CN102397394B - Preparation method of cephalocathartic hypertension pill - Google Patents
Preparation method of cephalocathartic hypertension pill Download PDFInfo
- Publication number
- CN102397394B CN102397394B CN2011103813518A CN201110381351A CN102397394B CN 102397394 B CN102397394 B CN 102397394B CN 2011103813518 A CN2011103813518 A CN 2011103813518A CN 201110381351 A CN201110381351 A CN 201110381351A CN 102397394 B CN102397394 B CN 102397394B
- Authority
- CN
- China
- Prior art keywords
- extract
- radix
- supercritical
- ethanol
- blood pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a preparation method of a cephalocathartic hypertension pill, which comprises the following steps that: radix scutellariae and bud of Chinese scholartree are extracted by microwave and are purified by daiamid chromatography column to obtain radix scutellariae and scholartree extract; self-heal, achyranthes, angelica, rehmanniae, Salvia miltiorrhiza, leech, cassia seed and earthworm are extracted under the carbon dioxide (CO2) supercritical condition to obtain supercritical extract; calcined magnetitum, mother-of-pearl and uncaria are respectively pulverized into fine power, the fine powder is uniformly blended and is mixed with the radix scutellariae and scholartree extract and the supercritical extract to be tableting pressed and coated with membrane. The cephalocathartic hypertension pill which is prepared with the above method is convenient to take.
Description
Technical field
The present invention relates to a kind of preparation method of medicine, especially a kind of preparation method of Chinese medicine.
Background technology
The brain-benefiting blood pressure-reducing sheet is to be made as crude drug by Radix Scutellariae, Spica Prunellae, the Flos Sophorae Immaturus, Magnetitum (calcined), Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Hirudo, Ramulus Uncariae Cum Uncis, Semen Cassiae, Pheretima, Concha Margaritifera, records in 2010 editions one one of the Pharmacopoeia of the People's Republic of China.Suppressing the hyperactive liver and subsiding YANG is used for dizzy due to the excessive rising of liver-YANG, and disease sees that dizziness, headache, stiffness of the nape, blood pressure are higher.
In the prior art, the report of brain-benefiting blood pressure-reducing sheet aspect function of gallbladder promoting do not arranged as yet.
In the prior art, the brain-benefiting blood pressure-reducing sheet prepare the method that adopts decocting to boil, technology is coarse, fall behind, impurity is many, causes patient's consumption per day excessive, is inconvenient to take, and has had a strong impact on this product and has used clinically.
Summary of the invention
Problem to be solved by this invention provides a kind of preparation method of brain-benefiting blood pressure-reducing sheet, makes it safe and effective, conveniently takes.
In order to solve the problems of the technologies described above, the present invention proposes following technical proposals.
Get Radix Scutellariae 100g, Flos Sophorae Immaturus 60g, pulverize, mix, 75% ethanol that adds 1.6L drops in the microwave extracting apparatus and carries out microwave extracting, extraction power 400-600W, extract 2 times, each 5 minutes, combining extraction liquid, concentrate, be added on the polyamide chromatography post, use 60% ethanol elution, collect 5 times of amount column volume eluents, decompression recycling ethanol concentrates and drying, get a kind of reed mentioned in ancient books Chinese scholartree extract, standby; Get Spica Prunellae 60g, Radix Achyranthis Bidentatae 60g, Radix Angelicae Sinensis 100g, Radix Rehmanniae 40g, Radix Salviae Miltiorrhizae 40g, Hirudo 20g, Semen Cassiae 100g, Pheretima 20g, join CO
2In the supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1-3%, extracting pressure 20-30MPa, temperature 50-70 ℃, CO
2Flow 1-3ml/g crude drug min, extraction time 120-140min gets supercritical extract, and is standby; Get Magnetitum (calcined) 60g, Ramulus Uncariae Cum Uncis 60g, Concha Margaritifera 40g, be ground into fine powder, mixing adds above-mentioned a kind of reed mentioned in ancient books Chinese scholartree extract, supercritical extract mixing, add dextrin, 70% alcohol granulation adds magnesium stearate, mixing, tabletting, the bag film-coat is made 250, every heavy 0.33g.
