CN1366915A - Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method - Google Patents
Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method Download PDFInfo
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- CN1366915A CN1366915A CN 01102055 CN01102055A CN1366915A CN 1366915 A CN1366915 A CN 1366915A CN 01102055 CN01102055 CN 01102055 CN 01102055 A CN01102055 A CN 01102055A CN 1366915 A CN1366915 A CN 1366915A
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Abstract
The present invention discloses a nano brain-benefiting blood-pressure reducing preparation medicine. It is made up by using 13 Chinese medicinal materials of nano scutellaria, nano prunella, nano sophora, nano loadstone, nano achyranthes and others as raw material through the processes of microwave extraction, reducing pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of suppressing the hyperactive liver and subsiding YANG, brain-benefiting blood pressure-reducing, cure mainly excessive rising of liver-YANG, blood pressure is higher, giddy is dizzy, the nano brain-benefiting blood pressure-reducing preparation medicine of insomnia forgetfulness, the invention still further relates to the method for this medication preparation.
The brain-benefiting blood pressure-reducing sheet is a kind of classical Chinese patent medicine, mainly contains effects such as suppressing the hyperactive liver and subsiding YANG, brain-benefiting blood pressure-reducing, is used for suppressing the hyperactive liver and subsiding YANG, brain-benefiting blood pressure-reducing.But traditional brain-benefiting blood pressure-reducing sheet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano brain-benefiting blood pressure-reducing preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano brain-benefiting blood pressure-reducing preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Scutellariae 60-150 part nanometer Spica Prunellae 40-80 part nanometer Flos Sophorae Immaturus 40-80 part
Nano magnetite 40-80 part nanometer Radix Achyranthis Bidentatae 40-80 part nano Chinese angelica 60-150 part
Nanometer Radix Rehmanniae 30-65 part nano red sage 30-65 part nanometer Hirudo 12-30 part
The sub-70-150 part of nanometer Ramulus Uncariae Cum Uncis 40-80 part nano jueming nanometer earthworm 12-30 part
The female 30-65 part of nano-pearl
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Scutellariae 80-120 part nanometer Spica Prunellae 50-70 part nanometer Flos Sophorae Immaturus 50-70 part
Nano magnetite 50-70 part nanometer Radix Achyranthis Bidentatae 50-70 part nano Chinese angelica 80-120 part
Nanometer Radix Rehmanniae 35-55 part nano red sage 35-55 part nanometer Hirudo 15-25 part
The sub-80-120 part of nanometer Ramulus Uncariae Cum Uncis 50-70 part nano jueming nanometer earthworm 15-25 part
The female 35-55 part of nano-pearl
The optimum weight proportioning of medicine of the present invention is:
60 parts of 60 portions of nanometer Flos Sophorae Immaturus of 100 parts of nanometer Spica Prunellaes of nanometer Radix Scutellariae
100 parts of 60 parts of nano Chinese angelicas of 60 parts of nanometer Radix Achyranthis Bidentataes of nano magnetite
20 parts of 40 parts of nanometer Hirudos of 40 parts of nano red sages of nanometer Radix Rehmanniae
20 parts of 100 parts of nanometer earthworms of 60 parts of nano jueming of nanometer Ramulus Uncariae Cum Uncis
Female 40 parts of nano-pearl
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the special construction-material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get brain-benefiting blood pressure-reducing preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano brain-benefiting blood pressure-reducing preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common brain-benefiting blood pressure-reducing tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano brain-benefiting blood pressure-reducing preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for excessive rising of liver-YANG, blood pressure is higher, giddy is dizzy, the insomnia forgetfulness treatment of conditions, and clinical efficacy significantly is better than traditional brain-benefiting blood pressure-reducing sheet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 60 portions of nanometer Flos Sophorae Immaturus of 100 parts of nanometer Spica Prunellaes of nanometer Radix Scutellariae
100 parts of 60 parts of nano Chinese angelicas of 60 parts of nanometer Radix Achyranthis Bidentataes of nano magnetite
20 parts of 40 parts of nanometer Hirudos of 40 parts of nano red sages of nanometer Radix Rehmanniae
20 parts of 100 parts of nanometer earthworms of 60 parts of nano jueming of nanometer Ramulus Uncariae Cum Uncis
Female 40 parts of nano-pearl
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 60 portions of nanometer Flos Sophorae Immaturus of 100 parts of nanometer Spica Prunellaes of nanometer Radix Scutellariae
