CN1366947A - Nano Fufang Qianzheng preparation medicine and preparation method - Google Patents
Nano Fufang Qianzheng preparation medicine and preparation method Download PDFInfo
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- CN1366947A CN1366947A CN 01102142 CN01102142A CN1366947A CN 1366947 A CN1366947 A CN 1366947A CN 01102142 CN01102142 CN 01102142 CN 01102142 A CN01102142 A CN 01102142A CN 1366947 A CN1366947 A CN 1366947A
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Abstract
The present invention discloses a nano compound pull aright preparation medicine. It is made up by using 14 Chinese medicinal materials of nano aconite/typhonium, nano earthworm, nano scorpion, nano silkworm, nano ligusticum and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of soothing the channels and quicking the network vessels, QI and blood regulating, cure mainly the nano Fufang Qianzheng preparation medicine of ailment said due to cold or exposure appoplexy involving the collateral, facial hemiparalysis, muscle numbness, bones and muscles pain, the invention still further relates to the method for this medication preparation.
Fufang Qianzheng cream is a kind of classical Chinese patent medicine, mainly contains effects such as soothing the channels and quicking the network vessels, QI and blood regulating, is used for ailment said due to cold or exposure appoplexy involving the collateral, facial hemiparalysis, muscle numbness, bones and muscles pain.But traditional Fufang Qianzheng cream absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Fufang Qianzheng preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Fufang Qianzheng preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Typhonii 50-150 part nanometer earthworm 50-300 part nanometer Scorpio 50-300 part
Nanometer Bombyx Batryticatus 50-300 part nanometer Rhizoma Chuanxiong 50-300 part nano angelica root 50-200 part
Nano Chinese angelica 50-300 part nanometer Radix Paeoniae Rubra 50-200 part nanometer Radix Saposhnikoviae 50-200 part
Nanometer Rhizoma Zingiberis Recens 50-200 part nanometer Camphora 1-10 part nanometer Borneolum Syntheticum 1-10 part
Nanometer Mentholum 1-10 part nano musk grass phenol 1-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Typhonii 80-120 part nanometer earthworm 100-200 part nanometer Scorpio 100-150 part
Nanometer Bombyx Batryticatus 100-200 part nanometer Rhizoma Chuanxiong 100-150 part nano angelica root 80-150 part
Nano Chinese angelica 100-200 part nanometer Radix Paeoniae Rubra 100-150 part nanometer Radix Saposhnikoviae 80-150 part
Nanometer Rhizoma Zingiberis Recens 100-150 part nanometer Camphora 3-8 part nanometer Borneolum Syntheticum 3-8 part
Nanometer Mentholum 3-8 part nano musk grass phenol 3-8 part
The optimum weight proportioning of medicine of the present invention is:
120 parts of 150 parts of nanometer Scorpios of 100 parts of nanometer earthworms of nanometer Rhizoma Typhonii
100 parts of 120 parts of nano angelica roots of 150 parts of nanometer Rhizoma Chuanxiongs of nanometer Bombyx Batryticatus
100 parts of 120 parts of nanometer Radix Saposhnikoviaes of 150 parts of nanometer Radix Paeoniae Rubra of nano Chinese angelica
5 parts of 5 parts of nanometer Borneolum Syntheticums of 120 parts of nanometer Camphoras of nanometer Rhizoma Zingiberis Recens
5 parts of 5 parts of nano musk grass phenol of nanometer Mentholum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Fufang Qianzheng preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Fufang Qianzheng preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Fufang Qianzheng paste formulation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano Fufang Qianzheng preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as ailment said due to cold or exposure appoplexy involving the collateral, facial hemiparalysis, muscle numbness, bones and muscles pain, and clinical efficacy significantly is better than traditional Fufang Qianzheng cream.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
120 parts of 150 parts of nanometer Scorpios of 100 parts of nanometer earthworms of nanometer Rhizoma Typhonii
100 parts of 120 parts of nano angelica roots of 150 parts of nanometer Rhizoma Chuanxiongs of nanometer Bombyx Batryticatus
100 parts of 120 parts of nanometer Radix Saposhnikoviaes of 150 parts of nanometer Radix Paeoniae Rubra of nano Chinese angelica
5 parts of 5 parts of nanometer Borneolum Syntheticums of 120 parts of nanometer Camphoras of nanometer Rhizoma Zingiberis Recens
5 parts of 5 parts of nano musk grass phenol of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
120 parts of 150 parts of nanometer Scorpios of 100 parts of nanometer earthworms of nanometer Rhizoma Typhonii
100 parts of 120 parts of nano angelica roots of 150 parts of nanometer Rhizoma Chuanxiongs of nanometer Bombyx Batryticatus
100 parts of 120 parts of nanometer Radix Saposhnikoviaes of 150 parts of nanometer Radix Paeoniae Rubra of nano Chinese angelica
5 parts of 5 parts of nanometer Borneolum Syntheticums of 120 parts of nanometer Camphoras of nanometer Rhizoma Zingiberis Recens
5 parts of 5 parts of nano musk grass phenol of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Fufang Qianzheng powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