Radix Scutellariae, Flos Sophorae Immaturus microwave extracting power 500W.
Polyamide is selected from the poly-adipoyl of chinlon 66(diamidogen), chinlon 6(polycaprolactam) in a kind of.
CO
2The percent by volume that the supercritical extraction entrainer accounts for total extractant is 2%.
CO
2The extracting pressure 25MPa of supercritical extraction, 60 ℃ of temperature, CO
2Flow 2ml/g crude drug min, extraction time 130min.
Adopt the brain-benefiting blood pressure-reducing sheet of technique scheme preparation, it is as the application of preparation function of gallbladder promoting medicine.
In the prior art, the brain-benefiting blood pressure-reducing sheet need be taken 4 (being equivalent to the 3.04g medical material) at every turn, and the brain-benefiting blood pressure-reducing sheet that adopts the present invention to be prepared from only need be taken 1 (being equivalent to the 3.04g medical material) at every turn, has significantly reduced dose under the similar situation of blood pressure lowering pharmacologically active.This conclusion can be by following evidence.
Test the comparison of content of baicalin in the brain-benefiting blood pressure-reducing sheet of distinct methods preparation.
1, instrument and reagent
Brain-benefiting blood pressure-reducing sheet (supercritical methanol technology is hereinafter to be referred as Q-LJ, down together): press the preparation of embodiment 3 methods.
Brain-benefiting blood pressure-reducing sheet (traditional method Q-CT, down together) is pressed 2010 editions methods preparations of the Pharmacopoeia of the People's Republic of China, the bag film-coat.
Agilent 1200 high performance liquid chromatographs; METTLER AE240 electronic analytical balance.
Baicalin reference substance (Nat'l Pharmaceutical ﹠ Biological Products Control Institute).
2, method
Chromatographic condition Kromasi C18 chromatographic column (4.6mm * 200mm, 5 μ m); Methanol-0.4% phosphoric acid solution (50:50) mobile phase; Flow velocity 1.0mLmin
-1, detect wavelength 278nm.Precision is measured reference substance solution, each 10 μ L of need testing solution.
It is an amount of that the baicalin reference substance is got in the preparation of solution, and accurate the title decides, and adds methanol and makes the reference substance solution that every 1ml contains 20 μ g.Get 10 of offerings respectively, remove coating, the accurate title, decide, porphyrize, precision takes by weighing 0.7g, puts in the tool plug conical flask, the accurate 70% ethanol 25ml that adds, close plug claims to decide weight, supersound process (power 220W, frequency 50kHz) 60 minutes is taken out, put coldly, claim again to decide weight, supply the weight that subtracts mistake with 70% ethanol, shake up, filter.Precision is measured subsequent filtrate 5ml, puts in the 50ml measuring bottle, adds methanol and is diluted to scale, shakes up, and filters, and gets subsequent filtrate, namely.
3, result
Result of the test sees Table 1, and the result shows that content of baicalin (13.9mg/ sheet) in the brain-benefiting blood pressure-reducing sheet that adopts the present invention's preparation is to adopt 4.1 times of traditional method (3.4mg/ sheet).
Content of baicalin in the brain-benefiting blood pressure-reducing sheet of table 1 distinct methods preparation
| Sample | Content (mg/ sheet) |
| Q-LJ | 13.9 |
| Q-CT | 3.4 |
Test the brain-benefiting blood pressure-reducing sheet pharmacodynamics of two distinct methods preparation relatively.
1, to the influence of spontaneous hypertensive rat blood pressure
1.1 material
Medicine brain-benefiting blood pressure-reducing sheet (supercritical methanol technology is hereinafter to be referred as Q-LJ): press the preparation of embodiment 3 methods.
Brain-benefiting blood pressure-reducing sheet (traditional method is called for short Q-CT) is pressed 2010 editions method preparations of the Pharmacopoeia of the People's Republic of China, the bag film-coat.
