CN104758713A - Chinese medicine preparation used for restless leg syndrome and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicine preparation used for the restless leg syndrome and belongs to the field of Chinese medicine invention. Raw materials of the Chinese medicine preparation include Chinese angelica, white peony roots, rhizoma chuanxiong, prepared rehmannia roots, unprocessed rehmannia roots, spina date seeds, a pawpaw, grassleaf sweelflag rhizome, gastrodia tubers, net cliffbean, loofah sponges, uncaria, scorpions, magnetite, crude dragon's bones, raw oyster shells, sea-ear shells, fourstamen stephania roots, plantain seeds, lophatherum gracile, radix cyathulae, carthamus tinctorious, leonurus and silkworm excrement. According to different characteristics of all the herbs, the herbs are cleaned, cut into blocks, pre-treated, proportioned and manufactured into the Chinese medicine preparation through a specific method, and the Chinese medicine preparation has the effects of reinforcing the kidneys, activating blood, relaxing muscles and tendons, warming channels, nourishing the liver and dredging collaterals. The combination and manufacturing method is specific, and through clinical verifications, the Chinese medicine preparation is remarkable in therapy effect, short in therapy period, low in price and free of adverse reaction and toxic and side effects, and has broad market application prospects.

Description

A kind of Chinese medicine preparation for restless legs syndrome and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for restless legs syndrome, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Restless legs syndrome (restless legs syndrome, RLS) is also known as Ekbom syndrome, and refer to the insufferable sense of discomfort in the two lower limb deeps of paroxysmal, patient can not keep quite, and forcing after activity could a kind of syndrome of respite.When main manifestations is rest, two shank deeps occur that the worm being difficult to stand climbs sense, scratchiness or acupuncture sample pain.Normal be both sides property, also can side obvious, idol can involve upper limb.Activity suffering limb, change position or walking time symptom can be made to alleviate, can occur again after stopping action, often forcing patient's ceaselessly movable lower limb, hovers and walks about or beat affected part and affect sleep in indoor.The course of disease is the several years.This syndrome is more common, about affects the population of 10% ~ 15%.Generally see old people with periodicity actor in sleep.The definite cause of disease of RLS is not yet completely clear, accumulates relevant by inference with tissue metabolism's product that local blood circulation obstacle causes.

Tcm theory is thought: restless legs syndrome is that stasis is sick, because of deficiency of vital energy hyperamization is stagnant or because of deficiency of YIN hyperamization stagnant.There is no specificity or radical treatment method at present.Western medical treatment medicine is mainly DOPA preparation for treating, but the long-term or short time uses these medicines to treat, the rising of obesity, hirsutism, acne, blood glucose, hypertension, edema, intestine gastric ulcer, orthostatic hypotension, Nausea and vomiting, dizziness can be caused, constipation etc. series of side effects symptom, and to the dependency that hormone creates, after drug withdrawal, primary affection knock-on increases the weight of the side effect with secondary, patient can be made to produce very large misery, therapeutic process again and again, DeGrain, expense is high, causes larger pressure at heart and ailing pressure to patient.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for restless legs syndrome, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment restless legs syndrome, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of restless legs syndrome repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

The effect of Chinese medicine of the present invention:

Wherein:

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " Japan hanako materia medica ": control a wind cutting, all blood, mend all labor, broken stagnant blood, supports fresh blood and main Disorder addiction.

The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactifiora Pall..Nature and flavor: bitter, sour, are slightly cold.Return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.Record in " herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort. (or Ligusticum wallichiiFranch.).Nature and flavor: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Record in " Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.

Radix Rehmanniae Preparata: be the Preparation process product of Radix Rehmanniae.Nature and flavor: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Record in " pearl sac ": enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting.

Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.

Semen Ziziphi Spinosae: be the dry mature seed of Rhamnaceae plant Ziziphi Spinosae Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chou.Nature and flavor: sweet, sour are flat.Return liver, gallbladder, heart channel.Effect: tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.Record in " book on Chinese herbal medicine is new again ": suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, and beneficial will is breathed out surely, hearing-improing and eyesight improving.

