CN105663512A - Apoplexy sequela treating traditional Chinese medicine composition for external use, preparation thereof and preparation method thereof - Google Patents
Apoplexy sequela treating traditional Chinese medicine composition for external use, preparation thereof and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention relates to an apoplexy sequela treating traditional Chinese medicine composition for external use, a preparation thereof and a preparation method thereof. The traditional Chinese medicine composition comprises Rhizoma Typhonii, Pheretima, Scorpio, Bombyx Batryticatus, Rhizoma Chuanxiong, Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Saposhnikoviae, camphor, Borneolum Syntheticum, menthol crystal, thymol and the like, and is prepared into the forms of plaster, cataplasm, ointment or patch. The invention further provides a preparation method of an external-use preparation of the traditional Chinese medicine composition. The traditional Chinese medicine composition and the preparation thereof have efficacy of repelling wind, stimulating blood circulation, smoothing channels, activating collaterals, improving immunity and repairing brain nerve cells and are applied to treatment of apoplexy sequela with remarkable effect, high safety and use convenience.
Description
Technical field
The present invention relates to a kind of external medicine composition, its preparation and its preparation method for the treatment of apoplexy sequela, belong to technical field of Chinese medicine.
Background technology
Apoplexy, also known as palsy, the cerebrovascular surprisingly, it is frequently-occurring disease, the common disease of person in middle and old age, in the world today, human death leads one of big disease of the highest three, also be with fastest developing speed, dead at most, disable one of the heaviest sick kind, greatly painful to millions upon millions of patient, bring serious harm to family and society. Theory of traditional Chinese medical science is thought, the apoplexy interpretation of the cause, onset and process of an illness is comparatively complicated, internal organs imbalance of YIN and YANG, deficiency of both the liver and kidney, physique is weak, outer heresy is taken advantage of a weak point in opponent's defence invasion, adds that feelings will is unsuccessful, the inducement such as excessively of being addicted to drink, so cause that gas blood is inverse disorderly, the resistance of brain vessle-Bi symptom-complex or blood overflow in brain, thus hemiplegia, numb limbs and tense tendons, aphasia, facial hemiparalysis occur, slobbering, the stroke symptom such as arthralgia and myalgia, also claim apoplexy sequela. If not as good as early treatment, then spasm is stiff gradually for limbs, the generation useless property of limbs is tetanic, contracture, cause cacomelia and afunction etc., so improving the prophylactic treatment level of cerebral apoplexy, the sickness rate reducing cerebral apoplexy, disability rate, treatment and the conditioning of strengthening cerebral apoplexy sequela are the task of top priority.
In correlation technique, the methods for the treatment of for apoplexy has dietotherapy, acupuncture, oral Chinese and Western patent medicine etc. Western medicine for anti-apoplexy is mainly Thrombolytic Drugs and channel blocker, has advantage rapid-action, with strong points more, but its mode of action is single, and mostly can produce resistance and side effect, and patient should not take for a long time, and therefore long-term treatment effect is unsatisfactory. The Chinese medicine for the treatment of apoplexy has the advantages that curative effect is steady, side effect is low, as CN105267416A discloses a kind of Chinese medicine composition treating apoplexy, hemiplegia, it is made up of following raw material medicine: safflower 3-8, root bark of tree peony 7-13, Ligusticum wallichii 7-12, root of herbaceous peony 8-13, dried rhizome of rehmannia 9-15, Root of Medicinal Cyathula 12-17, Radix Astragali 22-28, Radix Angelicae Sinensis 12-18, cassia twig 6-10, hawthorn 15-25. This medicine is based on benefiting QI for activating blood circulation, thin network of promoting blood circulation, and this Chinese medicine composition is prepared to tablet, capsule or oral liquid, takes with oral way. Although there being at present much Chinese patent medicines for apoplexy on the market, but treatment cycle is longer, to take dosage relatively big, and cost height, mechanism of action is indefinite.
Summary of the invention
For the deficiencies in the prior art, the present invention provides a kind of external medicine composition being used for the treatment of apoplexy sequela;This Chinese medicine composition to dispel the wind, invigorate blood circulation, have concurrently regulate channels and activate collateral, improve immunity, repair cranial nerve cell effect.
The present invention also provides preparation and its preparation method of described external medicine composition.
The technical scheme of the present invention is as follows:
Treat an external medicine composition for apoplexy sequela, it be made up of the bulk drug of following weight part:
Rhizoma Typhonii 20-100 part, earthworm 20-100 part, scorpio 10-80 part, stiff silkworm 10-80 part, Ligusticum wallichii 10-80 part, root of Dahurain angelica 20-80 part, Radix Angelicae Sinensis 10-80 part, windproof 20-100 part, camphor 5-20 part, borneol 5-20 part, mentha camphor 1-10 part, thymol 1-10 part.
According to such scheme of the present invention, it is preferable that, described raw material medicines in portions by weight is as follows:
Rhizoma Typhonii 20-80 part, earthworm 20-80 part, scorpio 10-60 part, stiff silkworm 10-60 part, Ligusticum wallichii 20-60 part, root of Dahurain angelica 20-60 part, Radix Angelicae Sinensis 10-50 part, windproof 20-70 part, camphor 5-15 part, borneol 5-15 part, mentha camphor 2-10 part, thymol 2-10 part.