Animal spontaneous hypertensive rat (SHR, Shanghai Slac Experimental Animal Co., Ltd.), body weight 180g-220g, clear-headed arteria caudalis systolic pressure 〉=160mmHg, male and female dual-purpose.
Instrument meiofauna survey meter of blood pressure (Huaibei Zhenghua Biological Instrument Co., Ltd.), eight road physiology monitors (RM-6000, Japan).
The date processing data are represented with mean ± s, analyze with SPSS11.0 software.Note amount data is carried out the significance,statistical analysis with one factor analysis of variance, the enumeration data X 2 test.
1.2 method and result
Get some of SHR, body weight 180g～220g.Survey its basic blood pressure with indirect manometry, divide into groups by the basic blood pressure that records, guaranteeing that mean blood pressure does not have significant difference between every group, 10 every group, the male and female dual-purpose.The blank group gives the normal saline of respective amount; Q-CT organizes (dosage 0.32g/kg is equivalent to the clinical consumption of people, i.e. 9.12g crude drug/day); The basic, normal, high dosage group of Q-LJ (dosage is respectively 0.04 g/kg, 0.08 g/kg, 0.16g/kg, and wherein middle dosage group is equivalent to the clinical consumption of people, i.e. 9.12g crude drug/day).SHR is with the anesthesia of 50mg/kg nembutal, fixing, cut skin of neck, separate trachea and intubate, separate right carotid and intubate, measure blood pressure and heart rate with direct manometry by eight road physiology monitors, the record arteriotony.Separate femoral vein and intubate liquid make-up, cut upper abdomen, separate duodenum, give over to administration, after operation finishes rat is stablized 20min, blood pressure before the opening entry administration.Carry out duodenal administration then, and observe, the blood pressure after the record administration 10,20,30,60,90,120,240, during 360min (above experiment is carried out in 25 ℃ of room temperatures).
The result of the test (seeing Table 2) that influences to SHR rat artery systolic pressure shows that before the administration, each group is compared zero difference with the blank group.After the administration, compare with the blank group, the Q-LJ high dose group begins to reduce SHR rat artery systolic pressure from 20min, and is maintained until after the 6h, and effect is (P＜0.05,0.01) significantly; Compare with the blank group, low, the middle dosage group of Q-LJ, the Q-CT group begins to reduce SHR rat artery systolic pressure from 30min, and is maintained until after the 6h, and effect is (P＜0.05,0.01) significantly.Q-CT group is compared there was no significant difference (P〉0.05) with dosage group among the Q-LJ, show under corresponding dosage (all to be equivalent to the clinical consumption of people) that both hypotensive effects are suitable.
The brain-benefiting blood pressure-reducing sheet of table 2 distinct methods preparation is to the influence (n=10, the pKA of unit) of SHR rat artery systolic pressure
Compare with the blank group: * P＜0.05, * * P＜0.01.
The result of the test (seeing Table 3) that influences to SHR rat artery diastolic pressure shows that before the administration, each group is compared zero difference with the blank group.After the administration, compare with the blank group, the Q-LJ high dose group begins to reduce SHR rat artery diastolic pressure from 20min, and is maintained until after the 6h, and effect is (P＜0.05,0.01) significantly; Compare with the blank group, low, the middle dosage group of Q-LJ, the Q-CT group begins to reduce SHR rat artery diastolic pressure from 30min, and is maintained until after the 6h, and effect is (P＜0.05,0.01) significantly.Q-CT group is compared there was no significant difference (P〉0.05) with dosage group among the Q-LJ, show under corresponding dosage (all to be equivalent to the clinical consumption of people) that both hypotensive effects are suitable.
The brain-benefiting blood pressure-reducing sheet of table 3 distinct methods preparation is to the influence (n=10, the pKA of unit) of SHR rat artery diastolic pressure
2, to rat bile secretion and bilirubinic influence
2.1 material
Animal SD rat.Provided by Shanghai Slac Experimental Animal Co., Ltd..
Medicine brain-benefiting blood pressure-reducing sheet (supercritical methanol technology is hereinafter to be referred as Q-LJ): press the preparation of embodiment 3 methods.