120 parts of 150 parts of nanometer Scorpios of 100 parts of nanometer earthworms of nanometer Rhizoma Typhonii
100 parts of 120 parts of nano angelica roots of 150 parts of nanometer Rhizoma Chuanxiongs of nanometer Bombyx Batryticatus
100 parts of 120 parts of nanometer Radix Saposhnikoviaes of 150 parts of nanometer Radix Paeoniae Rubra of nano Chinese angelica
5 parts of 5 parts of nanometer Borneolum Syntheticums of 120 parts of nanometer Camphoras of nanometer Rhizoma Zingiberis Recens
5 parts of 5 parts of nano musk grass phenol of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Fufang Qianzheng membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano Fufang Qianzheng preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Typhonii 50-150 part nanometer earthworm 50-300 part nanometer Scorpio 50-300 part
Nanometer Bombyx Batryticatus 50-300 part nanometer Rhizoma Chuanxiong 50-300 part nano angelica root 50-200 part
Nano Chinese angelica 50-300 part nanometer Radix Paeoniae Rubra 50-200 part nanometer Radix Saposhnikoviae 50-200 part
Nanometer Rhizoma Zingiberis Recens 50-200 part nanometer Camphora 1-10 part nanometer Borneolum Syntheticum 1-10 part
Nanometer Mentholum 1-10 part nano musk grass phenol 1-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Fufang Qianzheng preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Typhonii 80-120 part nanometer earthworm 100-200 part nanometer Scorpio 100-150 part
Nanometer Bombyx Batryticatus 100-200 part nanometer Rhizoma Chuanxiong 100-150 part nano angelica root 80-150 part
Nano Chinese angelica 100-200 part nanometer Radix Paeoniae Rubra 100-150 part nanometer Radix Saposhnikoviae 80-150 part
Nanometer Rhizoma Zingiberis Recens 100-150 part nanometer Camphora 3-8 part nanometer Borneolum Syntheticum 3-8 part
Nanometer Mentholum 3-8 part nano musk grass phenol 3-8 part
3, nano Fufang Qianzheng preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
120 parts of 150 parts of nanometer Scorpios of 100 parts of nanometer earthworms of nanometer Rhizoma Typhonii
100 parts of 120 parts of nano angelica roots of 150 parts of nanometer Rhizoma Chuanxiongs of nanometer Bombyx Batryticatus
100 parts of 120 parts of nanometer Radix Saposhnikoviaes of 150 parts of nanometer Radix Paeoniae Rubra of nano Chinese angelica
5 parts of 5 parts of nanometer Borneolum Syntheticums of 120 parts of nanometer Camphoras of nanometer Rhizoma Zingiberis Recens
5 parts of 5 parts of nano musk grass phenol of nanometer Mentholum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Fufang Qianzheng preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Fufang Qianzheng preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102142 CN1366947A (en) | 2001-01-20 | 2001-01-20 | Nano Fufang Qianzheng preparation medicine and preparation method |
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| CN 01102142 CN1366947A (en) | 2001-01-20 | 2001-01-20 | Nano Fufang Qianzheng preparation medicine and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949473A (en) * | 2012-11-27 | 2013-03-06 | 陕西中药研究所 | Preparation method of pullingqianzheng pills |
| CN105663512A (en) * | 2016-03-22 | 2016-06-15 | 山东明人福瑞达卫生材料有限公司 | Apoplexy sequela treating traditional Chinese medicine composition for external use, preparation thereof and preparation method thereof |
| CN105688170A (en) * | 2016-03-22 | 2016-06-22 | 山东明人福瑞达卫生材料有限公司 | External traditional Chinese medicinal composition for treating stroke, preparation of external traditional Chinese medicinal composition and preparation method of external traditional Chinese medicinal composition |
| CN105687798A (en) * | 2016-03-22 | 2016-06-22 | 山东明人福瑞达卫生材料有限公司 | External traditional Chinese medicinal preparation for treating stroke and preparation method of external traditional Chinese medicinal preparation |
| CN105709194A (en) * | 2016-03-22 | 2016-06-29 | 山东明人福瑞达卫生材料有限公司 | Traditional Chinese medicine composition for treating stroke and external preparation thereof and preparation method of external preparation |
-
2001
- 2001-01-20 CN CN 01102142 patent/CN1366947A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949473A (en) * | 2012-11-27 | 2013-03-06 | 陕西中药研究所 | Preparation method of pullingqianzheng pills |
| CN102949473B (en) * | 2012-11-27 | 2015-07-08 | 陕西中药研究所 | Preparation method of pullingqianzheng pills |
| CN105663512A (en) * | 2016-03-22 | 2016-06-15 | 山东明人福瑞达卫生材料有限公司 | Apoplexy sequela treating traditional Chinese medicine composition for external use, preparation thereof and preparation method thereof |
| CN105688170A (en) * | 2016-03-22 | 2016-06-22 | 山东明人福瑞达卫生材料有限公司 | External traditional Chinese medicinal composition for treating stroke, preparation of external traditional Chinese medicinal composition and preparation method of external traditional Chinese medicinal composition |
| CN105687798A (en) * | 2016-03-22 | 2016-06-22 | 山东明人福瑞达卫生材料有限公司 | External traditional Chinese medicinal preparation for treating stroke and preparation method of external traditional Chinese medicinal preparation |
| CN105709194A (en) * | 2016-03-22 | 2016-06-29 | 山东明人福瑞达卫生材料有限公司 | Traditional Chinese medicine composition for treating stroke and external preparation thereof and preparation method of external preparation |
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