CN1362085A - Nano mixed natural indigo medicine and its preparation - Google Patents
Nano mixed natural indigo medicine and its preparation Download PDFInfo
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- CN1362085A CN1362085A CN 01100068 CN01100068A CN1362085A CN 1362085 A CN1362085 A CN 1362085A CN 01100068 CN01100068 CN 01100068 CN 01100068 A CN01100068 A CN 01100068A CN 1362085 A CN1362085 A CN 1362085A
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Abstract
The invention discloses a preparation of nano indigo naturalis compound. It comprises materials as follows: nano indigo naturalis, nano dark plumn, nano dandelion, nano radix lithospermi, nano Angelica dehurica, nano root of red-rooted salvia, nano cortex dictamni, nano basket fern, nano rhizoma smilacis glabrae, nano verdolaga, nano scorched haw, nano Schisandra chinensis wine. Making up in proportion and to be fabricated into new medicine drug. Its particle fineness is 1200-1500 mesh and particle size 0.1-200 nm and most of the particle size is shorter than 100nm and gets new material properties. It is fabricated through steps such as microwave extraction, decompression and concentration, supersonic jet and spray drying.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, speckle removing blood stasis dispelling, dispelling wind for relieving itching, cure mainly the nano compound Indigo Naturalis preparation medicine of the phase of carrying out psoriasis, pityriasis rosea, drug eruption, the invention still further relates to the method for this medication preparation.
FUFANG QINGDAI WAN is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, speckle removing blood stasis dispelling, dispelling wind for relieving itching, is used to carry out phase psoriasis, pityriasis rosea, drug eruption.But traditional FUFANG QINGDAI WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano compound Indigo Naturalis preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano compound Indigo Naturalis preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano natural indigo 3-15 part nano dark plum 20-40 part nanometer Herba Taraxaci 4-20 part
Nanometer Radix Arnebiae (Radix Lithospermi) 4-20 part nano angelica root 5-25 part nano red sage 5-25 part
Nanometer Cortex Dictamni 5-25 part nanometer Massa Medicata Fermentata 3-15 part nanometer Rhizoma Osmundae 3-15 part
Nanometer Rhizoma Smilacis Glabrae 20-40 part nanometer Herba Portulacae 20-40 part nanometer Bi 5-25 part
Nanometer Fructus Crataegi (Jiao) 3-15 part nanometer Fructus Schisandrae Chinensis (wine) 5-25 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano natural indigo 5-13 part nano dark plum 25-35 part nanometer Herba Taraxaci 6-18 part
Nanometer Radix Arnebiae (Radix Lithospermi) 6-18 part nano angelica root 10-20 part nano red sage 10-20 part
Nanometer Cortex Dictamni 10-20 part nanometer Massa Medicata Fermentata 6-12 part nanometer Rhizoma Osmundae 6-12 part
Nanometer Rhizoma Smilacis Glabrae 25-35 part nanometer Herba Portulacae 25-35 part nanometer Bi 10-20 part
Nanometer Fructus Crataegi (Jiao) 6-12 part nanometer Fructus Schisandrae Chinensis (wine) 10-20 part
The optimum weight proportioning of medicine of the present invention is:
12 parts of 30 parts of nanometer Herba Taraxacis of 9 parts of nano dark plums of nano natural indigo
15 parts of 15 parts of nano red sages of 12 parts of nano angelica roots of nanometer Radix Arnebiae (Radix Lithospermi)
9 parts of 9 parts of nanometer Rhizoma Osmundae of 15 parts of nanometer Massa Medicata Fermentata of nanometer Cortex Dictamni
15 parts of 30 parts of nanometer Bi of 30 parts of nanometer Herba Portulacaes of nanometer Rhizoma Smilacis Glabrae
15 parts of 9 parts of nanometer Fructus Schisandrae Chinensis of nanometer Fructus Crataegi (Jiao) (wine)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get compound indigo preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano compound Indigo Naturalis preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common FUFANG QINGDAI WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano compound Indigo Naturalis preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for carrying out treatment of conditions such as phase psoriasis, pityriasis rosea, drug eruption, and clinical efficacy significantly is better than traditional FUFANG QINGDAI WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
12 parts of 30 parts of nanometer Herba Taraxacis of 9 parts of nano dark plums of nano natural indigo
15 parts of 15 parts of nano red sages of 12 parts of nano angelica roots of nanometer Radix Arnebiae (Radix Lithospermi)
9 parts of 9 parts of nanometer Rhizoma Osmundae of 15 parts of nanometer Massa Medicata Fermentata of nanometer Cortex Dictamni
15 parts of 30 parts of nanometer Bi of 30 parts of nanometer Herba Portulacaes of nanometer Rhizoma Smilacis Glabrae
15 parts of 9 parts of nanometer Fructus Schisandrae Chinensis of nanometer Fructus Crataegi (Jiao) (wine)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