Brain-benefiting blood pressure-reducing sheet (traditional method is called for short Q-CT) is pressed 2010 editions method preparations of the Pharmacopoeia of the People's Republic of China, the bag film-coat.
Data and statistical data are represented with mean ± s, analyze with SPSS11.0 software.Note amount data is carried out the significance,statistical analysis with one factor analysis of variance, the enumeration data X 2 test.
2.2 method and result
Male SD rat, body weight 180-220 gram is divided into 5 groups: the blank group at random; Q-CT organizes (dosage 0.32g/kg is equivalent to the clinical consumption of people, i.e. 9.12g crude drug/day); The basic, normal, high dosage group of Q-LJ (dosage is respectively 0.04 g/kg, 0.08 g/kg, 0.16g/kg, and wherein middle dosage group is equivalent to the clinical consumption of people, i.e. 9.12g crude drug/day).After the fasting 12 hours (freely drinking water), lumbar injection crow smooth (1g/kg) anesthesia, back of the body position is fixing, and 3cm opens abdomen under xiphoid-process, separates common bile duct, the nearly duodenum end of ligation, make the V-arrangement clip at common bile duct, after inserting the faint yellow bile of biliary drainage my humble opinion and flowing out, fixing drainage tube, close the abdominal cavity, stablize after 0.5 hour that to collect 0.5 hour bile earlier be contrast before the medicine.Thereafter each group gives different pharmaceutical through duodenum respectively, collects behind the medicine bile flow in 30,60,120,180 minutes respectively.Each animal day part bile of collecting merges, and measures content of bilirubin.
Result's (seeing Table 4) shows, compares with the blank group, and the basic, normal, high dosage group of Q-LJ all can significantly promote the secretory volume (p＜0.05,0.01) of rat bile, increases content of bilirubin (p＜0.05,0.01).Show that the bilocid sheet has tangible choleretic effect.The Q-CT group is compared with dosage among the Q-LJ, choleresis, the equal significant difference of content of bilirubin (p＜0.05), show under corresponding dosage and (be equivalent to the clinical consumption of people, be 6.3g crude drug/day), adopt the pharmacologically active of brain-benefiting blood pressure-reducing capsule aspect function of gallbladder promoting of the present invention's preparation to be better than adopting the traditional method person of preparation.
The brain-benefiting blood pressure-reducing sheet of table 4 distinct methods preparation is to rat bile secretion and bilirubinic influence (n=6)
Annotate: compare * p＜0.05, * * p＜0.01 with the blank group; Compare with dosage among the Q-LJ,
△P＜0.05.
Above-mentioned studies show that, adopting the brain-benefiting blood pressure-reducing sheet of the present invention's preparation, active constituent content is 4.3 times of the brain-benefiting blood pressure-reducing sheet that is equipped with of traditional law system.Under the situation of dose minimizing 3/4, both pharmacologically actives aspect blood pressure lowering are suitable.And the former activity aspect function of gallbladder promoting obviously is better than the latter.The former can use in preparation function of gallbladder promoting medicine.
Technical scheme of the present invention hereinafter will do further statement to its specific embodiment, but the scope of protection of present invention is not limited to following embodiment in order better to illustrate.
The specific embodiment
Embodiment 1
Get Radix Scutellariae 100g, Flos Sophorae Immaturus 60g, pulverize, mix, 75% ethanol that adds 1.6L drops in the microwave extracting apparatus and carries out microwave extracting, extraction power 400W, extract 2 times, each 5 minutes, combining extraction liquid, concentrate, be added on the chinlon 6 polyamide chromatography posts, use 60% ethanol elution, collect 5 times of amount column volume eluents, decompression recycling ethanol concentrates and drying, get a kind of reed mentioned in ancient books Chinese scholartree extract, standby; Get Spica Prunellae 60g, Radix Achyranthis Bidentatae 60g, Radix Angelicae Sinensis 100g, Radix Rehmanniae 40g, Radix Salviae Miltiorrhizae 40g, Hirudo 20g, Semen Cassiae 100g, Pheretima 20g, join CO
2In the supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1%, extracting pressure 20MPa, 50 ℃ of temperature, CO
2Flow 1ml/g crude drug min, extraction time 120min gets supercritical extract, and is standby; Get Magnetitum (calcined) 60g, Ramulus Uncariae Cum Uncis 60g, Concha Margaritifera 40g, be ground into fine powder, mixing adds above-mentioned a kind of reed mentioned in ancient books Chinese scholartree extract, supercritical extract mixing, add dextrin, 70% alcohol granulation adds magnesium stearate, mixing, tabletting, the bag film-coat is made 250, every heavy 0.33g.