Fructus Chaenomelis: be the mature fruit of Rosaceae defoliation bush plant chaenomeles lagenaria or Fructus Chaenomelis.Nature and flavor: acid, temperature.Return liver, spleen channel.Cure mainly relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture. the heavy pain of waist knee joint acid. heat-damp in summer is vomited and diarrhoea, convulsion spasm and pain, beriberi edema.

Rhizoma Acori Graminei: be the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.Nature and flavor: pungent, bitter, temperature.GUIXIN, stomach warp.Effect: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Record in essentials of Matea Medica: the tonifying liver benefit heart, dry by wind, expectorant removing food stagnancy, appetizing alleviating distention in middle-JIAO.Treatment is kept silent a mouthful fulminant dysentery, migratory arthralgia infantile convulsion.

Rhizoma Gastrodiae: be the rhizome of orchid Rhizoma Gastrodiae.Nature and flavor: sweet; Pungent; Flat; Nontoxicly return liver,spleen,kidney, gallbladder, the heart, urinary bladder channel.Effect: endogenous wind stopping relieving convulsion; Suppressing the hyperactive liver sun; Dispelling wind and removing obstruction in the collateral.Main anxious chronic infantile convulsion; Tic contracture; Dizzy; Headache; Hemiplegia; Limb fiber crops; Rheumatic arthralgia.Record in " book on Chinese herbal medicine converges and says ": main wind syndrome of head, headache, dizzy void is revolved, the strong convulsion of epilepsy, and extremity contraction is anxious, and language has some setbacks, all apoplexy, wind-phlegm.

Caulis Spatholobi: be the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor: bitter, sweet, temperature.Return liver, kidney channel.Cure mainly blood circulation promoting and enriching, menstruction regulating and pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion.

Retinervus Luffae Fructus: be the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Nature and flavor: sweet are flat.Return lung, stomach, Liver Channel.Effect: dredging collateral, invigorates blood circulation, and dispels the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.Record in " book on Chinese herbal medicine is new again ": the meridian dredging, and blood vessels, reduce phlegm pleasant.

Ramulus Uncariae Cum Uncis: be the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis Uncaria rhynchOphylla (Miq.) Jacks., Ramulus Uncariae macrophyllae Uncaria macrophylla Wall., Ramulus Uncariae Cum Uncis Uncaria hirsuta Havil., Uncaria sinensis (Oliv.) Havil. Uncaria sinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis Uncaria sessilifructusRoxb..Nature and flavor: sweet are cool.Return liver, pericardium channel.Effect: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension." book on Chinese herbal medicine is stated " is in record: control paralysis due to windstroke, facial hemiparalysis, and all brothers' migratory arthralgia caused by wind pain, and podomere contraction is anxious.Control again many years ago gout paralysis, spasm of muscles and vessels is had a pain endlessly person.

Scorpio: be the dry body of Buthidae animal Scorpio Buthus martensii Karsch.Nature and flavor: pungent are flat.Return Liver Channel.Effect: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Record in " detailed outline ": control adult Xuan malaria, deaf, hernia, all wind skin ulcers, woman's leukorrhagia, prolapse of the uterus.

Magnetitum: be oxide-based mineral spinelle race magnetic iron ore, main containing ferroso-ferric oxide (Fe304).After excavating, except roguing stone.Nature and flavor: salty, cold.Return liver, the heart, kidney channel.Effect: suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.For having a dizzy spell, blurring of vision, Hiccough and deaf, palpitation with fear insomnia, asthma of suffering from a deficiency of the kidney.Record in " not Lu ": support kidney and hide, bone strengthening gas, beneficial smart relieving restlessness, gets round by bribery, subduing inflammation scrofula, and neck core is had sore throat, pediatric epilepsy scared.