According to the present invention, a preferred embodiment, described raw material medicines in portions by weight is as follows:
Rhizoma Typhonii 60 parts, earthworm 50 parts, scorpio 60 parts, stiff silkworm 50 parts, Ligusticum wallichii 40 parts, the root of Dahurain angelica 50 parts, Radix Angelicae Sinensis 40 parts, windproof 50 parts, camphor 10 parts, borneol 10 parts, mentha camphor 5 parts, thymol 5 parts.
According to the present invention, another preferred embodiment, described raw material medicines in portions by weight is as follows:
Rhizoma Typhonii 60 parts, earthworm 60 parts, scorpio 50 parts, stiff silkworm 50 parts, Ligusticum wallichii 50 parts, the root of Dahurain angelica 40 parts, Radix Angelicae Sinensis 50 parts, windproof 40 parts, camphor 5 parts, borneol 10 parts, mentha camphor 10 parts, thymol 5 parts.
According to the present invention, another preferred embodiment, described raw material medicines in portions by weight is as follows:
Rhizoma Typhonii 50 parts, earthworm 60 parts, scorpio 60 parts, stiff silkworm 60 parts, Ligusticum wallichii 40 parts, the root of Dahurain angelica 50 parts, Radix Angelicae Sinensis 40 parts, windproof 40 parts, camphor 10 parts, borneol 5 parts, mentha camphor 10 parts, thymol 5 parts.
In above-mentioned each component:
Rhizoma Typhonii is the dry tuber of aroid Herba Typhonii gigantei TyphoniumgiganteumEngl.. Effect is dispeled the wind phlegm, and arresting convulsion is jerked, detoxicating and resolving a mass, pain relieving. .
Earthworm is the dry body of Ju Yin section animal ginseng Pheretimatschiliensis Pheretimaaspergillum (E.Perrier), popular Pheretimatschiliensis PheretimavulgarisChen, power simulation Pheretimaguillelmi (Michaelsen) or the blind Pheretimatschiliensis PheretimapectiniferaMichaelsen of comb. Effect heat-clearing is calmed the frightened, and logical network, relievings asthma, diuresis.
Scorpio is the dry body of Qian Xie section animal buthus martensii Karscs ButhusmartensiiKarsch. Effect breath wind antispastic, removes obstruction in channels to relieve pain, dispersing pathogen accumulation.
Stiff silkworm, the lethal dry body for the larva in Bombycidae insect silkworm BombyxmoriLinnaeus4～5 ages infects (or artificial inoculation) muscardine Beauveriaassiana (Bals.) Vuillant. Effect breath wind only convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses.
Ligusticum wallichii is the dry rhizome of samphire Ligusticum wallichii LigusticumchuanxiongHort.. Effect blood-activating and qi-promoting, wind-expelling pain-stopping.
The root of Dahurain angelica is the dry root of samphire root of Dahurain angelica Angelicadahurica (Fisch.exHoffm.) Benth.etHook.f. or Radix angelicae dahuricae Angelicadahurica (Fisch.exHoffm.) Benth.etHook.f.var.formosana (Boiss.) ShanetYuan. Effect is induced sweat loose cold, wind-expelling pain-stopping, and a surname's relieving stuffy nose, eliminating dampness is band only, detumescence and apocenosis.
Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelicasinensis (Oliv.) Diels.Effect is enriched blood and is invigorated blood circulation, and menstruction regulating and pain relieving relaxes bowel.
Windproof, it is the dry root of umbelliferae Saposhnikovia divaricata Saposhnikoviadivaricata (Turcz.) Schischk.. Dispel the wind and induce sweat, removing dampness to relieve pain, only convulsion.
Camphor, chemistry (1R, 4R)-1,7,7-trimethylammonium two ring [2.2.1] heptane-2-ketone by name is extract to obtain in canella. This product is skin irritation medicine.
Borneol is borneolum syntheticum, and effect is had one's ideas straightened out inducing resuscitation, clearing away heat to and alleviating pain.
Mentha camphor, this product is a kind of saturated cycloalcohol that the fresh stem of labiate peppermint MenthahaplocalyxBriq. and Ye Jing wet distillation, freezing, recrystallization obtain, chemistry l-1-methyl-4-isopropyl cyclohexanol-3 by name.
Thymol, chemistry 5-thymol by name. This product is Cidex-7, is mainly used in fungal infection.
The prescription of the present invention is made up of Rhizoma Typhonii, earthworm, scorpio, stiff silkworm, Ligusticum wallichii, the root of Dahurain angelica, Radix Angelicae Sinensis, windproof, camphor, borneol, mentha camphor, thymol. The present inventor is according to the cause of disease of apoplexy disease and the interpretation of the cause, onset and process of an illness, on traditional chinese medicine basis, researched and proposed the present invention by modern pharmacology, this Chinese medicine composition to dispel the wind, invigorate blood circulation, have concurrently regulate channels and activate collateral, improve immunity, repair cranial nerve cell effect.
According to the present invention, a kind of external medicine composition preparation, it is characterised in that, the formulation of preparation is rubber-emplastrum, cataplasma, ointment or plaster.