After testing, content of baicalin 13.3mg/ sheet in the finished product.
The antihypertensive pharmacological action of finished product sees Table 5.
The influence (n=10, the pKA of unit) of table 5 pair SHR rat artery systolic pressure
| Group | Dosage g/Kg | Before the administration | 30min behind the medicine |
| Blank group | - | 31.3±2.6 | 31.5±2.1 |
| Embodiment 1 | 0.08 ? | 31.5±2.5 | 27.6±2.4** |
Compare with the blank group: * P＜0.05, * * P＜0.01.
Embodiment 2
Get Radix Scutellariae 100g, Flos Sophorae Immaturus 60g, pulverize, mix, 75% ethanol that adds 1.6L drops in the microwave extracting apparatus and carries out microwave extracting, extraction power 600W, extract 2 times, each 5 minutes, combining extraction liquid, concentrate, be added on the chinlon 6 polyamide chromatography posts, use 60% ethanol elution, collect 5 times of amount column volume eluents, decompression recycling ethanol concentrates and drying, get a kind of reed mentioned in ancient books Chinese scholartree extract, standby; Get Spica Prunellae 60g, Radix Achyranthis Bidentatae 60g, Radix Angelicae Sinensis 100g, Radix Rehmanniae 40g, Radix Salviae Miltiorrhizae 40g, Hirudo 20g, Semen Cassiae 100g, Pheretima 20g, join CO
2In the supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 3%, extracting pressure 30MPa, 70 ℃ of temperature, CO
2Flow 3ml/g crude drug min, extraction time 140min gets supercritical extract, and is standby; Get Magnetitum (calcined) 60g, Ramulus Uncariae Cum Uncis 60g, Concha Margaritifera 40g, be ground into fine powder, mixing adds above-mentioned a kind of reed mentioned in ancient books Chinese scholartree extract, supercritical extract mixing, add dextrin, 70% alcohol granulation adds magnesium stearate, mixing, tabletting, the bag film-coat is made 250, every heavy 0.33g.
After testing, content of baicalin 13.2mg/ sheet in the finished product in the finished product.
The antihypertensive pharmacological action of finished product sees Table 6.
The influence (n=10, the pKA of unit) of table 6 pair SHR rat artery systolic pressure
| Group | Dosage g/Kg | Before the administration | 30min behind the medicine |
| Blank group | - | 31.3±2.6 | 31.5±2.1 |
| Embodiment 2 | 0.08 ? | 31.6±2.4 | 27.4±2.5** |
Compare with the blank group: * P＜0.05, * * P＜0.01.
Embodiment 3
Get Radix Scutellariae 100g, Flos Sophorae Immaturus 60g, pulverize, mix, 75% ethanol that adds 1.6L drops in the microwave extracting apparatus and carries out microwave extracting, extraction power 500W, extract 2 times, each 5 minutes, combining extraction liquid, concentrate, be added on the chinlon 66 polyamide chromatography posts, use 60% ethanol elution, collect 5 times of amount column volume eluents, decompression recycling ethanol concentrates and drying, get a kind of reed mentioned in ancient books Chinese scholartree extract, standby; Get Spica Prunellae 60g, Radix Achyranthis Bidentatae 60g, Radix Angelicae Sinensis 100g, Radix Rehmanniae 40g, Radix Salviae Miltiorrhizae 40g, Hirudo 20g, Semen Cassiae 100g, Pheretima 20g, join CO
2In the supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 2%, extracting pressure 25MPa, 60 ℃ of temperature, CO
2Flow 2ml/g crude drug min, extraction time 130min gets supercritical extract, and is standby; Get Magnetitum (calcined) 60g, Ramulus Uncariae Cum Uncis 60g, Concha Margaritifera 40g, be ground into fine powder, mixing adds above-mentioned a kind of reed mentioned in ancient books Chinese scholartree extract, supercritical extract mixing, add dextrin, 70% alcohol granulation adds magnesium stearate, mixing, tabletting, the bag film-coat is made 250, every heavy 0.33g.