Os Draconis: for ancient times mammal as if the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex etc.Likeness in form animal bone and thicker, not of uniform size.Surface canescence or yellow-white, more smooth, some tool textures and crack, or the brown striped of tool and speckle.Matter is hard, and section is uneven, and color is white, fine and smooth in opaque.Expand at joint, section has several cellular aperture.Moisture absorption is also strong.Odorless, tasteless.Nature and flavor: sweet, puckery are flat.Effect: calm, arresting sweating arresting seminal emission, promoting tissue regeneration and ulcer healing.For neurasthenia, cardiopalmus, insomnia, dreaminess, spontaneous perspiration, night sweat, seminal emission, the enuresis, metrorrhagia, leukorrhagia; External control skin infection for a long time burst do not hold back.Record in " property of medicine opinion ": by pathogen, tranquilizing mind, only cold-dysentery and defecation with blood and pus, woman's metrorrhagia leukorrhagia, only dream lets out essence, sexual intercourse in dream, controls hematuria, empty and dreaminess diverse and confused adding and use it.

Concha Ostreae: be the shell of Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostreatalienwhanensis Crosse or Crassostrea rivularis Ostrea rivularis Gould.Nature and flavor: salty, are slightly cold.Return liver, gallbladder, kidney channel.Effect: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.Record in " herbal classic ": typhoid fever cold and heat, pyrexial malaria is voluminous, frightened gas of being enraged, and except arresting slow scrofula, woman's leukorrhagia is in vain red.Take bone strengthening joint for a long time.

Concha Haliotidis: be the shell of Bao Ke animal Haliotis diversicolor (sea at the bottom of light certainly) Haliotis diversicolor Reeve, haliotis discus hannai Ino (sea at the bottom of hair certainly) Haliotis discus hannai Ino, sheep Bao (sea certainly) Haliotis ovina Gmelin, haliotis ruber Haliotis ruber (Leach), ear Bao Haliotis asinina Linnaeus or white Bao Haliotislaevigata (Donovan).Nature and flavor: salty, cold.Return Liver Channel.Effect: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.Record in " Haiyao Bencao, Oversea Materia Medica ": main optic atrophy, liver lung-wind syndrome heat, hectic fever due to YIN-deficiency labor pole.

Radix Stephaniae Tetrandrae: be the dry root of menispermaceous plants Radix stephaniae tetrandrae Stephania tetrandra S.Moore.Nature and flavor: bitter, cold.Return bladder, lung meridian.Effect: inducing diuresis to remove edema, wind-expelling pain-stopping.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia; Hypertension.Record in " book on Chinese herbal medicine is new again ": dampness removing, except wind, Xie Huo, removing blood stasis.Control bladder edema, strengthening the spleen and stomach, reduce phlegm.

Semen Plantaginis: be the dry mature seed of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressaWilld..Nature and flavor: sweet, are slightly cold.Return liver, kidney, lung, small intestine meridian.Effect: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.Record in " property of medicine opinion ": remove pathogenic wind toxic, the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart.

Herba Lophatheri: be the dry stem and leaf of grass Herba Lophatheri Lophatherum gracile Brongn..Nature and flavor: sweet, light, cold.GUIXIN, stomach, small intestine meridian.Effect: clearing heat and relieving fidgetness, diuresis.For calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.Record in " the SHENGCAO property of medicine is standby to be wanted ": expectorant is quenched the thirst, except part of the body cavity above the diaphragm housing the heart and lungs fire, bright eyes, diuresis, controls nebulousurine, brings down a fever, loose hemorrhoid poison.

Radix Cyathulae: be the dry root of Sichuan amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume..Nature and flavor: bitter, sour are flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.Record in " Traditional Chinese Medicine in Sichuan will ": expelling wind and removing dampness, stimulate the menstrual flow loose blood.Control cold-damp waist thigh bone pain, flaccidity of the lower limbs clonic spasm of the muscle, women's amenorrhea and lump in the abdomen, gonorrhea, hematuria, impotence, mistake are drowned.

Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow.

Herba Leonuri: be the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Nature and flavor: bitter, pungent, are slightly cold.Return liver, pericardium channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.

