CN1366921A - Nano Juhong preparation medicine and preparation method - Google Patents
Nano Juhong preparation medicine and preparation method Download PDFInfo
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- CN1366921A CN1366921A CN 01102061 CN01102061A CN1366921A CN 1366921 A CN1366921 A CN 1366921A CN 01102061 CN01102061 CN 01102061 CN 01102061 A CN01102061 A CN 01102061A CN 1366921 A CN1366921 A CN 1366921A
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Abstract
The present invention discloses a nano red tangerine peel preparation medicine. It is made up by using 15 Chinese medicinal materials of nano Huazhou pomelo rind, nano tangerine peel, nano pinellia, nano poria, nano licorice and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of lung heat clearing, reduce phlegm, the nano Juhong preparation medicine of cough-relieving, the invention still further relates to the method for this medication preparation.
Juhong Wan is a kind of classical Chinese patent medicine, mainly contains lung heat clearing, reduces phlegm, effect such as cough-relieving, is used for that cough with copious phlegm, expectorant are difficult for, xerostomia uncomfortable in chest.But traditional Juhong Wan disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Juhong preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Juhong preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The tangerine 40-120 part of nanorize nanometer Pericarpium Citri Reticulatae 30-80 part nano pinellia 25-60 part
Nano Poria 30-80 part nanometer Radix Glycyrrhizae 15-40 part nanometer Radix Platycodonis 25-60 part
Nanometer Semen Armeniacae Amarum 30-80 part nanometer Fructus Perillae 25-60 part nanometer Radix Asteris 25-60 part
Nanometer Flos Farfarae 15-40 part nanometer cortex trichosanthis 30-80 part nanometer Bulbus Fritillariae Thunbergii 30-80 part
Nanometer Radix Rehmanniae 35-80 part nanometer 35-80 Radix Ophiopogonis part nanometer Gypsum Fibrosum 35-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
The tangerine 50-100 part of nanorize nanometer Pericarpium Citri Reticulatae 40-60 part nano pinellia 30-50 part
Nano Poria 40-60 part nanometer Radix Glycyrrhizae 20-30 part nanometer Radix Platycodonis 30-50 part
Nanometer Semen Armeniacae Amarum 40-60 part nanometer Fructus Perillae 30-50 part nanometer Radix Asteris 30-50 part
Nanometer Flos Farfarae 20-30 part nanometer cortex trichosanthis 40-60 part nanometer Bulbus Fritillariae Thunbergii 40-60 part
Nanometer Radix Rehmanniae 40-60 part nanometer 40-60 Radix Ophiopogonis part nanometer Gypsum Fibrosum 40-60 part
The optimum weight proportioning of medicine of the present invention is:
37.5 parts of 50 parts of nano pinellias of the tangerine 75 parts of nanometer Pericarpium Citri Reticulataes of nanorize
37.5 parts of 25 parts of nanometer Radix Platycodoniss of 50 parts of nanometer Radix Glycyrrhizaes of nano Poria
37.5 parts of 37.5 parts of nanometer Radix Asteriss of 50 parts of nanometer Fructus Perillaes of nanometer Semen Armeniacae Amarum
50 parts of 50 parts of nanometer Bulbus Fritillariae Thunbergiis of 25 parts of nanometer cortex trichosanthis of nanometer Flos Farfarae
50 parts in 50 parts of nanometers of nanometer Radix Rehmanniae, 50 parts of nanometer Gypsum Fibrosum Radix Ophiopogonis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Juhong ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Juhong preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Juhong Wan preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Juhong preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as cough with copious phlegm, expectorant are difficult for, xerostomia uncomfortable in chest, and clinical efficacy significantly is better than traditional Juhong Wan.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
37.5 parts of 50 parts of nano pinellias of the tangerine 75 parts of nanometer Pericarpium Citri Reticulataes of nanorize
37.5 parts of 25 parts of nanometer Radix Platycodoniss of 50 parts of nanometer Radix Glycyrrhizaes of nano Poria
37.5 parts of 37.5 parts of nanometer Radix Asteriss of 50 parts of nanometer Fructus Perillaes of nanometer Semen Armeniacae Amarum
50 parts of 50 parts of nanometer Bulbus Fritillariae Thunbergiis of 25 parts of nanometer cortex trichosanthis of nanometer Flos Farfarae
50 parts in 50 parts of nanometers of nanometer Radix Rehmanniae, 50 parts of nanometer Gypsum Fibrosum Radix Ophiopogonis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
37.5 parts of 50 parts of nano pinellias of the tangerine 75 parts of nanometer Pericarpium Citri Reticulataes of nanorize
37.5 parts of 25 parts of nanometer Radix Platycodoniss of 50 parts of nanometer Radix Glycyrrhizaes of nano Poria
37.5 parts of 37.5 parts of nanometer Radix Asteriss of 50 parts of nanometer Fructus Perillaes of nanometer Semen Armeniacae Amarum