According to the present invention, the preparation method of described external medicine composition preparation, comprises the steps:
(1) take each feed composition in proportion, pulverize; Getting Rhizoma Typhonii wherein, earthworm, scorpio, stiff silkworm, Ligusticum wallichii, the root of Dahurain angelica, Radix Angelicae Sinensis, windproof mixing, gained mixed powder alcohol solvent extracts, concentrated, makes Chinese medicine fluid extract, for subsequent use;
(2) getting paste substrate, add Chinese medicine fluid extract and camphor, borneol, mentha camphor, the thymol of step (1), glue cream is made in refining.
Preparation method according to above-mentioned external medicine composition preparation, when formulation is rubber-emplastrum, cataplasma or plaster, also comprises step (3): gets glue cream prepared by step (2) and is coated on backing cloth, segment, lid lining (sealing coat), section, encapsulation. And ointment does not need to be coated on backing cloth.
In above-mentioned steps (2), described paste substrate is rubber-emplastrum matrix, ground substance of plaster ointment, ointment base or plaster substrate. The material composition of shown matrix is by state of the art. The present invention is preferably as follows matrix:
A. rubber-emplastrum matrix: the mixing thing of rubber, rosin, zinc oxide and Vaseline and/or lanolin;
B. ground substance of plaster ointment: sodium polyacrylate, Xylo-Mucine, citric acid, polyvidone, glycerine and micropowder silica gel;
C. ointment base: stearic acid, glyceryl monostearate, glycerine, polysorbate and trolamine soap class;
D. plaster substrate: sesame oil and red lead.
Preparation method according to the above-mentioned external medicine composition preparation of the present invention, it may be preferred that in step (1) with ethanol be solvent carry out extraction be adopt percolation carry out oozing filtering, collect percolate, concentrating under reduced pressure, reclaim ethanol, make Chinese medicine fluid extract. Preferred further:
Described alcohol solvent volumetric usage be mixed powder total mass 1-1.5 doubly (volume: the ratio unit of weight for ml/g), mixed powder and alcohol solvent are stirred after evenly, airtight placement infiltration 1-3 hour, makes medicinal material fully expand;Then get the loading of the mixed powder after infiltration and ooze device of filtering, add alcohol solvent and continue airtight placement dipping 24～48 hours, make the abundant diffusion of solvent, then start to carry out oozing filtering.
Preferably, the mixed powder loading after above-mentioned infiltration is oozed when filtering device, mixed powder gradation is evenly loaded and oozes device of filtering (degree of tightness is suitable for); Open and ooze mouth switch under device of filtering, slowly add alcohol solvent from top, close switch when there being liquid to flow out from lower mouth, to get rid of the interstitial air of medicinal powder, continue to add alcohol solvent to exceeding mixed powder upper surface 1-10 centimetre.
Preferably, above-mentioned starting to carry out oozing when filtering, the speed of filtering is oozed in control, makes effluent liquid per hour be equivalent to ooze the 1/48～1/24 of device useful volume of filtering, and constantly adds alcohol solvent from top, keeps solvent liquid level higher than mixed powder upper surface. Collect 5～6 times amount that percolate volume is mixed powder total mass, volume/mass unit: ml/g.
Preparation method according to the above-mentioned external medicine composition preparation of the present invention, it may be preferred that in step (1), described thickening temperature is 50～85 DEG C. The relative density of described Chinese medicine fluid extract is 1.05～1.10, and reference density is water, 50～65 DEG C of surveys.
Preparation method according to the above-mentioned external medicine composition preparation of the present invention, it may be preferred that in step (1), described alcohol solvent is the ethanol of massfraction 70-90%, the ethanol of further preferred mass mark 85%.
Preparation method according to the above-mentioned external medicine composition preparation of the present invention, it may be preferred that in described step (1), described bulk drug pulverizes into meal, whole mistake 24 order sieve and wherein can cross 65 orders sieve be no more than the 40% of meal total mass.
The granularity that in the present invention, raw material medicinal powder is broken into medicinal powder has special requirement, the most suitable to pulverize into meal, and described meal refers to and all by 24 orders sieves, but can wherein be mixed with a little fine powder by 65 orders sieves, and fine powder total amount is no more than the powder of 40%. As medicinal powder is excessively thick, not easily compressing when dress oozes device of filtering (cylinder), ooze solvent-oil ratio when filtering big, leach composition incomplete, leaching effect is poor; Device of filtering is oozed in easy blocking as meticulous in medicinal powder, and the speed of filtering is oozed in impact, and extraction efficiency is low.
In the present invention, preferred percolation and concentrating under reduced pressure are prepared Chinese medicine fluid extract and are soaked by medicinal powder and ooze operation of filtering and have special requirement, putting to ooze by the medicinal material that appropriateness is pulverized filters in device, solvent is constantly added by top, solvent oozed the method leaching medicinal ingredient in the dynamic process of medicinal material sulfate layer flows downhill, dynamically leach extraction, solvent utilization ratio height, effective constituent leaches completely, and can directly collect leach liquor, compared with soak by water method, the composition unrelated with therapeutic action is such as polysaccharide, protein, tannin, phlegmatic temperament is not suggested, avoid the loaded down with trivial details step that postorder removes invalid components, reduce cost, improve economic benefit, concentrating under reduced pressure prepares Chinese medicine fluid extract, and when percolate is concentrated, Heating temperature is low, and heated time is short, and effective constituent is destroyed few, and reservation is many, in maintenance curative effect simultaneously, can reduce again the volume of finished product. medicinal powder infiltrates, feeds, floods and oozes processing parameter main points of filtering: 1. infiltrate medicinal powder: appropriate wet with solvent should first be used by medicinal powder, makes it abundant expansion, avoid ooze filter device Chinese medicine powder expand and result in blockage, 2. feed: the medicinal powder gradation of swells is loaded and oozes device of filtering, answer degree of tightness to be suitable for, evenly flatten, first open during solubilizing agent and ooze mouth switch under device of filtering, add solvent from medicinal powder top and flow out from outlet to percolate, get rid of the interstitial air of medicinal powder, continue several centimetres, solubilizing agent submergence medicinal powder surface, close percolate outlet. 3. medicinal powder dipping: ooze and flood 24～48h in device of filtering, make the abundant diffusion of solvent, be beneficial to the leaching oozing effective constituent when filtering.4. oozing the speed of filtering: ooze when filtering, the speed of filtering is oozed in control, oozes excessive velocities of filtering, and leaches composition incomplete, consumes quantity of solvent big; Speed is excessively slow, affects extraction efficiency.