Bombyx mori L.: be the dry feces of Bombycidae animal bombyx mori larva.Nature and flavor: sweet in the mouth; Pungent; Warm in nature, return liver; Spleen; Stomach warp.Effect: expelling wind and removing dampness; Regulating the function of the stomach to resolve the turbidity; Promoting blood circulation to restore menstrual flow.Main air pain of dampness syndrome; Limbs are unsuccessful; Rubella pruritus; Vomit and diarrhoea and have a cramp; Amenorrhea; Metrorrhagia.

Side's solution of the present invention is: in side, Radix Rehmanniae Preparata, Caulis Spatholobi, Magnetitum, Os Draconis, Concha Ostreae return kidney channel, have tonify Qi of the kidney, tonifying the blood and stretching the tendon effect.Restless legs syndrome pathological changes endogenous cause of ill is self kidney qi virtual loss, deficiency of kidney-QI, muscles and bones lose its support, muscle cartilage withers, so that the uneasy disease of legs and feet.So tonify Qi of the kidney, tonifying the blood and stretching the tendon be treatment restless legs syndrome basis, above five kinds of Chinese medicine is monarch drug, first fundamentally tonifies Qi of the kidney, and nourish blood strong muscle, makes disease obtain basic control.Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Rehmanniae, Semen Ziziphi Spinosae, Fructus Chaenomelis, Rhizoma Gastrodiae, Retinervus Luffae Fructus, Ramulus Uncariae Cum Uncis, Concha Haliotidis, Semen Plantaginis return Liver Channel.Liver governing tendons, kidney governing bones, Liver and kidney is homology.Liver storing blood, kidney controlling essence storage, and liver, kidney passages through which vital energy circulates all follow row inside health and intersection in " sp 6 ", Liver and kidney be jointly under the jurisdiction of punching appoint arteries and veins.Above 12 taste medicines are as ministerial drug, and the auxiliary monarch drug of one side is tonified Qi of the kidney, tonifying the blood and stretching the tendon; As ministerial drug, there is warming the meridian and activating blood circulation, liver nourishing dredging collateral effect on the other hand.Rhizoma Acori Graminei, Scorpio, Radix Stephaniae Tetrandrae, Herba Lophatheri have yin nourishing QI invigorating, the effect of diuretic dredging collateral, above four Chinese medicine is as adjuvant drug, the inducement of restless legs syndrome is caused from pathology treatment, the kidney invigorating and essence nourishing, tonifying the blood and stretching the tendon effect of the monarch and his subjects two medicine can be promoted as adjuvant drug, again can using corrigent the monarch and his subjects two medicine, regulate body function.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have tonify Qi of the kidney, relaxing muscles and tendons to promote blood circulation, warming the meridian and activating blood circulation, liver nourishing dredging collateral effect of effect, effectively can treat restless legs syndrome.

Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, be rich in aminoacid and have more than 17 kinds, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus.Above nutritional labeling is all needed by human material, effectively can strengthen body immunity.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Angelicae Sinensis 16-20 part, Radix Paeoniae Alba 13-17 part, Rhizoma Chuanxiong 10-14 part, Radix Rehmanniae Preparata 13-17 part, Radix Rehmanniae 13-17 part, Semen Ziziphi Spinosae 18-22 part, Fructus Chaenomelis 18-22 part, Rhizoma Acori Graminei 13-17 part, Rhizoma Gastrodiae 10-14 part, Caulis Spatholobi 22-26 part, Retinervus Luffae Fructus 22-26 part, Ramulus Uncariae Cum Uncis 16-20 part, Scorpio 7-11 part, Magnetitum 28-32 part, Os Draconis 28-32 part, Concha Ostreae 28-32 part, Concha Haliotidis 28-32 part, Radix Stephaniae Tetrandrae 8-12 part, Semen Plantaginis 10-14 part, Herba Lophatheri 10-14 part, Radix Cyathulae 16-20 part, Flos Carthami 7-11 part, Herba Leonuri 13-17 part, Bombyx mori L. 7-11 part.