12 parts of 30 parts of nanometer Herba Taraxacis of 9 parts of nano dark plums of nano natural indigo
15 parts of 15 parts of nano red sages of 12 parts of nano angelica roots of nanometer Radix Arnebiae (Radix Lithospermi)
9 parts of 9 parts of nanometer Rhizoma Osmundae of 15 parts of nanometer Massa Medicata Fermentata of nanometer Cortex Dictamni
15 parts of 30 parts of nanometer Bi of 30 parts of nanometer Herba Portulacaes of nanometer Rhizoma Smilacis Glabrae
15 parts of 9 parts of nanometer Fructus Schisandrae Chinensis of nanometer Fructus Crataegi (Jiao) (wine)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano compound Indigo Naturalis powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
12 parts of 30 parts of nanometer Herba Taraxacis of 9 parts of nano dark plums of nano natural indigo
15 parts of 15 parts of nano red sages of 12 parts of nano angelica roots of nanometer Radix Arnebiae (Radix Lithospermi)
9 parts of 9 parts of nanometer Rhizoma Osmundae of 15 parts of nanometer Massa Medicata Fermentata of nanometer Cortex Dictamni
15 parts of 30 parts of nanometer Bi of 30 parts of nanometer Herba Portulacaes of nanometer Rhizoma Smilacis Glabrae
15 parts of 9 parts of nanometer Fructus Schisandrae Chinensis of nanometer Fructus Crataegi (Jiao) (wine)
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano compound Indigo Naturalis membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano compound Indigo Naturalis preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano natural indigo 3-15 part nano dark plum 20-40 part nanometer Herba Taraxaci 4-20 part
Nanometer Radix Arnebiae (Radix Lithospermi) 4-20 part nano angelica root 5-25 part nano red sage 5-25 part
Nanometer Cortex Dictamni 5-25 part nanometer Massa Medicata Fermentata 3-15 part nanometer Rhizoma Osmundae 3-15 part
Nanometer Rhizoma Smilacis Glabrae 20-40 part nanometer Herba Portulacae 20-40 part nanometer Bi 5-25 part
Nanometer Fructus Crataegi (Jiao) 3-15 part nanometer Fructus Schisandrae Chinensis (wine) 5-25 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano compound Indigo Naturalis preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano natural indigo 5-13 part nano dark plum 25-35 part nanometer Herba Taraxaci 6-18 part
Nanometer Radix Arnebiae (Radix Lithospermi) 6-18 part nano angelica root 10-20 part nano red sage 10-20 part
Nanometer Cortex Dictamni 10-20 part nanometer Massa Medicata Fermentata 6-12 part nanometer Rhizoma Osmundae 6-12 part
Nanometer Rhizoma Smilacis Glabrae 25-35 part nanometer Herba Portulacae 25-35 part nanometer Bi 10-20 part
Nanometer Fructus Crataegi (Jiao) 6-12 part nanometer Fructus Schisandrae Chinensis (wine) 10-20 part
3, nano compound Indigo Naturalis preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
12 parts of 30 parts of nanometer Herba Taraxacis of 9 parts of nano dark plums of nano natural indigo
15 parts of 15 parts of nano red sages of 12 parts of nano angelica roots of nanometer Radix Arnebiae (Radix Lithospermi)
9 parts of 9 parts of nanometer Rhizoma Osmundae of 15 parts of nanometer Massa Medicata Fermentata of nanometer Cortex Dictamni
15 parts of 30 parts of nanometer Bi of 30 parts of nanometer Herba Portulacaes of nanometer Rhizoma Smilacis Glabrae
15 parts of 9 parts of nanometer Fructus Schisandrae Chinensis of nanometer Fructus Crataegi (Jiao) (wine)
4, according to claim 1 or 2 or 3 described nano compound Indigo Naturalis preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano compound Indigo Naturalis preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100068 CN1362085A (en) | 2001-01-08 | 2001-01-08 | Nano mixed natural indigo medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100068 CN1362085A (en) | 2001-01-08 | 2001-01-08 | Nano mixed natural indigo medicine and its preparation |
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| Publication Number | Publication Date |
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| CN1362085A true CN1362085A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100068 Pending CN1362085A (en) | 2001-01-08 | 2001-01-08 | Nano mixed natural indigo medicine and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005023280A1 (en) * | 2003-09-11 | 2005-03-17 | Vital Pharmaceuticals (Sichuan) Company Limited | Oral treatment for anorectal conditions |
| CN102018736A (en) * | 2010-11-19 | 2011-04-20 | 成都中医药大学 | Natural indigo decoction piece and preparation method thereof |
| CN106029065A (en) * | 2013-12-20 | 2016-10-12 | 法斯瑞斯公司 | Indirubin solid dispersion composition |
-
2001
- 2001-01-08 CN CN 01100068 patent/CN1362085A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005023280A1 (en) * | 2003-09-11 | 2005-03-17 | Vital Pharmaceuticals (Sichuan) Company Limited | Oral treatment for anorectal conditions |
| CN102018736A (en) * | 2010-11-19 | 2011-04-20 | 成都中医药大学 | Natural indigo decoction piece and preparation method thereof |
| CN106029065A (en) * | 2013-12-20 | 2016-10-12 | 法斯瑞斯公司 | Indirubin solid dispersion composition |
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