The external medicine composition of the present invention, its preparation are used for the treatment of the externally applied medicine of apoplexy sequela disease, it may also be useful to time, the preparations such as rubber-emplastrum, cataplasma, ointment or plaster are sticked or are coated on and suffers from relevant acupuncture point, side. Before sticking, by relevant acupuncture point place's warm water cleaning or alcohol disinfecting. This medicine can be used for treating the facial hemiparalysis of apoplexy caused by network in ailment said due to cold or exposure, slobbers, speech not smoothgoing puckery, muscle is numb, the treatment of arthralgia and myalgia, its result for the treatment of significantly, security height, have no side effect, it may also be useful to convenient, cheap. All medicine reasonable compatibilities in the present invention, complementary collaborative, dialectical treatment, the various symptoms for apoplexy sequela have good curative effect, overcome existing treatment apoplexy medicine above shortcomings. Experiment research shows scientific and reasonable compatibility, medicine can not only be made to play the collaborative reinforced effects of drug effect, and can also significantly reduce the usage quantity of medicine.
The useful effect of the present invention:
1, Chinese medicine composition of the present invention is Chinese medicine preparation, has and dispels the wind, invigorates blood circulation, the effect such as regulate channels and activate collateral. The treatment of current apoplexy sequela, adopts oral pharmaceutical such as meticorten more, and the therapy such as acupuncture-moxibustion, and side effect is big, unsuitable life-time service. Oral preparation of Chinese traditional medicinal is had also to there is the defects such as the length course for the treatment of, mechanism is not clear, dosage is big. This room preparation of external application Chinese medicine of the present invention selects rubber-emplastrum etc. to stick acupuncture point and Huan Bu local application, and by Transdermal absorption, the channels and collaterals made regulate and reach therapeutic action, have security height, have no side effect, it may also be useful to advantage easily.
2, containing multiple drug component in Chinese medicine composition of the present invention, by sticking the relevant acupuncture point in patient, Transdermal absorption, channels and collaterals regulate and reach therapeutic action, action target spot is numerous, as sticked Sibai, Yingxiang, the sun, ShiShimonoseki, the medium acupoint therapy facial hemiparalysis of people, stick the acupoint therapy muscle such as chize, connected valleys, shou san li, tsu san li, gb 34 numb, stick Ashi point treatment arthralgia and myalgia etc. There is advantage rapid-action, that sphere of action is wide compared with existing Chinese medicine or Chinese patent medicine. Pharmacodynamics test shows: local big and small vessel, after skin absorption, is had and obviously expands use, volume of blood flow is increased, local muscle has the impact of physiological property by this medicine. Animal experiment proves, this product can increase rabbit sciatic nerves movement conduction speed, can shorten latent period; Evoked ptential action time-histories can be shortened; Evoked ptential wave amplitude height can be improved, so neural quickening conduction of velocity can be made and improves excitability.
3, the preferred percolation of Chinese medicine preparation preparation method of the present invention is combined with concentrating under reduced pressure, the preparation of Chinese medicine preparation is a complicated system, particularly extract, concentrated in processing parameter different, the pharmaceutical cpd obtained is just different, and thus produced effect is also different. Fully consider the effective constituent of each component, carry out a large amount of experimental studies, retain effective constituent with maximum degree, adopt modern technique simultaneously, both improve production efficiency, shortened man-hour, again reduced energy consumption.
Embodiment
Below in conjunction with embodiment, the technical scheme of the present invention is described further, but institute of the present invention protection domain is not limited to this. Raw material in embodiment is commercially available product, and wherein said " % " is mass percent.
Embodiment 1
Treat an external medicine composition preparation for apoplexy sequela, it be made up of the bulk drug of following weight parts:
Rhizoma Typhonii 60 parts, earthworm 50 parts, scorpio 60 parts, stiff silkworm 50 parts, Ligusticum wallichii 40 parts, the root of Dahurain angelica 50 parts, Radix Angelicae Sinensis 40 parts, windproof 50 parts, camphor 10 parts, borneol 10 parts, mentha camphor 5 parts, thymol 5 parts.