Wherein be preferably: Radix Angelicae Sinensis 18 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Chuanxiong 12 parts, Radix Rehmanniae Preparata 15 parts, Radix Rehmanniae 15 parts, Semen Ziziphi Spinosae 20 parts, Fructus Chaenomelis 20 parts, Rhizoma Acori Graminei 15 parts, 12 parts, Rhizoma Gastrodiae, Caulis Spatholobi 24 parts, Retinervus Luffae Fructus 24 parts, Ramulus Uncariae Cum Uncis 18 parts, Scorpio 9 parts, Magnetitum 30 parts, Os Draconis 30 parts, Concha Ostreae 30 parts, Concha Haliotidis 30 parts, Radix Stephaniae Tetrandrae 10 parts, Semen Plantaginis 12 parts, Herba Lophatheri 12 parts, Radix Cyathulae 18 parts, 9 parts, Flos Carthami, Herba Leonuri 15 parts, Bombyx mori L. 9 parts.

A kind of preparation method of the Chinese medicine preparation for restless legs syndrome is as follows:

Step one: by weight of the present invention, get Radix Rehmanniae Preparata, grinding, crosses 120 mesh sieves, for subsequent use;

Step 2: by weight proportion of the present invention, get Magnetitum, Os Draconis, Concha Ostreae, Concha Haliotidis, Bombyx mori L. medical material is placed in marmite, add the water of 8 times of volumes, after boiling, add the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Rehmanniae, Semen Ziziphi Spinosae, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Caulis Spatholobi, Retinervus Luffae Fructus, Ramulus Uncariae Cum Uncis, Scorpio, Radix Stephaniae Tetrandrae, Radix Cyathulae, Bombyx mori L. intense fire infusion 15 ~ 20 minutes, fiery infusion of larding speech with literary allusions is filtered for 30 ~ 40 minutes, add the water of 2 times of volumes again, by Radix Angelicae Sinensis, Fructus Chaenomelis, Semen Plantaginis, Herba Lophatheri, Flos Carthami, Herba Leonuri, drop in marmite, slow fire infusion obtains filtrate in 20 ~ 30 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use,

Step 3: by filtrate and the mixing of step one powder, stir evenly, both the decoction for the treatment of restless legs syndrome of the present invention.

Using method of the present invention: get decoction, decoction being taken warmly in a hour after meal, every day 2 times.It within 7 days, is a course for the treatment of.

Medicine of the present invention have tonify Qi of the kidney, relaxing muscles and tendons to promote blood circulation, warming the meridian and activating blood circulation, liver nourishing dredging collateral effect, and good analgesic effect, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviate the slight illness of patient, according to clinical 240 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 82.5%, two the total effective rate course for the treatment of 95%.

Detailed description of the invention

Embodiment one: Radix Angelicae Sinensis 18 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Chuanxiong 12 parts, Radix Rehmanniae Preparata 15 parts, Radix Rehmanniae 15 parts, Semen Ziziphi Spinosae 20 parts, Fructus Chaenomelis 20 parts, Rhizoma Acori Graminei 15 parts, 12 parts, Rhizoma Gastrodiae, Caulis Spatholobi 24 parts, Retinervus Luffae Fructus 24 parts, Ramulus Uncariae Cum Uncis 18 parts, Scorpio 9 parts, Magnetitum 30 parts, Os Draconis 30 parts, Concha Ostreae 30 parts, Concha Haliotidis 30 parts, Radix Stephaniae Tetrandrae 10 parts, Semen Plantaginis 12 parts, Herba Lophatheri 12 parts, Radix Cyathulae 18 parts, 9 parts, Flos Carthami, Herba Leonuri 15 parts, Bombyx mori L. 9 parts.