100 parts of 60 parts of nano Chinese angelicas of 60 parts of nanometer Radix Achyranthis Bidentataes of nano magnetite
20 parts of 40 parts of nanometer Hirudos of 40 parts of nano red sages of nanometer Radix Rehmanniae
20 parts of 100 parts of nanometer earthworms of 60 parts of nano jueming of nanometer Ramulus Uncariae Cum Uncis
Female 40 parts of nano-pearl
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano brain-benefiting blood pressure-reducing powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 60 portions of nanometer Flos Sophorae Immaturus of 100 parts of nanometer Spica Prunellaes of nanometer Radix Scutellariae
100 parts of 60 parts of nano Chinese angelicas of 60 parts of nanometer Radix Achyranthis Bidentataes of nano magnetite
20 parts of 40 parts of nanometer Hirudos of 40 parts of nano red sages of nanometer Radix Rehmanniae
20 parts of 100 parts of nanometer earthworms of 60 parts of nano jueming of nanometer Ramulus Uncariae Cum Uncis
Female 40 parts of nano-pearl
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano brain-benefiting blood pressure-reducing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano brain-benefiting blood pressure-reducing preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Scutellariae 60-150 part nanometer Spica Prunellae 40-80 part nanometer Flos Sophorae Immaturus 40-80 part
Nano magnetite 40-80 part nanometer Radix Achyranthis Bidentatae 40-80 part nano Chinese angelica 60-150 part
Nanometer Radix Rehmanniae 30-65 part nano red sage 30-65 part nanometer Hirudo 12-30 part
The sub-70-150 part of nanometer Ramulus Uncariae Cum Uncis 40-80 part nano jueming nanometer earthworm 12-30 part
The female 30-65 part of nano-pearl
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano brain-benefiting blood pressure-reducing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Scutellariae 80-120 part nanometer Spica Prunellae 50-70 part nanometer Flos Sophorae Immaturus 50-70 part
Nano magnetite 50-70 part nanometer Radix Achyranthis Bidentatae 50-70 part nano Chinese angelica 80-120 part
Nanometer Radix Rehmanniae 35-55 part nano red sage 35-55 part nanometer Hirudo 15-25 part
The sub-80-120 part of nanometer Ramulus Uncariae Cum Uncis 50-70 part nano jueming nanometer earthworm 15-25 part
The female 35-55 part of nano-pearl
3, nano brain-benefiting blood pressure-reducing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 60 portions of nanometer Flos Sophorae Immaturus of 100 parts of nanometer Spica Prunellaes of nanometer Radix Scutellariae
100 parts of 60 parts of nano Chinese angelicas of 60 parts of nanometer Radix Achyranthis Bidentataes of nano magnetite
20 parts of 40 parts of nanometer Hirudos of 40 parts of nano red sages of nanometer Radix Rehmanniae
20 parts of 100 parts of nanometer earthworms of 60 parts of nano jueming of nanometer Ramulus Uncariae Cum Uncis
Female 40 parts of nano-pearl
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano brain-benefiting blood pressure-reducing preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano brain-benefiting blood pressure-reducing preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102055 CN1366915A (en) | 2001-01-22 | 2001-01-22 | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102055 CN1366915A (en) | 2001-01-22 | 2001-01-22 | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100509002C (en) * | 2006-12-21 | 2009-07-08 | 中国科学院南海海洋研究所 | Marine medicine for treating hypertension, preparation process and dispersible tablet thereof |
| CN102397394A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cephalocathartic hypertension pill |
| CN102885935A (en) * | 2012-10-31 | 2013-01-23 | 江苏晨牌药业有限公司 | Production technology of cephalocathartic hypertension particles |
| CN102988577A (en) * | 2012-10-15 | 2013-03-27 | 李正梅 | Preparation method and application of brain-soothing hypertension pill |
-
2001
- 2001-01-22 CN CN 01102055 patent/CN1366915A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100509002C (en) * | 2006-12-21 | 2009-07-08 | 中国科学院南海海洋研究所 | Marine medicine for treating hypertension, preparation process and dispersible tablet thereof |
| CN102397394A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cephalocathartic hypertension pill |
| CN102397394B (en) * | 2011-11-26 | 2013-08-21 | 苏州派腾生物医药科技有限公司 | Preparation method of cephalocathartic hypertension pill |
| CN102988577A (en) * | 2012-10-15 | 2013-03-27 | 李正梅 | Preparation method and application of brain-soothing hypertension pill |
| CN102988577B (en) * | 2012-10-15 | 2013-11-06 | 李正梅 | Preparation method and application of brain-soothing hypertension pill |
| CN102885935A (en) * | 2012-10-31 | 2013-01-23 | 江苏晨牌药业有限公司 | Production technology of cephalocathartic hypertension particles |
| CN102885935B (en) * | 2012-10-31 | 2015-03-25 | 江苏晨牌药业集团股份有限公司 | Production technology of cephalocathartic hypertension particles |
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