Described Chinese medicinal composition preparation is rubber-emplastrum, and its preparation methods steps is as follows:
1, take each bulk drug by weight, by Rhizoma Typhonii wherein, earthworm, scorpio, stiff silkworm, Ligusticum wallichii, the root of Dahurain angelica, Radix Angelicae Sinensis, windproof, pulverize into meal, for subsequent use;
2, getting above-mentioned meal mixes even, add meal gross weight 1 times amount 85% ethanol (ethanol contend: the ratio unit of meal gross weight for ml/g), stir after evenly, airtight placement infiltration 2～3 hours; Then the flavour of a drug meal gradation of infiltration is evenly loaded and ooze device of filtering, degree of tightness is suitable for; Open again and ooze mouth switch under device of filtering, the ethanol of 85% is slowly added from top, switch is closed from lower mouth when liquid flows out, continue to add solvent to exceeding 5 centimetres, medicinal powder face, airtight placement dipping, after 48 hours, carries out oozing filtering, and it is that effluent liquid per hour about is equivalent to ooze the 1/24 of device useful volume of filtering and is advisable that the speed of filtering is oozed in control, and the alcohol solvent of 85% is constantly added from top, keep alcohol solvent higher than medicinal powder upper surface. Collect 5 times amount that percolate volume is mixed powder total mass, volume/mass unit: ml/g; Stop oozing filtering. The percolate concentrating under reduced pressure collected, reclaims ethanol, control thickening temperature 50～85 DEG C, concentrate to relative density be the Chinese medicine fluid extract of 1.07～1.10 (50 DEG C of surveys, reference density is water), for subsequent use.
3, get rubber and carry out pre-treatment, rubber mixing machine is plasticated into shape sheet, then carry out mixing with rosin, zinc oxide, Vaseline, lanolin, obtain rubber matrix.
4, get mixing after rubber matrix, add the Chinese medicine fluid extract that the camphor of pulverizing, borneol, mentha camphor, thymol and step 2 are obtained, glue cream is made in refining.
5, getting glue cream is coated on backing cloth, segment, and lid lining (sealing coat), cuts into pieces, and encapsulation, to obtain final product.
Embodiment 2
As described in Example 1, composed as follows the difference is that raw material medicines in portions by weight:
Rhizoma Typhonii 60 parts, earthworm 60 parts, scorpio 50 parts, stiff silkworm 50 parts, Ligusticum wallichii 50 parts, the root of Dahurain angelica 40 parts, Radix Angelicae Sinensis 50 parts, windproof 40 parts, camphor 5 parts, borneol 10 parts, mentha camphor 10 parts, thymol 5 parts.
Described Chinese medicinal composition preparation is rubber-emplastrum, preparation method with embodiment 1, institute the difference is that:
Step 2, get meal and mix even, add the ethanol (ethanol contend: the ratio unit of meal gross weight for ml/g) of meal gross weight 1 times amount 70%, stir after evenly, airtight placement infiltration 1～2 hour; Then the flavour of a drug meal gradation of infiltration is evenly loaded and ooze device of filtering, degree of tightness is suitable for; Open again and ooze mouth switch under device of filtering, 70% ethanol is slowly added from top, switch is closed from lower mouth when liquid flows out, continue to add solvent to exceeding medicinal powder face number centimetre, airtight placement dipping, after 24 hours, carries out oozing filtering, and it is that effluent liquid per hour about is equivalent to ooze the 1/48 of the effective container of device of filtering and is advisable that the speed of filtering is oozed in control, and the alcohol solvent of 70% is constantly added from top, keep alcohol solvent higher than medicinal powder upper surface. Collect 6 times amount that percolate volume is mixed powder total mass, volume/mass unit: ml/g.The percolate concentrating under reduced pressure collected, reclaims ethanol, control thickening temperature 50～85 DEG C, concentrate to relative density be the Chinese medicine fluid extract of 1.05～1.08 (65 DEG C of surveys, reference density is water), for subsequent use.
Embodiment 3 one kinds treats the external medicine composition (cataplasma) of apoplexy sequela, and weight part group part of raw material is as follows:
Rhizoma Typhonii 50 parts, earthworm 60 parts, scorpio 60 parts, stiff silkworm 60 parts, Ligusticum wallichii 40 parts, the root of Dahurain angelica 50 parts, Radix Angelicae Sinensis 40 parts, windproof 40 parts, camphor 10 parts, borneol 5 parts, mentha camphor 10 parts, thymol 5 parts.
Above-mentioned external medicine composition is made cataplasma, and its preparation methods steps is as follows:
1, take each feed composition in proportion, by Rhizoma Typhonii wherein, earthworm, scorpio, stiff silkworm, Ligusticum wallichii, the root of Dahurain angelica, Radix Angelicae Sinensis, windproof, pulverize into meal, mixed evenly even, obtain mixed powder, for subsequent use;
2, getting meal mixes even, adds the ethanol (ethanol contend: the ratio unit of meal gross weight for ml/g) of meal gross weight 1 times amount 80%, stirs after evenly, airtight placement infiltration 2～3 hours; Then the flavour of a drug meal gradation of infiltration is evenly loaded and ooze device of filtering, degree of tightness is suitable for; Open again and ooze mouth switch under device of filtering, 80% ethanol is slowly added from top, switch is closed from lower mouth when liquid flows out, continue to add solvent to exceeding medicinal powder upper surface 6 centimetres, airtight placement dipping, after 36 hours, carries out oozing filtering, and it is that effluent liquid per hour about is equivalent to ooze the 1/36 of the effective container of device of filtering and is advisable that the speed of filtering is oozed in control, and alcohol solvent is constantly added from top, keep alcohol solvent higher than medicinal powder upper surface. Collect 5.5 times amount that percolate volume is mixed powder total mass, volume/mass unit: ml/g; The percolate concentrating under reduced pressure collected, reclaims ethanol, control thickening temperature 50～85 DEG C, concentrate to relative density be the Chinese medicine fluid extract of 1.06～1.09 (60 DEG C of surveys, reference density is water), for subsequent use.
