts of nanometer Cortex Cinnamomis of nano Poria
150 parts of 100 parts of nanometer Radix Rehmanniae Preparata of 100 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
30 parts of 30 parts of nanometer Radix Polygalaes of 150 parts of nanometer Fructus Schisandrae Chinensis of nano astragalus
30 parts in nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get most valuable treasure Ganoderma preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Zhibao Lingzhi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common most valuable treasure Lucid Ganoderma wine preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, syrup, oral solution of nano medicine ' Zhibao Lingzhi ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for deficiency of both QI and blood, pale or sallow complexion, the cough with asthma of breathing hard has expectorant, extremity asthenia, inappetence, severe palpitation, have a dizzy spell, the treatment of disease such as weakness after being ill, clinical efficacy significantly is better than traditional most valuable treasure Lucid Ganoderma wine.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 120 parts of nano ginsengs of nano ganoderma
30 parts of 60 parts of nanometer Pericarpium Citri Reticulataes of 100 parts of nanometer Cortex Cinnamomis of nano Poria
150 parts of 100 parts of nanometer Radix Rehmanniae Preparata of 100 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
30 parts of 30 parts of nanometer Radix Polygalaes of 150 parts of nanometer Fructus Schisandrae Chinensis of nano astragalus
30 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 120 parts of nano ginsengs of nano ganoderma
30 parts of 60 parts of nanometer Pericarpium Citri Reticulataes of 100 parts of nanometer Cortex Cinnamomis of nano Poria
150 parts of 100 parts of nanometer Radix Rehmanniae Preparata of 100 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
30 parts of 30 parts of nanometer Radix Polygalaes of 150 parts of nanometer Fructus Schisandrae Chinensis of nano astragalus
30 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer most valuable treasure Ganoderma membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Zhibao Lingzhi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ganoderma 80-180 part nano ginseng 40-80 part nanometer Rhizoma Atractylodis Macrocephalae 70-150 part
Nano Poria 70-150 part nanometer Cortex Cinnamomi 40-80 part nanometer Pericarpium Citri Reticulatae 20-45 part
Nano Chinese angelica 70-150 part nanometer Radix Paeoniae Alba 70-150 part nanometer Radix Rehmanniae Preparata 100-200 part
Nano astragalus 100-200 part nanometer Fructus Schisandrae Chinensis 20-45 part nanometer Radix Polygalae 20-45 part
Nanometer Radix Glycyrrhizae 20-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Zhibao Lingzhi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ganoderma 100-150 part nano ginseng 50-70 part nanometer Rhizoma Atractylodis Macrocephalae 80-120 part
Nano Poria 80-120 part nanometer Cortex Cinnamomi 50-70 part nanometer Pericarpium Citri Reticulatae 25-35 part
Nano Chinese angelica 80-120 part nanometer Radix Paeoniae Alba 80-120 part nanometer Radix Rehmanniae Preparata 120-180 part
Nano astragalus 120-180 part nanometer Fructus Schisandrae Chinensis 24-35 part nanometer Radix Polygalae 25-35 part
Nanometer Radix Glycyrrhizae 25-35 part
3, nano medicine ' Zhibao Lingzhi ' according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 60 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 120 parts of nano ginsengs of nano ganoderma
30 parts of 60 parts of nanometer Pericarpium Citri Reticulataes of 100 parts of nanometer Cortex Cinnamomis of nano Poria
150 parts of 100 parts of nanometer Radix Rehmanniae Preparata of 100 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
30 parts of 30 parts of nanometer Radix Polygalaes of 150 parts of nanometer Fructus Schisandrae Chinensis of nano astragalus
30 parts in nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Zhibao Lingzhi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Zhibao Lingzhi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102628 CN1368274A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Zhibao Lingzhi' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102628 CN1368274A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Zhibao Lingzhi' and its preparing process |
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| CN1368274A true CN1368274A (en) | 2002-09-11 |
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| CN 01102628 Pending CN1368274A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Zhibao Lingzhi' and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1320912C (en) * | 2005-04-10 | 2007-06-13 | 浙江康德药业集团有限公司 | Mind easing oral liquor with gen-seng and lily bulb |
| CN105214039A (en) * | 2015-10-09 | 2016-01-06 | 刘焰琼 | A kind of formula for the treatment of abundant expectoration |
-
2001
- 2001-02-06 CN CN 01102628 patent/CN1368274A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1320912C (en) * | 2005-04-10 | 2007-06-13 | 浙江康德药业集团有限公司 | Mind easing oral liquor with gen-seng and lily bulb |
| CN105214039A (en) * | 2015-10-09 | 2016-01-06 | 刘焰琼 | A kind of formula for the treatment of abundant expectoration |
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| WD01 | Invention patent application deemed withdrawn after publication |