Claims (1)
1. the preparation method of a brain-benefiting blood pressure-reducing sheet is characterized in that: get Radix Scutellariae 100g, Flos Sophorae Immaturus 60g, pulverize, mix, add 75% ethanol of 1.6L, drop in the microwave extracting apparatus and carry out microwave extracting, extraction power 500W extracts each 5 minutes 2 times, combining extraction liquid concentrates, and is added on the chinlon 66 polyamide chromatography posts, use 60% ethanol elution, collect 5 times of amount column volume eluents, decompression recycling ethanol, concentrate and drying, get a kind of reed mentioned in ancient books Chinese scholartree extract, standby; Get Spica Prunellae 60g, Radix Achyranthis Bidentatae 60g, Radix Angelicae Sinensis 100g, Radix Rehmanniae 40g, Radix Salviae Miltiorrhizae 40g, Hirudo 20g, Semen Cassiae 100g, Pheretima 20g, join CO
2In the supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 2%, extracting pressure 25MPa, 60 ℃ of temperature, CO
2Flow 2ml/g crude drug min, extraction time 130min gets supercritical extract, and is standby; Get Magnetitum (calcined) 60g, Ramulus Uncariae Cum Uncis 60g, Concha Margaritifera 40g, be ground into fine powder, mixing adds above-mentioned a kind of reed mentioned in ancient books Chinese scholartree extract, supercritical extract mixing, add dextrin, 70% alcohol granulation adds magnesium stearate, mixing, tabletting, the bag film-coat is made 250, every heavy 0.33g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103813518A CN102397394B (en) | 2011-11-26 | 2011-11-26 | Preparation method of cephalocathartic hypertension pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103813518A CN102397394B (en) | 2011-11-26 | 2011-11-26 | Preparation method of cephalocathartic hypertension pill |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102397394A CN102397394A (en) | 2012-04-04 |
| CN102397394B true CN102397394B (en) | 2013-08-21 |
Family
ID=45880292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103813518A Expired - Fee Related CN102397394B (en) | 2011-11-26 | 2011-11-26 | Preparation method of cephalocathartic hypertension pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102397394B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988577B (en) * | 2012-10-15 | 2013-11-06 | 李正梅 | Preparation method and application of brain-soothing hypertension pill |
| CN102885935B (en) * | 2012-10-31 | 2015-03-25 | 江苏晨牌药业集团股份有限公司 | Production technology of cephalocathartic hypertension particles |
| JP5548931B1 (en) * | 2013-09-03 | 2014-07-16 | ワキ製薬株式会社 | Earthworm dry powder manufacturing method |
| CN104352561A (en) * | 2014-11-11 | 2015-02-18 | 成都华熹科技有限公司 | Radix achyranthis bidentatae-containing traditional Chinese medicine composition for lowering blood pressure |
| CN105497259A (en) * | 2016-01-04 | 2016-04-20 | 四川双鑫生物科技有限公司 | Orally-taken medicine for treating dizziness caused by hyperactivity of liver-yang and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1366915A (en) * | 2001-01-22 | 2002-09-04 | 杨孟君 | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method |
| CN101703610A (en) * | 2009-11-30 | 2010-05-12 | 贵阳新天药业股份有限公司 | Quality detection method of Qingnao antihypertensive tablet |
-
2011
- 2011-11-26 CN CN2011103813518A patent/CN102397394B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1366915A (en) * | 2001-01-22 | 2002-09-04 | 杨孟君 | Nano brain-benefiting blood pressure-reducing preparation medicine and preparation method |
| CN101703610A (en) * | 2009-11-30 | 2010-05-12 | 贵阳新天药业股份有限公司 | Quality detection method of Qingnao antihypertensive tablet |
Non-Patent Citations (4)
| Title |
|---|
| 史清文等.清脑降压片中几种主要有效成分的薄层层析鉴别.《中国医院药学杂志》.1992,(第03期), |