3, getting sodium polyacrylate, Xylo-Mucine, citric acid, polyvidone, glycerine and micropowder silica gel substrate material carries out mixing, makes uniform ground substance of plaster ointment.
4, get mixing after ground substance of plaster ointment, add the Chinese medicine fluid extract that the camphor of pulverizing, borneol, mentha camphor, thymol and step 2 are obtained, glue cream is made in refining.
5, getting glue cream is coated on backing cloth, segment, lid lining (sealing coat), section, encapsulation.
Experimental example 1, tuerculoderma
For the external medicine composition preparation of reagent product: embodiment of the present invention 1-3
1, Skin Irritation Test: experimental animal is rabbit.
Test method: get rabbit 24 (each use of the experiment of each embodiment 8), body weight 2.0～2.3kg, ♀ ♂ holds concurrently use, animal backbone both sides is gone hair in first 24 hours in administration, and every day is administered twice, administration district, left side, right side blank matrix check plot, continuous 7 days, observes skin reaction situation every day, carefully observe with or without erythema, oedema, protuberance, eschar formation etc., again observe 3 days continuously after stopping medicine.
Test-results: rabbit was successive administration 7 days, and agents area skin has no rubescent, the irritative symptoms such as erythema, oedema does not occur, compare with blank matrix check plot and have no obvious otherness, all rabbit skin stops after medicine 72 hours, also has no erythema and oedema, also has no pigment deposition etc. Other symptom all no abnormality seens such as the rabbit mental status, activity, breathing, food ration, body weight, outward appearance, stool, urine shape and color, back of the body hair, the colour of skin, nose, eye, oral cavity also secretory product without exception, proves for reagent product without skin wound repair.
2, skin anaphylactic test: experimental animal is albino guinea-pig.
Extracting waste cavy, male and female half and half, body weight 290～320g, takes off in administration for first 24 hours by guinea pig back backbone both sides hair. experimental animal is divided at random 5 groups, often organize 10 (male and female half and half), each treated animal coats tested material (first group respectively, 2nd group and three components Wei embodiments 1, 2, 3), blank matrix (the 4th group), 1%2.4-dinitrochlorobenzene (the 5th group, positive controls) repeated once every 2 hours, coating is washed with clear water after 6 hours, all animals all sub-cage rearings, 7th day, 14th day repeats once, in rechallenge in the 28th day, in another side of experimental animal backbone difference tested material, blank matrix, 0.1%2.4-dinitrochlorobenzene, coating is removed after 6 hours, allergic situation can be observed, afterwards in 24 hours, 48 hours, within 72 hours, again observe anaphylaxis situation, with reference to skin reaction standards of grading, observe with or without erythema, oedema, animal is stood situation, whether there is asthma, shock etc. skin anaphylactic test result: administration group (first group, the 2nd group and the 3rd group), blank matrix (the 4th group) are stood the anaphylaxis such as shakiness, asthma and shock without erythema, oedema, animal, positive controls (the 5th group) sensitization rate reaches 100%, proves for reagent product without skin allergy.
Experimental example 2, clinical trial
Methods for the treatment of: external curing apoplexy sequela patient, sticks in relevant acupuncture point, trouble side. Before sticking, by relevant acupuncture point place's warm water cleaning or alcohol disinfecting.
The Case definition of apoplexy sequela:
1. primary symptom: hemiplegia, dispute is crooked, and god knows dusk and covers, and tongue is sayed by force not smoothgoing or in silence, hemianesthesia;
2. Acute onset;
3. sick sending out has inducement more, often has premonitory symptom before not sending out;
4. send out well the age many more than 40 years old;
Having primary symptom two or more, Acute onset, the feature in conjunction with aspects such as tongue, arteries and veins, inducement, tendency, ages can determine diagnosis, does not possess above condition, also can make a definite diagnosis in conjunction with imaging examination result.
Standard by stages:
1. acute phase: after morbidity within 2 weeks. Hitting Viscera grows to 1 month most.
2. decubation: fall ill 2 weeks or within 1 month to half a year.
3. sequela stage: more than half a year of falling ill.
Effect for the treatment of sequela of apoplexy evaluation criteria:
Adopt score method: the recovery extent being conceived to mind, language, motor function.
One, point system:
1. mind state: conscious 4 points; Mind in a trance (drowsy, wake up after can and people's words) 3 points; Mind fan cover (drowsiness, exhale answer imprecise) 2 points; Coma 1 point; Muddle-headed (coma has the exhaustion of vital energy at the critical stage of an illness concurrently simultaneously) 0 point.
2. language performance: normal 4 points; General expression, anomia 3 points; Speak and form a complete sentence and express incomplete 2 points; Word, phrase 1 point can not be said; Language can not or substantially can not 0 point.
3. upper limb shoulder joint: normal 4 points; Upper act is complete and flesh power differs from 3 points; Upper act is flat takes on or omited shoulder 2 points; Upper act is less than shoulder 1 point; Inactive or front and back slightly swing 0 point.