50 parts of 50 parts of nanometer Bulbus Fritillariae Thunbergiis of 25 parts of nanometer cortex trichosanthis of nanometer Flos Farfarae
50 parts in 50 parts of nanometers of nanometer Radix Rehmanniae, 50 parts of nanometer Gypsum Fibrosum Radix Ophiopogonis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Juhong powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
37.5 parts of 50 parts of nano pinellias of the tangerine 75 parts of nanometer Pericarpium Citri Reticulataes of nanorize
37.5 parts of 25 parts of nanometer Radix Platycodoniss of 50 parts of nanometer Radix Glycyrrhizaes of nano Poria
37.5 parts of 37.5 parts of nanometer Radix Asteriss of 50 parts of nanometer Fructus Perillaes of nanometer Semen Armeniacae Amarum
50 parts of 50 parts of nanometer Bulbus Fritillariae Thunbergiis of 25 parts of nanometer cortex trichosanthis of nanometer Flos Farfarae
50 parts in 50 parts of nanometers of nanometer Radix Rehmanniae, 50 parts of nanometer Gypsum Fibrosum Radix Ophiopogonis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Juhong membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano Juhong preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The tangerine 40-120 part of nanorize nanometer Pericarpium Citri Reticulatae 30-80 part nano pinellia 25-60 part
Nano Poria 30-80 part nanometer Radix Glycyrrhizae 15-40 part nanometer Radix Platycodonis 25-60 part
Nanometer Semen Armeniacae Amarum 30-80 part nanometer Fructus Perillae 25-60 part nanometer Radix Asteris 25-60 part
Nanometer Flos Farfarae 15-40 part nanometer cortex trichosanthis 30-80 part nanometer Bulbus Fritillariae Thunbergii 30-80 part
Nanometer Radix Rehmanniae 35-80 part nanometer 35-80 Radix Ophiopogonis part nanometer Gypsum Fibrosum 35-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Juhong preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
The tangerine 50-100 part of nanorize nanometer Pericarpium Citri Reticulatae 40-60 part nano pinellia 30-50 part
Nano Poria 40-60 part nanometer Radix Glycyrrhizae 20-30 part nanometer Radix Platycodonis 30-50 part
Nanometer Semen Armeniacae Amarum 40-60 part nanometer Fructus Perillae 30-50 part nanometer Radix Asteris 30-50 part
Nanometer Flos Farfarae 20-30 part nanometer cortex trichosanthis 40-60 part nanometer is Bulbus Fritillariae Uninbracteatae 40-60 part gradually
Nanometer Radix Rehmanniae 40-60 part nanometer 40-60 Radix Ophiopogonis part nanometer Gypsum Fibrosum 40-60 part
3, nano Juhong preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
37.5 parts of 50 parts of nano pinellias of the tangerine 75 parts of nanometer Pericarpium Citri Reticulataes of nanorize
37.5 parts of 25 parts of nanometer Radix Platycodoniss of 50 parts of nanometer Radix Glycyrrhizaes of nano Poria
37.5 parts of 37.5 parts of nanometer Radix Asteriss of 50 parts of nanometer Fructus Perillaes of nanometer Semen Armeniacae Amarum
50 parts of 50 parts of nanometer Bulbus Fritillariae Thunbergiis of 25 parts of nanometer cortex trichosanthis of nanometer Flos Farfarae
50 parts in 50 parts of nanometers of nanometer Radix Rehmanniae, 50 parts of nanometer Gypsum Fibrosum Radix Ophiopogonis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Juhong preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Juhong preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102061 CN1366921A (en) | 2001-01-22 | 2001-01-22 | Nano Juhong preparation medicine and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102061 CN1366921A (en) | 2001-01-22 | 2001-01-22 | Nano Juhong preparation medicine and preparation method |
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| CN1366921A true CN1366921A (en) | 2002-09-04 |
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| CN 01102061 Pending CN1366921A (en) | 2001-01-22 | 2001-01-22 | Nano Juhong preparation medicine and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100394964C (en) * | 2005-05-20 | 2008-06-18 | 太极集团重庆中药二厂 | Method for preparing epicarp citri pills concentrates |
| CN101011527B (en) * | 2007-02-01 | 2010-05-19 | 四川美大康药业股份有限公司 | Improved preparation of Juhong pill, its preparation method and quality inspection method |
| CN103656579A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for relieving cough |
-
2001
- 2001-01-22 CN CN 01102061 patent/CN1366921A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100394964C (en) * | 2005-05-20 | 2008-06-18 | 太极集团重庆中药二厂 | Method for preparing epicarp citri pills concentrates |
| CN101011527B (en) * | 2007-02-01 | 2010-05-19 | 四川美大康药业股份有限公司 | Improved preparation of Juhong pill, its preparation method and quality inspection method |
| CN103656579A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for relieving cough |
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