Embodiment two: Radix Angelicae Sinensis 19 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Chuanxiong 11 parts, Radix Rehmanniae Preparata 17 parts, Radix Rehmanniae 16 parts, Semen Ziziphi Spinosae 20 parts, Fructus Chaenomelis 21 parts, Rhizoma Acori Graminei 14 parts, 11 parts, Rhizoma Gastrodiae, Caulis Spatholobi 24 parts, Retinervus Luffae Fructus 23 parts, Ramulus Uncariae Cum Uncis 18 parts, Scorpio 9 parts, Magnetitum 32 parts, Os Draconis 31 parts, Concha Ostreae 30 parts, Concha Haliotidis 30 parts, Radix Stephaniae Tetrandrae 11 parts, Semen Plantaginis 12 parts, Herba Lophatheri 12 parts, Radix Cyathulae 17 parts, 10 parts, Flos Carthami, Herba Leonuri 16 parts, Bombyx mori L. 10 parts.

Embodiment three: Radix Angelicae Sinensis 17 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Chuanxiong 12 parts, Radix Rehmanniae Preparata 15 parts, Radix Rehmanniae 14 parts, Semen Ziziphi Spinosae 22 parts, Fructus Chaenomelis 21 parts, Rhizoma Acori Graminei 15 parts, 12 parts, Rhizoma Gastrodiae, Caulis Spatholobi 24 parts, Retinervus Luffae Fructus 24 parts, Ramulus Uncariae Cum Uncis 18 parts, Scorpio 9 parts, Magnetitum 30 parts, Os Draconis 30 parts, Concha Ostreae 31 parts, Concha Haliotidis 31 parts, Radix Stephaniae Tetrandrae 10 parts, Semen Plantaginis 13 parts, Herba Lophatheri 11 parts, Radix Cyathulae 17 parts, 10 parts, Flos Carthami, Herba Leonuri 16 parts, Bombyx mori L. 10 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 240 example for medical treatment, patient is divided at random observation group and each 120 examples of matched group, wherein male 117 example, women 123 example, M-F 1:1.05, max age 75 years old, minimal ages 50 years old, course of disease some months is not by several years etc.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).

Two, diagnostic criteria

1, because of paraesthesia, feel to go down, activity suffering limb in spite of oneself.

2, motion is not peaceful.

3, fall ill during rest or increase the weight of, alleviating after movable.

4, exacerbation of symptoms after falling asleep night.

Three, Therapeutic Method:

1, observation group is according to Medications Example one of the present invention, and weighting raw materials, by the treatment of invention implementation method, gets decoction, decoction being taken warmly in a hour after meal, every day 2 times.It within 7 days, is a course for the treatment of.

2, matched group adopts conventional western medicine Pa Jinning Therapeutic Method, and the Ureteral Calculus phase is 15 days.

Four, efficacy assessment standard:

1, cure: cardinal symptom recovers normal substantially, directed sound, life can be taken care of oneself, and recovers mass society activity, does not recur in 1 year.

2, take a turn for the better: cardinal symptom major part recovers normal, and sleeping at night symptom alleviates, occur that motion is not peaceful once in a while.

3, invalid: cardinal symptom is without changing and continuing development.

Five, therapeutic outcome statistics:

Matched group result is added up

Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of

Group	Number of cases	Cure [n (%)]	Take a turn for the better [n (%)]	Invalid [n (%)]	Total effective rate (%)
						Observation group	120	81(67.5)	33(27.5)	6(5)	95
Matched group	120	60(50)	40(33.3)	20(16.7)	83.3

Wherein: total effective rate=cure rate+improvement rate

Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness on treatment restless legs syndrome, effectively can improve the cure rate for the treatment of, Be very effective, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground.

Model case and curative effect:

Case one, patient Wang, man, 66 years old, people from Qingdao City, once in the working of Qingdao aquatic products processing company, existing retirement was in.Come here on January 18th, 2010 to go to a doctor.Clinical symptoms:: two lower limb muscles acid is swollen, numb, tired heavy unable, like the non-pain of pain; Have worm to climb sense, light night in daytime is heavy, and spiritlessness and weakness, poor appetite cold extremities, pale tongue, thin lingual fur, deep pulse is thin and delicate.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur for 1 year.