4. upper limbs articulations digitorum manus: normal 4 points; Point action respectively effectively and flesh power differs from 3 points; Clench fist to stretch and refer to 2 points; Count on one's fingers, can not hold fist, 1 point can not be stretched; 0 point can not be moved.
5. lower limb hip joint: normal 4 points; Raise more than 45 ° 3 points; Less than 45 ° 2 points; Swing can translate 1 point; Inactive 0 point.
6. lower limb toe joint: normal 4 points; Stretch and bend freely, weak 3 points of power; Stretch and bend incomplete 2 points; Slightly dynamic 1 point; 0 point can not be moved.
7. comprehensive function: life can be taken care of oneself, and freely talks 4 points; Live on one's own life simple work and have part functional defect 3 points; Can walking, part is taken care of oneself, auxiliary 2 points of the people that still needs; Can stand and take a step, need people to take care of 1 point at any time; Lie in bed 0 point.
Two, efficacy evaluation:
Full marks 28 points, starting point is divided and the highest is no more than 18 points, its efficacy evaluation:
1. worsen: aggravation integration reduces or death person;
2. invalid: integration increases less than 4 points of persons;
3. effective: integration increases above more than 4 points persons;
4. effective: integration increases above 10 points of persons;
5. substantially fully recover: integration reaches more than 24 points persons.
Three, clinical trial:
1. treatment group:
A. applying the external medicine composition preparation for treating apoplexy sequela of the embodiment of the present invention 1, stick in relevant acupuncture point, trouble side, treatment cycle is three months. Altogether after treatment 332 example apoplexy in disease patient, male patient 206 example, female patient 126 example, the age is between 40 years old～75 years old. Basic recovery from illness 58 example, curative ratio 17.5%; Effective 164 examples, obvious effective rate 49.4%; Effective 296 examples, have efficiency 89.2%; Invalid 36 examples, inefficiency 10.8%, worsens 0 example. Efficiency is always had to be 89.2%.
B. the external medicine composition preparation for treating apoplexy sequela applying the embodiment of the present invention 2 sticks in relevant acupuncture point, trouble side, and treatment cycle is three months. Altogether after treatment 271 example apoplexy in disease patient, male patient 192 example, female patient 79 example, the age is between 40 years old～70 years old. Basic recovery from illness 49 example, curative ratio 18.1%; Effective 137 examples, obvious effective rate 50.6%; Effective 243 examples, have efficiency 89.7%; Invalid 28 examples, inefficiency 10.3%, worsens 0 example. Efficiency is always had to be 89.7%.
C. the external medicine composition preparation for treating apoplexy sequela applying the embodiment of the present invention 3 sticks in relevant acupuncture point, trouble side, and treatment cycle is three months. Altogether after treatment 228 example apoplexy in disease patient, male patient 161 example, female patient 67 example, the age is between 40 years old～70 years old. Basic recovery from illness 41 example, curative ratio 18.0%; Effective 112 examples, obvious effective rate 49.1%; Effective 207 examples, have efficiency 90.8%; Invalid 21 examples, inefficiency 9.2%, worsens 0 example. Efficiency is always had to be 90.8%.
2. control group: selecting areal apoplexy sequela patient 85 example, the age is between 40～75 years old. Male patient 63 example, women 22 example, the conventional western medicines in treatment of application hospital three months is treatment cycle. Basic recovery from illness 12 example, curative ratio 14.1%; Effective 34 examples, obvious effective rate 40%; Effective 67 examples, have efficiency 78.8%; Invalid 18 examples, inefficiency 21.2%, worsens 0 example. Efficiency is always had to be 78.8%.
Statistical result shows: treatment group and control group difference are remarkable. Clinical trial shows: Chinese medicine composition of the present invention is that one has and dispels the wind, invigorates blood circulation, the Chinese medicine preparation of effect of regulating channels and activating collateral, this medicine reasonable compatibility, complementary collaborative, dialectical treatment, can be used for treating the muscular paralysis of apoplexy caused by network in ailment said due to cold or exposure, facial muscle paralysis and through contraction disease, disease is seen facial hemiparalysis, is slobbered, the strong language of tongue is stuttering, muscle is numb, arthralgia and myalgia etc., and effect is remarkable.
Claims (10)
1. treat the external medicine composition of apoplexy sequela for one kind, it is characterised in that, it is made up of the bulk drug of following weight part:
Rhizoma Typhonii 20-100 part, earthworm 20-100 part, scorpio 10-80 part, stiff silkworm 10-80 part, Ligusticum wallichii 10-80 part, root of Dahurain angelica 20-80 part, Radix Angelicae Sinensis 10-80 part, windproof 20-100 part, camphor 5-20 part, borneol 5-20 part, mentha camphor 1-10 part, thymol 1-10 part.
2. the external medicine composition for the treatment of apoplexy as claimed in claim 1, it is characterized in that, described raw material medicines in portions by weight is as follows: Rhizoma Typhonii 20-80 part, earthworm 20-80 part, scorpio 10-60 part, stiff silkworm 10-60 part, Ligusticum wallichii 20-60 part, root of Dahurain angelica 20-60 part, Radix Angelicae Sinensis 10-50 part, windproof 20-70 part, camphor 5-15 part, borneol 5-15 part, mentha camphor 2-10 part, thymol 2-10 part.