| 曾惠芳等.清脑降压片质量标准研究.《时珍国医国药》.2007,(第07期), |
| 清脑降压片中几种主要有效成分的薄层层析鉴别;史清文等;《中国医院药学杂志》;19920328(第03期);117-119 * |
| 清脑降压片质量标准研究;曾惠芳等;《时珍国医国药》;20070720(第07期);1722-1724 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102397394A (en) | 2012-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2589994C (en) | A pharmaceutical composition for the treatment and/or prevention of hyperlipidemia, processes for producing the same and the use thereof | |
| CN102397394B (en) | Preparation method of cephalocathartic hypertension pill | |
| CN102397451A (en) | Preparation method of cholagogic tablet | |
| CN101919979B (en) | Detection method of traditional Chinese medicine composition for soothing liver-qi stagnation and tonifying spleen and removing dampness | |
| CN102397497B (en) | Method for preparing tablets for treating pharyngitis | |
| CN1814170B (en) | Medicinal drop pills for treating cardiovascular disease and preparing method | |
| CN101357203B (en) | Preparation for treating cancer and carcinoma and preparation method thereof | |
| CN102397460B (en) | Preparation method of Kang'erxin capsule | |
| CN100571761C (en) | A kind of Chinese medicine composition and preparation method for the treatment of hepatopathy | |
| CN105031005A (en) | Micro pills capable of tonifying qi and benefiting blood | |
| CN103524578B (en) | A kind of method of extraction and isolation paeoniflorin compound from tree peony stamen | |
| CN106266343A (en) | A kind of preparation method of dispersing brain blood | |
| CN102397346B (en) | Method for preparing hepatitis B health-energy-strengthening capsule | |
| CN102397453B (en) | Method for preparing tablets for treating rhinitis | |
| CN106466396B (en) | Gynaecologic menstruation regulating sustained-release dropping pill and preparation method thereof | |
| CN104415111A (en) | Kuhuang injection liquid and preparation method thereof | |
| CN102397349A (en) | Method for preparing Xinning tablets | |
| CN101444609B (en) | Traditional Chinese medicine with drug treatment function and preparation technique thereof | |
| CN107982375B (en) | Preparation method of wind-cold double-throw piece | |
| CN107551099A (en) | It is a kind of to be used to treat Chinese medicine composition of senile dementia and preparation method thereof | |
| CN101757123B (en) | Composition for treating hypertension and preparation method thereof | |
| CN103566168B (en) | Preparation method and application of tranquilizing tablets | |
| CN102210763B (en) | Chinese medicinal composition for promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain and preparation method thereof | |
| CN102106966B (en) | Preparation method of Chinese medicinal composition with functions of supplementing qi and nourishing blood | |
| CN102018740A (en) | Medicinal composition containing extracts of leaves of helianthus and application of the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: GUANGXI SHIBIAO PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SUZHOU PAITENG BIOPHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20140703 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 215011 SUZHOU, JIANGSU PROVINCE TO: 535300 QINZHOU, GUANGXI ZHUANG AUTONOMOUS REGION |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140703 Address after: 535300 the Guangxi Zhuang Autonomous Region Pubei County town Town Road No. 8 Patentee after: Guangxi Shibiao Pharmaceutical Co., Ltd. Address before: 215011 Jiangsu high tech Zone Suzhou City Binhe Road, No. 1326 Patentee before: Suzhou Paiteng Biopharmaceutical Technology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130821 Termination date: 20151126 |
|
| EXPY | Termination of patent right or utility model |