Case two, patient Lee, female, 59 years old, people from Qingzhou in Shandong province.Come here on May 14th, 2010 to go to a doctor, symptom is as follows after diagnosing: two lower limb muscles acid is swollen, numbness of the skin, tired heavy weak, and like the non-pain of pain, have contracture to feel nervous pain or the sense of ant row during gastrocnemius place, two dry and astringent.Dry mouth and throat, soreness of the waist and knees, thin of shape is dim, red tongue, few tongue, thready and rapid pulse string.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur half a year.

Claims (4)

1. the Chinese medicine preparation for restless legs syndrome, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Angelicae Sinensis 16-20 part, Radix Paeoniae Alba 13-17 part, Rhizoma Chuanxiong 10-14 part, Radix Rehmanniae Preparata 13-17 part, Radix Rehmanniae 13-17 part, Semen Ziziphi Spinosae 18-22 part, Fructus Chaenomelis 18-22 part, Rhizoma Acori Graminei 13-17 part, Rhizoma Gastrodiae 10-14 part, Caulis Spatholobi 22-26 part, Retinervus Luffae Fructus 22-26 part, Ramulus Uncariae Cum Uncis 16-20 part, Scorpio 7-11 part, Magnetitum 28-32 part, Os Draconis 28-32 part, Concha Ostreae 28-32 part, Concha Haliotidis 28-32 part, Radix Stephaniae Tetrandrae 8-12 part, Semen Plantaginis 10-14 part, Herba Lophatheri 10-14 part, Radix Cyathulae 16-20 part, Flos Carthami 7-11 part, Herba Leonuri 13-17 part, Bombyx mori L. 7-11 part.

2. the Chinese medicine preparation for restless legs syndrome according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Angelicae Sinensis 18 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Chuanxiong 12 parts, Radix Rehmanniae Preparata 15 parts, Radix Rehmanniae 15 parts, Semen Ziziphi Spinosae 20 parts, Fructus Chaenomelis 20 parts, Rhizoma Acori Graminei 15 parts, 12 parts, Rhizoma Gastrodiae, Caulis Spatholobi 24 parts, Retinervus Luffae Fructus 24 parts, Ramulus Uncariae Cum Uncis 18 parts, Scorpio 9 parts, Magnetitum 30 parts, Os Draconis 30 parts, Concha Ostreae 30 parts, Concha Haliotidis 30 parts, Radix Stephaniae Tetrandrae 10 parts, Semen Plantaginis 12 parts, Herba Lophatheri 12 parts, Radix Cyathulae 18 parts, 9 parts, Flos Carthami, Herba Leonuri 15 parts, Bombyx mori L. 9 parts.

3. the Chinese medicine preparation for restless legs syndrome according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. for a preparation method for the Chinese medicine preparation of restless legs syndrome, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, get Radix Rehmanniae Preparata, grinding, crosses 120 mesh sieves, for subsequent use, step 2: by weight proportion of the present invention, get Magnetitum, Os Draconis, Concha Ostreae, Concha Haliotidis, Bombyx mori L. medical material is placed in marmite, add the water of 8 times of volumes, after boiling, add the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Rehmanniae, Semen Ziziphi Spinosae, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Caulis Spatholobi, Retinervus Luffae Fructus, Ramulus Uncariae Cum Uncis, Scorpio, Radix Stephaniae Tetrandrae, Radix Cyathulae, Bombyx mori L. intense fire infusion 15 ~ 20 minutes, fiery infusion of larding speech with literary allusions is filtered for 30 ~ 40 minutes, add the water of 2 times of volumes again, by Radix Angelicae Sinensis, Fructus Chaenomelis, Semen Plantaginis, Herba Lophatheri, Flos Carthami, Herba Leonuri, drop in marmite, slow fire infusion obtains filtrate in 20 ~ 30 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use, step 3: by filtrate and the mixing of step one powder, stir evenly, both the decoction for the treatment of restless legs syndrome of the present invention.