3. the external medicine composition for the treatment of apoplexy as claimed in claim 1, it is characterised in that, described raw material medicines in portions by weight is as follows:
Rhizoma Typhonii 60 parts, earthworm 50 parts, scorpio 60 parts, stiff silkworm 50 parts, Ligusticum wallichii 40 parts, the root of Dahurain angelica 50 parts, Radix Angelicae Sinensis 40 parts, windproof 50 parts, camphor 10 parts, borneol 10 parts, mentha camphor 5 parts, thymol 5 parts; Or,
Rhizoma Typhonii 60 parts, earthworm 60 parts, scorpio 50 parts, stiff silkworm 50 parts, Ligusticum wallichii 50 parts, the root of Dahurain angelica 40 parts, Radix Angelicae Sinensis 50 parts, windproof 40 parts, camphor 5 parts, borneol 10 parts, mentha camphor 10 parts, thymol 5 parts; Or,
Rhizoma Typhonii 50 parts, earthworm 60 parts, scorpio 60 parts, stiff silkworm 60 parts, Ligusticum wallichii 40 parts, the root of Dahurain angelica 50 parts, Radix Angelicae Sinensis 40 parts, windproof 40 parts, camphor 10 parts, borneol 5 parts, mentha camphor 10 parts, thymol 5 parts.
4. external medicine composition as described in item as arbitrary in claim 1-3, it is characterised in that its formulation is rubber-emplastrum, cataplasma, ointment or plaster.
5. the preparation method of external medicine composition as described in item as arbitrary in claim 4, comprises the steps:
(1) take each feed composition in proportion, pulverize; Getting Rhizoma Typhonii wherein, earthworm, scorpio, stiff silkworm, Ligusticum wallichii, the root of Dahurain angelica, Radix Angelicae Sinensis, windproof mixing, gained mixed powder alcohol solvent extracts, concentrated, makes Chinese medicine fluid extract, for subsequent use;
(2) getting paste substrate, add Chinese medicine fluid extract and camphor, borneol, mentha camphor, the thymol of step (1), glue cream is made in refining;
Preferably, described paste substrate is rubber-emplastrum matrix, ground substance of plaster ointment, ointment base or plaster substrate.
6. the preparation method of the external preparation of Chinese medicine composition as claimed in claim 5, it is characterized in that in step (1) with ethanol be solvent carry out extraction be adopt percolation carry out oozing filtering, collect percolate, concentrating under reduced pressure, reclaim ethanol, make Chinese medicine fluid extract.
7. the preparation method of the external preparation of Chinese medicine composition as described in claim 5 or 6, it is characterised in that described alcohol solvent volumetric usage be mixed powder total mass 1-1.5 doubly, volume: quality than unit be ml/g or liter/kilogram; Mixed powder and alcohol solvent being stirred after evenly, airtight placement infiltrates 1-3 hour, and medicinal material is fully expanded; Then get the loading of the mixed powder after infiltration and ooze device of filtering, add alcohol solvent and continue airtight placement dipping 24～48 hours, make the abundant diffusion of solvent, then start to carry out oozing filtering.
8. the preparation method of the external preparation of Chinese medicine composition as claimed in claim 7, it is characterised in that, the mixed powder loading after infiltration is oozed when filtering device, mixed powder gradation is evenly loaded and oozes device of filtering; Open and ooze mouth switch under device of filtering, slowly add alcohol solvent from top, close switch when there being liquid to flow out from lower mouth, to get rid of the interstitial air of medicinal powder, continue to add alcohol solvent to exceeding mixed powder upper surface 1-10 centimetre.
9. the preparation method of the external preparation of Chinese medicine composition as claimed in claim 7, it is characterized in that, start to carry out oozing when filtering, the speed of filtering is oozed in control, effluent liquid per hour is made to be equivalent to ooze the 1/48～1/24 of device useful volume of filtering, and alcohol solvent is constantly added from top, keep solvent liquid level higher than mixed powder upper surface;Collect 5～6 times amount that percolate volume is mixed powder total mass, unit: ml/g, or rise/kilogram.
10. the preparation method of the external preparation of Chinese medicine composition as claimed in claim 7, it is characterised in that, in step (1), described thickening temperature is 50～85 DEG C;
The relative density of described Chinese medicine fluid extract is 1.05～1.10, and reference density is water, 50～65 DEG C of surveys;
Described alcohol solvent is the ethanol of volume fraction 70-90;
Described bulk drug pulverizes into meal, whole mistake 24 order sieve and wherein can cross 65 orders sieve be no more than the 40% of meal total mass.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1366947A (en) * | 2001-01-20 | 2002-09-04 | 杨孟君 | Nano Fufang Qianzheng preparation medicine and preparation method |
| CN1698815A (en) * | 2005-06-07 | 2005-11-23 | 广西花红药业有限责任公司 | Chinese medicinal composite ointment, its preparation process, cataplasm thereof and method for preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1366947A (en) * | 2001-01-20 | 2002-09-04 | 杨孟君 | Nano Fufang Qianzheng preparation medicine and preparation method |
| CN1698815A (en) * | 2005-06-07 | 2005-11-23 | 广西花红药业有限责任公司 | Chinese medicinal composite ointment, its preparation process, cataplasm thereof and method for preparing the same |
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